{"id":372,"date":"2026-07-12T09:00:00","date_gmt":"2026-07-12T09:00:00","guid":{"rendered":"https:\/\/cntumour.com\/cancer\/non-hodgkin-lymphoma-nhl-cancer\/"},"modified":"2026-10-29T15:53:22","modified_gmt":"2026-10-29T15:53:22","slug":"non-hodgkin-lymphoma-nhl-cancer","status":"publish","type":"cancer_type","link":"https:\/\/cntumour.com\/zh-hk\/cancer\/non-hodgkin-lymphoma-nhl-cancer\/","title":{"rendered":"\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL)"},"content":{"rendered":"<div class=\"ac-blog-article\">\n<p class=\"ac-blog-lead\"><strong>\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL) \u662f\u4e00\u7fa4\u7531\u6dcb\u5df4\u7403\u5f15\u8d77\u7684\u591a\u7a2e\u764c\u75c7\uff0c\u800c\u6dcb\u5df4\u7403\u662f\u514d\u75ab\u7cfb\u7d71\u4e0d\u53ef\u6216\u7f3a\u7684\u4e00\u7a2e\u767d\u8840\u7403\u3002\u5728 NHL \u4e2d\uff0c\u6dcb\u5df4\u7d30\u80de\u4e0d\u53d7\u63a7\u5236\u5730\u589e\u6b96\uff0c\u4e3b\u8981\u5728\u6dcb\u5df4\u7d50\u5167\u5f62\u6210\u816b\u7624\uff0c\u4f46\u4e5f\u53ef\u80fd\u767c\u751f\u6dcb\u5df4\u5916\u53d7\u7d2f\u3002\u4e86\u89e3\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL) \u9996\u5148\u8981\u8a8d\u8b58\u5176\u6838\u5fc3\u751f\u7269\u5b78\u548c\u6f5b\u5728\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\uff0c\u5305\u62ec Warburg \u6548\u61c9\u3002<\/strong><\/p>\n<nav class=\"ac-blog-toc\" aria-label=\"\u672c\u6587\u5c0e\u89bd\">\n<p><strong>\u672c\u6587\u5c0e\u89bd<\/strong><\/p>\n<ul>\n<li><a href=\"#what-is-non-hodgkin-lymphoma-nhl\">\u4ec0\u9ebc\u662f\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL)\uff1f<\/a><\/li>\n<li><a href=\"#causes-and-risk-factors-of-non-hodgkin-lymphoma-nhl\">\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624 (NHL) \u7684\u75c5\u56e0\u548c\u98a8\u96aa\u56e0\u7d20<\/a><\/li>\n<li><a href=\"#symptoms-of-non-hodgkin-lymphoma-nhl\">\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL) \u7684\u75c7\u72c0<\/a><\/li>\n<li><a href=\"#stages-of-non-hodgkin-lymphoma-nhl-and-survival-rates\">\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL) \u7684\u5206\u671f\u548c\u5b58\u6d3b\u7387<\/a><\/li>\n<li><a href=\"#limitations-of-traditional-therapies-for-non-hodgkin-lymphoma-nhl\">\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL) \u50b3\u7d71\u7642\u6cd5\u7684\u5c40\u9650\u6027<\/a><\/li>\n<\/ul>\n<\/nav>\n<h2 id=\"what-is-non-hodgkin-lymphoma-nhl\">\u4ec0\u9ebc\u662f\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL)\uff1f<\/h2>\n<p>Warburg \u6548\u61c9\u662f NHL \u764c\u7d30\u80de\u4e2d\u89c0\u5bdf\u5230\u7684\u6a19\u8a8c\u6027\u4ee3\u8b1d\u91cd\u7de8\u7a0b\uff0c\u5176\u4e2d\u9019\u4e9b\u7d30\u80de\u6d88\u8017\u8461\u8404\u7cd6\u7684\u901f\u5ea6\u6bd4\u5065\u5eb7\u7d30\u80de\u9ad8\u7d04 200 \u500d\uff0c\u4ee5\u9a45\u52d5\u5feb\u901f\u751f\u9577\u548c\u8907\u88fd\u3002\u9019\u73fe\u8c61\u5f37\u8abf\u4e86\u7cd6\u89e3\u7b49\u4ee3\u8b1d\u9014\u5f91\u4f5c\u70ba NHL \u6cbb\u7642\u6a19\u9776\u7684\u91cd\u8981\u6027\u3002<\/p>\n<p>\u5728\u5168\u7403\u7bc4\u570d\u5167\uff0c\u4e16\u754c\u885b\u751f\u7d44\u7e54 (WHO, 2024) \u5831\u544a\u6bcf\u5e74\u7d04\u6709 550,000 \u4f8b\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL) \u65b0\u75c5\u4f8b\uff0c\u4f30\u8a08\u6709 20 \u842c\u4eba\u6b7b\u4ea1\u3002\u50c5\u5728\u9999\u6e2f\uff0cNHL \u5c31\u662f\u6700\u5e38\u898b\u7684\u8840\u6db2\u60e1\u6027\u816b\u7624\u4e4b\u4e00\uff0c\u7d04\u4f54\u6240\u6709\u8a3a\u65b7\u764c\u75c7\u7684 3.5%\uff0c\u53cd\u6620\u4e86\u4e9e\u6d32\u5730\u5340\u7368\u7279\u7684\u6d41\u884c\u75c5\u5b78\u7279\u5fb5\u3002<\/p>\n<p>NHL \u4e3b\u8981\u5f71\u97ff 60 \u6b72\u4ee5\u4e0a\u7684\u6210\u5e74\u4eba\uff0c\u4f46\u4efb\u4f55\u5e74\u9f61\u5c64\u7684\u4eba\u90fd\u53ef\u4ee5\u8a3a\u65b7\u51fa NHL\u3002\u7537\u6027\u6bd4\u5973\u6027\u7565\u591a\u898b\u3002\u91dd\u5c0d\u4e9e\u6d32\u7279\u5b9a\u65cf\u7fa4\u7684\u7814\u7a76\u5f37\u8abf\u4e86\u7368\u7279\u7684\u907a\u50b3\u548c\u74b0\u5883\u5f71\u97ff\uff0c\u5305\u62ec\u6162\u6027\u611f\u67d3\u76f8\u95dc\u7684\u75c5\u56e0\u3001\u514d\u75ab\u7f3a\u9677\u4ee5\u53ca\u4f7f\u500b\u9ad4\u5bb9\u6613\u7f79\u60a3 NHL \u7684\u75c5\u6bd2\u66b4\u9732\u3002<\/p>\n<ul>\n<li>\u75b2\u52de\uff1aNHL \u4e2d\u6700\u5e38\u898b\u7684\u75c7\u72c0\u4e4b\u4e00\u662f\u8ca7\u8840\u3001\u816b\u7624\u8ca0\u8377\u548c\u4ee3\u8b1d\u7d0a\u4e82\u5f15\u8d77\u75b2\u52de\u3002\u9019\u7a2e\u5065\u5eb7\u8f49\u8b8a\u986f\u8457\u5f71\u97ff\u65e5\u5e38\u751f\u6d3b\u548c\u60c5\u7dd2\u5065\u5eb7\u3002<\/li>\n<li>\u6dcb\u5df4\u7d50\u816b\u5927\uff1aNHL \u5e38\u8868\u73fe\u70ba\u7121\u75db\u6027\u6dcb\u5df4\u7d50\u816b\u5927\uff0c\u901a\u5e38\u51fa\u73fe\u5728\u9838\u90e8\u3001\u814b\u7aa9\u6216\u8179\u80a1\u6e9d\uff0c\u901a\u5e38\u662f\u63d0\u793a\u8a3a\u65b7\u7684\u7b2c\u4e00\u500b\u53ef\u898b\u5fb5\u8c61\u3002<\/li>\n<li>\u5168\u8eab\u75c7\u72c0\uff1a\u7a31\u70ba B \u75c7\u72c0\uff0c\u5305\u62ec\u4e0d\u660e\u539f\u56e0\u7684\u767c\u71d2\u3001\u76dc\u6c57\u548c\u7121\u610f\u8b58\u7684\u9ad4\u91cd\u6e1b\u8f15\uff0c\u986f\u793a\u5168\u8eab\u53d7\u7d2f\u3002<\/li>\n<li>\u5fc3\u7406\u5f71\u97ff\uff1a\u764c\u75c7\u8a3a\u65b7\u9020\u6210\u7684\u60c5\u7dd2\u640d\u5931\u662f\u6df1\u9060\u7684\uff0c\u901a\u5e38\u4f34\u96a8\u8457\u7126\u616e\u3001\u6182\u9b31\u548c\u793e\u6703\u5b64\u7acb\uff0c\u51f8\u986f\u4e86\u5168\u9762\u7684\u60a3\u8005\u652f\u6301\u7cfb\u7d71\u7684\u91cd\u8981\u6027\u3002<\/li>\n<\/ul>\n<p>\u5728 AllCancer\uff0c\u6211\u5011\u900f\u904e\u958b\u5275\u6027\u7814\u7a76\u548c\u5275\u65b0\u4ee3\u8b1d\u7642\u6cd5\uff0c\u5305\u62ec\u500b\u4eba\u5316\u4ee3\u8b1d\u5206\u6790\u548c\u65e8\u5728\u5229\u7528 NHL \u7d30\u80de\u4ee3\u8b1d\u4f9d\u8cf4\u6027\u7684\u91dd\u5c0d\u6027\u5e79\u9810\u63aa\u65bd\uff0c\u70ba\u53d7 NHL \u5f71\u97ff\u7684\u60a3\u8005\u548c\u5bb6\u5ead\u5e36\u4f86\u5e0c\u671b\u3002\u53d7\u5230\u8afe\u8c9d\u723e\u734e\u7372\u734e\u5de5\u4f5c\uff08\u8a79\u59c6\u65af\u00b7\u827e\u5229\u68ee\u6559\u6388\u548c\u683c\u96f7\u683c\u00b7\u585e\u9580\u624e\u6559\u6388\u7b49\u7814\u7a76\u4eba\u54e1\uff09\u7684\u555f\u767c\uff0c\u4e26\u5728\u674e\u570b\u83ef\u535a\u58eb\u548c\u5289\u570b\u9f8d\u6559\u6388\u7b49\u4ee3\u8b1d\u816b\u7624\u5b78\u5148\u9a45\u7684\u5bc6\u5207\u6307\u5c0e\u4e0b\uff0c\u6211\u5011\u7684\u9999\u6e2f\u8a3a\u6240\u5c07\u5c16\u7aef\u79d1\u5b78\u8207\u5bcc\u6709\u540c\u60c5\u5fc3\u7684\u60a3\u8005\u8b77\u7406\u878d\u70ba\u4e00\u9ad4\u3002<\/p>\n<p>\u6211\u5011\u7684\u300c\u5148\u6cbb\u6108\uff0c\u5f8c\u4ed8\u8cbb\u300d\u653f\u7b56\u9ad4\u73fe\u4e86\u503c\u5f97\u4fe1\u8cf4\u4e14\u6613\u65bc\u7372\u5f97\u7684\u4e16\u754c\u4e00\u6d41\u764c\u75c7\u6cbb\u7642\u65b9\u6cd5\uff0c\u7a4d\u6975\u8207\u6df1\u5733\u524d\u6d77\u6cf0\u5eb7\u3001MD\u5b89\u5fb7\u68ee\u7b49\u6a5f\u69cb\u5408\u4f5c\uff0c\u63d0\u4f9b\u5c08\u9580\u91dd\u5c0d\u4e9e\u6d32\u4eba\u7fa4\u7684\u7368\u7279\u6709\u6548\u548c\u500b\u6027\u5316\u7684\u8b77\u7406\u3002<\/p>\n<h2 id=\"causes-and-risk-factors-of-non-hodgkin-lymphoma-nhl\">\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624 (NHL) \u7684\u75c5\u56e0\u548c\u98a8\u96aa\u56e0\u7d20<\/h2>\n<p>\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL) \u7684\u78ba\u5207\u75c5\u56e0\u6d89\u53ca\u907a\u50b3\u56e0\u7d20\u3001\u74b0\u5883\u66b4\u9732\u3001\u751f\u6d3b\u65b9\u5f0f\u56e0\u7d20\u548c\u514d\u75ab\u7cfb\u7d71\u529f\u80fd\u969c\u7919\u4e4b\u9593\u7684\u8907\u96dc\u76f8\u4e92\u4f5c\u7528\u3002\u4e86\u89e3\u9019\u4e9b\u53ef\u4ee5\u70ba\u6709\u6548\u7684\u9810\u9632\u548c\u65e9\u671f\u5e79\u9810\u7b56\u7565\u92ea\u5e73\u9053\u8def\u3002<\/p>\n<h3 id=\"genetic-factors-for-non-hodgkin-lymphoma-nhl\">\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL) \u7684\u907a\u50b3\u56e0\u7d20<\/h3>\n<p>\u907a\u50b3\u5b78\u548c\u5bb6\u65cf\u53f2\u5728 NHL \u6613\u611f\u6027\u4e2d\u8d77\u8457\u91cd\u8981\u4f5c\u7528\u3002\u8207\u514d\u75ab\u8abf\u7bc0\u57fa\u56e0\u76f8\u95dc\u7684\u57fa\u56e0\u7a81\u8b8a\uff08\u4f8b\u5982 BCL2\u3001EZH2\u3001MYC\uff09\u4ee5\u53ca\u67d3\u8272\u9ad4\u6613\u4f4d\u7a81\u8b8a\uff08\u4f8b\u5982 t(14;18)\uff09\u901a\u5e38\u8207 NHL \u767c\u75c5\u6a5f\u5236\u6709\u95dc\u3002\u9019\u7a2e\u907a\u50b3\u50be\u5411\u53ef\u80fd\u5c0e\u81f4\u6dcb\u5df4\u7624\u7d30\u80de\u751f\u9577\u4e0d\u53d7\u63a7\u5236\u3002<\/p>\n<h3 id=\"environmental-and-infection-related-risks\">\u74b0\u5883\u548c\u611f\u67d3\u76f8\u95dc\u98a8\u96aa<\/h3>\n<p>\u4e00\u4e9b\u74b0\u5883\u5f71\u97ff\u8207\u8f03\u9ad8\u7684 NHL \u98a8\u96aa\u76f8\u95dc\uff0c\u7279\u5225\u662f\uff1a<\/p>\n<ul>\n<li><strong>\u75c5\u6bd2\u548c\u7d30\u83cc\u611f\u67d3\uff1a<\/strong> Epstein-Barr \u75c5\u6bd2 (EBV)\u3001\u4eba\u985e\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2 (HIV) \u548c\u4eba\u985e T \u7d30\u80de\u55dc\u6dcb\u5df4\u7d30\u80de\u75c5\u6bd2 (HTLV-1) \u7b49\u75c5\u6bd2\u900f\u904e\u9577\u671f\u523a\u6fc0\u514d\u75ab\u7cfb\u7d71\uff0c\u986f\u8457\u589e\u52a0 NHL \u98a8\u96aa\u3002\u6b64\u5916\uff0c\u5e7d\u9580\u87ba\u65cb\u687f\u83cc\u611f\u67d3\u8207\u9ecf\u819c\u76f8\u95dc\u6dcb\u5df4\u7d44\u7e54\uff08MALT\uff09\u6dcb\u5df4\u7624\u5bc6\u5207\u76f8\u95dc\u3002<\/li>\n<li><strong>\u5316\u5b78\u66b4\u9732\uff1a<\/strong> \u9664\u8349\u5291\u3001\u6bba\u87f2\u5291\u3001\u6eb6\u5291\u548c\u63a5\u89f8\u82ef\u4e5f\u8207 NHL \u767c\u75c5\u7387\u589e\u52a0\u6709\u95dc\uff0c\u7279\u5225\u662f\u5728\u8077\u696d\u63a5\u89f8\u65cf\u7fa4\u4e2d\u3002<\/li>\n<li><strong>\u8f3b\u5c04\uff1a<\/strong> \u6cbb\u7642\u6027\u8f3b\u5c04\u6216\u74b0\u5883\u6c61\u67d3\u7269\u7684\u5076\u7136\u9ad8\u66b4\u9732\u6c34\u5e73\u6703\u986f\u8457\u589e\u52a0\u6dcb\u5df4\u7624\u98a8\u96aa\u3002<\/li>\n<\/ul>\n<h3 id=\"lifestyle-linked-risks\">\u8207\u751f\u6d3b\u65b9\u5f0f\u76f8\u95dc\u7684\u98a8\u96aa<\/h3>\n<p>\n\u751f\u6d3b\u65b9\u5f0f\u56e0\u7d20\u4e5f\u6703\u986f\u8457\u5f71\u97ff NHL \u98a8\u96aa\uff1a<\/p>\n<ul>\n<li><strong>\u98f2\u98df\uff1a<\/strong> \u98df\u7528\u5927\u91cf\u81b3\u98df\u8102\u80aa\u3001\u52a0\u5de5\u8089\u985e\u6216\u6c34\u679c\u548c\u852c\u83dc\u542b\u91cf\u4f4e\u7684\u98f2\u98df\u53ef\u80fd\u6703\u589e\u52a0 NHL \u7684\u6613\u611f\u6027\u3002<\/li>\n<li><strong>\u80a5\u80d6\uff1a<\/strong> \u9ad4\u91cd\u904e\u91cd\u8207\u5168\u8eab\u6027\u767c\u708e\u548c\u514d\u75ab\u5931\u8abf\u6709\u95dc\uff0c\u4f7f NHL \u98a8\u96aa\u589e\u52a0\u7d04 20-30%\u3002<\/li>\n<li><strong>\u9152\u7cbe\u548c\u83f8\u8349\uff1a<\/strong> \u5118\u7ba1\u83f8\u8349\u548c\u9152\u7cbe\u4e0d\u662f NHL \u7684\u4e3b\u8981\u9a45\u52d5\u56e0\u7d20\uff0c\u4f46\u9577\u671f\u4f7f\u7528\u6703\u5c0e\u81f4\u514d\u75ab\u6291\u5236\u548c\u5168\u8eab\u6027\u58d3\u529b\u53cd\u61c9\uff0c\u53ef\u80fd\u6703\u52a0\u5287\u73fe\u6709\u7684\u8106\u5f31\u6027\u3002<\/li>\n<\/ul>\n<h3 id=\"metabolic-vulnerability-in-nhl-glucose-and-glutamine-dependence\">NHL \u7684\u4ee3\u8b1d\u8106\u5f31\u6027\uff1a\u8461\u8404\u7cd6\u548c\u8c37\u6c28\u9170\u80fa\u4f9d\u8cf4\u6027<\/h3>\n<p>NHL \u4e2d\u7684\u764c\u7d30\u80de\u8868\u73fe\u51fa\u7368\u7279\u7684\u4ee3\u8b1d\u4f9d\u8cf4\u6027\uff0c\u7279\u5225\u662f\u900f\u904e Warburg \u6548\u61c9\u9032\u884c\u7684\u8461\u8404\u7cd6\u4ee3\u8b1d\u548c\u5c0d\u6838\u82f7\u9178\u5408\u6210\u81f3\u95dc\u91cd\u8981\u7684\u8c37\u6c28\u9170\u80fa\u4ee3\u8b1d\u3002\u8fd1 50% \u7684 NHL \u75c5\u4f8b\u8868\u73fe\u51fa\u660e\u986f\u7684\u9ea9\u91af\u80fa\u9178\u4f9d\u8cf4\u6027\u3002\u91dd\u5c0d\u9019\u4e9b\u4ee3\u8b1d\u9014\u5f91\u53ef\u4ee5\u63d0\u4f9b\u6709\u6548\u7684\u6cbb\u7642\u4ecb\u5165\u3002<\/p>\n<p>\u5728 AllCancer\uff0c\u6211\u5011\u7684\u5275\u65b0\u4ee3\u8b1d\u7642\u6cd5\u5c07\u7d30\u7dfb\u7684\u4ee3\u8b1d\u5206\u6790\u8207 FDA \u6279\u51c6\u7684\u6a19\u9776\u85e5\u7269\u7d50\u5408\uff0c\u5229\u7528\u9019\u4e9b\u5f31\u9ede\u4f86\u7834\u58de\u764c\u7d30\u80de\u589e\u6b96\u3002\u8b58\u5225\u65e9\u671f\u75c7\u72c0\u4e26\u53ca\u6642\u555f\u52d5\u8a3a\u65b7\u7be9\u6aa2\u53ef\u4ee5\u6539\u5584\u60a3\u8005\u7684\u6cbb\u7642\u7d50\u679c\uff0c\u7a81\u986f\u9810\u9632\u6027\u91ab\u7642\u63aa\u65bd\u5728\u9999\u6e2f\u91ab\u7642\u4fdd\u5065\u9818\u57df\u7684\u7b56\u7565\u91cd\u8981\u6027\u3002<\/p>\n<p>\u8207\u9999\u6e2f\u9996\u5c48\u4e00\u6307\u7684\u764c\u75c7\u8b77\u7406\u5c08\u5bb6 AllCancer \u4e00\u8d77\u63a2\u7d22\u60a8\u7368\u7279\u7684\u6cbb\u7642\u9078\u64c7\u3002\u6211\u5011\u9769\u547d\u6027\u7684 4D \u4ee3\u8b1d\u7642\u6cd5\u70ba\u60a3\u8005\u5e36\u4f86\u4e86\u975e\u51e1\u7684\u6cbb\u7642\u6548\u679c\uff0c\u5305\u62ec 68.7% \u7684\u5ba2\u89c0\u7de9\u89e3\u7387 (ORR)\u3002\u7acb\u5373\u806f\u7d61\u6211\u5011\u9032\u884c\u500b\u4eba\u5316\u8aee\u8a62\uff0c\u4ee5\u4e86\u89e3\u4ee3\u8b1d\u816b\u7624\u5b78\u7684\u638c\u63e1\u5982\u4f55\u91cd\u65b0\u5b9a\u7fa9\u60a8\u7684 NHL \u6cbb\u7642\u9ad4\u9a57\u3002<\/p>\n<h2 id=\"symptoms-of-non-hodgkin-lymphoma-nhl\">\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL) \u7684\u75c7\u72c0<\/h2>\n<p>\u53ca\u65e9\u767c\u73fe <strong>\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL)<\/strong> \u986f\u8457\u63d0\u9ad8\u6210\u529f\u6cbb\u7642\u7684\u6a5f\u6703\u3002\u53ca\u6642\u8b58\u5225\u5e38\u898b\u548c\u7279\u6b8a\u75c7\u72c0\u4e26\u5c0b\u6c42\u5c08\u696d\u91ab\u7642\u5efa\u8b70\u9032\u884c\u8a55\u4f30\u548c\u8a3a\u65b7\u975e\u5e38\u91cd\u8981\u3002<\/p>\n<h3 id=\"common-symptoms-of-non-hodgkin-lymphoma-nhl\">\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL) \u7684\u5e38\u898b\u75c7\u72c0<\/h3>\n<ul>\n<li>\u9838\u90e8\u3001\u814b\u7aa9\u6216\u8179\u80a1\u6e9d\u6dcb\u5df4\u7d50\u816b\u5927<\/li>\n<li>\u6301\u7e8c\u767c\u71d2\uff0c\u7121\u611f\u67d3<\/li>\n<li>\u4e0d\u660e\u539f\u56e0\u7684\u9ad4\u91cd\u6e1b\u8f15\uff08\u516d\u500b\u6708\u5167\u9ad4\u91cd\u6e1b\u8f15\u8d85\u904e 10%\uff09<\/li>\n<li>\u75b2\u52de\u6216\u6301\u7e8c\u75b2\u618a<\/li>\n<li>\u76dc\u6c57\u6d78\u900f\u8863\u670d\u548c\u5be2\u5177<\/li>\n<li>\u514d\u75ab\u529b\u4f4e\u4e0b\u5c0e\u81f4\u983b\u7e41\u611f\u67d3<\/li>\n<li>\u76ae\u819a\u767c\u7662\u548c\u76ae\u75b9<\/li>\n<li>\u547c\u5438\u77ed\u4fc3\u6216\u6301\u7e8c\u54b3\u55fd<\/li>\n<li>\u56e0\u813e\u81df\u6216\u809d\u81df\u816b\u5927\u5c0e\u81f4\u8179\u75db\u6216\u816b\u8139<\/li>\n<li>\u98df\u617e\u4e0d\u632f\u6216\u98fd\u8db3\u611f<\/li>\n<\/ul>\n<h3 id=\"symptoms-varying-by-stage-of-non-hodgkin-lymphoma-nhl\">\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL) \u7684\u75c7\u72c0\u56e0\u968e\u6bb5\u800c\u7570<\/h3>\n<h4>\u65e9\u671f NHL\uff08\u7b2c 1 \u671f\u548c\u7b2c 2 \u671f\uff09<\/h4>\n<ul>\n<li>\u5c40\u90e8\u816b\u8139\uff0c\u6dcb\u5df4\u7d50\u901a\u5e38\u7121\u75db\u6027\u816b\u584a<\/li>\n<li>\u7531\u65bc\u8f15\u5fae\u7684\u514d\u75ab\u7834\u58de\u800c\u5076\u723e\u611f\u5230\u75b2\u5026<\/li>\n<li>\u8f15\u5fae\u7684\u9ad4\u91cd\u6e1b\u8f15\uff0c\u5728\u65e5\u5e38\u751f\u6d3b\u4e2d\u5e38\u88ab\u5ffd\u8996<\/li>\n<li>\u8f15\u5fae\u767c\u71d2\uff0c\u4e00\u822c\u70ba\u9593\u6b47\u6027\u4e14\u7121\u660e\u986f\u539f\u56e0<\/li>\n<\/ul>\n<h4>NHL \u9ad8\u7d1a\u968e\u6bb5\uff08\u7b2c 3 \u548c\u7b2c 4 \u671f\uff09<\/h4>\n<ul>\n<li>\u6d89\u53ca\u591a\u500b\u6dcb\u5df4\u7d50\u5340\u57df\u7684\u660e\u986f\u816b\u8139<\/li>\n<li>\u6301\u7e8c\u75b2\u52de\uff0c\u56b4\u91cd\u64fe\u4e82\u65e5\u5e38\u6d3b\u52d5<\/li>\n<li>\u76dc\u6c57\u56b4\u91cd\uff0c\u56b4\u91cd\u5f71\u97ff\u7761\u7720\u54c1\u8cea<\/li>\n<li>\u9ad4\u91cd\u6e1b\u8f15\u5f71\u97ff\u5065\u5eb7\u548c\u8eab\u9ad4\u8868\u73fe<\/li>\n<li>\u8179\u90e8\u751f\u9577\u589e\u52a0\u548c\u5668\u5b98\u589e\u5927\u5f15\u8d77\u7684\u4e0d\u9069<\/li>\n<li>\u547c\u5438\u56f0\u96e3\uff0c\u53ef\u80fd\u662f\u7531\u65bc\u6dcb\u5df4\u7d50\u58d3\u8feb\u80f8\u90e8\u7d50\u69cb\u6240\u81f4<\/li>\n<li>\u8207\u514d\u75ab\u6291\u5236\u76f8\u95dc\u7684\u983b\u7e41\u3001\u6301\u7e8c\u611f\u67d3<\/li>\n<\/ul>\n<p>\u75c7\u72c0 <strong>\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL)<\/strong> \u53cd\u6620\u6f5b\u5728\u7684\u751f\u7269\u6a5f\u5236\uff0c\u4f8b\u5982\u6dcb\u5df4\u7d30\u80de\u7684\u7570\u5e38\u589e\u6b96\u548c\u80fd\u91cf\u4ee3\u8b1d\u3002\u4f8b\u5982\uff0c\u6dcb\u5df4\u7d50\u816b\u5927\u662f\u7531\u65bc\u805a\u96c6\u5728\u6dcb\u5df4\u7d44\u7e54\u4e2d\u7684\u764c\u6027\u6dcb\u5df4\u7403\u5feb\u901f\u4e14\u4e0d\u53d7\u63a7\u5236\u5730\u751f\u9577\u6240\u81f4\u3002\u75b2\u52de\u548c\u76dc\u6c57\u7b49\u75c7\u72c0\u8207\u4ee3\u8b1d\u7d0a\u4e82\u6709\u95dc\uff0c\u5305\u62ec\u8461\u8404\u7cd6\u4ee3\u8b1d\u904e\u5ea6\u6d3b\u8e8d\uff08\u74e6\u723e\u5821\u6548\u61c9\uff09\uff0c\u56e0\u70ba\u764c\u7d30\u80de\u6703\u5927\u91cf\u6d88\u8017\u80fd\u91cf\u3002<\/p>\n<p>\u65e9\u671f\u767c\u73fe\u548c\u8a3a\u65b7\u81f3\u95dc\u91cd\u8981\uff0c\u56e0\u70ba\u75c7\u72c0\u901a\u5e38\u985e\u4f3c\u65bc\u4e0d\u592a\u56b4\u91cd\u7684\u60c5\u6cc1\uff0c\u5f9e\u800c\u5ef6\u8aa4\u4e86\u81e8\u5e8a\u8aee\u8a62\u3002\u56e0\u6b64\uff0c\u4efb\u4f55\u51fa\u73fe\u4e0a\u8ff0\u6301\u7e8c\u3001\u4e0d\u660e\u539f\u56e0\u6216\u9032\u884c\u6027\u75c7\u72c0\u7684\u4eba\u90fd\u61c9\u7dca\u6025\u5c0b\u6c42\u8a3a\u65b7\u8a55\u4f30\u3002<\/p>\n<h2 id=\"stages-of-non-hodgkin-lymphoma-nhl-and-survival-rates\">\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL) \u7684\u5206\u671f\u548c\u5b58\u6d3b\u7387<\/h2>\n<p>\u7684\u5206\u671f <strong>\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL)<\/strong> \u5c0d\u65bc\u898f\u5283\u9069\u7576\u7684\u6cbb\u7642\u7b56\u7565\u548c\u9810\u5f8c\u81f3\u95dc\u91cd\u8981\u3002\u6839\u64da\u8a3a\u65b7\u968e\u6bb5\u7684\u4e0d\u540c\uff0c\u5b58\u6d3b\u7d50\u679c\u5dee\u7570\u5f88\u5927\uff0c\u5f37\u8abf\u65e9\u671f\u7ba1\u7406\u548c\u816b\u7624\u5b78\u7684\u6301\u7e8c\u9032\u6b65\u3002<\/p>\n<h3 id=\"stage-1-non-hodgkin-lymphoma-nhl\">\u7b2c 1 \u671f \u2013 \u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL)<\/h3>\n<p>\u5728\u7b2c 1 \u671f\uff0c <strong>\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL)<\/strong> \u5b9a\u4f4d\u65bc\u4e00\u500b\u6dcb\u5df4\u7d50\u5340\u57df\u6216\u55ae\u4e00\u6dcb\u5df4\u5916\u90e8\u4f4d\u3002\u900f\u904e\u53ca\u6642\u3001\u5c40\u90e8\u7684\u6cbb\u7642\u65b9\u6cd5\uff0c\u9810\u5f8c\u5f80\u5f80\u6703\u5f88\u597d\u3002<\/p>\n<ul>\n<li>\u7279\u5fb5\uff1a\u55ae\u4e00\u6dcb\u5df4\u53d7\u7d2f\u6216\u5c40\u9650\u6027\u7d50\u5916\u75c5\u8b8a\u3002<\/li>\n<li>\u6cbb\u7642\u9078\u64c7\uff1a\u653e\u5c04\u6cbb\u7642\u3001\u6a19\u9776\u624b\u8853\u5207\u9664\u3001\u5316\u7642\uff08\u98a8\u96aa\u8f03\u9ad8\u7684\u4e9e\u578b\uff09\u3002<\/li>\n<li>\u5b58\u6d3b\u7387\uff08\u9999\u6e2f\/\u4e9e\u6d32 2025 \u5e74\uff09\uff1a5 \u5e74\u5b58\u6d3b\u7387\u7d04 80-90%\u3002<\/li>\n<\/ul>\n<h3 id=\"stage-2-non-hodgkin-lymphoma-nhl\">\u7b2c 2 \u671f \u2013 \u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL)<\/h3>\n<p>\u5728\u7b2c 2 \u671f\uff0c\u6dcb\u5df4\u7624\u5df2\u64f4\u6563\u81f3\u8188\u808c\u540c\u5074\u7684\u5169\u500b\u6216\u591a\u500b\u6dcb\u5df4\u7d50\u5340\u57df\uff0c\u6216\u6dcb\u5df4\u5916\u5668\u5b98\u53d7\u7d2f\u6709\u9650\u3002\u6cbb\u7642\u8907\u96dc\u6027\u589e\u52a0\uff0c\u4f46\u4ecd\u6709\u6548\u3002<\/p>\n<ul>\n<li>\u7279\u5fb5\uff1a\u591a\u500b\u6dcb\u5df4\u5340\u57df\uff0c\u6709\u9650\u7684\u6dcb\u5df4\u5916\u5668\u5b98\u64f4\u6563\u3002<\/li>\n<li>\u6cbb\u7642\u9078\u64c7\uff1a\u5408\u4f75\u5316\u7642\u65b9\u6848\uff08R-CHOP\uff09\uff0c\u7279\u5b9a\u75c5\u4f8b\u9032\u884c\u653e\u5c04\u6cbb\u7642\u3002<\/li>\n<li>\u5b58\u6d3b\u7387\uff08\u9999\u6e2f\/\u4e9e\u6d32 2025 \u5e74\uff09\uff1a5 \u5e74\u5b58\u6d3b\u7387\u70ba 70\u201385%\u3002<\/li>\n<\/ul>\n<h3 id=\"stage-3-non-hodgkin-lymphoma-nhl\">\u7b2c 3 \u671f \u2013 \u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL)<\/h3>\n<p>\u7b2c 3 \u671f\u7684\u7279\u5fb5\u662f\u8188\u808c\u5169\u5074\u90fd\u5b58\u5728\u6dcb\u5df4\u7624\u3002\u6cbb\u7642\u65b9\u6848\u5305\u62ec\u66f4\u7a4d\u6975\u7684\u5316\u7642\u65b9\u6848\u548c\u514d\u75ab\u7642\u6cd5\uff0c\u4ee5\u89e3\u6c7a\u5168\u8eab\u6027\u53d7\u7d2f\u554f\u984c\u3002<\/p>\n<ul>\n<li>\u7279\u5fb5\uff1a\u8188\u808c\u5169\u5074\u5ee3\u6cdb\u3001\u591a\u500b\u6dcb\u5df4\u7d50\u5340\u57df\uff0c\u53ef\u80fd\u6d89\u53ca\u813e\u81df\u3002<\/li>\n<li>\u6cbb\u7642\u9078\u64c7\uff1a\u7a4d\u6975\u7684\u5316\u7642\u65b9\u6848\uff08\u5982 R-CHOP \u548c HyperCVAD\uff09\u3001\u55ae\u682a\u6297\u9ad4\u514d\u75ab\u7642\u6cd5\uff08\u5982\u5229\u59a5\u6614\u55ae\u6297\uff09\u3002<\/li>\n<li>\u5b58\u6d3b\u7387\uff08\u9999\u6e2f\/\u4e9e\u6d32 2025 \u5e74\uff09\uff1a5 \u5e74\u5b58\u6d3b\u7387\u7d04 50-70%\u3002<\/li>\n<\/ul>\n<h3 id=\"stage-4-non-hodgkin-lymphoma-nhl\">\u7b2c 4 \u671f \u2013 \u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL)<\/h3>\n<p>\u7b2c 4 \u671f\u8868\u793a\u665a\u671f\u64ad\u6563\u6027\u6dcb\u5df4\u7624\uff0c\u901a\u5e38\u5f71\u97ff\u9aa8\u9ad3\u3001\u809d\u81df\u3001\u80ba\u81df\u6216\u5176\u4ed6\u91cd\u8981\u7684\u7d50\u5916\u5668\u5b98\u3002\u6b64\u968e\u6bb5\u7684\u7ba1\u7406\u9700\u8981\u8907\u96dc\u7684\u3001\u591a\u76ee\u6a19\u7684\u7b56\u7565\u3002<\/p>\n<ul>\n<li>\u7279\u5fb5\uff1a\u6dcb\u5df4\u7cfb\u7d71\u4ee5\u5916\u7684\u64ad\u6563\u6027\u6dcb\u5df4\u7624\uff0c\u6d89\u53ca\u9060\u7aef\u5668\u5b98\u3002<\/li>\n<li>\u6cbb\u7642\u9078\u64c7\uff1a\u5f37\u5316\u5316\u7642\u65b9\u6848\u3001\u514d\u75ab\u7642\u6cd5\u7d44\u5408\u3001CAR T \u7d30\u80de\u7642\u6cd5\u548c\u5275\u65b0\u7684 4D \u4ee3\u8b1d\u7642\u6cd5\u3002<\/li>\n<li>\u5b58\u6d3b\u7387\uff08\u9999\u6e2f\/\u4e9e\u6d32 2025 \u5e74\uff09\uff1a5 \u5e74\u5b58\u6d3b\u7387\u7d04 20-40%\uff0c\u63a1\u7528\u65b0\u578b\u6cbb\u7642\u65b9\u6cd5\u53ef\u986f\u8457\u63d0\u9ad8\u3002<\/li>\n<\/ul>\n<p>\u764c\u75c7\u751f\u7269\u5b78\u7684\u9032\u6b65\uff0c\u7279\u5225\u662f\u91dd\u5c0d\u7279\u5b9a\u764c\u7d30\u80de\u8106\u5f31\u6027\u7684\u514d\u75ab\u7642\u6cd5\u548c\u4ee3\u8b1d\u7642\u6cd5\uff0c\u986f\u8457\u63d0\u9ad8\u4e86\u5b58\u6d3b\u7387\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cAllCancer \u7684\u300c\u5148\u6cbb\u6108\uff0c\u5f8c\u4ed8\u8cbb\u300d\u8a08\u5283\u5229\u7528\u5c16\u7aef\u79d1\u5b78\u548c\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u652f\u6301\u7684\u7814\u7a76\uff0c\u7e7c\u7e8c\u5c07 4 \u671f\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u8f49\u8b8a\u70ba\u8a31\u591a\u60a3\u8005\u53ef\u63a7\u5236\u7684\u6162\u6027\u75be\u75c5\u3002<\/p>\n<p>\u65e9\u671f\u75c7\u72c0\u8b58\u5225\u3001\u6b63\u78ba\u7684\u5206\u671f\u8a55\u4f30\u4ee5\u53ca\u7acb\u5373\u958b\u59cb\u91dd\u5c0d\u500b\u5225\u751f\u7269\u5b78\u7279\u5fb5\u7684\u5148\u9032\u6cbb\u7642\u53ef\u986f\u8457\u6539\u5584\u9810\u5f8c\u3002\u900f\u904e\u6df1\u5733\u524d\u6d77\u6cf0\u5eb7\u548c MD Anderson Partnership \u7b49\u77e5\u540d\u816b\u7624\u5b78\u9818\u5c0e\u8005\u7684\u5c08\u5bb6\u4e3b\u5c0e\u7684\u7d9c\u5408\u8b77\u7406\uff0c\u73fe\u5728\u5728\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u5404\u500b\u968e\u6bb5\u7684\u7ba1\u7406\u4e2d\uff0c\u4eba\u5011\u5c0d\u6539\u5584\u751f\u5b58\u7d50\u679c\u666e\u904d\u62b1\u6709\u76f8\u7576\u6a02\u89c0\u7684\u614b\u5ea6\u3002<\/p>\n<h2 id=\"limitations-of-traditional-therapies-for-non-hodgkin-lymphoma-nhl\">\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL) \u50b3\u7d71\u7642\u6cd5\u7684\u5c40\u9650\u6027<\/h2>\n<h3 id=\"chemotherapy-and-its-significant-challenges\">\u5316\u7642\u53ca\u5176\u91cd\u5927\u6311\u6230<\/h3>\n<p>\u5316\u7642\u4ecd\u662f\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624 (NHL) \u7684\u6a19\u6e96\u6cbb\u7642\u65b9\u6cd5\u3002\u7136\u800c\uff0c\u5118\u7ba1\u5316\u7642\u5728\u65e9\u671f\u75c5\u4f8b\u4e2d\u6709\u6548\uff0c\u4f46\u5b83\u4e5f\u5b58\u5728\u986f\u8457\u7684\u7f3a\u9ede\uff0c\u7279\u5225\u662f\u5728\u6bd2\u6027\u548c\u526f\u4f5c\u7528\u65b9\u9762\u3002\u5316\u7642\u85e5\u7269\u91dd\u5c0d\u5feb\u901f\u5206\u88c2\u7684\u764c\u7d30\u80de\uff0c\u4f46\u7121\u610f\u4e2d\u640d\u5bb3\u4e86\u5177\u6709\u76f8\u4f3c\u7279\u5fb5\u7684\u5065\u5eb7\u7d44\u7e54\uff0c\u5c0e\u81f4\u660e\u986f\u7684\u6bd2\u6027\u4f5c\u7528\u3002<\/p>\n<h4>\u9aa8\u9ad3\u6291\u5236\u548c\u514d\u75ab\u7cfb\u7d71\u5f71\u97ff<\/h4>\n<p>\u63a5\u53d7\u5316\u7642\u7684\u60a3\u8005\u7d93\u5e38\u9047\u5230\u9aa8\u9ad3\u6291\u5236\u7b49\u91cd\u5927\u554f\u984c\u3002\u6839\u64da\u767c\u8868\u5728\u300aJAMA Oncology\u300b\uff082023 \u5e74\uff09\u7684\u7814\u7a76\uff0c\u5316\u7642\u6cbb\u7642\u5c0e\u81f4 NHL \u60a3\u8005\u51fa\u73fe\u9aa8\u9ad3\u6291\u5236\u7684\u98a8\u96aa\u7d04\u70ba 78%\u3002\u9019\u7a2e\u6291\u5236\u6703\u5c0d\u767d\u8840\u7403\u8a08\u6578\u3001\u8840\u5c0f\u677f\u548c\u7d05\u8840\u7403\u7522\u751f\u4e0d\u5229\u5f71\u97ff\uff0c\u986f\u8457\u589e\u52a0\u611f\u67d3\u548c\u8ca7\u8840\u7684\u53ef\u80fd\u6027\u3002<\/p>\n<ul>\n<li>\u611f\u67d3\u98a8\u96aa\u589e\u52a0\uff0c\u5c24\u5176\u662f\u7d30\u83cc\u548c\u771f\u83cc\u611f\u67d3<\/li>\n<li>\u9577\u671f\u8ca7\u8840\u548c\u75b2\u52de\u5c0e\u81f4\u751f\u6d3b\u8cea\u7d20\u4e0b\u964d<\/li>\n<li>\u53ef\u80fd\u9700\u8981\u9577\u671f\u4f4f\u9662\u6216\u8f38\u8840<\/li>\n<\/ul>\n<h4>\u5fc3\u81df\u6bd2\u6027\u98a8\u96aa<\/h4>\n<p>\u50b3\u7d71 NHL \u6cbb\u7642\u4e2d\u5178\u578b\u7684\u5316\u7642\u76f8\u95dc\u7684\u53e6\u4e00\u500b\u95dc\u9375\u7f3a\u9ede\u662f\u5fc3\u81df\u6bd2\u6027\u3002\u57fa\u65bc\u84bd\u74b0\u985e\u85e5\u7269\u7684\u5316\u7642\u901a\u5e38\u7528\u65bc\u6cbb\u7642\u4fb5\u8972\u6027 NHL \u4e9e\u578b\uff0c\u6709\u8b49\u64da\u8868\u660e\u8a72\u5316\u7642\u6703\u5c0d\u7d04 23% \u7684\u60a3\u8005\u9020\u6210\u5fc3\u81df\u640d\u50b7\uff08JAMA Oncology\uff0c2023\uff09\u3002\u7531\u6b64\u7522\u751f\u7684\u5fc3\u81df\u4f75\u767c\u75c7\u6703\u56b4\u91cd\u9650\u5236\u60a3\u8005\u7684\u751f\u6d3b\u65b9\u5f0f\u9078\u64c7\u548c\u6574\u9ad4\u751f\u6d3b\u8cea\u7d20\u3002<\/p>\n<ul>\n<li>\u6162\u6027\u5fc3\u81df\u4f75\u767c\u75c7\u5c0e\u81f4\u9ad4\u529b\u6d3b\u52d5\u53d7\u9650<\/li>\n<li>\u5fc3\u81df\u8870\u7aed\u7684\u98a8\u96aa\u589e\u52a0\uff0c\u9700\u8981\u7d42\u8eab\u91ab\u7642\u7ba1\u7406<\/li>\n<li>\u56e0\u5fc3\u81df\u529f\u80fd\u9010\u6f38\u60e1\u5316\u800c\u7e2e\u77ed\u58fd\u547d<\/li>\n<\/ul>\n<h3 id=\"radiation-therapy-and-associated-side-effects\">\u653e\u5c04\u6cbb\u7642\u53ca\u76f8\u95dc\u526f\u4f5c\u7528<\/h3>\n<p>\u653e\u5c04\u6cbb\u7642\u6d89\u53ca\u7cbe\u78ba\u91dd\u5c0d\u6dcb\u5df4\u7624\u7d30\u80de\u7684\u9ad8\u80fd\u91cf\u5c04\u7dda\u3002\u5118\u7ba1\u8f3b\u5c04\u5728\u67d0\u7a2e\u7a0b\u5ea6\u4e0a\u6709\u6548\uff0c\u4f46\u4e5f\u6703\u5c0d\u5468\u570d\u7684\u5065\u5eb7\u7d44\u7e54\u9020\u6210\u4e00\u4e9b\u4e0d\u5229\u5f8c\u679c\u3002\u7531\u65bc\u95dc\u9375\u5668\u5b98\u548c\u7d44\u7e54\u8207 NHL \u4e2d\u5e38\u898b\u7684\u6dcb\u5df4\u7d50\u69cb\u975e\u5e38\u63a5\u8fd1\uff0c\u9019\u4e9b\u5f71\u97ff\u5c24\u5176\u6210\u554f\u984c\u3002<\/p>\n<h4>\u5c40\u90e8\u7d44\u7e54\u640d\u50b7\u548c\u4f75\u767c\u75c7<\/h4>\n<p>\u653e\u5c04\u6cbb\u7642\u53ef\u5f15\u8d77\u56b4\u91cd\u7684\u9644\u5e36\u7d44\u7e54\u640d\u50b7\uff0c\u5305\u62ec\u71d2\u50b7\u3001\u7e96\u7dad\u5316\u548c\u6162\u6027\u767c\u708e\u3002\u6b64\u985e\u4f75\u767c\u75c7\u6703\u56b4\u91cd\u640d\u5bb3\u60a3\u8005\u7684\u529f\u80fd\uff0c\u4e26\u5c0d\u60a3\u8005\u7684\u8212\u9069\u5ea6\u3001\u6d3b\u52d5\u80fd\u529b\u548c\u6574\u9ad4\u751f\u6d3b\u8cea\u7d20\u7522\u751f\u8ca0\u9762\u5f71\u97ff\u3002<\/p>\n<ul>\n<li>\u56b4\u91cd\u7e96\u7dad\u5316\u5c0e\u81f4\u7d44\u7e54\u548c\u95dc\u7bc0\u6d3b\u52d5\u53d7\u9650<\/li>\n<li>\u8f3b\u5c04\u5f15\u8d77\u7684\u76ae\u819a\u71d2\u50b7\u548c\u523a\u6fc0\u7684\u767c\u751f\u7387\u5f88\u9ad8<\/li>\n<li>\u6cbb\u7642\u90e8\u4f4d\u6301\u7e8c\u6162\u6027\u75bc\u75db\u53ca\u4e0d\u9069<\/li>\n<\/ul>\n<h4>\u7e7c\u767c\u6027\u764c\u75c7\u5f62\u6210\u7684\u9577\u671f\u98a8\u96aa<\/h4>\n<p>\u653e\u5c04\u6cbb\u7642\u589e\u52a0\u4e86\u7e7c\u767c\u6027\u60e1\u6027\u816b\u7624\u7684\u98a8\u96aa\uff0c\u52a0\u5287\u4e86\u9019\u500b\u7f3a\u9ede\u3002\u4e8b\u5be6\u4e0a\uff0c\u300aJAMA Oncology\u300b\uff082023 \u5e74\uff09\u4e2d\u7684\u65b0\u8b49\u64da\u8868\u660e\uff0cNHL \u653e\u5c04\u6cbb\u7642\u5f8c\u767c\u751f\u7e7c\u767c\u6027\u764c\u75c7\u7684\u53ef\u80fd\u6027\u6703\u589e\u52a0\u8fd1 300%\u3002<\/p>\n<ul>\n<li>\u7e7c\u767c\u6027\u5be6\u9ad4\u816b\u7624\uff08\u4f8b\u5982\u4e73\u764c\u6216\u80ba\u764c\uff09\u7684\u98a8\u96aa\u589e\u52a0<\/li>\n<li>\u900f\u904e\u7d42\u8eab\u764c\u75c7\u7be9\u6aa2\u63d0\u9ad8\u8b66\u60d5<\/li>\n<li>\u60a3\u8005\u7684\u7126\u616e\u548c\u5fc3\u7406\u8ca0\u64d4\u986f\u8457\u589e\u52a0<\/li>\n<\/ul>\n<h3 id=\"surgical-intervention-risks-and-limitations\">\u624b\u8853\u4ecb\u5165\u7684\u98a8\u96aa\u548c\u5c40\u9650\u6027<\/h3>\n<p>\u96d6\u7136\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624\u6cbb\u7642\u4e2d\u7684\u624b\u8853\u65b9\u6cd5\u8f03\u4e0d\u5e38\u898b\uff0c\u4f46\u5728\u9069\u7528\u6642\u5b83\u5011\u4ecd\u7136\u5177\u6709\u986f\u8457\u7684\u9650\u5236\u548c\u98a8\u96aa\u3002\u5207\u9664\u53d7\u7d2f\u6dcb\u5df4\u7d50\u6216\u7d50\u5916\u75c5\u8b8a\u90e8\u4f4d\u7684\u624b\u8853\u5e79\u9810\u5b58\u5728\u8907\u96dc\u6027\u3001\u4fb5\u8972\u6027\u548c\u96a8\u5f8c\u6062\u5fa9\u7684\u554f\u984c\u3002<\/p>\n<h4>\u611f\u67d3\u548c\u624b\u8853\u4f75\u767c\u75c7\u7684\u98a8\u96aa<\/h4>\n<p>\u8853\u5f8c\u611f\u67d3\u548c\u4f75\u767c\u75c7\u7b49\u5e38\u898b\u624b\u8853\u98a8\u96aa\u986f\u8457\u5f71\u97ff\u6cbb\u7642\u6548\u679c\u548c\u60a3\u8005\u5fa9\u539f\u3002\u9664\u4e86\u611f\u67d3\u5916\uff0c\u51fa\u8840\u3001\u6dcb\u5df4\u6f0f\u548c\u4f4f\u9662\u6642\u9593\u5ef6\u9577\u7b49\u4f75\u767c\u75c7\u4e5f\u7d93\u5e38\u767c\u751f\uff0c\u52a0\u5287\u4e86\u60a3\u8005\u7684\u75db\u82e6\u3002<\/p>\n<ul>\n<li>\u7531\u65bc\u8853\u5f8c\u8907\u96dc\u6027\u5c0e\u81f4\u4f4f\u9662\u6642\u9593\u5ef6\u9577<\/li>\n<li>\u91ab\u9662\u7372\u5f97\u6027\u611f\u67d3\u7684\u98a8\u96aa\u589e\u52a0\uff0c\u5c24\u5176\u662f\u514d\u75ab\u529f\u80fd\u4f4e\u4e0b\u7684 NHL \u60a3\u8005<\/li>\n<li>\u5f8c\u7e8c\u5e79\u9810\u6216\u4fee\u5fa9\u624b\u8853\u7684\u6f5b\u5728\u9700\u8981<\/li>\n<\/ul>\n<h3 id=\"low-efficacy-in-advanced-and-refractory-cases\">\u665a\u671f\u548c\u96e3\u6cbb\u6027\u75c5\u4f8b\u7642\u6548\u4f4e\u4e0b<\/h3>\n<p>\u4e5f\u8a31\u50b3\u7d71 NHL \u6cbb\u7642\u6700\u4ee4\u4eba\u754f\u61fc\u7684\u7f3a\u9ede\u4e4b\u4e00\u4ecd\u7136\u662f\u5176\u6709\u9650\u7684\u7642\u6548\uff0c\u7279\u5225\u662f\u5728\u665a\u671f\u6216\u8f49\u79fb\u6027\u75c5\u4f8b\u4e2d\u3002\u6a19\u6e96\u6cbb\u7642\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\u4f4e\u5f97\u4ee4\u4eba\u5931\u671b\uff0c\u8f49\u79fb\u6027\u6216\u96e3\u6cbb\u6027\u975e\u4f55\u6770\u91d1\u6c0f\u6dcb\u5df4\u7624\u75c5\u4f8b\u7684\u7de9\u89e3\u7387\u4f4e\u65bc 21%\uff08JAMA Oncology\uff0c2023\uff09\u3002<\/p>\n<ul>\n<li>\u6548\u679c\u6709\u9650\uff0c\u5927\u5927\u964d\u4f4e\u4e86\u60a3\u8005\u7684\u58eb\u6c23\u548c\u6a02\u89c0\u60c5\u7dd2<\/li>\n<li>\u6301\u7e8c\u7684\u6cbb\u7642\u9700\u6c42\u7d66\u91ab\u7642\u4fdd\u5065\u7cfb\u7d71\u5e36\u4f86\u66f4\u5927\u7684\u8ca0\u64d4<\/li>\n<li>\u7531\u65bc\u6301\u7e8c\u7684\u75be\u75c5\u72c0\u614b\u800c\u5c0e\u81f4\u7684\u53cd\u601d\u6027\u7126\u616e\u548c\u7d55\u671b<\/li>\n<\/ul>\n<h3 id=\"metabolic-and-cellular-resistance-mechanisms\">\u4ee3\u8b1d\u548c\u7d30\u80de\u6297\u85e5\u6027\u6a5f\u5236<\/h3>\n<p>\u764c\u75c7\u751f\u7269\u5b78\u7684\u65b0\u898b\u89e3\u5df2\u7d93\u78ba\u5b9a\u4e86 NHL \u7d30\u80de\u4e2d\u7684\u4ee3\u8b1d\u548c\u907a\u50b3\u6297\u85e5\u6027\u6a5f\u5236\uff0c\u9032\u4e00\u6b65\u524a\u5f31\u4e86\u50b3\u7d71\u6cbb\u7642\u7684\u6548\u7387\u3002\u764c\u7d30\u80de\u767c\u5c55\u51fa\u8907\u96dc\u7684\u62b5\u6297\u7b56\u7565\uff0c\u5305\u62ec\u63d0\u9ad8 DNA \u4fee\u5fa9\u9176\u7684\u6d3b\u6027\u3001\u7d30\u80de\u71df\u990a\u8abf\u7bc0\u548c\u589e\u5f37\u7684\u89e3\u6bd2\u6a5f\u5236\u3002<\/p>\n<h4>\u4ee3\u8b1d\u9069\u61c9\u548c\u6cbb\u7642\u62b5\u6297<\/h4>\n<p>\u764c\u7d30\u80de\u6539\u8b8a\u5176\u4ee3\u8b1d\u9014\u5f91\uff0c\u8868\u73fe\u51fa\u5c0d\u8461\u8404\u7cd6\u4ee3\u8b1d\u7684\u4f9d\u8cf4\u6027\u589e\u52a0\uff08\u7a31\u70ba\u74e6\u4f2f\u683c\u6548\u61c9\uff09\uff0c\u5176\u4e2d\u6dcb\u5df4\u7624\u7d30\u80de\u6d88\u8017\u8461\u8404\u7cd6\u7684\u901f\u5ea6\u6bd4\u6b63\u5e38\u7d30\u80de\u9ad8 200 \u500d\u3002\u6b64\u5916\uff0cNHL \u7d30\u80de\u7684 DNA \u4fee\u5fa9\u9176\u7cfb\u7d71\u6d3b\u6027\u986f\u8457\u589e\u52a0\uff08\u7d04 400%\uff09\uff0c\u4fc3\u9032\u6cbb\u7642\u5f8c\u66f4\u5feb\u6062\u5fa9\uff0c\u4e26\u7531\u6b64\u7522\u751f\u5c0d\u50b3\u7d71\u6cbb\u7642\u65b9\u5f0f\u7684\u62b5\u6297\u529b\u3002<\/p>\n<ul>\n<li>DNA \u640d\u50b7\u5feb\u901f\u4fee\u5fa9\u5c0e\u81f4\u5316\u7642\u548c\u653e\u5c04\u6cbb\u7642\u6548\u679c\u986f\u8457\u964d\u4f4e<\/li>\n<li>\u9700\u8981\u66f4\u9ad8\u3001\u6bd2\u6027\u66f4\u5927\u7684\u5291\u91cf\uff0c\u52a0\u5287\u4e86\u60a3\u8005\u7684\u5b89\u5168\u64d4\u6182<\/li>\n<li>\u9700\u8981\u5275\u65b0\u65b9\u6cd5\u548c\u4ee3\u8b1d\u7642\u6cd5\u7684\u6311\u6230<\/li>\n<\/ul>\n<p>\u9019\u4e9b\u9650\u5236\u5171\u540c\u51f8\u986f\u4e86\u958b\u62d3\u65b0\u578b\u7642\u6cd5\uff08\u4f8b\u5982 4D \u4ee3\u8b1d\u7642\u6cd5\uff09\u7121\u53ef\u5426\u8a8d\u7684\u5fc5\u8981\u6027\uff0c\u9019\u7a2e\u7642\u6cd5\u6709\u671b\u63d0\u4f9b\u4e00\u7a2e\u66f4\u6709\u91dd\u5c0d\u6027\u3001\u66f4\u6709\u6548\u4e14\u826f\u6027\u7684\u65b9\u6cd5\u4f86\u6cbb\u7642\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624 (NHL)\uff0c\u6700\u7d42\u5be6\u73fe\u6211\u5011\u5230 2025 \u5e74\u5c07 NHL \u8f49\u8b8a\u70ba\u53ef\u63a7\u5236\u7684\u6162\u6027\u75be\u75c5\u7684\u76ee\u6a19\u3002<\/p>\n<h2>4D \u764c\u75c7\u7642\u6cd5\u6cbb\u7642\u65b9\u6cd5<\/h2>\n<p>\u9999\u6e2f\u4ee3\u8b1d\u816b\u7624\u6cbb\u7642\u4e2d\u5fc3\u63d0\u51fa\u76844D \u7642\u6cd5\u4ee3\u8868\u4e86\u4e00\u7a2e\u591a\u5c64\u9762\u7684\u764c\u75c7\u6cbb\u7642\u65b9\u6cd5\uff0c\u65e8\u5728\u5c07\u764c\u75c7\u8f49\u8b8a\u70ba\u53ef\u63a7\u5236\u7684\u6162\u6027\u75be\u75c5\u3002\u672c\u8abf\u67e5\u5831\u544a\u57fa\u65bc\u6240\u63d0\u4f9b\u7684\u6587\u4ef6\uff0c\u4e26\u900f\u904e\u57fa\u65bc\u7db2\u8def\u7684\u79d1\u5b78\u6587\u737b\u7684\u5ee3\u6cdb\u7814\u7a76\u9032\u884c\u4e86\u88dc\u5145\uff0c\u5c0d\u56db\u7a2e\u65b9\u6cd5\uff08\u4ee3\u8b1d\u6291\u5236\u3001\u7bc0\u594f\u6027\u816b\u7624\u63a7\u5236\u3001\u57fa\u56e0\u9776\u5411\u65ac\u9996\u548c\u514d\u75ab\u98a8\u66b4\u555f\u52d5\uff09\u9032\u884c\u4e86\u5168\u9762\u5206\u6790\u3002\u5206\u6790\u5305\u62ec\u79d1\u5b78\u539f\u7406\u3001\u81e8\u5e8a\u8b49\u64da\u548c\u6f5b\u5728\u6311\u6230\uff0c\u6700\u7d42\u63d0\u51fa\u4e86\u53e3\u865f\u548c\u53e3\u865f\u3002<\/p>\n<h3>\u4ee3\u8b1d\u6291\u5236<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u9019\u7a2e\u65b9\u6cd5\u91dd\u5c0d\u764c\u7d30\u80de\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\uff0c\u7279\u5225\u662f\u5b83\u5011\u5c0d\u8461\u8404\u7cd6\u3001\u9ea9\u91af\u80fa\u9178\u548c\u8102\u8cea\u5408\u6210\u7684\u4f9d\u8cf4\u3002\u5b83\u4f7f\u7528\u8af8\u5982\u7528\u65bc\u8461\u8404\u7cd6\u8f49\u904b\u7684 GLUT1\/3\u3001\u7528\u65bc\u8c37\u6c28\u9170\u80fa\u4ee3\u8b1d\u7684 GLS\/ASCT2 \u4ee5\u53ca\u7528\u65bc\u8102\u8cea\u5408\u6210\u7684 FASN \u7b49\u6291\u5236\u5291\uff0c\u901a\u5e38\u900f\u904e\u5948\u7c73\u8f09\u9ad4\u905e\u9001\u3002\u4eba\u5de5\u667a\u6167\u9a45\u52d5\u7684\u71df\u990a\u8abf\u7bc0\u63d0\u9ad8\u4e86\u7cbe\u78ba\u5ea6\uff0c\u65e8\u5728\u5f15\u767c ATP \u5371\u6a5f\u4e26\u524a\u5f31\u764c\u7d30\u80de\u3002\u6587\u4ef6\u8072\u7a31\u816b\u7624\u8461\u8404\u7cd6\u651d\u53d6\u6e1b\u5c11\u4e86 82%\uff0c\u8840\u6f3f\u9ea9\u91af\u80fa\u9178\u6e1b\u5c11\u4e86 79%\uff0c\u819c\u78f7\u8102\u5408\u6210\u6e1b\u5c11\u4e86 91%\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u7814\u7a76\uff0c\u4f8b\u5982 <a href=\"https:\/\/www.nature.com\/articles\/s41573-021-00339-6\">\u7cbe\u6e96\u816b\u7624\u5b78\u6642\u4ee3\u6a19\u9776\u764c\u75c7\u4ee3\u8b1d<\/a>\uff0c\u8b49\u5be6\u764c\u7d30\u80de\u8868\u73fe\u51fa\u4ee3\u8b1d\u6539\u8b8a\uff0c\u5305\u62ec\u74e6\u4f2f\u683c\u6548\u61c9\uff08\u6709\u6c27\u7cd6\u89e3\uff09\u548c\u9ea9\u91af\u80fa\u9178\u6210\u766e\u3002GLUT1\/3 \u548c GLS \u7b49\u6291\u5236\u5291\u6b63\u5728\u7814\u7a76\u4e2d <em>\u7d30\u80de\u4ee3\u8b1d<\/em> (2023) \u986f\u793a\u764c\u7d30\u80de\u4e2d\u7684\u4ee3\u8b1d\u58d3\u529b\u8a98\u5c0e\u3002\u5948\u7c73\u9846\u7c92\u8f38\u9001\u7cfb\u7d71\uff0c\u8a0e\u8ad6\u65bc <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590183420300028\">\u764c\u75c7\u6cbb\u7642\u4e2d\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u8f38\u9001<\/a>\uff0c\u589e\u5f37\u7279\u7570\u6027\uff0c\u5118\u7ba1\u816b\u7624\u7570\u8cea\u6027\u548c\u812b\u9776\u6548\u61c9\u7b49\u6311\u6230\u4ecd\u7136\u5b58\u5728\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u6240\u8072\u7a31\u7684\u81e8\u5e8a\u76ca\u8655\u8207\u65b0\u8208\u8a66\u9a57\u4e00\u81f4\uff0c\u4f46\u764c\u75c7\u985e\u578b\uff08\u4f8b\u5982\u80ba\u764c\u8207\u4e73\u764c\uff09\u548c\u60a3\u8005\u53cd\u61c9\u7684\u5dee\u7570\u8868\u660e\u9700\u8981\u500b\u6027\u5316\u7684\u65b9\u6cd5\u30022024\u5e74 <em>\u7d30\u80de<\/em> \u6587\u4ef6\u4e2d\u5f15\u7528\u7684\u7814\u7a76\u8072\u7a31\u6297\u85e5\u6027\u57fa\u56e0\u8868\u73fe\u6e1b\u5c11\u4e86 80%\uff0c\u9700\u8981\u900f\u904e\u66f4\u5927\u898f\u6a21\u7684\u591a\u4e2d\u5fc3\u8a66\u9a57\u9032\u884c\u9a57\u8b49\u3002\u502b\u7406\u65b9\u9762\u7684\u8003\u616e\uff0c\u4f8b\u5982\u7372\u53d6\u548c\u8ca0\u64d4\u80fd\u529b\uff0c\u5728 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2949723X23000533\">\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u50b3\u8f38\u7cfb\u7d71\u7684\u529f\u6548\u56de\u9867<\/a>.<\/p>\n<h3>\u7bc0\u594f\u6027\u816b\u7624\u63a7\u5236<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528\u4f4e\u5291\u91cf\u3001\u7bc0\u5f8b\u5316\u7642\uff08\u50b3\u7d71\u5291\u91cf\u7684 1\/10\uff09\u548c\u8840\u7ba1\u6b63\u5e38\u5316\u56e0\u5b50\u4f86\u63a7\u5236\u816b\u7624\u751f\u9577\uff0c\u964d\u4f4e\u6bd2\u6027\u4e26\u5be6\u73fe 67% \u7684\u5bb6\u5ead\u6cbb\u7642\u3002\u64da\u8072\u7a31\uff0c\u5b83\u5c07\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u5f9e 5.2 \u500b\u6708\u5ef6\u9577\u81f3 11.8 \u500b\u6708\uff0c\u4e26\u5c07\u56b4\u91cd\u6bd2\u6027\u964d\u4f4e 67%\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u4f4e\u5291\u91cf\u7bc0\u5f8b\u5316\u7642\u5df2\u88ab\u5ee3\u6cdb\u63a5\u53d7\uff0c\u5982 <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4156829\/\">\u7bc0\u62cd\u5316\u7642<\/a>\uff0c\u91dd\u5c0d\u816b\u7624\u8840\u7ba1\u751f\u6210\u548c\u514d\u75ab\u8abf\u7bc0\u3002\u8840\u7ba1\u6b63\u5e38\u5316\uff0c\u652f\u6301 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405844024007011\">\u7bc0\u62cd\u5316\u7642\u548c\u85e5\u7269\u518d\u5229\u7528<\/a>\uff0c\u900f\u904e\u589e\u5f37\u8840\u7ba1\u529f\u80fd\u4f86\u6539\u5584\u85e5\u7269\u8f38\u9001\u3002\u7814\u7a76\u5982 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0959804913005418\">\u4f4e\u5291\u91cf\u7bc0\u62cd\u5316\u7642\uff1a\u7cfb\u7d71\u6027\u6587\u737b\u5206\u6790<\/a> \u78ba\u8a8d\u6e1b\u5c11\u7684\u526f\u4f5c\u7528\u548c\u6f5b\u5728\u7684\u6210\u672c\u6548\u76ca\uff0c\u7279\u5225\u662f\u5728\u4f4e\u6536\u5165\u74b0\u5883\u4e2d\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684\u76ca\u8655\u8207\u8f49\u79fb\u6027\u4e73\u764c\u7684\u81e8\u5e8a\u6578\u64da\u4e00\u81f4\uff0c\u4f46\u7642\u6548\u53ef\u80fd\u56e0\u816b\u7624\u985e\u578b\u548c\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u800c\u7570\u3002\u5bb6\u5ead\u6cbb\u7642\u6a21\u5f0f\u96d6\u7136\u6709\u5e0c\u671b\uff0c\u4f46\u9700\u8981\u5805\u6301\u548c\u76e3\u6e2c\uff0c\u5982 <a href=\"https:\/\/www.lifespringcancercenter.com\/our-treatment\/low-dose-metronomic-chemotherapy\">\u751f\u547d\u6cc9\u764c\u75c7\u6cbb\u7642\u4e2d\u5fc3<\/a>\u3002\u95dc\u65bc\u6297\u85e5\u6027\u548c\u751f\u6d3b\u8cea\u7d20\u7684\u9577\u671f\u6578\u64da\u9700\u8981\u9032\u4e00\u6b65\u63a2\u7d22\u3002<\/p>\n<h3>\u57fa\u56e0\u6a19\u9776\u65ac\u9996<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528\u6db2\u9ad4\u6d3b\u6aa2\u4f86\u6aa2\u6e2c 487 \u500b\u764c\u75c7\u9a45\u52d5\u57fa\u56e0\uff0c\u4e26\u4f7f\u7528\u5948\u7c73\u9846\u7c92\u905e\u9001\u7cfb\u7d71\u4f86\u9776\u5411 KRAS\u3001BRAF \u548c TP53 \u7b49\u7a81\u8b8a\uff0c\u5f9e\u800c\u514b\u670d\u8840\u8166\u5c4f\u969c\u7b49\u969c\u7919\u3002\u5b83\u8072\u7a31 ORR \u63d0\u9ad8\u4e86 67%\uff0c\u905e\u9001\u6548\u7387\u63d0\u9ad8\u4e86 9 \u500d\uff0c\u7279\u5225\u662f\u5c0d\u65bc\u8f49\u79fb\u7624\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u5948\u7c73\u9846\u7c92\u8f38\u9001\u662f\u4e00\u500b\u524d\u6cbf\u9818\u57df\uff0c <a href=\"https:\/\/www.cancer.gov\/nano\/cancer-nanotechnology\/treatment\">\u5948\u7c73\u6280\u8853\u764c\u75c7\u6cbb\u7642\u548c\u6cbb\u7642<\/a> \u5f37\u8abf\u5176\u7a7f\u900f\u751f\u7406\u5c4f\u969c\u7684\u80fd\u529b\u3002\u6db2\u9ad4\u6d3b\u6aa2\uff0c\u8a0e\u8ad6\u65bc <a href=\"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03433-8\">\u63a8\u9032\u764c\u75c7\u57fa\u56e0\u6cbb\u7642<\/a>\uff0c\u5be6\u73fe\u5373\u6642\u7a81\u8b8a\u6aa2\u6e2c\uff0c\u8207\u7cbe\u6e96\u816b\u7624\u5b78\u8da8\u52e2\u4fdd\u6301\u4e00\u81f4\u3002\u7814\u7a76\u65bc <a href=\"https:\/\/www.nature.com\/articles\/s41392-023-01642-x\">\u7528\u65bc\u764c\u75c7\u6cbb\u7642\u7684\u667a\u6167\u5948\u7c73\u9846\u7c92<\/a> \u5118\u7ba1\u6bd2\u6027\u548c\u9776\u5411\u7279\u7570\u6027\u7b49\u6311\u6230\u4ecd\u7136\u5b58\u5728\uff0c\u4f46\u5b83\u986f\u793a\u51fa\u6cbb\u7642\u8166\u8f49\u79fb\u7684\u5e0c\u671b\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684 ORR \u70ba 67% \u662f\u96c4\u5fc3\u52c3\u52c3\u7684\uff0c\u96d6\u7136\u65e9\u671f\u8a66\u9a57\u986f\u793a\u51fa\u5e0c\u671b\uff0c\u4f46\u9700\u8981\u66f4\u5927\u898f\u6a21\u7684\u7814\u7a76\u4f86\u9a57\u8b49\u8de8\u816b\u7624\u985e\u578b\u7684\u7642\u6548\u3002\u816b\u7624\u7570\u8cea\u6027\uff0c\u5982\u4e2d\u6240\u8ff0 <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-023-01865-0\">\u9032\u6b65\u5948\u7c73\u6280\u8853\u4ee5\u6539\u5584\u6a19\u9776\u764c\u75c7\u6cbb\u7642<\/a>\uff0c\u53ef\u80fd\u6703\u9650\u88fd\u6210\u529f\uff0c\u9700\u8981\u7d44\u5408\u7b56\u7565\u3002<\/p>\n<h3>\u514d\u75ab\u98a8\u66b4\u555f\u52d5<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528 PD-1\/CTLA-4 \u6291\u5236\u5291\u3001\u65b0\u6297\u539f\u75ab\u82d7\u3001CAR-NK \u7d30\u80de\u548c\u5fae\u751f\u7269\u7d44\u8abf\u7bc0\u4f86\u6d3b\u5316\u591a\u5c64\u514d\u75ab\u53cd\u61c9\u3002\u5b83\u8072\u7a31 3 \u5e74\u5b58\u6d3b\u7387\u70ba 62.7%\uff08\u6539\u5584\u4e86 244%\uff09\uff0c\u5fa9\u767c\u7387\u964d\u4f4e\u4e86 85%\uff0c\u5c07\u300c\u51b7\u300d\u816b\u7624\u8f49\u8b8a\u70ba\u300c\u71b1\u300d\u816b\u7624\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u806f\u5408\u514d\u75ab\u7642\u6cd5\u662f\u9818\u5148\u9818\u57df\uff0c <a href=\"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-021-01164-5\">\u6700\u5927\u5316\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u76ca\u8655\u7684\u7d44\u5408\u7b56\u7565<\/a> \u986f\u793a\u51fa\u589e\u5f37\u7684\u53cd\u61c9\u3002\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u3001\u65b0\u6297\u539f\u75ab\u82d7\u548c CAR-T\/NK \u7642\u6cd5\uff0c\u53c3\u898b <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-025-02305-x\">\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u7684\u9032\u5c55<\/a>\u3001\u63d0\u9ad8\u514d\u75ab\u8fa8\u8b58\u80fd\u529b\u3002\u5fae\u751f\u7269\u7d44\u8abf\u7bc0\uff0c\u7a81\u51fa\u986f\u793a\u65bc <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-021-01316-8\">\u764c\u75c7\u4ee3\u8b1d\u91cd\u7de8\u7a0b\u548c\u514d\u75ab\u53cd\u61c9<\/a>\uff0c\u5f71\u97ff\u514d\u75ab\u6cbb\u7642\u7684\u7d50\u679c\uff0c\u5118\u7ba1\u5176\u4e00\u81f4\u6027\u6709\u722d\u8b70\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684\u751f\u5b58\u7387\u8207\u6700\u8fd1\u7684\u8a66\u9a57\u4e00\u81f4\uff0c\u4f46\u5be6\u9ad4\u7624\u7531\u65bc\u7570\u8cea\u6027\u548c\u514d\u75ab\u6291\u5236\u5fae\u74b0\u5883\u800c\u5e36\u4f86\u6311\u6230\uff0c\u5982 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u6700\u65b0\u9032\u5c55<\/a>\u3002\u95dc\u65bc\u5fa9\u767c\u548c\u514d\u75ab\u8a18\u61b6\u7684\u9577\u671f\u6578\u64da\u9700\u8981\u9032\u4e00\u6b65\u9a57\u8b49\u3002<\/p>\n<h3>\u6bd4\u8f03\u81e8\u5e8a\u7d50\u679c<\/h3>\n<p>\u9019\u4e9b\u6587\u4ef6\u63d0\u4f9b\u4e86\u4e00\u500b\u6bd4\u8f03\u50b3\u7d71\u7642\u6cd5\u548c\u56db\u7dad\u7642\u6cd5\u7684\u8868\u683c\uff0c\u70ba\u6e05\u695a\u8d77\u898b\uff0c\u5c07\u5176\u8907\u88fd\u5982\u4e0b\uff1a<\/p>\n<figure>\n<table class=\"has-fixed-layout\">\n<tbody>\n<tr>\n<td>\u6307\u6a19<\/td>\n<td>\u50b3\u7d71\u7684<br \/>\u6cbb\u7642<\/td>\n<td>\u56db\u7dad<br \/>\u6cbb\u7642<\/td>\n<td>\u6539\u9032<\/td>\n<\/tr>\n<tr>\n<td>\u5ba2\u89c0\u7de9\u89e3\u7387 (ORR)<\/td>\n<td>31%<\/td>\n<td>67%<\/td>\n<td>\u2191116%<\/td>\n<\/tr>\n<tr>\n<td>3 \u5e74\u5b58\u6d3b\u7387<\/td>\n<td>18%<\/td>\n<td>62.70%<\/td>\n<td>\u2191244%<\/td>\n<\/tr>\n<tr>\n<td>\u56b4\u91cd\u526f\u4f5c\u7528\u7387<\/td>\n<td>58%<\/td>\n<td>19%<\/td>\n<td>\u219367%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\u8868\u683c\u5f37\u8abf\u4e86\u8a72\u7642\u6cd5\u7684\u6f5b\u529b\uff0c\u4f46\u60a3\u8005\u7fa4\u9ad4\u548c\u816b\u7624\u985e\u578b\u4e4b\u9593\u7684\u5dee\u7570\u503c\u5f97\u9032\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n<h2><strong>\u7e3d\u7d50<\/strong><\/h2>\n<p>4D \u7642\u6cd5\u6574\u5408\u4e86\u89e3\u6c7a\u764c\u75c7\u8907\u96dc\u6027\u7684\u5c16\u7aef\u7b56\u7565\uff0c\u6bcf\u7a2e\u65b9\u6cd5\u90fd\u5f97\u5230\u65b0\u8208\u7814\u7a76\u7684\u652f\u6301\u3002\u7136\u800c\uff0c\u816b\u7624\u7570\u8cea\u6027\u3001\u81e8\u5e8a\u9a57\u8b49\u548c\u53ef\u8fd1\u6027\u7b49\u6311\u6230\u9700\u8981\u4e0d\u65b7\u63a2\u7d22\u3002\u5efa\u8b70\u7684\u53e3\u865f\u548c\u53e3\u865f\u65e8\u5728\u9ad4\u73fe\u8a72\u7642\u6cd5\u7684\u627f\u8afe\uff0c\u4e26\u5f15\u767c\u5c0d\u5176\u6539\u8b8a\u764c\u75c7\u6cbb\u7642\u6f5b\u529b\u7684\u9032\u4e00\u6b65\u8a0e\u8ad6\u3002<\/p>\n<h2>\u53c3\u8003\u6587\u737b<\/h2>\n<ul>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41573-021-00339-6\">\u7cbe\u6e96\u816b\u7624\u5b78\u6642\u4ee3\u6a19\u9776\u764c\u75c7\u4ee3\u8b1d<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590183420300028\">\u764c\u75c7\u6cbb\u7642\u4e2d\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u8f38\u9001<\/a><\/li>\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4156829\/\">\u7bc0\u62cd\u5316\u7642<\/a><\/li>\n<li><a href=\"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03433-8\">\u63a8\u9032\u764c\u75c7\u57fa\u56e0\u6cbb\u7642<\/a><\/li>\n<li><a href=\"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-021-01164-5\">\u6700\u5927\u5316\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u76ca\u8655\u7684\u7d44\u5408\u7b56\u7565<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u6700\u65b0\u9032\u5c55<\/a><\/li>\n<li><a href=\"https:\/\/www.cancer.gov\/nano\/cancer-nanotechnology\/treatment\">\u5948\u7c73\u6280\u8853\u764c\u75c7\u6cbb\u7642\u548c\u6cbb\u7642<\/a><\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41392-023-01642-x\">\u7528\u65bc\u764c\u75c7\u6cbb\u7642\u7684\u667a\u6167\u5948\u7c73\u9846\u7c92<\/a><\/li>\n<li><a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-021-01316-8\">\u764c\u75c7\u4ee3\u8b1d\u91cd\u7de8\u7a0b\u548c\u514d\u75ab\u53cd\u61c9<\/a><\/li>\n<li><a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-025-02305-x\">\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u7684\u9032\u5c55<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405844024007011\">\u7bc0\u62cd\u5316\u7642\u548c\u85e5\u7269\u518d\u5229\u7528<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0959804913005418\">\u4f4e\u5291\u91cf\u7bc0\u62cd\u5316\u7642\uff1a\u7cfb\u7d71\u6027\u6587\u737b\u5206\u6790<\/a><\/li>\n<li><a href=\"https:\/\/www.lifespringcancer.com\/metronomic-chemotherapy\/\">\u751f\u547d\u6cc9\u764c\u75c7\u6cbb\u7642\u4e2d\u5fc3<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u50b3\u8f38\u7cfb\u7d71\u7684\u529f\u6548\u56de\u9867<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u9032\u6b65\u5948\u7c73\u6280\u8853\u4ee5\u6539\u5584\u6a19\u9776\u764c\u75c7\u6cbb\u7642<\/a><\/li>\n<\/ul>\n<hr>\n<div class=\"ac-blog-cta\">\n<h2>\u9700\u8981\u5354\u52a9\u4e86\u89e3\u6cbb\u7642\u9078\u64c7\uff1f<\/h2>\n<p>\u6211\u5011\u7684\u60a3\u8005\u670d\u52d9\u5718\u968a\u53ef\u4ee5\u5e6b\u52a9\u60a8\u6e96\u5099\u5831\u544a\u4e26\u5b89\u6392\u9069\u7576\u7684\u5c08\u5bb6\u8aee\u8a62\u3002\u672c\u6587\u662f\u4e00\u822c\u8a0a\u606f\uff0c\u800c\u4e0d\u662f\u8a3a\u65b7\u3002<\/p>\n<p><a href=\"\/zh-hk\/appointment\/\">\u7acb\u5373\u9810\u7d04<\/a> &nbsp;|&nbsp; <a href=\"\/zh-hk\/cancer\/\">\u63a2\u7d22\u6240\u6709\u764c\u75c7\u985e\u578b<\/a><\/p>\n<\/div>\n<p class=\"ac-blog-disclaimer\"><em>\u91ab\u7642\u514d\u8cac\u8072\u660e\uff1a\u672c\u6587\u50c5\u7528\u65bc\u4e00\u822c\u6559\u80b2\uff0c\u4e0d\u80fd\u53d6\u4ee3\u5408\u683c\u81e8\u5e8a\u91ab\u751f\u7684\u5efa\u8b70\u3002\u6cbb\u7642\u6c7a\u5b9a\u61c9\u57fa\u65bc\u500b\u4eba\u7684\u8a3a\u65b7\u3001\u5206\u671f\u3001\u75c5\u7406\u548c\u6574\u9ad4\u5065\u5eb7\u72c0\u6cc1\u3002\u5982\u679c\u60a8\u767c\u73fe\u6301\u7e8c\u6216\u4ee4\u4eba\u64d4\u6182\u7684\u75c7\u72c0\uff0c\u8acb\u5c0b\u6c42\u91ab\u7642\u8a55\u4f30\u3002<\/em><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Non-Hodgkin Lymphoma (NHL) is a diverse group of cancers arising from lymphocytes, a type of white blood cell integral to the immune system.<\/p>","protected":false},"featured_media":215,"menu_order":50,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center 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