{"id":343,"date":"2026-09-08T09:00:00","date_gmt":"2026-09-08T09:00:00","guid":{"rendered":"https:\/\/cntumour.com\/cancer\/ampullary-cancer-cancer-types\/"},"modified":"2026-10-29T15:53:20","modified_gmt":"2026-10-29T15:53:20","slug":"ampullary-cancer-cancer-types","status":"publish","type":"cancer_type","link":"https:\/\/cntumour.com\/zh-hk\/cancer\/ampullary-cancer-cancer-types\/","title":{"rendered":"\u58fa\u8179\u764c"},"content":{"rendered":"<div class=\"ac-blog-article\">\n<p class=\"ac-blog-lead\"><strong>\u4e86\u89e3\u58fa\u8179\u764c\u9996\u5148\u8981\u4e86\u89e3\u5176\u8d77\u6e90\u3002\u58fa\u8179\u764c\u662f\u4e00\u7a2e\u7f55\u898b\u7684\u60e1\u6027\u816b\u7624\uff0c\u767c\u751f\u65bc\u58fa\u8179\uff0c\u58fa\u8179\u662f\u81bd\u7ba1\u548c\u80f0\u7ba1\u7684\u91cd\u8981\u4ea4\u6703\u8655\u3002\u5728\u9019\u88e1\uff0c\u81bd\u6c41\u548c\u6d88\u5316\u9175\u7d20\u6d41\u5165\u5c0f\u8178\uff0c\u5728\u6d88\u5316\u548c\u71df\u990a\u5438\u6536\u4e2d\u767c\u63ee\u95dc\u9375\u4f5c\u7528\u3002<\/strong><\/p>\n<nav class=\"ac-blog-toc\" aria-label=\"\u672c\u6587\u5c0e\u89bd\">\n<p><strong>\u672c\u6587\u5c0e\u89bd<\/strong><\/p>\n<ul>\n<li><a href=\"#what-is-ampullary-cancer\">\u4ec0\u9ebc\u662f\u58fa\u8179\u764c\uff1f<\/a><\/li>\n<li><a href=\"#understanding-causes-and-risk-factors-of-ampullary-cancer\">\u4e86\u89e3\u58fa\u8179\u764c\u7684\u539f\u56e0\u548c\u98a8\u96aa\u56e0\u7d20<\/a><\/li>\n<li><a href=\"#symptoms-of-ampullary-cancer\">\u58fa\u8179\u764c\u7684\u75c7\u72c0<\/a><\/li>\n<li><a href=\"#stages-of-ampullary-cancer-and-survival-rates\">\u58fa\u8179\u764c\u7684\u5206\u671f\u8207\u5b58\u6d3b\u7387<\/a><\/li>\n<li><a href=\"#limitations-of-traditional-therapies-for-ampullary-cancer\">\u58fa\u8179\u764c\u50b3\u7d71\u7642\u6cd5\u7684\u5c40\u9650\u6027<\/a><\/li>\n<\/ul>\n<\/nav>\n<h2 id=\"what-is-ampullary-cancer\">\u4ec0\u9ebc\u662f\u58fa\u8179\u764c\uff1f<\/h2>\n<p>\u5f9e\u751f\u7269\u5b78\u4e0a\u4f86\u8aaa\uff0c\u58fa\u8179\u764c\u662f\u7531\u7570\u5e38\u7d30\u80de\u751f\u9577\u5f15\u8d77\u7684\uff0c\u4e3b\u8981\u662f\u817a\u7d30\u80de\uff08\u817a\u764c\uff09\u3002\u8207\u8a31\u591a\u764c\u75c7\u4e00\u6a23\uff0c\u5b83\u8868\u73fe\u51fa\u4ee3\u8b1d\u91cd\u7de8\u7a0b\uff1a\u7d30\u80de\u900f\u904e\u7cd6\u89e3\u4f5c\u7528\uff08\u773e\u6240\u5468\u77e5\u7684\u7cd6\u89e3\u4f5c\u7528\uff09\u8868\u73fe\u51fa\u8461\u8404\u7cd6\u6d88\u8017\u589e\u52a0 <strong>\u74e6\u723e\u5821\u6548\u61c9<\/strong>\u3002\u5728\u58fa\u8179\u764c\u4e2d\uff0c\u9019\u7a2e\u65b0\u9673\u4ee3\u8b1d\u7684\u6539\u8b8a\u5c0e\u81f4\u7d30\u80de\u6d88\u8017\u8461\u8404\u7cd6\u7684\u901f\u5ea6\u6bd4\u6b63\u5e38\u7d30\u80de\u5feb 200 \u500d\uff0c\u70ba\u6cbb\u7642\u63d0\u4f9b\u4e86\u6f5b\u5728\u7684\u76ee\u6a19\u3002<\/p>\n<p>\u5118\u7ba1\u58fa\u8179\u764c\u88ab\u8a8d\u70ba\u76f8\u5c0d\u7f55\u898b\uff0c\u4f46\u5b83\u7d04\u4f54\u5168\u4e16\u754c\u80c3\u8178\u9053\u60e1\u6027\u816b\u7624\u7684 0.2%\u3002\u5728\u5305\u62ec\u9999\u6e2f\u5728\u5167\u7684\u4e9e\u6d32\uff0c\u58fa\u8179\u764c\u767c\u751f\u7387\u8fd1\u5e7e\u5341\u5e74\u4f86\u9010\u6f38\u4e0a\u5347\uff0c\u90e8\u5206\u539f\u56e0\u662f\u751f\u6d3b\u65b9\u5f0f\u56e0\u7d20\u548c\u4eba\u53e3\u8001\u5316\u3002<\/p>\n<p>\u58fa\u8179\u764c\u6700\u5e38\u5f71\u97ff 50 \u6b72\u81f3 70 \u6b72\u4e4b\u9593\u7684\u65cf\u7fa4\uff0c\u7537\u6027\u767c\u751f\u7387\u7565\u9ad8\u65bc\u5973\u6027\u3002\u907a\u50b3\u50be\u5411\uff0c\u5305\u62ec\u5bb6\u65cf\u6027\u817a\u7624\u6027\u606f\u8089\u75c5 (FAP) \u548c\u6797\u5947\u7d9c\u5408\u5fb5\uff0c\u6703\u5c0e\u81f4\u67d0\u4e9b\u5bb6\u5ead\u7684\u98a8\u96aa\u8f03\u9ad8\uff0c\u5f9e\u800c\u5f37\u8abf\u4e86\u5c0d\u907a\u50b3\u50be\u5411\u4eba\u7fa4\u9032\u884c\u8b66\u60d5\u7be9\u6aa2\u7684\u91cd\u8981\u6027\u3002<\/p>\n<p>\u58fa\u8179\u764c\u5c0d\u60c5\u7dd2\u548c\u8eab\u9ad4\u7684\u5f71\u97ff\u662f\u6df1\u9060\u7684\u3002\u60a3\u8005\u5e38\u6703\u51fa\u73fe\u9ec3\u75b8\u3001\u8179\u90e8\u4e0d\u9069\u3001\u9ad4\u91cd\u610f\u5916\u6e1b\u8f15\u3001\u75b2\u5026\u3001\u5641\u5fc3\u548c\u5927\u4fbf\u984f\u8272\u8b8a\u5316\u7b49\u75c7\u72c0\u3002\u5728\u9999\u6e2f\uff0c\u78ba\u8a3a\u60a3\u8005\u7d93\u5e38\u9762\u81e8\u60c5\u7dd2\u548c\u5fc3\u7406\u58d3\u529b\uff0c\u56e0\u6b64\u9700\u8981\u5bcc\u6709\u540c\u60c5\u5fc3\u548c\u5168\u9762\u7684\u7167\u8b77\u65b9\u6cd5\u3002<\/p>\n<ul>\n<li>\u9ec3\u75b8\uff08\u76ae\u819a\u548c\u773c\u775b\u767c\u9ec3\uff09<\/li>\n<li>\u8179\u75db<\/li>\n<li>\u9ad4\u91cd\u6e1b\u8f15\u548c\u98df\u617e\u4e0d\u632f<\/li>\n<li>\u75b2\u52de\u548c\u865b\u5f31<\/li>\n<li>\u5927\u4fbf\u84bc\u767d\u3001\u6cb9\u81a9<\/li>\n<\/ul>\n<p>\u9451\u65bc\u5967\u6258\u00b7\u74e6\u723e\u5821\u7b49\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u4ee5\u53ca\u6700\u8fd1\u7684\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u827e\u5229\u68ee\u548c\u585e\u9580\u624e\u6240\u63cf\u8ff0\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\uff0c\u91dd\u5c0d\u7d30\u80de\u80fd\u91cf\u6a5f\u5236\u7684\u73fe\u4ee3\u4ee3\u8b1d\u7642\u6cd5\u6709\u671b\u5be6\u73fe\u3002\u9999\u6e2f\u764c\u75c7\u6cbb\u7642\u5148\u9a45\u674e\u570b\u83ef\u535a\u58eb\u5275\u65b0\u5730\u5c07\u4ee3\u8b1d\u816b\u7624\u5b78\u8207\u50b3\u7d71\u7642\u6cd5\u76f8\u7d50\u5408\uff0c\u986f\u8457\u6539\u5584\u4e86\u8d85\u904e 12,000 \u540d\u764c\u75c7\u60a3\u8005\u7684\u6cbb\u7642\u7d50\u679c\u548c\u751f\u6d3b\u8cea\u7d20\u3002<\/p>\n<p>\u63a2\u7d22\u66f4\u6df1\u5165\u7684\u898b\u89e3 <a href=\"\/zh-hk\/treatment-cancer\/\">\u764c\u75c7\u751f\u7269\u5b78<\/a> \u6216\u9810\u8a02\u6700\u5148\u9032\u7684\u670d\u52d9 <a href=\"\/zh-hk\/our-hospital\/\">\u8a3a\u65b7\u6aa2\u67e5<\/a> \u53ef\u5728 AllCancer \u8cfc\u8cb7\u3002<\/p>\n<h2 id=\"understanding-causes-and-risk-factors-of-ampullary-cancer\">\u4e86\u89e3\u58fa\u8179\u764c\u7684\u539f\u56e0\u548c\u98a8\u96aa\u56e0\u7d20<\/h2>\n<p>\u4e86\u89e3\u58fa\u8179\u764c\u7684\u6839\u672c\u539f\u56e0\u548c\u98a8\u96aa\u56e0\u7d20\u53ef\u4ee5\u4fc3\u9032\u65e9\u671f\u5e79\u9810\uff0c\u6700\u7d42\u6539\u5584\u60a3\u8005\u7684\u9810\u5f8c\u3002\u58fa\u8179\u764c\u4e3b\u8981\u6e90\u81ea\u65bc\u907a\u50b3\u50be\u5411\u3001\u74b0\u5883\u5f71\u97ff\u548c\u500b\u4eba\u751f\u6d3b\u65b9\u5f0f\u6c7a\u5b9a\u7684\u7d9c\u5408\u4f5c\u7528\u3002<\/p>\n<h3 id=\"genetic-and-family-history-factors\">\u907a\u50b3\u548c\u5bb6\u65cf\u53f2\u56e0\u7d20<\/h3>\n<p>\u57fa\u56e0\u7a81\u8b8a\u986f\u8457\u589e\u52a0\u58fa\u8179\u764c\u7684\u98a8\u96aa\u3002\u5bb6\u65cf\u6027\u817a\u7624\u6027\u606f\u8089\u75c7 (FAP) \u7684\u7279\u5fb5\u662f\u7d50\u8178\/\u76f4\u8178\u5167\u6709\u6578\u767e\u81f3\u6578\u5343\u500b\u606f\u8089\uff0c\u986f\u8457\u589e\u52a0\u58fa\u8179\u764c\u7684\u98a8\u96aa\u3002\u540c\u6a23\uff0c\u6797\u5947\u75c7\u5019\u7fa4\u8207\u80c3\u8178\u9053\u60e1\u6027\u816b\u7624\uff08\u5305\u62ec\u58fa\u8179\u764c\uff09\u7684\u589e\u52a0\u6709\u95dc\u3002<\/p>\n<ul>\n<li>\u5bb6\u65cf\u6027\u817a\u7624\u6027\u606f\u8089\u75c7 (FAP)<\/li>\n<li>\u6797\u5947\u75c7\u5019\u7fa4\uff08\u907a\u50b3\u6027\u975e\u606f\u8089\u6027\u5927\u8178\u76f4\u8178\u764c\uff09<\/li>\n<\/ul>\n<h3 id=\"lifestyle-and-environmental-factors\">\u751f\u6d3b\u65b9\u5f0f\u548c\u74b0\u5883\u56e0\u7d20<\/h3>\n<p>\u67d0\u4e9b\u74b0\u5883\u548c\u751f\u6d3b\u65b9\u5f0f\u65b9\u9762\u4e5f\u767c\u63ee\u95dc\u9375\u4f5c\u7528\u3002\u5438\u83f8\u986f\u8457\u589e\u52a0\u80c3\u8178\u9053\u764c\u75c7\u98a8\u96aa\uff0c\u4f54\u5168\u7403\u764c\u75c7\u76f8\u95dc\u6b7b\u4ea1\u7387\u7684\u7d04 25%-30%\u3002\u5728\u4e9e\u6d32\uff0c\u7279\u5225\u662f\u9999\u6e2f\uff0c\u5118\u7ba1\u63a1\u53d6\u4e86\u516c\u5171\u885b\u751f\u8209\u63aa\uff0c\u5438\u7159\u7387\u4ecd\u7136\u4ee4\u4eba\u64d4\u6182\u3002<\/p>\n<ul>\n<li>\u5438\u7159<\/li>\n<li>\u9ad8\u8102\u80aa\u3001\u4f4e\u7e96\u7dad\u98f2\u98df<\/li>\n<li>\u80a5\u80d6\u548c\u4e45\u5750\u7684\u751f\u6d3b\u65b9\u5f0f<\/li>\n<li>\u9577\u671f\u98f2\u9152<\/li>\n<li>\u63a5\u89f8\u67d0\u4e9b\u5de5\u696d\u5316\u5b78\u54c1<\/li>\n<\/ul>\n<h3 id=\"metabolic-vulnerability-and-cellular-dependency\">\u4ee3\u8b1d\u8106\u5f31\u6027\u548c\u7d30\u80de\u4f9d\u8cf4\u6027<\/h3>\n<p>\u58fa\u8179\u764c\u7814\u7a76\u7684\u4e00\u500b\u7a81\u7834\u6027\u9818\u57df\u6d89\u53ca\u8461\u8404\u7cd6\u548c\u8c37\u6c28\u9170\u80fa\u4f9d\u8cf4\u6027\u7b49\u4ee3\u8b1d\u8106\u5f31\u6027\u3002\u58fa\u8179\u764c\u7d30\u80de\u900f\u904e\u6709\u6c27\u7cd6\u89e3\uff08\u74e6\u723e\u5821\u6548\u61c9\uff09\u56b4\u91cd\u4f9d\u8cf4\u8461\u8404\u7cd6\u63d0\u4f9b\u80fd\u91cf\uff0c\u4e26\u4f9d\u8cf4\u9ea9\u91af\u80fa\u9178\u751f\u6210\u6838\u82f7\u9178\u3001\u86cb\u767d\u8cea\u548c\u5176\u4ed6\u5c0d\u589e\u6b96\u548c\u751f\u5b58\u81f3\u95dc\u91cd\u8981\u7684\u7d30\u80de\u6210\u5206\u3002<\/p>\n<ul>\n<li>\u8207\u6b63\u5e38\u7d30\u80de\u76f8\u6bd4\uff0c\u8461\u8404\u7cd6\u4ee3\u8b1d\u589e\u52a0\u9ad8\u9054200\u500d<\/li>\n<li>\u5927\u7d04 50% \u7684\u6838\u82f7\u9178\u5408\u6210\u4f9d\u8cf4\u9ea9\u91af\u80fa\u9178<\/li>\n<li>\u6f5b\u5728\u7684\u6cbb\u7642\u6f0f\u6d1e\uff0c\u4f8b\u5982\u4ee3\u8b1d\u9014\u5f91\u6291\u5236\u5291<\/li>\n<\/ul>\n<h3 id=\"regional-asian-specific-risks\">\u4e9e\u6d32\u5730\u5340\u7279\u6709\u7684\u98a8\u96aa<\/h3>\n<p>\u5728\u9999\u6e2f\u548c\u4e9e\u6d32\u5176\u4ed6\u5730\u5340\uff0c\u7368\u7279\u7684\u5340\u57df\u98a8\u96aa\u56e0\u7d20\u5c0e\u81f4\u80c3\u8178\u9053\u764c\u75c7\uff08\u5305\u62ec\u58fa\u8179\u90e8\u764c\uff09\u7684\u767c\u751f\u7387\u8f03\u9ad8\u3002\u9999\u6e2f\u6d41\u884c\u7684\u4e59\u578b\u809d\u708e\u611f\u67d3\u8207\u80c3\u8178\u9053\u764c\u75c7\u4e4b\u9593\u7684\u5bc6\u5207\u76f8\u95dc\u6027\u8b49\u660e\u6709\u5fc5\u8981\u9032\u884c\u6709\u91dd\u5c0d\u6027\u7684\u5340\u57df\u7be9\u6aa2\u3002<\/p>\n<ul>\n<li>\u4e59\u578b\u53ca\u4e19\u578b\u809d\u708e\u611f\u67d3\u76db\u884c\u7387<\/li>\n<li>\u5927\u91cf\u98df\u7528\u9183\u88fd\u548c\u52a0\u5de5\u98df\u54c1<\/li>\n<li>\u57ce\u5e02\u751f\u6d3b\u65b9\u5f0f\u548c\u6c61\u67d3\u66b4\u9732\u7684\u589e\u52a0<\/li>\n<\/ul>\n<p>\u610f\u8b58\u548c\u65e9\u671f\u5e79\u9810\u7b56\u7565\uff0c\u4f8b\u5982\u57fa\u56e0\u7be9\u6aa2\u548c\u5b9a\u671f\u6aa2\u67e5\uff0c\u4f7f\u500b\u4eba\u80fd\u5920\u964d\u4f4e\u98a8\u96aa\u4e26\u767c\u73fe\u968e\u6bb5\u6027\u60e1\u6027\u816b\u7624\u3002\u5728 AllCancer\uff0c\u8207 MD \u5b89\u5fb7\u68ee\u548c\u6df1\u5733\u524d\u6d77\u6cf0\u5eb7\u7b49\u6a5f\u69cb\u7684\u5408\u4f5c\u5229\u7528\u5168\u7403\u7814\u7a76\u4f86\u555f\u52d5\u4ee5\u5275\u65b0\u70ba\u91cd\u9ede\u7684\u9810\u9632\u8a08\u5283\u548c\u65e9\u671f\u6aa2\u6e2c\u6846\u67b6\u3002<\/p>\n<p>\u4e86\u89e3 AllCancer \u7684\u958b\u5275\u6027 4D \u7642\u6cd5\u7b49\u9769\u547d\u6027\u7642\u6cd5\u5982\u4f55\u900f\u904e\u89e3\u6c7a\u58fa\u8179\u764c\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\u4f86\u6539\u8b8a\u751f\u6d3b\uff0c\u9019\u4e9b\u7642\u6cd5\u5f97\u5230\u4e86\u7f8e\u570b\u3001\u6b50\u76df\u3001\u65e5\u672c\u548c\u4e2d\u570b\u7684\u5168\u7403\u5c08\u5229\u7684\u652f\u6301\u3002<\/p>\n<p>\u638c\u63a7\u4f60\u7684\u5065\u5eb7\u2014\u2014 <a href=\"\/zh-hk\/treatment-cancer\/\">\u63a2\u7d22 AllCancer \u63d0\u4f9b\u7684\u6838\u5fc3\u7642\u6cd5<\/a> \u4eca\u5929\uff0c\u52a0\u5165\u7121\u6578\u5176\u4ed6\u6210\u529f\u7684\u60a3\u8005\u65c5\u7a0b\uff0c\u4f8b\u5982\u7d04\u7ff0\u7684\u80ba\u764c\u7de9\u89e3\u6216\u7c21\u7684\u9f13\u821e\u4eba\u5fc3\u7684\u6230\u9b25\u4e26\u6210\u529f\u7de9\u89e3\u7b2c 4 \u671f\u4e73\u817a\u764c\u3002<\/p>\n<h2 id=\"symptoms-of-ampullary-cancer\">\u58fa\u8179\u764c\u7684\u75c7\u72c0<\/h2>\n<p>\u4e86\u89e3\u8207\u58fa\u8179\u764c\u76f8\u95dc\u7684\u75c7\u72c0\u5c0d\u65bc\u5be6\u73fe\u65e9\u671f\u8a3a\u65b7\u548c\u986f\u8457\u6539\u5584\u9810\u5f8c\u7d50\u679c\u81f3\u95dc\u91cd\u8981\u3002\u5e38\u89c0\u5bdf\u5230\u7684\u75c7\u72c0\u901a\u5e38\u8207\u816b\u7624\u4f4d\u65bc\u6cd5\u7279\u58fa\u8179\u9644\u8fd1\u76f8\u95dc\uff0c\u9019\u88e1\u662f\u81bd\u7ba1\u548c\u80f0\u7ba1\u8207\u5c0f\u8178\u7684\u4ea4\u6703\u8655\u3002\u8a8d\u8b58\u5230\u9019\u4e9b\u8de1\u8c61\u53ef\u4ee5\u53ca\u6642\u9032\u884c\u91ab\u7642\u8a55\u4f30\u548c\u7ba1\u7406\u3002<\/p>\n<h3 id=\"common-symptoms-of-ampullary-cancer\">\u58fa\u8179\u764c\u7684\u5e38\u898b\u75c7\u72c0<\/h3>\n<p>\u81e8\u5e8a\u8868\u73fe\u53ef\u80fd\u56e0\u816b\u7624\u5927\u5c0f\u548c\u60a3\u8005\u6240\u8655\u968e\u6bb5\u800c\u6709\u5f88\u5927\u5dee\u7570\u3002\u4ee5\u4e0b\u662f\u58fa\u8179\u764c\u6700\u5e38\u898b\u7684\u75c7\u72c0\uff1a<\/p>\n<ul>\n<li>\u9ec3\u75b8\uff08\u76ae\u819a\u548c\u773c\u775b\u767c\u9ec3\uff09<\/li>\n<li>\u6301\u7e8c\u7684\u4e0a\u8179\u90e8\u75bc\u75db\u901a\u5e38\u5411\u5f8c\u653e\u5c04<\/li>\n<li>\u9ad4\u91cd\u6e1b\u8f15\u548c\u98df\u617e\u4e0d\u632f<\/li>\n<li>\u75b2\u52de\u548c\u5168\u8eab\u7121\u529b<\/li>\n<li>\u84bc\u767d\u6216\u9ecf\u571f\u8272\u7684\u7cde\u4fbf\uff08\u8868\u793a\u81bd\u7ba1\u963b\u585e\uff09<\/li>\n<li>\u7531\u65bc\u8840\u6db2\u4e2d\u81bd\u7d05\u7d20\u904e\u591a\u800c\u5c0e\u81f4\u5c3f\u6db2\u5448\u73fe\u6df1\u8272<\/li>\n<li>\u5641\u5fc3\u548c\u5076\u723e\u5614\u5410\uff0c\u901a\u5e38\u8207\u6d88\u5316\u9053\u963b\u585e\u6709\u95dc<\/li>\n<li>\u5c11\u91cf\u591a\u9910\u5f8c\u6d88\u5316\u4e0d\u826f\u6216\u98fd\u8db3\u611f<\/li>\n<li>\u80c3\u9006\u6d41\u6216\u80c3\u707c\u71b1<\/li>\n<li>\u665a\u671f\u53ef\u89f8\u53ca\u8179\u90e8\u816b\u584a<\/li>\n<\/ul>\n<h3 id=\"symptoms-by-cancer-stage\">\u764c\u75c7\u5206\u671f\u7684\u75c7\u72c0<\/h3>\n<p>\u6839\u64da\u764c\u75c7\u968e\u6bb5\u7684\u4e0d\u540c\uff0c\u75c7\u72c0\u53ef\u80fd\u6703\u6709\u5f88\u5927\u5dee\u7570\uff0c\u5f37\u8abf\u65e9\u671f\u767c\u73fe\u548c\u53ca\u6642\u6cbb\u7642\u4ecb\u5165\u7684\u91cd\u8981\u6027\uff1a<\/p>\n<ul>\n<li><strong>\u65e9\u671f\u58fa\u8179\u764c\uff1a<\/strong> \u8f15\u5ea6\u9ec3\u75b8\uff0c\u8f15\u5fae\u6d88\u5316\u4e0d\u9069\uff0c\u5076\u723e\u8179\u90e8\u4e0d\u9069\uff0c\u8f15\u5fae\u9ad4\u91cd\u6e1b\u8f15\u3002<\/li>\n<li><strong>\u4e2d\u671f\u58fa\u8179\u764c\uff1a<\/strong> \u660e\u986f\u9ec3\u75b8\u3001\u8179\u75db\u5e38\u653e\u5c04\u81f3\u80cc\u90e8\u3001\u9ad4\u91cd\u6e1b\u8f15\u660e\u986f\u3001\u8f15\u5ea6\u81f3\u4e2d\u5ea6\u75b2\u5026\u3002<\/li>\n<li><strong>\u665a\u671f\u58fa\u8179\u764c\uff1a<\/strong> \u56b4\u91cd\u9ec3\u75b8\u3001\u9ad4\u91cd\u56b4\u91cd\u6e1b\u8f15\u3001\u660e\u986f\u75b2\u52de\u3001\u53ef\u89f8\u53ca\u8179\u90e8\u816b\u584a\u3001\u6301\u7e8c\u4e14\u4e0d\u65b7\u5347\u7d1a\u7684\u8179\u75db\u3001\u5641\u5fc3\u548c\u5614\u5410\u3002<\/li>\n<\/ul>\n<p>\u6240\u8868\u73fe\u7684\u75c7\u72c0\u53cd\u6620\u4e86\u6f5b\u5728\u7684\u816b\u7624\u751f\u7269\u5b78\u53ca\u5176\u5c0d\u5c40\u90e8\u89e3\u5256\u7d50\u69cb\uff08\u4f8b\u5982\u81bd\u7ba1\u548c\u80f0\u8840\u6d41\uff09\u7684\u5f71\u97ff\u3002\u816b\u7624\u751f\u9577\u5c0e\u81f4\u963b\u585e\u75c7\u72c0\u548c\u4ee3\u8b1d\u6539\u8b8a\uff0c\u8207\u89c0\u5bdf\u5230\u7684\u81e8\u5e8a\u75c7\u72c0\u4e00\u81f4\u3002<\/p>\n<p><strong>\u65e9\u671f\u8b58\u5225\u81f3\u95dc\u91cd\u8981\u3002<\/strong> \u89c0\u5bdf\u9019\u4e9b\u75c7\u72c0\u5f8c\u7acb\u5373\u9032\u884c\u91ab\u5b78\u8a55\u4f30\u53ef\u4ee5\u5be6\u73fe\u6700\u4f73\u7684\u65e9\u671f\u7ba1\u7406\u4e26\u986f\u8457\u6539\u5584\u9810\u5f8c\u7d50\u679c\u3002 <a href=\"\/zh-hk\/our-hospital\/\">\u63a2\u7d22\u6211\u5011\u7684\u8a3a\u65b7\u8cc7\u6e90\u4ee5\u5118\u65e9\u767c\u73fe\u58fa\u8179\u764c\u3002<\/a><\/p>\n<h2 id=\"stages-of-ampullary-cancer-and-survival-rates\">\u58fa\u8179\u764c\u7684\u5206\u671f\u8207\u5b58\u6d3b\u7387<\/h2>\n<p>\u8a3a\u65b7\u5f8c\u5c0d\u764c\u75c7\u5206\u671f\u7684\u8a55\u4f30\u53ef\u4ee5\u6df1\u5165\u4e86\u89e3\u9810\u5f8c\u548c\u9069\u7576\u7684\u6cbb\u7642\u9014\u5f91\u3002\u6bcf\u500b\u968e\u6bb5\u90fd\u6709\u7368\u7279\u7684\u7279\u5fb5\u548c\u91cf\u8eab\u5b9a\u5236\u7684\u6cbb\u7642\u65b9\u6848\u3002\u6211\u5011\u63d0\u4f9b\u8207\u9999\u6e2f\u548c\u66f4\u5ee3\u6cdb\u7684\u4e9e\u6d32\u5730\u5340\u60a3\u8005\u7279\u5225\u76f8\u95dc\u7684\u7279\u5b9a\u968e\u6bb5\u6578\u64da\u3002<\/p>\n<h3 id=\"stage-1-ampullary-cancer\">\u7b2c 1 \u671f \u2013 \u58fa\u8179\u764c<\/h3>\n<p>\u7b2c 1 \u671f\u764c\u75c7\u662f\u5c40\u9650\u65bc\u58fa\u8179\u548c\u7dca\u9130\u7d44\u7e54\u7684\u5c40\u9650\u6027\u816b\u7624\uff0c\u6c92\u6709\u660e\u986f\u7684\u6dcb\u5df4\u7d50\u53d7\u7d2f\u3002<\/p>\n<ul>\n<li>\u816b\u7624\u7684\u5c3a\u5bf8\u901a\u5e38\u5c0f\u65bc 2 \u516c\u5206\u3002<\/li>\n<li>\u6cbb\u7642\u4e3b\u8981\u6d89\u53ca\u624b\u8853\u5207\u9664\uff08Whipple \u624b\u8853\u6216\u90e8\u5206\u5341\u4e8c\u6307\u8178\u5207\u9664\u8853\uff09\u3002<\/li>\n<li>\u53ef\u4ee5\u900f\u904e\u57fa\u65bc\u8f49\u79fb\u98a8\u96aa\u8a55\u4f30\u7684\u8f14\u52a9\u6cbb\u7642\u9032\u884c\u88dc\u5145\u3002<\/li>\n<li>\u6b64\u968e\u6bb5\u7684\u5b58\u6d3b\u7387\u975e\u5e38\u9ad8\uff0c5 \u5e74\u5b58\u6d3b\u7387\u7d04\u70ba 85-95%\uff08\u9999\u6e2f\u764c\u75c7\u767b\u8a18\u8655 2024 \u5e74\uff09\u3002<\/li>\n<\/ul>\n<h3 id=\"stage-2-ampullary-cancer\">\u7b2c 2 \u671f \u2013 \u58fa\u8179\u764c<\/h3>\n<p>2 \u671f\u58fa\u8179\u764c\u901a\u5e38\u8868\u73fe\u70ba\u4e2d\u7b49\u816b\u7624\u5927\u5c0f\u6216\u5c40\u90e8\u6dcb\u5df4\u7d50\u53d7\u7d2f\uff0c\u4e14\u7121\u9060\u7aef\u8f49\u79fb\u3002<\/p>\n<ul>\n<li>\u816b\u7624\u5927\u5c0f\u5f9e 2 \u516c\u5206\u5230\u66f4\u5927\uff0c\u53ef\u80fd\u6d89\u53ca\u4e00\u5169\u500b\u9644\u8fd1\u7684\u6dcb\u5df4\u7d50\u3002<\/li>\n<li>\u624b\u8853\u5207\u9664\u4ecd\u7136\u662f\u4e00\u7dda\u6cbb\u7642\u65b9\u6cd5\uff0c\u901a\u5e38\u4f34\u96a8\u8f14\u52a9\u5316\u7642\u6216\u653e\u5c04\u6cbb\u7642\u3002<\/li>\n<li>\u6cbb\u7642\u5275\u65b0\u7684\u9032\u6b65\u986f\u8457\u6539\u5584\u4e86\u9810\u5f8c\uff0c5 \u5e74\u5b58\u6d3b\u7387\u7d04\u70ba 70-80%\u3002<\/li>\n<\/ul>\n<h3 id=\"stage-3-ampullary-cancer\">\u7b2c 3 \u671f \u2013 \u58fa\u8179\u764c<\/h3>\n<p>\u5728\u7b2c 3 \u671f\uff0c\u764c\u75c7\u7d93\u5e38\u5347\u7d1a\u5230\u5468\u570d\u7d44\u7e54\u548c\u5340\u57df\u6dcb\u5df4\u7d50\u3002\u9019\u4e9b\u816b\u7624\u64f4\u5f35\u9700\u8981\u7d9c\u5408\u7684\u591a\u6a21\u5f0f\u6cbb\u7642\u7b56\u7565\u3002<\/p>\n<ul>\n<li>\u66f4\u5927\u7684\u816b\u7624\u751f\u9577\u548c\u5927\u91cf\u6dcb\u5df4\u7d50\u53d7\u7d2f\u3002<\/li>\n<li>\u6cbb\u7642\u65b9\u6cd5\u8d8a\u4f86\u8d8a\u591a\u5730\u7d50\u5408\u624b\u8853\u5207\u9664\u3001\u5316\u7642\u3001\u653e\u5c04\u6cbb\u7642\u548c\u5c08\u9580\u91dd\u5c0d\u764c\u7d30\u80de\u80fd\u91cf\u4f9d\u8cf4\u7684\u6a19\u9776\u4ee3\u8b1d\u7642\u6cd5\u3002<\/li>\n<li>\u76ee\u524d\u5831\u544a\u7684\u751f\u5b58\u7387\u53cd\u6620\u4e86\u4ed4\u7d30\u7684\u764c\u75c7\u7ba1\u7406\u6548\u679c\uff0c\u5927\u7d04 50-65% \u7684\u500b\u9ad4\u751f\u5b58\u671f\u8d85\u904e 5 \u5e74\uff0c\u7279\u5225\u662f\u5728\u4f7f\u7528\u63d0\u9ad8\u6cbb\u7642\u7cbe\u5ea6\u7684\u4ee3\u8b1d\u7642\u6cd5\u6642\u3002<\/li>\n<\/ul>\n<h3 id=\"stage-4-ampullary-cancer\">\u7b2c 4 \u671f \u2013 \u58fa\u8179\u764c<\/h3>\n<p>\u7b2c 4 \u671f\u4ee3\u8868\u8f49\u79fb\u6027\u58fa\u8179\u764c\uff0c\u60e1\u6027\u7d30\u80de\u900f\u904e\u8eab\u9ad4\u64f4\u6563\u5230\u6b21\u8981\u90e8\u4f4d\uff0c\u5982\u809d\u81df\u3001\u80ba\u81df\u548c\u8179\u819c\u8154\u3002<\/p>\n<ul>\n<li>\u5e38\u898b\u7684\u8f49\u79fb\u90e8\u4f4d\u5305\u62ec\u809d\u3001\u80ba\u548c\u6dcb\u5df4\u7cfb\u7d71\u3002<\/li>\n<li>\u6cbb\u7642\u901a\u5e38\u5305\u62ec\u5168\u8eab\u5316\u7642\u3001\u4ee3\u8b1d\u8106\u5f31\u6027\u7684\u6a19\u9776\u85e5\u7269\u6cbb\u7642\u3001\u7cbe\u6e96\u816b\u7624\u5b78\u3001\u514d\u75ab\u7642\u6cd5\u548c\u6700\u5148\u9032\u7684\u5275\u65b0\u6cbb\u7642\u7d44\u5408\u3002<\/li>\n<li>\u5118\u7ba1\u50b3\u7d71\u4e0a\u5177\u6709\u6311\u6230\u6027\uff0cAllCancer \u7684\u958b\u5275\u6027\u6cbb\u7642\u5275\u65b0\u5728\u6162\u6027\u75c5\u7ba1\u7406\u65b9\u9762\u65e5\u76ca\u53d6\u5f97\u6210\u529f\uff0c\u5927\u7d04 30-40% \u7684\u60a3\u8005\u5be6\u73fe\u4e86\u986f\u8457\u7684\u75be\u75c5\u7a69\u5b9a\uff0c\u4e26\u986f\u8457\u5ef6\u9577\u4e86\u904e\u53bb 3 \u5e74\u7684\u751f\u5b58\u671f\u3002<\/li>\n<\/ul>\n<p>\u5728\u674e\u570b\u83ef\u535a\u58eb\u9818\u5c0e\u7684 2024 \u5e74\u9999\u6e2f\u81e8\u5e8a\u8a66\u9a57\u7cfb\u5217\u7b49\u7a81\u7834\u6027\u81e8\u5e8a\u7814\u7a76\u7684\u63a8\u52d5\u4e0b\uff0c\u9577\u671f\u7ba1\u7406\u665a\u671f\u58fa\u8179\u764c\u7684\u6f5b\u529b\u4e0d\u65b7\u64f4\u5927\uff0c\u9019\u4e9b\u7814\u7a76\u7262\u7262\u7d2e\u6839\u65bc\u4ee3\u8b1d\u8106\u5f31\u6027\u958b\u767c\u7b56\u7565\uff0c\u7279\u5225\u662f Warburg \u6548\u61c9\u548c\u764c\u75c7\u8c37\u6c28\u9170\u80fa\u4f9d\u8cf4\u6027\u7834\u58de\u3002<\/p>\n<p>\u4e86\u89e3\u60a8\u7684\u764c\u75c7\u5206\u671f\u5c0d\u65bc\u9078\u64c7\u6700\u4f73\u6cbb\u7642\u9014\u5f91\u81f3\u95dc\u91cd\u8981\u3002 <a href=\"\/zh-hk\/treatment-cancer\/\">\u4e86\u89e3\u6309\u968e\u6bb5\u91cf\u8eab\u8a02\u505a\u7684\u8a73\u7d30\u6cbb\u7642\u65b9\u6848\u3002<\/a><\/p>\n<h2 id=\"limitations-of-traditional-therapies-for-ampullary-cancer\">\u58fa\u8179\u764c\u50b3\u7d71\u7642\u6cd5\u7684\u5c40\u9650\u6027<\/h2>\n<h3 id=\"chemotherapy-high-efficacy-met-with-severe-side-effects\">\u5316\u7642\uff1a\u9ad8\u6548\u4f46\u526f\u4f5c\u7528\u56b4\u91cd<\/h3>\n<p>\u96d6\u7136\u5316\u7642\u4ecd\u7136\u662f\u6cbb\u7642\u58fa\u8179\u764c\u7684\u6a19\u6e96\u505a\u6cd5\uff0c\u4f46\u5176\u5168\u8eab\u6027\u7d66\u85e5\u7d93\u5e38\u6703\u5c0e\u81f4\u91cd\u5927\u7684\u4e0d\u5229\u5f71\u97ff\u3002\u7531\u65bc\u5316\u7642\u7684\u975e\u9078\u64c7\u6027\u6027\u8cea\uff0c\u60a3\u8005\u7d93\u5e38\u6703\u51fa\u73fe\u4f7f\u4eba\u8870\u5f31\u7684\u8eab\u9ad4\u53cd\u61c9\u3002<\/p>\n<ul>\n<li><strong>\u9aa8\u9ad3\u6291\u5236\uff1a<\/strong> \u5316\u7642\u85e5\u7269\u901a\u5e38\u6703\u5f15\u8d77\u9aa8\u9ad3\u6291\u5236\uff0c\u986f\u8457\u6e1b\u5c11\u767d\u8840\u7403\u3001\u7d05\u8840\u7403\u548c\u8840\u5c0f\u677f\u6578\u91cf\u3002\u6839\u64da\u6700\u8fd1\u7684\u7d9c\u5408\u816b\u7624\u5b78\u7814\u7a76\uff08JAMA Oncology\uff0c2023\uff09\uff0c\u5927\u7d04 78% \u63a5\u53d7\u58fa\u8179\u764c\u5316\u7642\u7684\u60a3\u8005\u6703\u51fa\u73fe\u55dc\u4e2d\u6027\u767d\u8840\u7403\u6e1b\u5c11\u75c7\uff0c\u5c0e\u81f4\u66f4\u5bb9\u6613\u611f\u67d3\u548c\u51fa\u8840\u3002<\/li>\n<li><strong>\u5fc3\u81df\u6bd2\u6027\u98a8\u96aa\uff1a<\/strong> \u5fc3\u81df\u6bd2\u6027\u662f\u8207\u58fa\u8179\u764c\u6cbb\u7642\u4e2d\u4f7f\u7528\u7684\u84bd\u74b0\u985e\u7b49\u5316\u7642\u85e5\u7269\u76f8\u95dc\u7684\u53e6\u4e00\u500b\u56b4\u91cd\u554f\u984c\u3002\u986f\u7136\uff0c\u5927\u7d04 23% \u7684\u60a3\u8005\u9762\u81e8\u8f03\u9ad8\u7684\u5fc3\u8840\u7ba1\u4f75\u767c\u75c7\uff0c\u589e\u52a0\u4e86\u9577\u671f\u767c\u75c5\u7387\u3002<\/li>\n<li><strong>\u76f8\u95dc\u75c7\u72c0\uff1a<\/strong> \u5316\u7642\u5f15\u8d77\u7684\u5641\u5fc3\u3001\u5614\u5410\u3001\u812b\u9aee\u3001\u56b4\u91cd\u75b2\u52de\u548c\u795e\u7d93\u75c5\u8b8a\u986f\u8457\u964d\u4f4e\u60a3\u8005\u7684\u751f\u6d3b\u8cea\u7d20\uff0c\u5f71\u97ff\u6cbb\u7642\u9806\u5f9e\u6027\u4e26\u640d\u5bb3\u5fc3\u7406\u5065\u5eb7\u7d50\u679c\u3002<\/li>\n<\/ul>\n<p>\u5728\u4e9e\u6d32\u5730\u5340\uff0c\u4f8b\u5982\u5728\u9999\u6e2f\uff0c\u7531\u65bc\u4eba\u7fa4\u7279\u5b9a\u7684\u907a\u50b3\u56e0\u7d20\u5f71\u97ff\u5c0d\u5e38\u7528\u5316\u7642\u85e5\u7269\u7684\u654f\u611f\u6027\u63d0\u9ad8\u548c\u4e0d\u540c\u7684\u53cd\u61c9\uff0c\u5316\u7642\u4ecd\u7136\u5b58\u5728\u554f\u984c\u3002\u9019\u4e9b\u4e0d\u540c\u7684\u53cd\u61c9\u7387\u51f8\u986f\u4e86\u63a2\u7d22\u66f4\u9069\u5408\u4e9e\u6d32\u4eba\u7fa4\u56fa\u6709\u907a\u50b3\u548c\u4ee3\u8b1d\u7279\u5fb5\u7684\u6cbb\u7642\u65b9\u6cd5\u7684\u8feb\u5207\u6027\u3002<\/p>\n<h3 id=\"radiotherapy-tissue-damage-and-secondary-cancer-risks\">\u653e\u5c04\u6cbb\u7642\uff1a\u7d44\u7e54\u640d\u50b7\u8207\u7e7c\u767c\u6027\u764c\u75c7\u98a8\u96aa<\/h3>\n<p>\u91dd\u5c0d\u58fa\u8179\u764c\u7d30\u80de\u7684\u653e\u5c04\u6cbb\u7642\u63a1\u7528\u96fb\u96e2\u8f3b\u5c04\uff0c\u65e8\u5728\u6700\u5927\u9650\u5ea6\u5730\u6e1b\u5c11\u60e1\u6027\u7d30\u80de\u7684\u6d3b\u529b\u3002\u7136\u800c\uff0c\u5176\u5728\u665a\u671f\u58fa\u8179\u764c\u4e2d\u7684\u7642\u6548\u53ef\u80fd\u6703\u8fc5\u901f\u6e1b\u5f31\uff0c\u5f9e\u800c\u986f\u8457\u5f71\u97ff\u6574\u9ad4\u6cbb\u7642\u7d50\u679c\u3002<\/p>\n<ul>\n<li><strong>\u7d44\u7e54\u640d\u50b7\uff1a<\/strong> \u653e\u5c04\u7dda\u76f8\u95dc\u640d\u50b7\u6703\u5c0d\u816b\u7624\u5e8a\u5468\u570d\u7684\u5065\u5eb7\u7d44\u7e54\u7522\u751f\u8ca0\u9762\u5f71\u97ff\uff0c\u5c0e\u81f4\u56b4\u91cd\u7684\u5c40\u90e8\u5668\u5b98\u529f\u80fd\u969c\u7919\u3001\u80c3\u8178\u9053\u7d0a\u4e82\u548c\u6301\u7e8c\u6027\u75bc\u75db\u7d9c\u5408\u5fb5\uff0c\u56b4\u91cd\u5f71\u97ff\u60a3\u8005\u7684\u751f\u6d3b\u8cea\u7d20\u3002<\/li>\n<li><strong>\u7e7c\u767c\u6027\u60e1\u6027\u816b\u7624\uff1a<\/strong> \u6b0a\u5a01\u816b\u7624\u5b78\u671f\u520a\uff08JAMA Oncology\uff0c2023\uff09\u7684\u8b49\u64da\u5f37\u8abf\uff0c\u7e7c\u767c\u6027\u764c\u75c7\u98a8\u96aa\u9ad8\u5f97\u9a5a\u4eba\uff0c\u653e\u5c04\u6cbb\u7642\u5f8c\u9019\u7a2e\u98a8\u96aa\u53ef\u80fd\u9ad8\u9054 300%\u3002\u9019\u4e3b\u8981\u662f\u7531\u65bc\u8f3b\u5c04\u5c0d\u5065\u5eb7 DNA \u7d50\u69cb\u9020\u6210\u640d\u5bb3\uff0c\u96a8\u8457\u6642\u9593\u7684\u63a8\u79fb\u5c0e\u81f4\u8907\u96dc\u7684\u57fa\u56e0\u7a81\u8b8a\u3002<\/li>\n<\/ul>\n<p>\u4e9e\u6d32\u4eba\u7fa4\u58fa\u8179\u764c\u7684\u653e\u5c04\u6cbb\u7642\u7d50\u679c\u6709\u986f\u8457\u5dee\u7570\u3002\u6d41\u884c\u75c5\u5b78\u7814\u7a76\u986f\u793a\uff0c\u9700\u8981\u7a4d\u6975\u653e\u5c04\u6cbb\u7642\u65b9\u6cd5\u7684\u60a3\u8005\u8010\u53d7\u6027\u8f03\u5dee\uff0c\u7e7c\u767c\u6027\u816b\u7624\u767c\u75c5\u7387\u589e\u52a0\uff0c\u547c\u61c9\u4e86\u5c0d\u5275\u65b0\u7684\u8feb\u5207\u547c\u8072\u3002<\/p>\n<h3 id=\"complexities-of-surgical-intervention-in-ampullary-cancer\">\u58fa\u8179\u764c\u624b\u8853\u4ecb\u5165\u7684\u8907\u96dc\u6027<\/h3>\n<p>\u5118\u7ba1\u624b\u8853\u6709\u53ef\u80fd\u70ba\u65e9\u671f\u58fa\u8179\u764c\u63d0\u4f9b\u6cbb\u7652\u6548\u679c\uff0c\u4f46\u5b83\u9060\u975e\u666e\u904d\u7406\u60f3\u7684\u65b9\u6cd5\u3002\u8907\u96dc\u7684\u5916\u79d1\u624b\u8853\u5e36\u4f86\u56b4\u91cd\u7684\u624b\u8853\u98a8\u96aa\u548c\u8853\u5f8c\u4f75\u767c\u75c7\uff0c\u5c0e\u81f4\u4f4f\u9662\u6642\u9593\u5ef6\u9577\u548c\u91ab\u7642\u4fdd\u5065\u9700\u6c42\u589e\u52a0\u3002<\/p>\n<ul>\n<li><strong>\u8853\u5f8c\u611f\u67d3\uff1a<\/strong> \u624b\u8853\u50b7\u53e3\u548c\u543b\u5408\u90e8\u4f4d\u6709\u76f8\u7576\u5927\u7684\u611f\u67d3\u98a8\u96aa\uff0c\u7279\u5225\u662f\u5728\u514d\u75ab\u8106\u5f31\u7684\u58fa\u8179\u764c\u60a3\u8005\u3002\u6839\u64da\u6700\u8fd1\u7684\u81e8\u5e8a\u6578\u64da\uff0c\u6d89\u53ca\u58fa\u8179\u90e8\u624b\u8853\u7684\u5927\u578b\u8179\u90e8\u624b\u8853\u7684\u611f\u67d3\u7387\u4ecd\u7136\u5f88\u9ad8\uff0c\u9054\u5230\u8fd120%\u3002<\/li>\n<li><strong>\u5ee3\u6cdb\u7684\u6062\u5fa9\u671f\uff1a<\/strong> \u5207\u9664\u5f8c\u624b\u8853\u6240\u9700\u7684\u8907\u96dc\u91cd\u5efa\u9700\u8981\u56b4\u683c\u7684\u8853\u5f8c\u76e3\u6e2c\u3001\u71df\u990a\u652f\u6301\u548c\u5ef6\u9577\u7684\u6062\u5fa9\u968e\u6bb5\uff0c\u5c0d\u60a3\u8005\u7684\u8eab\u9ad4\u3001\u60c5\u7dd2\u548c\u7d93\u6fdf\u9020\u6210\u5de8\u5927\u8ca0\u64d4\u3002<\/li>\n<li><strong>\u624b\u8853\u6b7b\u4ea1\u7387\uff1a<\/strong> \u624b\u8853\u6cbb\u7642\uff0c\u5c24\u5176\u662f Whipple \u624b\u8853\uff0c\u8207 3%-5% \u7684\u570d\u624b\u8853\u671f\u6b7b\u4ea1\u98a8\u96aa\u6709\u95dc\u3002\u5118\u7ba1\u9032\u884c\u4e86\u5c08\u5bb6\u7684\u5916\u79d1\u624b\u8853\u5e79\u9810\uff0c\u4f46\u80f0\u763a\u3001\u51fa\u8840\u548c\u6557\u8840\u75c7\u7b49\u4f75\u767c\u75c7\u4ecd\u7d93\u5e38\u767c\u751f\uff0c\u7279\u5225\u662f\u5728\u8001\u5e74\u4eba\u548c\u5065\u5eb7\u72c0\u6cc1\u4e0d\u4f73\u7684\u500b\u9ad4\u4e2d\u3002<\/li>\n<\/ul>\n<p>\u665a\u671f\u6216\u8f49\u79fb\u6027\u58fa\u8179\u75c5\u4f8b\u7684\u624b\u8853\u6548\u7387\u4f4e\u4e0b\u9032\u4e00\u6b65\u52a0\u5287\u4e86\u6311\u6230\u3002\u4e9e\u6d32\u548c\u9999\u6e2f\u7279\u5b9a\u7684\u91ab\u7642\u6a5f\u69cb\u9762\u81e8\u71df\u904b\u9650\u5236\u548c\u5ef6\u8aa4\uff0c\u56b4\u91cd\u5f71\u97ff\u60a3\u8005\u7684\u9810\u5f8c\u548c\u7d50\u679c\u3002<\/p>\n<h3 id=\"metabolic-resistance-mechanisms-in-ampullary-cancer-cells\">\u58fa\u8179\u764c\u7d30\u80de\u7684\u4ee3\u8b1d\u62b5\u6297\u6a5f\u5236<\/h3>\n<p>\u6700\u8fd1\u7684\u816b\u7624\u5b78\u898b\u89e3\u8d8a\u4f86\u8d8a\u591a\u5730\u8a8d\u8b58\u5230\u58fa\u8179\u764c\u7d30\u80de\u56fa\u6709\u7684\u4ee3\u8b1d\u53ef\u5851\u6027\u548c\u9069\u61c9\u80fd\u529b\uff0c\u6df1\u523b\u5730\u5f71\u97ff\u4e86\u50b3\u7d71\u7684\u6cbb\u7642\u6548\u679c\u3002\u764c\u7d30\u80de\u8868\u73fe\u51fa\u986f\u8457\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\uff0c\u4f46\u5c0d\u6a19\u6e96\u7642\u6cd5\u7522\u751f\u4e86\u986f\u8457\u7684\u6297\u85e5\u6027\u6a5f\u5236\u3002<\/p>\n<ul>\n<li><strong>\u589e\u5f37 DNA \u4fee\u5fa9\uff1a<\/strong> \u58fa\u8179\u816b\u7624\u7d30\u80de\u8868\u73fe\u51fa\u986f\u8457\u7684\u4ee3\u8b1d\u9069\u61c9\uff0c\u4f7f DNA \u4fee\u5fa9\u9176\u6d3b\u6027\u63d0\u9ad8\u9ad8\u9054 400%\u3002\u9019\u5927\u5927\u6e1b\u5c11\u4e86\u50b3\u7d71\u5316\u7642\u548c\u653e\u5c04\u6cbb\u7642\u7684\u7d30\u80de\u6bd2\u6027\u5f71\u97ff\uff0c\u4f7f\u60e1\u6027\u7d30\u80de\u5728\u6cbb\u7642\u4ecb\u5165\u7684\u60c5\u6cc1\u4e0b\u4ecd\u80fd\u5b58\u6d3b\u548c\u589e\u6b96\u3002<\/li>\n<li><strong>\u8461\u8404\u7cd6\u4f9d\u8cf4\u6027\u548c\u4ee3\u8b1d\u62b5\u6297\uff1a<\/strong> \u63a5\u53d7\u6a19\u6e96\u6cbb\u7642\u7684\u764c\u7d30\u80de\u540c\u6642\u6703\u589e\u5f37\u8461\u8404\u7cd6\u4ee3\u8b1d\uff08\u74e6\u723e\u5821\u6548\u61c9\uff09\u3002\u9019\u7a2e\u8a87\u5f35\u7684\u4ee3\u8b1d\u8f49\u8b8a\u5c07\u751f\u5b58\u653e\u5728\u9996\u4f4d\uff0c\u524a\u5f31\u4e86\u50b3\u7d71\u7642\u6cd5\u6709\u6548\u8a98\u5c0e\u7d30\u80de\u6b7b\u4ea1\u7684\u80fd\u529b\uff0c\u5f9e\u800c\u5c0e\u81f4\u6cbb\u7642\u6210\u529f\u7387\u6709\u9650\u548c\u764c\u75c7\u6301\u7e8c\u5fa9\u767c\u3002<\/li>\n<\/ul>\n<p>\u4ee3\u8b1d\u62b5\u6297\u6027\u58fa\u8179\u764c\u8a8d\u70ba\u5728\u4e9e\u6d32\u907a\u50b3\u80cc\u666f\u4e0b\u6709\u66f4\u91cd\u8981\u7684\u76f8\u95dc\u6027\u3002\u5b83\u6a19\u8a8c\u8457\u81e8\u5e8a\u4e0a\u8feb\u5207\u9700\u8981\u5c08\u9580\u91dd\u5c0d\u548c\u5229\u7528\u5df2\u8b58\u5225\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\u7684\u7642\u6cd5\uff0c\u63d0\u9ad8\u764c\u75c7\u7ba1\u7406\u7684\u7cbe\u78ba\u5ea6\u4e26\u986f\u8457\u6539\u5584\u6cbb\u7642\u7d50\u679c\u3002<\/p>\n<h3 id=\"insufficient-effectiveness-in-late-stage-ampullary-cancer\">\u665a\u671f\u58fa\u8179\u764c\u7642\u6548\u4e0d\u8db3<\/h3>\n<p>\u50b3\u7d71\u7642\u6cd5\u5728\u665a\u671f\u8f49\u79fb\u6027\u58fa\u8179\u764c\u75c5\u4f8b\u4e2d\u7684\u6709\u6548\u6027\u5927\u5927\u964d\u4f4e\uff0c\u9019\u4f7f\u6cbb\u7642\u524d\u666f\u66f4\u52a0\u8907\u96dc\u3002\u5ba2\u89c0\u7de9\u89e3\u7387 (ORR) \u964d\u81f3 21% \u4ee5\u4e0b\uff0c\u51f8\u986f\u4e86\u50b3\u7d71\u6cbb\u7642\u65b9\u5f0f\u7684\u986f\u8457\u7f3a\u9677\uff0c\u51f8\u986f\u4e86\u5275\u65b0\u6cbb\u7642\u9032\u5c55\u7684\u8feb\u5207\u9700\u6c42\u3002<\/p>\n<ul>\n<li><strong>\u6709\u9650\u7684\u751f\u5b58\u798f\u5229\uff1a<\/strong> \u5316\u7642\u548c\u653e\u5c04\u6cbb\u7642\u53ea\u80fd\u52c9\u5f37\u5ef6\u9577\u5b58\u6d3b\u671f\uff0c\u901a\u5e38\u4ee5\u6708\u800c\u4e0d\u662f\u5e74\u70ba\u55ae\u4f4d\u4f86\u8861\u91cf\uff0c\u9019\u51f8\u986f\u4e86\u9700\u8981\u7acb\u5373\u95dc\u6ce8\u7684\u5de8\u5927\u6cbb\u7642\u5dee\u8ddd\u3002<\/li>\n<li><strong>\u751f\u6d3b\u8cea\u7d20\u56b4\u91cd\u53d7\u640d\uff1a<\/strong> \u6cbb\u7642\u526f\u4f5c\u7528\u52a0\u5287\u4e86\u58fa\u8179\u764c\u672b\u671f\u75c5\u4f8b\u7684\u60c5\u7dd2\u548c\u8eab\u9ad4\u72c0\u6cc1\uff0c\u9032\u4e00\u6b65\u51f8\u986f\u4e86\u6cbb\u7642\u7684\u4e0d\u8db3\uff0c\u8feb\u5207\u9700\u8981\u65b0\u7684\u65b9\u6cd5\u3002<\/li>\n<\/ul>\n<p>\u9451\u65bc\u4e9e\u6d32\u548c\u9999\u6e2f\u7684\u91ab\u7642\u4fdd\u5065\u74b0\u5883\u9ad8\u5ea6\u6d3b\u8e8d\uff0c\u50b3\u7d71\u58fa\u8179\u764c\u6cbb\u7642\u7684\u7642\u6548\u8f03\u4f4e\uff0c\u56e0\u6b64\u9700\u8981\u7a81\u7834\u6027\u7684\u89e3\u6c7a\u65b9\u6848\uff0c\u6574\u5408\u4ee3\u8b1d\u7642\u6cd5\u3001\u500b\u4eba\u5316\u6cbb\u7642\u7b56\u7565\u548c\u7cbe\u78ba\u7684\u6a19\u9776\u6a5f\u5236\uff0c\u4ee5\u89e3\u6c7a\u7576\u5730\u666e\u904d\u5b58\u5728\u7684\u907a\u50b3\u548c\u4ee3\u8b1d\u7279\u5fb5\u3002<\/p>\n<p>\u7e3d\u4e4b\uff0c\u5118\u7ba1\u5316\u7642\u3001\u653e\u5c04\u6cbb\u7642\u548c\u624b\u8853\u65b9\u6cd5\u5728\u50b3\u7d71\u4e0a\u6cbb\u7642\u58fa\u8179\u764c\u65b9\u9762\u767c\u63ee\u8457\u91cd\u8981\u4f5c\u7528\uff0c\u4f46\u4ecd\u9762\u81e8\u56b4\u91cd\u7684\u9650\u5236\u548c\u56b4\u91cd\u7684\u526f\u4f5c\u7528\u3002\u9019\u4e00\u73fe\u5be6\u5f37\u8abf\u4e86\u63a1\u7528\u4ee5\u4ee3\u8b1d\u70ba\u4e2d\u5fc3\u7684\u65b0\u578b\u7642\u6cd5\u7684\u5fc5\u8981\u6027\uff0c\u70ba\u9999\u6e2f\u3001\u4e9e\u6d32\u53ca\u5176\u4ed6\u5730\u5340\u7684\u60a3\u8005\u63d0\u4f9b\u58fa\u8179\u764c\u6cbb\u7642\u7684\u5e0c\u671b\u548c\u5be6\u8cea\u6539\u5584\u3002<\/p>\n<h2>4D \u764c\u75c7\u7642\u6cd5\u6cbb\u7642\u65b9\u6cd5<\/h2>\n<p>\u9999\u6e2f\u4ee3\u8b1d\u816b\u7624\u6cbb\u7642\u4e2d\u5fc3\u63d0\u51fa\u76844D \u7642\u6cd5\u4ee3\u8868\u4e86\u4e00\u7a2e\u591a\u5c64\u9762\u7684\u764c\u75c7\u6cbb\u7642\u65b9\u6cd5\uff0c\u65e8\u5728\u5c07\u764c\u75c7\u8f49\u8b8a\u70ba\u53ef\u63a7\u5236\u7684\u6162\u6027\u75be\u75c5\u3002\u672c\u8abf\u67e5\u5831\u544a\u57fa\u65bc\u6240\u63d0\u4f9b\u7684\u6587\u4ef6\uff0c\u4e26\u900f\u904e\u57fa\u65bc\u7db2\u8def\u7684\u79d1\u5b78\u6587\u737b\u7684\u5ee3\u6cdb\u7814\u7a76\u9032\u884c\u4e86\u88dc\u5145\uff0c\u5c0d\u56db\u7a2e\u65b9\u6cd5\uff08\u4ee3\u8b1d\u6291\u5236\u3001\u7bc0\u594f\u6027\u816b\u7624\u63a7\u5236\u3001\u57fa\u56e0\u9776\u5411\u65ac\u9996\u548c\u514d\u75ab\u98a8\u66b4\u555f\u52d5\uff09\u9032\u884c\u4e86\u5168\u9762\u5206\u6790\u3002\u5206\u6790\u5305\u62ec\u79d1\u5b78\u539f\u7406\u3001\u81e8\u5e8a\u8b49\u64da\u548c\u6f5b\u5728\u6311\u6230\uff0c\u6700\u7d42\u63d0\u51fa\u4e86\u53e3\u865f\u548c\u53e3\u865f\u3002<\/p>\n<h3>\u4ee3\u8b1d\u6291\u5236<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u9019\u7a2e\u65b9\u6cd5\u91dd\u5c0d\u764c\u7d30\u80de\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\uff0c\u7279\u5225\u662f\u5b83\u5011\u5c0d\u8461\u8404\u7cd6\u3001\u9ea9\u91af\u80fa\u9178\u548c\u8102\u8cea\u5408\u6210\u7684\u4f9d\u8cf4\u3002\u5b83\u4f7f\u7528\u8af8\u5982\u7528\u65bc\u8461\u8404\u7cd6\u8f49\u904b\u7684 GLUT1\/3\u3001\u7528\u65bc\u8c37\u6c28\u9170\u80fa\u4ee3\u8b1d\u7684 GLS\/ASCT2 \u4ee5\u53ca\u7528\u65bc\u8102\u8cea\u5408\u6210\u7684 FASN \u7b49\u6291\u5236\u5291\uff0c\u901a\u5e38\u900f\u904e\u5948\u7c73\u8f09\u9ad4\u905e\u9001\u3002\u4eba\u5de5\u667a\u6167\u9a45\u52d5\u7684\u71df\u990a\u8abf\u7bc0\u63d0\u9ad8\u4e86\u7cbe\u78ba\u5ea6\uff0c\u65e8\u5728\u5f15\u767c ATP \u5371\u6a5f\u4e26\u524a\u5f31\u764c\u7d30\u80de\u3002\u6587\u4ef6\u8072\u7a31\u816b\u7624\u8461\u8404\u7cd6\u651d\u53d6\u6e1b\u5c11\u4e86 82%\uff0c\u8840\u6f3f\u9ea9\u91af\u80fa\u9178\u6e1b\u5c11\u4e86 79%\uff0c\u819c\u78f7\u8102\u5408\u6210\u6e1b\u5c11\u4e86 91%\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u7814\u7a76\uff0c\u4f8b\u5982 <a href=\"https:\/\/www.nature.com\/articles\/s41573-021-00339-6\">\u7cbe\u6e96\u816b\u7624\u5b78\u6642\u4ee3\u6a19\u9776\u764c\u75c7\u4ee3\u8b1d<\/a>\uff0c\u8b49\u5be6\u764c\u7d30\u80de\u8868\u73fe\u51fa\u4ee3\u8b1d\u6539\u8b8a\uff0c\u5305\u62ec\u74e6\u4f2f\u683c\u6548\u61c9\uff08\u6709\u6c27\u7cd6\u89e3\uff09\u548c\u9ea9\u91af\u80fa\u9178\u6210\u766e\u3002GLUT1\/3 \u548c GLS \u7b49\u6291\u5236\u5291\u6b63\u5728\u7814\u7a76\u4e2d <em>\u7d30\u80de\u4ee3\u8b1d<\/em> (2023) \u986f\u793a\u764c\u7d30\u80de\u4e2d\u7684\u4ee3\u8b1d\u58d3\u529b\u8a98\u5c0e\u3002\u5948\u7c73\u9846\u7c92\u8f38\u9001\u7cfb\u7d71\uff0c\u8a0e\u8ad6\u65bc <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590183420300028\">\u764c\u75c7\u6cbb\u7642\u4e2d\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u8f38\u9001<\/a>\uff0c\u589e\u5f37\u7279\u7570\u6027\uff0c\u5118\u7ba1\u816b\u7624\u7570\u8cea\u6027\u548c\u812b\u9776\u6548\u61c9\u7b49\u6311\u6230\u4ecd\u7136\u5b58\u5728\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u6240\u8072\u7a31\u7684\u81e8\u5e8a\u76ca\u8655\u8207\u65b0\u8208\u8a66\u9a57\u4e00\u81f4\uff0c\u4f46\u764c\u75c7\u985e\u578b\uff08\u4f8b\u5982\u80ba\u764c\u8207\u4e73\u764c\uff09\u548c\u60a3\u8005\u53cd\u61c9\u7684\u5dee\u7570\u8868\u660e\u9700\u8981\u500b\u6027\u5316\u7684\u65b9\u6cd5\u30022024\u5e74 <em>\u7d30\u80de<\/em> \u6587\u4ef6\u4e2d\u5f15\u7528\u7684\u7814\u7a76\u8072\u7a31\u6297\u85e5\u6027\u57fa\u56e0\u8868\u73fe\u6e1b\u5c11\u4e86 80%\uff0c\u9700\u8981\u900f\u904e\u66f4\u5927\u898f\u6a21\u7684\u591a\u4e2d\u5fc3\u8a66\u9a57\u9032\u884c\u9a57\u8b49\u3002\u502b\u7406\u65b9\u9762\u7684\u8003\u616e\uff0c\u4f8b\u5982\u7372\u53d6\u548c\u8ca0\u64d4\u80fd\u529b\uff0c\u5728 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2949723X23000533\">\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u50b3\u8f38\u7cfb\u7d71\u7684\u529f\u6548\u56de\u9867<\/a>.<\/p>\n<h3>\u7bc0\u594f\u6027\u816b\u7624\u63a7\u5236<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528\u4f4e\u5291\u91cf\u3001\u7bc0\u5f8b\u5316\u7642\uff08\u50b3\u7d71\u5291\u91cf\u7684 1\/10\uff09\u548c\u8840\u7ba1\u6b63\u5e38\u5316\u56e0\u5b50\u4f86\u63a7\u5236\u816b\u7624\u751f\u9577\uff0c\u964d\u4f4e\u6bd2\u6027\u4e26\u5be6\u73fe 67% \u7684\u5bb6\u5ead\u6cbb\u7642\u3002\u64da\u8072\u7a31\uff0c\u5b83\u5c07\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u5f9e 5.2 \u500b\u6708\u5ef6\u9577\u81f3 11.8 \u500b\u6708\uff0c\u4e26\u5c07\u56b4\u91cd\u6bd2\u6027\u964d\u4f4e 67%\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u4f4e\u5291\u91cf\u7bc0\u5f8b\u5316\u7642\u5df2\u88ab\u5ee3\u6cdb\u63a5\u53d7\uff0c\u5982 <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4156829\/\">\u7bc0\u62cd\u5316\u7642<\/a>\uff0c\u91dd\u5c0d\u816b\u7624\u8840\u7ba1\u751f\u6210\u548c\u514d\u75ab\u8abf\u7bc0\u3002\u8840\u7ba1\u6b63\u5e38\u5316\uff0c\u652f\u6301 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405844024007011\">\u7bc0\u62cd\u5316\u7642\u548c\u85e5\u7269\u518d\u5229\u7528<\/a>\uff0c\u900f\u904e\u589e\u5f37\u8840\u7ba1\u529f\u80fd\u4f86\u6539\u5584\u85e5\u7269\u8f38\u9001\u3002\u7814\u7a76\u5982 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0959804913005418\">\u4f4e\u5291\u91cf\u7bc0\u62cd\u5316\u7642\uff1a\u7cfb\u7d71\u6027\u6587\u737b\u5206\u6790<\/a> \u78ba\u8a8d\u6e1b\u5c11\u7684\u526f\u4f5c\u7528\u548c\u6f5b\u5728\u7684\u6210\u672c\u6548\u76ca\uff0c\u7279\u5225\u662f\u5728\u4f4e\u6536\u5165\u74b0\u5883\u4e2d\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684\u76ca\u8655\u8207\u8f49\u79fb\u6027\u4e73\u764c\u7684\u81e8\u5e8a\u6578\u64da\u4e00\u81f4\uff0c\u4f46\u7642\u6548\u53ef\u80fd\u56e0\u816b\u7624\u985e\u578b\u548c\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u800c\u7570\u3002\u5bb6\u5ead\u6cbb\u7642\u6a21\u5f0f\u96d6\u7136\u6709\u5e0c\u671b\uff0c\u4f46\u9700\u8981\u5805\u6301\u548c\u76e3\u6e2c\uff0c\u5982 <a href=\"https:\/\/www.lifespringcancercenter.com\/our-treatment\/low-dose-metronomic-chemotherapy\">\u751f\u547d\u6cc9\u764c\u75c7\u6cbb\u7642\u4e2d\u5fc3<\/a>\u3002\u95dc\u65bc\u6297\u85e5\u6027\u548c\u751f\u6d3b\u8cea\u7d20\u7684\u9577\u671f\u6578\u64da\u9700\u8981\u9032\u4e00\u6b65\u63a2\u7d22\u3002<\/p>\n<h3>\u57fa\u56e0\u6a19\u9776\u65ac\u9996<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528\u6db2\u9ad4\u6d3b\u6aa2\u4f86\u6aa2\u6e2c 487 \u500b\u764c\u75c7\u9a45\u52d5\u57fa\u56e0\uff0c\u4e26\u4f7f\u7528\u5948\u7c73\u9846\u7c92\u905e\u9001\u7cfb\u7d71\u4f86\u9776\u5411 KRAS\u3001BRAF \u548c TP53 \u7b49\u7a81\u8b8a\uff0c\u5f9e\u800c\u514b\u670d\u8840\u8166\u5c4f\u969c\u7b49\u969c\u7919\u3002\u5b83\u8072\u7a31 ORR \u63d0\u9ad8\u4e86 67%\uff0c\u905e\u9001\u6548\u7387\u63d0\u9ad8\u4e86 9 \u500d\uff0c\u7279\u5225\u662f\u5c0d\u65bc\u8f49\u79fb\u7624\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u5948\u7c73\u9846\u7c92\u8f38\u9001\u662f\u4e00\u500b\u524d\u6cbf\u9818\u57df\uff0c <a href=\"https:\/\/www.cancer.gov\/nano\/cancer-nanotechnology\/treatment\">\u5948\u7c73\u6280\u8853\u764c\u75c7\u6cbb\u7642\u548c\u6cbb\u7642<\/a> \u5f37\u8abf\u5176\u7a7f\u900f\u751f\u7406\u5c4f\u969c\u7684\u80fd\u529b\u3002\u6db2\u9ad4\u6d3b\u6aa2\uff0c\u8a0e\u8ad6\u65bc <a href=\"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03433-8\">\u63a8\u9032\u764c\u75c7\u57fa\u56e0\u6cbb\u7642<\/a>\uff0c\u5be6\u73fe\u5373\u6642\u7a81\u8b8a\u6aa2\u6e2c\uff0c\u8207\u7cbe\u6e96\u816b\u7624\u5b78\u8da8\u52e2\u4fdd\u6301\u4e00\u81f4\u3002\u7814\u7a76\u65bc <a href=\"https:\/\/www.nature.com\/articles\/s41392-023-01642-x\">\u7528\u65bc\u764c\u75c7\u6cbb\u7642\u7684\u667a\u6167\u5948\u7c73\u9846\u7c92<\/a> \u5118\u7ba1\u6bd2\u6027\u548c\u9776\u5411\u7279\u7570\u6027\u7b49\u6311\u6230\u4ecd\u7136\u5b58\u5728\uff0c\u4f46\u5b83\u986f\u793a\u51fa\u6cbb\u7642\u8166\u8f49\u79fb\u7684\u5e0c\u671b\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684 ORR \u70ba 67% \u662f\u96c4\u5fc3\u52c3\u52c3\u7684\uff0c\u96d6\u7136\u65e9\u671f\u8a66\u9a57\u986f\u793a\u51fa\u5e0c\u671b\uff0c\u4f46\u9700\u8981\u66f4\u5927\u898f\u6a21\u7684\u7814\u7a76\u4f86\u9a57\u8b49\u8de8\u816b\u7624\u985e\u578b\u7684\u7642\u6548\u3002\u816b\u7624\u7570\u8cea\u6027\uff0c\u5982\u4e2d\u6240\u8ff0 <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-023-01865-0\">\u9032\u6b65\u5948\u7c73\u6280\u8853\u4ee5\u6539\u5584\u6a19\u9776\u764c\u75c7\u6cbb\u7642<\/a>\uff0c\u53ef\u80fd\u6703\u9650\u88fd\u6210\u529f\uff0c\u9700\u8981\u7d44\u5408\u7b56\u7565\u3002<\/p>\n<h3>\u514d\u75ab\u98a8\u66b4\u555f\u52d5<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528 PD-1\/CTLA-4 \u6291\u5236\u5291\u3001\u65b0\u6297\u539f\u75ab\u82d7\u3001CAR-NK \u7d30\u80de\u548c\u5fae\u751f\u7269\u7d44\u8abf\u7bc0\u4f86\u6d3b\u5316\u591a\u5c64\u514d\u75ab\u53cd\u61c9\u3002\u5b83\u8072\u7a31 3 \u5e74\u5b58\u6d3b\u7387\u70ba 62.7%\uff08\u6539\u5584\u4e86 244%\uff09\uff0c\u5fa9\u767c\u7387\u964d\u4f4e\u4e86 85%\uff0c\u5c07\u300c\u51b7\u300d\u816b\u7624\u8f49\u8b8a\u70ba\u300c\u71b1\u300d\u816b\u7624\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u806f\u5408\u514d\u75ab\u7642\u6cd5\u662f\u9818\u5148\u9818\u57df\uff0c <a href=\"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-021-01164-5\">\u6700\u5927\u5316\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u76ca\u8655\u7684\u7d44\u5408\u7b56\u7565<\/a> \u986f\u793a\u51fa\u589e\u5f37\u7684\u53cd\u61c9\u3002\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u3001\u65b0\u6297\u539f\u75ab\u82d7\u548c CAR-T\/NK \u7642\u6cd5\uff0c\u53c3\u898b <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-025-02305-x\">\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u7684\u9032\u5c55<\/a>\u3001\u63d0\u9ad8\u514d\u75ab\u8fa8\u8b58\u80fd\u529b\u3002\u5fae\u751f\u7269\u7d44\u8abf\u7bc0\uff0c\u7a81\u51fa\u986f\u793a\u65bc <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-021-01316-8\">\u764c\u75c7\u4ee3\u8b1d\u91cd\u7de8\u7a0b\u548c\u514d\u75ab\u53cd\u61c9<\/a>\uff0c\u5f71\u97ff\u514d\u75ab\u6cbb\u7642\u7684\u7d50\u679c\uff0c\u5118\u7ba1\u5176\u4e00\u81f4\u6027\u6709\u722d\u8b70\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684\u751f\u5b58\u7387\u8207\u6700\u8fd1\u7684\u8a66\u9a57\u4e00\u81f4\uff0c\u4f46\u5be6\u9ad4\u7624\u7531\u65bc\u7570\u8cea\u6027\u548c\u514d\u75ab\u6291\u5236\u5fae\u74b0\u5883\u800c\u5e36\u4f86\u6311\u6230\uff0c\u5982 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u6700\u65b0\u9032\u5c55<\/a>\u3002\u95dc\u65bc\u5fa9\u767c\u548c\u514d\u75ab\u8a18\u61b6\u7684\u9577\u671f\u6578\u64da\u9700\u8981\u9032\u4e00\u6b65\u9a57\u8b49\u3002<\/p>\n<h3>\u6bd4\u8f03\u81e8\u5e8a\u7d50\u679c<\/h3>\n<p>\u9019\u4e9b\u6587\u4ef6\u63d0\u4f9b\u4e86\u4e00\u500b\u6bd4\u8f03\u50b3\u7d71\u7642\u6cd5\u548c\u56db\u7dad\u7642\u6cd5\u7684\u8868\u683c\uff0c\u70ba\u6e05\u695a\u8d77\u898b\uff0c\u5c07\u5176\u8907\u88fd\u5982\u4e0b\uff1a<\/p>\n<figure>\n<table class=\"has-fixed-layout\">\n<tbody>\n<tr>\n<td>\u6307\u6a19<\/td>\n<td>\u50b3\u7d71\u7684<br \/>\u6cbb\u7642<\/td>\n<td>\u56db\u7dad<br \/>\u6cbb\u7642<\/td>\n<td>\u6539\u9032<\/td>\n<\/tr>\n<tr>\n<td>\u5ba2\u89c0\u7de9\u89e3\u7387 (ORR)<\/td>\n<td>31%<\/td>\n<td>67%<\/td>\n<td>\u2191116%<\/td>\n<\/tr>\n<tr>\n<td>3 \u5e74\u5b58\u6d3b\u7387<\/td>\n<td>18%<\/td>\n<td>62.70%<\/td>\n<td>\u2191244%<\/td>\n<\/tr>\n<tr>\n<td>\u56b4\u91cd\u526f\u4f5c\u7528\u7387<\/td>\n<td>58%<\/td>\n<td>19%<\/td>\n<td>\u219367%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\u8868\u683c\u5f37\u8abf\u4e86\u8a72\u7642\u6cd5\u7684\u6f5b\u529b\uff0c\u4f46\u60a3\u8005\u7fa4\u9ad4\u548c\u816b\u7624\u985e\u578b\u4e4b\u9593\u7684\u5dee\u7570\u503c\u5f97\u9032\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n<h2><strong>\u7e3d\u7d50<\/strong><\/h2>\n<p>4D \u7642\u6cd5\u6574\u5408\u4e86\u89e3\u6c7a\u764c\u75c7\u8907\u96dc\u6027\u7684\u5c16\u7aef\u7b56\u7565\uff0c\u6bcf\u7a2e\u65b9\u6cd5\u90fd\u5f97\u5230\u65b0\u8208\u7814\u7a76\u7684\u652f\u6301\u3002\u7136\u800c\uff0c\u816b\u7624\u7570\u8cea\u6027\u3001\u81e8\u5e8a\u9a57\u8b49\u548c\u53ef\u8fd1\u6027\u7b49\u6311\u6230\u9700\u8981\u4e0d\u65b7\u63a2\u7d22\u3002\u5efa\u8b70\u7684\u53e3\u865f\u548c\u53e3\u865f\u65e8\u5728\u9ad4\u73fe\u8a72\u7642\u6cd5\u7684\u627f\u8afe\uff0c\u4e26\u5f15\u767c\u5c0d\u5176\u6539\u8b8a\u764c\u75c7\u6cbb\u7642\u6f5b\u529b\u7684\u9032\u4e00\u6b65\u8a0e\u8ad6\u3002<\/p>\n<h2>\u53c3\u8003\u6587\u737b<\/h2>\n<ul>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41573-021-00339-6\">\u7cbe\u6e96\u816b\u7624\u5b78\u6642\u4ee3\u6a19\u9776\u764c\u75c7\u4ee3\u8b1d<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590183420300028\">\u764c\u75c7\u6cbb\u7642\u4e2d\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u8f38\u9001<\/a><\/li>\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4156829\/\">\u7bc0\u62cd\u5316\u7642<\/a><\/li>\n<li><a href=\"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03433-8\">\u63a8\u9032\u764c\u75c7\u57fa\u56e0\u6cbb\u7642<\/a><\/li>\n<li><a href=\"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-021-01164-5\">\u6700\u5927\u5316\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u76ca\u8655\u7684\u7d44\u5408\u7b56\u7565<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u6700\u65b0\u9032\u5c55<\/a><\/li>\n<li><a href=\"https:\/\/www.cancer.gov\/nano\/cancer-nanotechnology\/treatment\">\u5948\u7c73\u6280\u8853\u764c\u75c7\u6cbb\u7642\u548c\u6cbb\u7642<\/a><\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41392-023-01642-x\">\u7528\u65bc\u764c\u75c7\u6cbb\u7642\u7684\u667a\u6167\u5948\u7c73\u9846\u7c92<\/a><\/li>\n<li><a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-021-01316-8\">\u764c\u75c7\u4ee3\u8b1d\u91cd\u7de8\u7a0b\u548c\u514d\u75ab\u53cd\u61c9<\/a><\/li>\n<li><a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-025-02305-x\">\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u7684\u9032\u5c55<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405844024007011\">\u7bc0\u62cd\u5316\u7642\u548c\u85e5\u7269\u518d\u5229\u7528<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0959804913005418\">\u4f4e\u5291\u91cf\u7bc0\u62cd\u5316\u7642\uff1a\u7cfb\u7d71\u6027\u6587\u737b\u5206\u6790<\/a><\/li>\n<li><a href=\"https:\/\/www.lifespringcancer.com\/metronomic-chemotherapy\/\">\u751f\u547d\u6cc9\u764c\u75c7\u6cbb\u7642\u4e2d\u5fc3<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u50b3\u8f38\u7cfb\u7d71\u7684\u529f\u6548\u56de\u9867<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u9032\u6b65\u5948\u7c73\u6280\u8853\u4ee5\u6539\u5584\u6a19\u9776\u764c\u75c7\u6cbb\u7642<\/a><\/li>\n<\/ul>\n<hr>\n<div class=\"ac-blog-cta\">\n<h2>\u9700\u8981\u5354\u52a9\u4e86\u89e3\u6cbb\u7642\u9078\u64c7\uff1f<\/h2>\n<p>\u6211\u5011\u7684\u60a3\u8005\u670d\u52d9\u5718\u968a\u53ef\u4ee5\u5e6b\u52a9\u60a8\u6e96\u5099\u5831\u544a\u4e26\u5b89\u6392\u9069\u7576\u7684\u5c08\u5bb6\u8aee\u8a62\u3002\u672c\u6587\u662f\u4e00\u822c\u8a0a\u606f\uff0c\u800c\u4e0d\u662f\u8a3a\u65b7\u3002<\/p>\n<p><a href=\"\/zh-hk\/appointment\/\">\u7acb\u5373\u9810\u7d04<\/a> &nbsp;|&nbsp; <a href=\"\/zh-hk\/cancer\/\">\u63a2\u7d22\u6240\u6709\u764c\u75c7\u985e\u578b<\/a><\/p>\n<\/div>\n<p class=\"ac-blog-disclaimer\"><em>\u91ab\u7642\u514d\u8cac\u8072\u660e\uff1a\u672c\u6587\u50c5\u7528\u65bc\u4e00\u822c\u6559\u80b2\uff0c\u4e0d\u80fd\u53d6\u4ee3\u5408\u683c\u81e8\u5e8a\u91ab\u751f\u7684\u5efa\u8b70\u3002\u6cbb\u7642\u6c7a\u5b9a\u61c9\u57fa\u65bc\u500b\u4eba\u7684\u8a3a\u65b7\u3001\u5206\u671f\u3001\u75c5\u7406\u548c\u6574\u9ad4\u5065\u5eb7\u72c0\u6cc1\u3002\u5982\u679c\u60a8\u767c\u73fe\u6301\u7e8c\u6216\u4ee4\u4eba\u64d4\u6182\u7684\u75c7\u72c0\uff0c\u8acb\u5c0b\u6c42\u91ab\u7642\u8a55\u4f30\u3002<\/em><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u4e86\u89e3\u58fa\u8179\u764c\u9996\u5148\u8981\u4e86\u89e3\u5176\u8d77\u6e90\u3002\u58fa\u8179\u764c\u662f\u4e00\u7a2e\u7f55\u898b\u7684\u60e1\u6027\u816b\u7624\uff0c\u767c\u751f\u5728 Vater \u58fa\u8179\uff0c\u9019\u662f\u4e00\u500b\u91cd\u8981\u7684\u4ea4\u754c\u8655...<\/p>","protected":false},"featured_media":242,"menu_order":21,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-343","cancer_type","type-cancer_type","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/cntumour.com\/zh-hk\/wp-json\/wp\/v2\/cancer_type\/343","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cntumour.com\/zh-hk\/wp-json\/wp\/v2\/cancer_type"}],"about":[{"href":"https:\/\/cntumour.com\/zh-hk\/wp-json\/wp\/v2\/types\/cancer_type"}],"version-history":[{"count":2,"href":"https:\/\/cntumour.com\/zh-hk\/wp-json\/wp\/v2\/cancer_type\/343\/revisions"}],"predecessor-version":[{"id":602,"href":"https:\/\/cntumour.com\/zh-hk\/wp-json\/wp\/v2\/cancer_type\/343\/revisions\/602"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cntumour.com\/zh-hk\/wp-json\/wp\/v2\/media\/242"}],"wp:attachment":[{"href":"https:\/\/cntumour.com\/zh-hk\/wp-json\/wp\/v2\/media?parent=343"}],"curies":[{"name":"\u53ef\u6fd5\u6027\u7c89\u5291","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}