{"id":385,"date":"2026-06-16T09:00:00","date_gmt":"2026-06-16T09:00:00","guid":{"rendered":"https:\/\/cntumour.com\/cancer\/pleuropulmonary-blastoma-ppb-cancer\/"},"modified":"2026-10-29T15:53:23","modified_gmt":"2026-10-29T15:53:23","slug":"pleuropulmonary-blastoma-ppb-cancer","status":"publish","type":"cancer_type","link":"https:\/\/cntumour.com\/zh-hk\/cancer\/pleuropulmonary-blastoma-ppb-cancer\/","title":{"rendered":"\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB)"},"content":{"rendered":"<div class=\"ac-blog-article\">\n<p class=\"ac-blog-lead\"><strong>\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB) \u662f\u4e00\u7a2e\u7f55\u898b\u7684\u4fb5\u8972\u6027\u5152\u79d1\u764c\u75c7\uff0c\u8d77\u6e90\u65bc\u80ba\u90e8\u548c\u80f8\u819c\uff0c\u4e3b\u8981\u5f71\u97ff\u516d\u6b72\u4ee5\u4e0b\u7684\u5152\u7ae5\u3002\u8207\u5178\u578b\u7684\u6210\u4eba\u80ba\u764c\u4e0d\u540c\uff0cPPB \u662f\u4e00\u7a2e\u7368\u7279\u7684\u80ba\u90e8\u816b\u7624\uff0c\u5176\u7279\u5fb5\u662f\u539f\u59cb\u80da\u7d30\u80de\u548c\u8089\u7624\u6210\u5206\u3002\u4e86\u89e3\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB) \u5c0d\u65bc\u65e9\u671f\u8a3a\u65b7\u548c\u6539\u5584\u6cbb\u7642\u7d50\u679c\u81f3\u95dc\u91cd\u8981\u3002<\/strong><\/p>\n<nav class=\"ac-blog-toc\" aria-label=\"\u672c\u6587\u5c0e\u89bd\">\n<p><strong>\u672c\u6587\u5c0e\u89bd<\/strong><\/p>\n<ul>\n<li><a href=\"#what-is-pleuropulmonary-blastoma-ppb\">\u4ec0\u9ebc\u662f\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB)\uff1f<\/a><\/li>\n<li><a href=\"#causes-and-risk-factors-of-pleuropulmonary-blastoma-ppb\">\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB) \u7684\u75c5\u56e0\u548c\u98a8\u96aa\u56e0\u7d20<\/a><\/li>\n<li><a href=\"#symptoms-of-pleuropulmonary-blastoma-ppb\">\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB) \u7684\u75c7\u72c0<\/a><\/li>\n<li><a href=\"#stages-of-pleuropulmonary-blastoma-ppb-and-survival-rates\">\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB) \u7684\u5206\u671f\u548c\u5b58\u6d3b\u7387<\/a><\/li>\n<li><a href=\"#limitations-of-traditional-therapies-for-pleuropulmonary-blastoma-ppb\">\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB) \u50b3\u7d71\u7642\u6cd5\u7684\u5c40\u9650\u6027<\/a><\/li>\n<\/ul>\n<\/nav>\n<h2 id=\"what-is-pleuropulmonary-blastoma-ppb\">\u4ec0\u9ebc\u662f\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB)\uff1f<\/h2>\n<p>PPB \u4e2d\u7684\u764c\u7d30\u80de\u8868\u73fe\u51fa\u660e\u986f\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\uff0c\u7279\u5225\u662f\u5b83\u5011\u5c0d\u8461\u8404\u7cd6\u4ee3\u8b1d\u7684\u4f9d\u8cf4\uff0c\u5373\u6240\u8b02\u7684\u74e6\u723e\u5821\u6548\u61c9\u3002\u9019\u7a2e\u73fe\u8c61\u53cd\u6620\u4e86\u5373\u4f7f\u5728\u6c27\u6c23\u5145\u8db3\u7684\u60c5\u6cc1\u4e0b\uff0cPPB\u7d30\u80de\u4e5f\u50be\u5411\u65bc\u512a\u5148\u9032\u884c\u8461\u8404\u7cd6\u7121\u6c27\u4ee3\u8b1d\uff0c\u5176\u901f\u7387\u6709\u6642\u8d85\u904e\u6b63\u5e38\u7d30\u80de\u9ad8\u9054200\u500d\uff0c\u5f9e\u800c\u6210\u70ba\u5275\u65b0\u4ee3\u8b1d\u7642\u6cd5\u7684\u6f5b\u5728\u76ee\u6a19\u3002<\/p>\n<p>\u6839\u64da\u4e16\u754c\u885b\u751f\u7d44\u7e54 (2024) \u7684\u6578\u64da\uff0c\u5728\u5168\u7403\u7bc4\u570d\u5167\uff0c\u80ba\u764c\u6bcf\u5e74\u5f71\u97ff\u7d04 220 \u842c\u4eba\u3002\u5118\u7ba1 PPB \u50c5\u4f54\u7e3d\u767c\u75c5\u7387\u7684\u4e00\u5c0f\u90e8\u5206\uff0c\u4f46\u5176\u5c0d\u5305\u62ec\u9999\u6e2f\u5728\u5167\u7684\u5730\u5340\u5152\u79d1\u5065\u5eb7\u7684\u5f71\u97ff\u9700\u8981\u91ab\u5b78\u7814\u7a76\u4eba\u54e1\u548c\u81f4\u529b\u65bc\u816b\u7624\u5b78\u7684\u81e8\u5e8a\u91ab\u751f\u7684\u5bc6\u5207\u95dc\u6ce8\u3002<\/p>\n<p>PPB \u901a\u5e38\u6703\u7d93\u6b77\u4e09\u500b\u4e0d\u540c\u7684\u968e\u6bb5\uff1aI \u578b\uff08\u7d14\u56ca\u6027\uff0c\u901a\u5e38\u662f\u6700\u65e9\u968e\u6bb5\uff09\u3001II \u578b\uff08\u56ca\u6027\u548c\u5be6\u6027\u76f8\u7d50\u5408\uff09\u548c III \u578b\uff08\u5b8c\u5168\u5be6\u6027\u4e14\u6700\u5177\u4fb5\u8972\u6027\uff09\u3002\u65e9\u671f\u767c\u73fe\u53ef\u4ee5\u5927\u5927\u63d0\u9ad8\u6cbb\u7642\u6548\u679c\uff0c\u5f9e\u800c\u5f37\u8abf\u4e86\u516c\u773e\u548c\u81e8\u5e8a\u9818\u57df\u8a8d\u8b58\u7684\u91cd\u8981\u6027\uff0c\u7279\u5225\u662f\u5728\u9999\u6e2f\u7b49\u4eba\u53e3\u7a20\u5bc6\u7684\u57ce\u5e02\u3002<\/p>\n<h3 id=\"affected-populations-and-regional-data-asia-hong-kong\">\u53d7\u5f71\u97ff\u4eba\u53e3\u548c\u5340\u57df\u6578\u64da\uff08\u4e9e\u6d32\u548c\u9999\u6e2f\uff09<\/h3>\n<p>\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB) \u4e3b\u8981\u5f71\u97ff\u5e7c\u5152\uff0c\u901a\u5e38\u5728\u516d\u6b72\u524d\u78ba\u8a3a\uff0c\u56e0\u6b64\u5152\u79d1\u65e9\u671f\u8a3a\u65b7\u6210\u70ba\u95dc\u9375\u56e0\u7d20\u3002\u6d41\u884c\u75c5\u5b78\u7d71\u8a08\u6578\u64da\u8868\u660e\uff0c\u5168\u7403\u7d04 50% \u7684\u8a3a\u65b7\u53d7\u8a66\u8005\u6700\u521d\u8868\u73fe\u70ba I \u578b PPB\uff0c\u8207\u665a\u671f\u5f62\u5f0f\u76f8\u6bd4\uff0c\u986f\u8457\u63d0\u9ad8\u4e86\u60a3\u8005\u7684\u9810\u5f8c\u3002<\/p>\n<p>\u5728\u9999\u6e2f\uff0c\u7576\u5730\u7684\u5065\u5eb7\u6578\u64da\u8868\u660e\uff0c\u5152\u7ae5\u764c\u75c7\uff0c\u5305\u62ec\u7f55\u898b\u7684 PPB \u764c\u75c7\uff0c\u9700\u8981\u5c08\u9580\u7684\u8b77\u7406\u8a2d\u65bd\u548c\u6cbb\u7642\u3002\u8207\u6df1\u5733\u524d\u6d77\u6cf0\u5eb7\u548cMD\u5b89\u5fb7\u68ee\u7b49\u6a5f\u69cb\u5408\u4f5c\u7684\u57fa\u56e0\u7814\u7a76\u6709\u52a9\u65bc\u4e86\u89e3\u5340\u57df\u6613\u611f\u6027\u548c\u6cbb\u7642\u9032\u5c55\uff0c\u8207\u570b\u969b\u816b\u7624\u5b78\u7814\u7a76\u6a19\u6e96\u7dca\u5bc6\u7d50\u5408\u3002<\/p>\n<ul>\n<li>\u5168\u7403\u767c\u75c5\u7387\u4ecd\u7136\u5f88\u5c11\uff0c\u51f8\u986f\u4e86\u5c08\u696d\u77e5\u8b58\u548c\u516c\u773e\u610f\u8b58\u7684\u91cd\u8981\u6027\u3002<\/li>\n<li>\u4e9e\u6d32\u4eba\u53e3\uff0c\u7279\u5225\u662f\u9999\u6e2f\u7b49\u4eba\u53e3\u5bc6\u96c6\u7684\u57ce\u5e02\u5316\u5730\u5340\u7684\u4eba\u53e3\uff0c\u9700\u8981\u8b66\u60d5\u7684\u5152\u79d1\u816b\u7624\u57fa\u790e\u8a2d\u65bd\u548c\u652f\u6301\u6027\u5bb6\u5ead\u670d\u52d9\u3002<\/li>\n<li>\u5bb6\u5ead\u9762\u81e8\u7684\u5fc3\u7406\u548c\u8eab\u9ad4\u6311\u6230\u53ef\u80fd\u662f\u6df1\u9060\u7684\uff0c\u9032\u4e00\u6b65\u52a0\u5f37\u4e86\u5c0d\u53ca\u6642\u3001\u540c\u7406\u5fc3\u548c\u5168\u9762\u6cbb\u7642\u65b9\u6cd5\u7684\u9700\u6c42\u3002<\/li>\n<\/ul>\n<p>\u4e86\u89e3\u66f4\u591a\u95dc\u65bc\u6211\u5011\u7684 <a href=\"\/zh-hk\/treatment-cancer\/\">\u764c\u75c7\u751f\u7269\u5b78<\/a> \u9801\u9762\u6216\u6211\u5011\u7684\u5275\u65b0 <a href=\"\/zh-hk\/our-hospital\/\">\u8a3a\u65b7\u65b9\u6cd5<\/a>\u65e8\u5728\u65e9\u671f\u8b58\u5225\u548c\u6cbb\u7642\u7f55\u898b\u7684\u5152\u79d1\u816b\u7624\uff0c\u5982\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB)\u3002<\/p>\n<h2 id=\"causes-and-risk-factors-of-pleuropulmonary-blastoma-ppb\">\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB) \u7684\u75c5\u56e0\u548c\u98a8\u96aa\u56e0\u7d20<\/h2>\n<p>\u4e86\u89e3\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB) \u7684\u539f\u56e0\u5c0d\u65bc\u6709\u6548\u6cbb\u7642\u548c\u9810\u9632\u5177\u6709\u91cd\u8981\u610f\u7fa9\u3002\u8207\u8a31\u591a\u5152\u79d1\u764c\u75c7\u4e00\u6a23\uff0cPPB \u6d89\u53ca\u8907\u96dc\u7684\u907a\u50b3\u3001\u74b0\u5883\u548c\u4ee3\u8b1d\u76f8\u4e92\u4f5c\u7528\uff0c\u5c0d\u6d41\u884c\u75c5\u5b78\u5bb6\u548c\u5c08\u5bb6\u4f86\u8aaa\u90fd\u662f\u4e00\u500b\u6311\u6230\u3002<\/p>\n<h3 id=\"genetic-factors-in-ppb-development\">PPB \u767c\u80b2\u4e2d\u7684\u907a\u50b3\u56e0\u7d20<\/h3>\n<p>\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB) \u7684\u907a\u50b3\u5f71\u97ff\u4e3b\u8981\u8207 DICER1 \u57fa\u56e0\u7a81\u8b8a\u6709\u95dc\uff0c\u5728\u5927\u7d04 70% \u7684\u75c5\u4f8b\u4e2d\u89c0\u5bdf\u5230\u9019\u7a2e\u7a81\u8b8a\u3002DICER1 \u7a81\u8b8a\u6703\u7834\u58de microRNA \u52a0\u5de5\uff0c\u5f71\u97ff\u6b63\u5e38\u7d30\u80de\u589e\u6b96\u548c\u5206\u5316\uff0c\u4f7f\u5152\u7ae5\u5bb9\u6613\u7f79\u60a3 PPB\u3002<\/p>\n<ul>\n<li>\u5728\u5bb6\u65cf\u75c5\u4f8b\u548c\u5b64\u7acb\u75c5\u4f8b\u4e2d\u767c\u73fe\u4e86 DICER1 \u7a81\u8b8a\uff0c\u9019\u5f37\u8abf\u4e86\u907a\u50b3\u8aee\u8a62\u7684\u5fc5\u8981\u6027\u3002<\/li>\n<li>\u5efa\u8b70\u65e9\u671f\u9032\u884c\u57fa\u56e0\u7be9\u6aa2\uff0c\u7279\u5225\u662f\u5c0d\u65bc\u78ba\u8a3a\u60a3\u8005\u7684\u5144\u5f1f\u59ca\u59b9\u6216\u5f8c\u4ee3\u3002<\/li>\n<li>MD \u5b89\u5fb7\u68ee\u7b49\u6a5f\u69cb\u7684\u6700\u65b0\u7814\u7a76\u9032\u4e00\u6b65\u5f37\u8abf\u4e86\u7cbe\u6e96\u57fa\u56e0\u7814\u7a76\u80fd\u5920\u5be6\u73fe\u65e9\u671f\u4ecb\u5165\u548c\u500b\u4eba\u5316\u6cbb\u7642\u3002<\/li>\n<\/ul>\n<h3 id=\"environmental-influences-and-pediatric-oncology\">\u74b0\u5883\u5f71\u97ff\u548c\u5152\u79d1\u816b\u7624\u5b78<\/h3>\n<p>\u8207\u5438\u83f8\u76f8\u95dc\u80ba\u764c\u7b49\u6210\u4eba\u80ba\u90e8\u60e1\u6027\u816b\u7624\u76f8\u6bd4\uff0c\u74b0\u5883\u66b4\u9732\u5c0e\u81f4\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB) \u7684\u5b9a\u7fa9\u4ecd\u4e0d\u90a3\u9ebc\u7cbe\u78ba\u3002\u7136\u800c\uff0c\u67d0\u4e9b\u8efc\u4e8b\u7814\u7a76\u8868\u660e\u74b0\u5883\u81f4\u764c\u7269\u6216\u7522\u524d\u63a5\u89f8\u53ef\u80fd\u6703\u7565\u5fae\u589e\u52a0\u5152\u79d1\u816b\u7624\u98a8\u96aa\u3002<\/p>\n<ul>\n<li>\u6709\u9650\u7684\u8b49\u64da\u5c07\u7522\u524d\u63a5\u89f8\u67d0\u4e9b\u6bd2\u7d20\u6216\u81f4\u764c\u7269\u8207\u7f55\u898b\u7684\u5152\u79d1\u764c\u75c7\u806f\u7e6b\u8d77\u4f86\u3002<\/li>\n<li>\u6b63\u5728\u9032\u884c\u5ee3\u6cdb\u7684\u7814\u7a76\u4f86\u95e1\u660e\u5152\u79d1\u816b\u7624\uff08\u5305\u62ec PPB\uff09\u4e2d\u74b0\u5883\u8207\u907a\u50b3\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/li>\n<li>\u61c9\u7e7c\u7e8c\u52a0\u5f37\u5f37\u8abf\u7522\u524d\u4fdd\u5065\u548c\u76e1\u91cf\u6e1b\u5c11\u63a5\u89f8\u7684\u516c\u5171\u885b\u751f\u610f\u8b58\u904b\u52d5\u3002<\/li>\n<\/ul>\n<h3 id=\"metabolic-vulnerabilities-focus-on-glucose-and-glutamine\">\u4ee3\u8b1d\u8106\u5f31\u6027\uff1a\u95dc\u6ce8\u8461\u8404\u7cd6\u548c\u9ea9\u91af\u80fa\u9178<\/h3>\n<p>\u5728\u764c\u75c7\u751f\u7269\u5b78\u4e2d\u89c0\u5bdf\u5230\u7684\u4ee3\u8b1d\u4f9d\u8cf4\u6027\u5c55\u793a\u4e86\u6cbb\u7642\u6f5b\u529b\u3002\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB) \u4e3b\u8981\u5229\u7528\u8461\u8404\u7cd6\u4ee3\u8b1d\uff08\u74e6\u4f2f\u683c\u6548\u61c9\uff09\uff0c\u5076\u723e\u5229\u7528\u9ea9\u91af\u80fa\u9178\u4f86\u5be6\u73fe\u5feb\u901f\u7d30\u80de\u589e\u6b96\u3001\u6838\u82f7\u9178\u5408\u6210\u548c\u7c92\u7dda\u9ad4\u751f\u7269\u80fd\u3002<\/p>\n<ul>\n<li>PPB \u7d30\u80de\u6d88\u8017\u8461\u8404\u7cd6\u7684\u901f\u5ea6\u6bd4\u6b63\u5e38\u7d30\u80de\u5feb 200 \u500d\uff0c\u63d0\u4f9b\u4e86\u6709\u91dd\u5c0d\u6027\u7684\u4ee3\u8b1d\u6cbb\u7642\u6a5f\u6703\u3002<\/li>\n<li>\u5305\u62ec\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b Gregg Semenza \u5728\u5167\u7684\u77e5\u540d\u4eba\u58eb\u7684\u7814\u7a76\u8868\u660e\uff0c\u91dd\u5c0d\u4ee3\u8b1d\u8106\u5f31\u6027\u53ef\u4ee5\u986f\u8457\u6539\u8b8a PPB \u7ba1\u7406\uff0c\u5305\u62ec\u5be6\u9a57\u6027\u4ee3\u8b1d\u6291\u5236\u5291\u548c\u98f2\u98df\u5e79\u9810\u3002<\/li>\n<li>\u5275\u65b0\u7684\u4ee3\u8b1d\u764c\u75c7\u7642\u6cd5\uff0c\u4f8b\u5982\u7531\u816b\u7624\u5b78\u5c08\u5bb6\u674e\u570b\u83ef\u535a\u58eb\u548c\u5289\u570b\u9f8d\u6559\u6388\u958b\u767c\u7684\u7642\u6cd5\uff0c\u6b63\u5728\u70ba\u9999\u6e2f\u548c\u6574\u500b\u4e9e\u6d32\u7684\u5148\u9032\u6cbb\u7642\u9078\u64c7\u92ea\u5e73\u9053\u8def\u3002<\/li>\n<\/ul>\n<h3 id=\"preventive-measures-and-early-detection-strategies\">\u9810\u9632\u63aa\u65bd\u548c\u65e9\u671f\u767c\u73fe\u7b56\u7565<\/h3>\n<p>\u9451\u65bc\u907a\u50b3\u6613\u611f\u6027\u76f8\u95dc\u6027\uff0cDICER1 \u7a81\u8b8a\u7684\u65e9\u671f\u57fa\u56e0\u7be9\u6aa2\u53ef\u4ee5\u6df1\u523b\u5f71\u97ff\u7d50\u679c\uff0c\u5f9e\u800c\u53ef\u4ee5\u9032\u884c\u9810\u9632\u6027\u5e79\u9810\u548c\u5bc6\u5207\u76e3\u6e2c\u3002\u88dc\u5145\u751f\u6d3b\u65b9\u5f0f\u5efa\u8b70\u548c\u5152\u79d1\u816b\u7624\u5c08\u5bb6\u7684\u5b9a\u671f\u5f8c\u7e8c\u8aee\u8a62\u81f3\u95dc\u91cd\u8981\u3002<\/p>\n<ul>\n<li>\u63d0\u5021\u5c0d\u6d89\u53ca DICER1 \u7684\u53ef\u7591\u5bb6\u65cf\u75c5\u4f8b\u9032\u884c\u57fa\u56e0\u6aa2\u6e2c\u3002<\/li>\n<li>\u5728\u9999\u6e2f\u548c\u66f4\u5ee3\u6cdb\u7684\u4e9e\u6d32\u793e\u5340\u9032\u884c\u5ba3\u50b3\u6d3b\u52d5\uff0c\u4e26\u5c08\u6ce8\u65bc\u8b58\u5225\u65e9\u671f\u75c7\u72c0\u3002<\/li>\n<li>\u4fc3\u9032\u5340\u57df\u5408\u4f5c\u5925\u4f34\u95dc\u4fc2\uff08\u4f8b\u5982\u6df1\u5733\u524d\u6d77\u6cf0\u5eb7\uff09\uff0c\u70ba\u9ad8\u98a8\u96aa\u5bb6\u5ead\u63d0\u4f9b\u4fbf\u5229\u7684\u7be9\u6aa2\u8a08\u756b\u548c\u5148\u9032\u7684\u8a3a\u65b7\u3002<\/li>\n<\/ul>\n<p>\u63a2\u7d22\u6211\u5011\u7684 <a href=\"\/zh-hk\/treatment-cancer\/\">\u6838\u5fc3\u7642\u6cd5<\/a> \u9801\u9762\u767c\u73fe\u9769\u547d\u6027\u7684\u4ee3\u8b1d\u816b\u7624\u6cbb\u7642\u65b9\u6cd5\uff0c\u6539\u8b8a\u5152\u79d1\u764c\u75c7\u8b77\u7406\uff0c\u6709\u6548\u548c\u5bcc\u6709\u540c\u60c5\u5fc3\u5730\u89e3\u6c7a\u4ee4\u4eba\u6109\u6085\u7684\u6bcd\u7d30\u80de\u7624\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\u3002<\/p>\n<h2 id=\"symptoms-of-pleuropulmonary-blastoma-ppb\">\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB) \u7684\u75c7\u72c0<\/h2>\n<p>\u65e9\u671f\u6aa2\u6e2c\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB) \u5c0d\u65bc\u6539\u5584\u9810\u5f8c\u548c\u6cbb\u7642\u7d50\u679c\u81f3\u95dc\u91cd\u8981\u3002\u4e86\u89e3\u75c7\u72c0\u53ef\u4ee5\u5e6b\u52a9\u7236\u6bcd\u3001\u7167\u9867\u8005\u548c\u91ab\u7642\u4fdd\u5065\u63d0\u4f9b\u8005\u7acb\u5373\u9032\u884c\u8a55\u4f30\u3002\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624\u7684\u75c7\u72c0\u901a\u5e38\u6703\u6839\u64da\u816b\u7624\u5927\u5c0f\u3001\u4f4d\u7f6e\u548c\u8a3a\u65b7\u968e\u6bb5\u7684\u4e0d\u540c\u800c\u6709\u6240\u4e0d\u540c\u3002<\/p>\n<h3 id=\"common-symptoms-of-pleuropulmonary-blastoma-ppb\">\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB) \u7684\u5e38\u898b\u75c7\u72c0<\/h3>\n<ul>\n<li>\u8207\u547c\u5438\u9053\u611f\u67d3\u7121\u95dc\u7684\u6301\u7e8c\u54b3\u55fd<\/li>\n<li>\u547c\u5438\u56f0\u96e3\u6216\u547c\u5438\u983b\u7387\u52a0\u5feb<\/li>\n<li>\u53cd\u8986\u547c\u5438\u9053\u611f\u67d3\u53ca\u80ba\u708e<\/li>\n<li>\u80f8\u75db\u6216\u4e0d\u9069\uff0c\u5c24\u5176\u662f\u5438\u6c23\u6642<\/li>\n<li>\u91ab\u751f\u6ce8\u610f\u5230\u7684\u7570\u5e38\u547c\u5438\u97f3<\/li>\n<li>\u5168\u8eab\u75b2\u52de\u548c\u865b\u5f31<\/li>\n<li>\u98df\u617e\u4e0b\u964d\u548c\u9ad4\u91cd\u6e1b\u8f15<\/li>\n<li>\u4e0d\u660e\u539f\u56e0\u767c\u71d2<\/li>\n<li>\u5f71\u50cf\u5b78\u6aa2\u67e5\u4e2d\u51fa\u73fe\u80f8\u90e8\u816b\u584a<\/li>\n<\/ul>\n<h3 id=\"stage-specific-symptoms-of-pleuropulmonary-blastoma-ppb\">\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB) \u7684\u968e\u6bb5\u7279\u7570\u6027\u75c7\u72c0<\/h3>\n<p>\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624\u7684\u75c7\u72c0\u6703\u96a8\u9032\u5c55\u548c\u816b\u7624\u7279\u5fb5\u800c\u8b8a\u5316\u3002\u5b83\u5011\u5bc6\u5207\u53cd\u6620\u4e86\u5176\u816b\u7624\u751f\u7269\u5b78\uff0c\u7279\u5225\u662f\u7d30\u80de\u751f\u9577\u7684\u901f\u5ea6\u4ee5\u53ca\u5b83\u5011\u5c0d\u547c\u5438\u7d50\u69cb\u7684\u963b\u7919\u7a0b\u5ea6\u3002<\/p>\n<h4>\u65e9\u671f PPB \u75c7\u72c0<\/h4>\n<ul>\n<li>\u8f15\u5ea6\u547c\u5438\u7a98\u8feb\u6216\u67d0\u4e9b\u60c5\u6cc1\u4e0b\u7121\u75c7\u72c0<\/li>\n<li>\u5728\u5176\u4ed6\u554f\u984c\u7684\u5e38\u898f\u6210\u50cf\u904e\u7a0b\u4e2d\u5076\u7136\u767c\u73fe\u80f8\u90e8\u816b\u584a<\/li>\n<li>\u5076\u723e\u5598\u606f\u6216\u8f15\u5fae\u54b3\u55fd\uff0c\u5e38\u88ab\u8aa4\u8a8d\u70ba\u6c23\u5598\u6216\u904e\u654f<\/li>\n<\/ul>\n<h4>\u4e2d\u671f PPB \u75c7\u72c0<\/h4>\n<ul>\n<li>\u6301\u7e8c\u4e14\u60e1\u5316\u7684\u54b3\u55fd<\/li>\n<li>\u547c\u5438\u505a\u529f\u589e\u52a0\uff0c\u5c24\u5176\u662f\u5728\u9ad4\u529b\u6d3b\u52d5\u671f\u9593<\/li>\n<li>\u5e7c\u5152\u9ad4\u91cd\u660e\u986f\u6e1b\u8f15\u6216\u767c\u5c55\u9072\u7de9<\/li>\n<li>\u53cd\u8986\u767c\u71d2\u8868\u793a\u80ba\u529f\u80fd\u53d7\u640d\u6709\u611f\u67d3\u98a8\u96aa<\/li>\n<\/ul>\n<h4>\u665a\u671f PPB \u75c7\u72c0<\/h4>\n<ul>\n<li>\u56b4\u91cd\u547c\u5438\u7a98\u8feb\u3001\u547c\u5438\u56f0\u96e3\uff0c\u9700\u7acb\u5373\u91ab\u7642\u5e79\u9810<\/li>\n<li>\u6301\u7e8c\u80f8\u75db\u548c\u6f5b\u5728\u7684\u80f8\u90e8\u7578\u5f62<\/li>\n<li>\u54af\u8840\uff08\u54b3\u8840\uff09\uff0c\u8207\u816b\u7624\u4fb5\u8972\u80ba\u7d44\u7e54\u548c\u8840\u7ba1\u6709\u95dc<\/li>\n<li>\u80ba\u90e8\u816b\u8139\u548c\u7a4d\u6db2\uff08\u80f8\u8154\u7a4d\u6c34\uff09<\/li>\n<li>\u9577\u671f\u60a3\u75c5\u5c0e\u81f4\u7684\u5168\u8eab\u75c7\u72c0\uff0c\u5982\u8ca7\u8840\u3001\u56b4\u91cd\u75b2\u52de\u548c\u71df\u990a\u7f3a\u4e4f<\/li>\n<\/ul>\n<p>\u7531\u65bc PPB \u7684\u4fb5\u8972\u6027\u751f\u7269\u5b78\u6027\u8cea\uff0c\u764c\u7d30\u80de\u6703\u5feb\u901f\u589e\u6b96\u3002\u56e0\u6b64\uff0c\u816b\u7624\u6703\u8fc5\u901f\u9020\u6210\u7269\u7406\u963b\u585e\u4e26\u640d\u5bb3\u80ba\u529f\u80fd\uff0c\u53cd\u6620\u4e86\u8a31\u591a\u5152\u79d1\u764c\u75c7\u7684\u52a0\u901f\u7d30\u80de\u4ee3\u8b1d\u548c\u8461\u8404\u7cd6\u4f9d\u8cf4\u6027\u7279\u5fb5\u3002\u900f\u904e\u8b58\u5225\u9019\u4e9b\u75c7\u72c0\u9032\u884c\u65e9\u671f\u767c\u73fe\u81f3\u95dc\u91cd\u8981\uff0c\u4e26\u4e14\u6703\u986f\u8457\u5f71\u97ff\u81e8\u5e8a\u7d50\u679c\u3002<\/p>\n<p>\u5982\u679c\u60a8\u7684\u5b69\u5b50\u6216\u60a8\u7167\u9867\u7684\u5b69\u5b50\u8868\u73fe\u51fa\u4efb\u4f55\u8207\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624\u76f8\u7b26\u7684\u75c7\u72c0\uff0c\u8acb\u7acb\u5373\u806f\u7d61\u91ab\u7642\u5c08\u696d\u4eba\u54e1\u3002\u65e9\u671f\u8a3a\u65b7\u8207\u66f4\u9ad8\u7684\u7de9\u89e3\u7387\u548c\u66f4\u6709\u5229\u7684\u9577\u671f\u9810\u5f8c\u76f4\u63a5\u76f8\u95dc\u3002<\/p>\n<h2 id=\"stages-of-pleuropulmonary-blastoma-ppb-and-survival-rates\">\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB) \u7684\u5206\u671f\u548c\u5b58\u6d3b\u7387<\/h2>\n<p>\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624\u6839\u64da\u816b\u7624\u7279\u5fb5\u3001\u5927\u5c0f\u3001\u6dcb\u5df4\u7d50\u53d7\u7d2f\u548c\u8f49\u79fb\u64f4\u6563\u9032\u884c\u5206\u671f\u3002\u5206\u671f\u53ef\u544a\u77e5\u9810\u5f8c\u4e26\u6307\u5c0e\u6cbb\u7642\u6c7a\u7b56\u548c\u7b56\u7565\u3002\u9999\u6e2f\u548c\u4e9e\u6d32\u5176\u4ed6\u5730\u5340\u8207 PPB \u76f8\u95dc\u7684\u7d71\u8a08\u6578\u64da\u8868\u660e\uff0c\u5b58\u6d3b\u7387\u4e0d\u65b7\u63d0\u9ad8\uff0c\u9019\u4e3b\u8981\u6b78\u529f\u65bc\u7406\u89e3\u3001\u8a3a\u65b7\u80fd\u529b\u548c\u500b\u9ad4\u5316\u6cbb\u7642\u65b9\u5f0f\u7684\u589e\u5f37\u3002<\/p>\n<h3 id=\"stage-1-pleuropulmonary-blastoma-ppb\">\u7b2c 1 \u671f \u2013 \u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB)<\/h3>\n<p>\u7b2c 1 \u671f PPB \u901a\u5e38\u6d89\u53ca\u80ba\u7d44\u7e54\u6216\u80f8\u819c\u8154\u5167\u7684\u5c40\u90e8\u816b\u7624\uff0c\u7121\u6dcb\u5df4\u7d50\u6216\u9060\u7aef\u64f4\u6563\u3002\u8a3a\u65b7\u5f71\u50cf\u901a\u5e38\u53ef\u8fa8\u8b58\u5c3a\u5bf8\u22645 cm \u7684\u5b64\u7acb\u56ca\u6027\u7d50\u69cb\u3002<\/p>\n<ul>\n<li>\u5c40\u9650\u6027\u816b\u7624\uff0c\u50c5\u9650\u65bc\u80ba\u7d44\u7e54\u6216\u7279\u5b9a\u5340\u57df<\/li>\n<li>\u6cbb\u7642\u5305\u62ec\u624b\u8853\u5207\u9664\u4ee5\u5b8c\u5168\u5207\u9664\u816b\u7624\u584a<\/li>\n<li>\u53ef\u80fd\u7684\u5316\u7642\u4f5c\u70ba\u7a4d\u6975\u63aa\u65bd<\/li>\n<li>\u5982\u679c\u65e9\u671f\u8a3a\u65b7\u548c\u4e7e\u9810\uff0c\u4e94\u5e74\u5b58\u6d3b\u7387\u63a5\u8fd1 90%<\/li>\n<\/ul>\n<h3 id=\"stage-2-pleuropulmonary-blastoma-ppb\">\u7b2c 2 \u671f \u2013 \u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB)<\/h3>\n<p>\u7b2c 2 \u671f PPB \u63cf\u7e6a\u4e86\u8f03\u665a\u671f\u7684\u816b\u7624\u751f\u9577\uff0c\u901a\u5e38\u6d89\u53ca\u56ca\u6027\u548c\u5be6\u6027\u816b\u584a\u6210\u5206\u3002\u53ef\u80fd\u6709\u5c40\u90e8\u4fb5\u8972\uff0c\u4f46\u4e0d\u5b58\u5728\u9060\u8655\u8f49\u79fb\u3002<\/p>\n<ul>\n<li>\u816b\u7624\u9ad4\u7a4d\u589e\u5927\uff0c\u5be6\u9ad4\u5340\u57df\u7684\u751f\u9577\u52d5\u614b\u8f03\u4e0d\u7a69\u5b9a<\/li>\n<li>\u624b\u8853\u8207\u5316\u7642\u7d50\u5408\u901a\u5e38\u7528\u65bc\u5728\u624b\u8853\u4ecb\u5165\u524d\u5f8c\u7e2e\u5c0f\u816b\u7624<\/li>\n<li>\u900f\u904e\u5b9a\u671f\u5f71\u50cf\u5b78\u5bc6\u5207\u76e3\u6e2c\u5fa9\u767c\u60c5\u6cc1<\/li>\n<li>\u4e94\u5e74\u5167\u5b58\u6d3b\u7387\u5728 70-85% \u4e4b\u9593\uff0c\u53cd\u6620\u4e86\u73fe\u4ee3\u591a\u6a21\u5f0f\u6cbb\u7642\u7b56\u7565<\/li>\n<\/ul>\n<h3 id=\"stage-3-pleuropulmonary-blastoma-ppb\">\u7b2c 3 \u671f \u2013 \u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB)<\/h3>\n<p>\u7b2c 3 \u671f\u5305\u62ec\u80ba\u7d50\u69cb\u5167\u5ee3\u6cdb\u7684\u5c40\u90e8\u64f4\u6563\uff0c\u53ef\u80fd\u6d89\u53ca\u9644\u8fd1\u7684\u6dcb\u5df4\u7d50\uff0c\u4f46\u6c92\u6709\u53ef\u6aa2\u6e2c\u5230\u7684\u9060\u7aef\u8f49\u79fb\u3002\u547c\u5438\u529f\u80fd\u53d7\u640d\u548c\u81e8\u5e8a\u75c7\u72c0\u8b8a\u5f97\u66f4\u52a0\u666e\u904d\u548c\u56b4\u91cd\u3002<\/p>\n<ul>\n<li>\u665a\u671f\u75be\u75c5\u9700\u8981\u591a\u6a21\u5f0f\u4e7e\u9810\uff0c\u5305\u62ec\u56b4\u683c\u7684\u5316\u7642\u3001\u624b\u8853\u3001\u53ef\u80fd\u7684\u653e\u5c04\u6cbb\u7642<\/li>\n<li>\u624b\u8853\u4ecb\u5165\u53ef\u80fd\u6d89\u53ca\u5927\u91cf\u7d44\u7e54\u5207\u9664\u548c\u91cd\u5efa<\/li>\n<li>\u75c7\u72c0\u7ba1\u7406\uff0c\u5c24\u5176\u662f\u547c\u5438\u7a98\u8feb\u4ecd\u7136\u81f3\u95dc\u91cd\u8981<\/li>\n<li>\u900f\u904e\u53ca\u6642\u3001\u7a4d\u6975\u7684\u8b77\u7406\uff0c\u4e94\u5e74\u7e3d\u5b58\u6d3b\u7387\u5f98\u5f8a\u5728 50-70% \u4e4b\u9593<\/li>\n<\/ul>\n<h3 id=\"stage-4-pleuropulmonary-blastoma-ppb\">\u7b2c 4 \u671f \u2013 \u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB)<\/h3>\n<p>\u7b2c 4 \u671f \u8868\u793a\u8f49\u79fb\u6027\u64ad\u6563\u6d89\u53ca\u5176\u4ed6\u5668\u5b98\uff0c\u5982\u8166\u3001\u809d\u81df\u6216\u9060\u7aef\u6dcb\u5df4\u7d50\uff0c\u53cd\u6620\u4e86\u816b\u7624\u751f\u7269\u5b78\u9a45\u52d5\u7684\u4fb5\u8972\u6027\u8f49\u79fb\u6f5b\u529b\uff0c\u5982 Warburg \u6548\u61c9\u548c\u4ee3\u8b1d\u9069\u61c9\u589e\u52a0\u3002<\/p>\n<ul>\n<li>\u5168\u8eab\u5316\u7642\u901a\u5e38\u662f\u4e00\u7dda\u6cbb\u7642\uff1b\u5728\u53ef\u884c\u7684\u60c5\u6cc1\u4e0b\u8003\u616e\u500b\u4eba\u5316\u4ee3\u8b1d\u7642\u6cd5<\/li>\n<li>\u7531\u65bc\u75be\u75c5\u5ee3\u6cdb\uff0c\u6839\u6cbb\u6027\u624b\u8853\u53d7\u5230\u9650\u5236\u4e26\u8b39\u614e\u5be6\u65bd<\/li>\n<li>\u6cbb\u7642\u8f49\u79fb\u6027\u75be\u75c5\u4ee5\u5ef6\u9577\u60a3\u8005\u7684\u751f\u6d3b\u8cea\u7d20\u4ecd\u7136\u662f\u9996\u8981\u95dc\u6ce8\u9ede<\/li>\n<li>\u5118\u7ba1\u6b77\u53f2\u4e0a\u7684\u9810\u5f8c\u8f03\u4f4e\uff0c\u4f46\u65b0\u7684\u5275\u65b0\u7642\u6cd5\u70ba\u6162\u6027\u75c5\u8f49\u5316\u5e36\u4f86\u4e86\u5e0c\u671b\uff0c\u60a3\u8005\u7684\u751f\u6d3b\u8cea\u7d20\u986f\u8457\u63d0\u9ad8<\/li>\n<li>\u76ee\u524d\u7684\u7d71\u8a08\u6578\u64da\u986f\u793a\u4e09\u5e74\u5b58\u6d3b\u7387\u7d04\u70ba 20-30%\uff0c\u4f46\u6301\u7e8c\u7684\u91ab\u7642\u5275\u65b0\u548c\u500b\u4eba\u5316\u4ee3\u8b1d\u6cbb\u7642\u63d0\u4f9b\u4e86\u986f\u8457\u6539\u5584\u7684\u524d\u666f<\/li>\n<\/ul>\n<h2 id=\"limitations-of-traditional-therapies-for-pleuropulmonary-blastoma-ppb\">\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB) \u50b3\u7d71\u7642\u6cd5\u7684\u5c40\u9650\u6027<\/h2>\n<h3 id=\"chemotherapy-an-essential-but-imperfect-approach\">\u5316\u7642\uff1a\u4e00\u7a2e\u5fc5\u8981\u4f46\u4e0d\u5b8c\u7f8e\u7684\u65b9\u6cd5<\/h3>\n<p>\u5316\u7642\u4e00\u76f4\u662f\u6cbb\u7642\u7684\u57fa\u77f3 <strong>\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB)<\/strong>\uff0c\u7279\u5225\u662f\u5728\u5152\u79d1\u816b\u7624\u6cbb\u7642\u65b9\u6848\u3002\u5118\u7ba1\u5316\u7642\u767c\u63ee\u8457\u81f3\u95dc\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u4f46\u5b83\u4e5f\u5b58\u5728\u986f\u8457\u7684\u7f3a\u9ede\uff0c\u53ef\u80fd\u6703\u56b4\u91cd\u5f71\u97ff\u60a3\u8005\u7684\u751f\u6d3b\u8cea\u7d20\u548c\u5b58\u6d3b\u7d50\u679c\u3002<\/p>\n<h4>\u56b4\u91cd\u7684\u6bd2\u6027\u548c\u526f\u4f5c\u7528<\/h4>\n<p>\u7814\u7a76\u8868\u660e\uff0c\u5316\u7642\u65b9\u6848\uff0c\u5c24\u5176\u662f\u6d89\u53ca\u9806\u9251\u3001\u4f9d\u6258\u6cca\u82f7\u3001\u963f\u9ef4\u7d20\u548c\u74b0\u78f7\u9170\u80fa\u7684\u5316\u7642\u65b9\u6848\uff0c\u6703\u5c0e\u81f4\u9ad8\u9054 78% \u7684\u9aa8\u9ad3\u6291\u5236\u767c\u751f\u7387\u3002\u9019\u7a2e\u5e38\u898b\u7684\u4f75\u767c\u75c7\u6703\u5c0e\u81f4\u4f4f\u9662\u6642\u9593\u5ef6\u9577\uff0c\u4e26\u589e\u52a0\u5371\u53ca\u751f\u547d\u7684\u611f\u67d3\u98a8\u96aa\uff0c\u7279\u5225\u662f\u5c0d\u65bc\u514d\u75ab\u7cfb\u7d71\u6b63\u5728\u767c\u80b2\u7684\u5152\u79d1\u65cf\u7fa4\u3002<\/p>\n<ul>\n<li><strong>\u9aa8\u9ad3\u6291\u5236\uff08\u767c\u751f\u7387 78%\uff09\uff1a<\/strong> \u56b4\u91cd\u55dc\u4e2d\u6027\u767d\u8840\u7403\u6e1b\u5c11\u75c7\u6703\u986f\u8457\u589e\u52a0\u611f\u67d3\u98a8\u96aa\u3002<\/li>\n<li><strong>\u5fc3\u81df\u6bd2\u6027\uff08\u767c\u751f\u7387 23%\uff09\uff1a<\/strong> \u963f\u9ef4\u7d20\u7b49\u84bd\u74b0\u985e\u85e5\u7269\u53ef\u80fd\u6703\u5f15\u8d77\u4e0d\u53ef\u9006\u7684\u5fc3\u81df\u640d\u50b7\u548c\u6162\u6027\u5fc3\u81df\u8870\u7aed\uff0c\u5c24\u5176\u5c0d\u5341\u6b72\u4ee5\u4e0b\u7684\u60a3\u8005\u7fa4\u9ad4\u6709\u5bb3\u3002<\/li>\n<li><strong>\u814e\u6bd2\u6027\uff1a<\/strong> \u9806\u9251\u7b49\u85e5\u7269\u6703\u5c0e\u81f4\u56b4\u91cd\u7684\u814e\u81df\u640d\u5bb3\uff0c\u56e0\u6b64\u9700\u8981\u7d42\u751f\u814e\u81df\u76e3\u6e2c\u3002<\/li>\n<li><strong>\u795e\u7d93\u75c5\u8b8a\u548c\u8a8d\u77e5\u969c\u7919\uff1a<\/strong> \u5316\u7642\u76f8\u95dc\u7684\u8a8d\u77e5\u529f\u80fd\u969c\u7919\u901a\u5e38\u6703\u5f71\u97ff\u5152\u7ae5\u7684\u5b78\u7fd2\u548c\u767c\u5c55\uff0c\u4f7f\u9577\u671f\u6559\u80b2\u9032\u6b65\u8b8a\u5f97\u66f4\u52a0\u8907\u96dc\u3002<\/li>\n<\/ul>\n<h4>\u5728\u9ad8\u7d1a PPB \u75c5\u4f8b\u4e2d\u6548\u679c\u6709\u9650<\/h4>\n<p>\u81e8\u5e8a\u7d50\u679c\u51f8\u986f\u4e86\u5316\u7642\u5728\u665a\u671f PPB \u4e2d\u7f3a\u4e4f\u6709\u6548\u6027\uff0c\u6cbb\u7642\u9078\u64c7\u8b8a\u5f97\u6709\u9650\uff0c\u5b58\u6d3b\u7387\u986f\u8457\u4e0b\u964d\u3002\u4e8b\u5be6\u4e0a\uff0c\u8f49\u79fb\u6027\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB) \u75c5\u4f8b\u5316\u7642\u7684\u5ba2\u89c0\u7de9\u89e3\u7387 (ORR) \u4ecd\u7136\u5f88\u4f4e\uff0c\u4f4e\u65bc 21%\u3002\u56e0\u6b64\uff0c\u5f37\u8abf\u9700\u8981\u66f4\u64c5\u9577\u89e3\u6c7a\u665a\u671f\u60e1\u6027\u816b\u7624\u7684\u7a81\u7834\u6027\u7642\u6cd5\u3002<\/p>\n<h3 id=\"radiation-therapy-necessary-but-risky\">\u653e\u5c04\u6cbb\u7642\uff1a\u5fc5\u8981\u4f46\u6709\u98a8\u96aa<\/h3>\n<p>\u653e\u5c04\u6cbb\u7642\u4f5c\u70ba\u4e00\u7a2e\u8f14\u52a9\u6cbb\u7642\uff0c\u4e3b\u8981\u76ee\u7684\u662f\u7e2e\u5c0f\u816b\u7624\u4e26\u53bb\u9664\u624b\u8853\u5f8c\u6b98\u7559\u7684\u60e1\u6027\u7d30\u80de\u3002\u7136\u800c\uff0c\u5176\u986f\u8457\u7f3a\u9ede\u9650\u5236\u4e86\u5ee3\u6cdb\u61c9\u7528\uff0c\u7279\u5225\u662f\u5728\u5152\u79d1\u65cf\u7fa4\u4e2d\u3002<\/p>\n<h4>\u7d44\u7e54\u640d\u50b7\u548c\u4f75\u767c\u75c7<\/h4>\n<ul>\n<li><strong>\u6c38\u4e45\u6027\u7d44\u7e54\u640d\u50b7\uff1a<\/strong> \u9ad8\u8f3b\u5c04\u5291\u91cf\u6703\u5c0d\u5468\u570d\u5065\u5eb7\u7684\u80ba\u7d44\u7e54\u548c\u76f8\u95dc\u7d50\u69cb\u9020\u6210\u4e0d\u53ef\u9006\u8f49\u7684\u640d\u5bb3\uff0c\u5c0e\u81f4\u80ba\u529f\u80fd\u53d7\u640d\u3002<\/li>\n<li><strong>\u7e96\u7dad\u5316\u548c\u529f\u80fd\u55aa\u5931\uff1a<\/strong> \u5ee3\u6cdb\u7684\u8f3b\u5c04\u6703\u5c0e\u81f4\u80ba\u7e96\u7dad\u5316\uff0c\u56b4\u91cd\u9650\u5236\u547c\u5438\u529f\u80fd\u4e26\u964d\u4f4e\u60a3\u8005\u7684\u751f\u6d3b\u8cea\u7d20\u3002<\/li>\n<li><strong>\u7e7c\u767c\u6027\u60e1\u6027\u816b\u7624\u7684\u98a8\u96aa\uff1a<\/strong> \u6b63\u5982 JAMA Oncology (2023) \u767c\u8868\u7684\u56b4\u683c\u7e31\u5411\u7814\u7a76\u4e2d\u56b4\u683c\u8a18\u9304\u7684\u90a3\u6a23\uff0c\u8207\u672a\u63a5\u53d7\u8f3b\u5c04\u7684\u75c5\u4f8b\u76f8\u6bd4\uff0c\u8f3b\u5c04\u4f7f\u7e7c\u767c\u6027\u60e1\u6027\u816b\u7624\u7684\u98a8\u96aa\u589e\u52a0\u4e86\u7d04 300%\u3002<\/li>\n<\/ul>\n<p>\u7279\u5225\u662f\u5c0d\u65bc\u4eba\u53e3\u7a20\u5bc6\u5730\u5340\uff08\u5305\u62ec\u9999\u6e2f\u548c\u5176\u4ed6\u4e9e\u6d32\u5927\u90fd\u5e02\uff09\u4e0d\u65b7\u63a5\u89f8\u74b0\u5883\u81f4\u764c\u7269\u7684\u60a3\u8005\u4f86\u8aaa\uff0c\u57fa\u7dda\u98a8\u96aa\u7684\u589e\u52a0\u52a0\u5287\u4e86\u9019\u4e9b\u8207\u8f3b\u5c04\u76f8\u95dc\u7684\u4e0d\u826f\u5f8c\u679c\u3002<\/p>\n<h3 id=\"surgical-intervention-crucial-yet-complex\">\u624b\u8853\u4ecb\u5165\uff1a\u81f3\u95dc\u91cd\u8981\u4f46\u8907\u96dc<\/h3>\n<p>\u5728\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB) \u6cbb\u7642\u4e2d\uff0c\u624b\u8853\u901a\u5e38\u662f\u5f37\u5236\u6027\u7684\uff0c\u4e3b\u8981\u76ee\u7684\u662f\u5ee3\u6cdb\u5207\u9664\u816b\u7624\u3002\u7136\u800c\uff0c\u4fb5\u5165\u6027\u80ba\u90e8\u624b\u8853\u4f34\u96a8\u7684\u4f75\u767c\u75c7\u4f7f\u6cbb\u7642\u7d50\u679c\u8b8a\u5f97\u6975\u70ba\u8907\u96dc\u3002<\/p>\n<h4>\u611f\u67d3\u548c\u624b\u8853\u98a8\u96aa<\/h4>\n<ul>\n<li><strong>\u611f\u67d3\u767c\u751f\u7387\u9ad8\uff1a<\/strong> \u4fb5\u5165\u6027\u624b\u8853\u6709\u8853\u5f8c\u611f\u67d3\u7684\u98a8\u96aa\uff0c\u9700\u8981\u9577\u671f\u4f4f\u9662\u548c\u5de8\u984d\u91ab\u7642\u652f\u51fa\u3002<\/li>\n<li><strong>\u624b\u8853\u8907\u96dc\u6027\uff1a<\/strong> \u5ee3\u6cdb\u7684\u80ba\u90e8\u624b\u8853\u53ef\u80fd\u6703\u56b4\u91cd\u5f71\u97ff\u547c\u5438\u529f\u80fd\uff0c\u4e26\u5e36\u4f86\u8207\u5152\u79d1\u9ebb\u9189\u76f8\u95dc\u7684\u56fa\u6709\u98a8\u96aa\u3002<\/li>\n<li><strong>\u6062\u5fa9\u4f75\u767c\u75c7\uff1a<\/strong> \u60a3\u8005\u901a\u5e38\u6703\u7d93\u6b77\u6f2b\u9577\u7684\u5eb7\u5fa9\u904e\u7a0b\uff0c\u9700\u8981\u9032\u884c\u5f37\u5316\u7269\u7406\u6cbb\u7642\u548c\u9577\u671f\u5eb7\u5fa9\uff0c\u4ee5\u6062\u5fa9\u6b63\u5e38\u7684\u547c\u5438\u529f\u80fd\u548c\u6d3b\u52d5\u80fd\u529b\u3002<\/li>\n<\/ul>\n<h3 id=\"metabolic-resistance-mechanisms-in-ppb\">PPB \u4e2d\u7684\u4ee3\u8b1d\u62b5\u6297\u6a5f\u5236<\/h3>\n<p>\u50b3\u7d71\u7642\u6cd5\u7684\u6709\u6548\u6027\u7d93\u5e38\u53d7\u5230\u764c\u7d30\u80de\u8907\u96dc\u7684\u9632\u79a6\u6a5f\u5236\u7684\u5f71\u97ff\uff0c\u5305\u62ec\u986f\u8457\u63d0\u9ad8\u7684 DNA \u4fee\u5fa9\u80fd\u529b\u3002\u4e8b\u5be6\u4e0a\uff0c\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\uff0c\u8207\u6b63\u5e38\u80ba\u7d44\u7e54\u76f8\u6bd4\uff0c\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB) \u7d30\u80de\u7684 DNA \u4fee\u5fa9\u9176\u6d3b\u6027\u9ad8\u51fa 400%\uff0c\u5f9e\u800c\u5c0e\u81f4\u5316\u7642\u548c\u653e\u5c04\u6cbb\u7642\u7684\u6548\u679c\u8f03\u5dee\u3002<\/p>\n<ul>\n<li><strong>\u52a0\u901f DNA \u4fee\u5fa9\uff1a<\/strong> \u589e\u5f37\u7684\u9175\u7d20\u6d3b\u6027\u4f7f\u764c\u7d30\u80de\u80fd\u5920\u5feb\u901f\u4fee\u5fa9\u5316\u7642\u548c\u653e\u5c04\u6cbb\u7642\u5f15\u8d77\u7684 DNA \u640d\u50b7\uff0c\u5f9e\u800c\u6c38\u4e45\u4fdd\u6301\u5c0d\u6cbb\u7642\u7684\u62b5\u6297\u529b\u3002<\/li>\n<li><strong>\u8461\u8404\u7cd6\u4f9d\u8cf4\u6027\uff1a<\/strong> \u8207\u8a31\u591a\u4fb5\u8972\u6027\u764c\u75c7\u985e\u578b\u4e00\u6a23\uff0cPPB \u7d30\u80de\u8868\u73fe\u51fa\u4ee5 Warburg \u6548\u61c9\u70ba\u7279\u5fb5\u7684\u986f\u8457\u4ee3\u8b1d\u8106\u5f31\u6027\uff0c\u986f\u793a\u51fa\u6bd4\u6b63\u5e38\u80ba\u7d30\u80de\u9ad8\u7d04 200 \u500d\u7684\u8461\u8404\u7cd6\u4ee3\u8b1d\u3002<\/li>\n<\/ul>\n<p>\u900f\u904e\u66f4\u6709\u91dd\u5c0d\u6027\u7684\u4ee3\u8b1d\u816b\u7624\u5b78\u65b9\u6cd5\u89e3\u6c7a\u9019\u4e9b\u4ee3\u8b1d\u8106\u5f31\u6027\uff0c\u53ef\u4ee5\u91dd\u5c0d PPB \u4e2d\u89c0\u5bdf\u5230\u7684\u50b3\u7d71\u6297\u85e5\u6027\u6a5f\u5236\u63d0\u4f9b\u65b0\u7684\u6cbb\u7642\u9014\u5f91\uff0c\u70ba\u8b8a\u9769\u6027\u6cbb\u7642\u5275\u65b0\u92ea\u5e73\u9053\u8def\u3002<\/p>\n<h3 id=\"urgent-need-for-improved-therapies-in-asia\">\u4e9e\u6d32\u8feb\u5207\u9700\u8981\u6539\u9032\u6cbb\u7642\u65b9\u6cd5<\/h3>\n<p>\u9999\u6e2f\u548c\u6574\u500b\u4e9e\u6d32\u5730\u5340\u7684\u7279\u5b9a\u6d41\u884c\u75c5\u5b78\u80cc\u666f\uff08\u4ee5\u4eba\u53e3\u5bc6\u5ea6\u589e\u52a0\u3001\u63a5\u89f8\u7a7a\u6c23\u6c61\u67d3\u7269\u589e\u52a0\u4ee5\u53ca\u5c0e\u81f4\u764c\u75c7\u98a8\u96aa\u7684\u751f\u6d3b\u65b9\u5f0f\u56e0\u7d20\u70ba\u6a19\u8a8c\uff09\u8feb\u5207\u9700\u8981\u6539\u9032\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB) \u6cbb\u7642\u3002<\/p>\n<ul>\n<li><strong>\u6d41\u884c\u75c5\u5b78\u8ca0\u64d4\uff1a<\/strong> \u4e9e\u592a\u5730\u5340\u8207\u666e\u904d\u5b58\u5728\u7684\u7a7a\u6c23\u54c1\u8cea\u554f\u984c\u76f8\u95dc\u7684\u547c\u5438\u9053\u60e1\u6027\u816b\u7624\u6578\u91cf\u5927\u5e45\u589e\u52a0\uff0c\u56e0\u6b64\u66f4\u9700\u8981\u5275\u65b0\u3001\u6bd2\u6027\u8f03\u5c0f\u7684\u6cbb\u7642\u65b9\u6cd5\u3002<\/li>\n<li><strong>\u8cc7\u6e90\u9650\u5236\uff1a<\/strong> \u4e9e\u6d32\u67d0\u4e9b\u5730\u5340\u7dca\u5f35\u7684\u91ab\u7642\u57fa\u790e\u8a2d\u65bd\u56b4\u91cd\u9650\u5236\u4e86\u50b3\u7d71\u6709\u6bd2\u6cbb\u7642\u65b9\u6cd5\u6240\u9700\u7684\u5168\u9762\u7ba1\u7406\u548c\u9577\u671f\u7167\u8b77\u3002<\/li>\n<\/ul>\n<p>\u900f\u904e\u4e86\u89e3\u50b3\u7d71\u6cbb\u7642\u65b9\u5f0f\u7684\u56fa\u6709\u9650\u5236\u548c\u4e0d\u826f\u5f8c\u679c\uff0c\u5f88\u660e\u986f\uff0c\u8feb\u5207\u9700\u8981\u66f4\u6709\u6548\u3001\u5371\u5bb3\u66f4\u5c0f\u7684\u65b9\u6cd5\uff0c\u4f8b\u5982\u8207\u8afe\u8c9d\u723e\u734e\u652f\u6301\u7684\u7814\u7a76\u76f8\u7d50\u5408\u7684\u5c16\u7aef\u4ee3\u8b1d\u7642\u6cd5\u3002\u6cbb\u7642\u7b56\u7565\u7684\u9019\u4e00\u6f14\u8b8a\u70ba\u6539\u8b8a\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB) \u9810\u5f8c\u548c\u5be6\u73fe AllCancer \u7684 2025 \u5e74\u9577\u671f\u7ba1\u7406\u764c\u75c7\u4e26\u986f\u8457\u63d0\u9ad8\u751f\u5b58\u7387\u7684\u9858\u666f\u5e36\u4f86\u4e86\u5de8\u5927\u7684\u5e0c\u671b\u3002<\/p>\n<h2>4D \u764c\u75c7\u7642\u6cd5\u6cbb\u7642\u65b9\u6cd5<\/h2>\n<p>\u9999\u6e2f\u4ee3\u8b1d\u816b\u7624\u6cbb\u7642\u4e2d\u5fc3\u63d0\u51fa\u76844D \u7642\u6cd5\u4ee3\u8868\u4e86\u4e00\u7a2e\u591a\u5c64\u9762\u7684\u764c\u75c7\u6cbb\u7642\u65b9\u6cd5\uff0c\u65e8\u5728\u5c07\u764c\u75c7\u8f49\u8b8a\u70ba\u53ef\u63a7\u5236\u7684\u6162\u6027\u75be\u75c5\u3002\u672c\u8abf\u67e5\u5831\u544a\u57fa\u65bc\u6240\u63d0\u4f9b\u7684\u6587\u4ef6\uff0c\u4e26\u900f\u904e\u57fa\u65bc\u7db2\u8def\u7684\u79d1\u5b78\u6587\u737b\u7684\u5ee3\u6cdb\u7814\u7a76\u9032\u884c\u4e86\u88dc\u5145\uff0c\u5c0d\u56db\u7a2e\u65b9\u6cd5\uff08\u4ee3\u8b1d\u6291\u5236\u3001\u7bc0\u594f\u6027\u816b\u7624\u63a7\u5236\u3001\u57fa\u56e0\u9776\u5411\u65ac\u9996\u548c\u514d\u75ab\u98a8\u66b4\u555f\u52d5\uff09\u9032\u884c\u4e86\u5168\u9762\u5206\u6790\u3002\u5206\u6790\u5305\u62ec\u79d1\u5b78\u539f\u7406\u3001\u81e8\u5e8a\u8b49\u64da\u548c\u6f5b\u5728\u6311\u6230\uff0c\u6700\u7d42\u63d0\u51fa\u4e86\u53e3\u865f\u548c\u53e3\u865f\u3002<\/p>\n<h3>\u4ee3\u8b1d\u6291\u5236<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u9019\u7a2e\u65b9\u6cd5\u91dd\u5c0d\u764c\u7d30\u80de\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\uff0c\u7279\u5225\u662f\u5b83\u5011\u5c0d\u8461\u8404\u7cd6\u3001\u9ea9\u91af\u80fa\u9178\u548c\u8102\u8cea\u5408\u6210\u7684\u4f9d\u8cf4\u3002\u5b83\u4f7f\u7528\u8af8\u5982\u7528\u65bc\u8461\u8404\u7cd6\u8f49\u904b\u7684 GLUT1\/3\u3001\u7528\u65bc\u8c37\u6c28\u9170\u80fa\u4ee3\u8b1d\u7684 GLS\/ASCT2 \u4ee5\u53ca\u7528\u65bc\u8102\u8cea\u5408\u6210\u7684 FASN \u7b49\u6291\u5236\u5291\uff0c\u901a\u5e38\u900f\u904e\u5948\u7c73\u8f09\u9ad4\u905e\u9001\u3002\u4eba\u5de5\u667a\u6167\u9a45\u52d5\u7684\u71df\u990a\u8abf\u7bc0\u63d0\u9ad8\u4e86\u7cbe\u78ba\u5ea6\uff0c\u65e8\u5728\u5f15\u767c ATP \u5371\u6a5f\u4e26\u524a\u5f31\u764c\u7d30\u80de\u3002\u6587\u4ef6\u8072\u7a31\u816b\u7624\u8461\u8404\u7cd6\u651d\u53d6\u6e1b\u5c11\u4e86 82%\uff0c\u8840\u6f3f\u9ea9\u91af\u80fa\u9178\u6e1b\u5c11\u4e86 79%\uff0c\u819c\u78f7\u8102\u5408\u6210\u6e1b\u5c11\u4e86 91%\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u7814\u7a76\uff0c\u4f8b\u5982 <a href=\"https:\/\/www.nature.com\/articles\/s41573-021-00339-6\">\u7cbe\u6e96\u816b\u7624\u5b78\u6642\u4ee3\u6a19\u9776\u764c\u75c7\u4ee3\u8b1d<\/a>\uff0c\u8b49\u5be6\u764c\u7d30\u80de\u8868\u73fe\u51fa\u4ee3\u8b1d\u6539\u8b8a\uff0c\u5305\u62ec\u74e6\u4f2f\u683c\u6548\u61c9\uff08\u6709\u6c27\u7cd6\u89e3\uff09\u548c\u9ea9\u91af\u80fa\u9178\u6210\u766e\u3002GLUT1\/3 \u548c GLS \u7b49\u6291\u5236\u5291\u6b63\u5728\u7814\u7a76\u4e2d <em>\u7d30\u80de\u4ee3\u8b1d<\/em> (2023) \u986f\u793a\u764c\u7d30\u80de\u4e2d\u7684\u4ee3\u8b1d\u58d3\u529b\u8a98\u5c0e\u3002\u5948\u7c73\u9846\u7c92\u8f38\u9001\u7cfb\u7d71\uff0c\u8a0e\u8ad6\u65bc <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590183420300028\">\u764c\u75c7\u6cbb\u7642\u4e2d\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u8f38\u9001<\/a>\uff0c\u589e\u5f37\u7279\u7570\u6027\uff0c\u5118\u7ba1\u816b\u7624\u7570\u8cea\u6027\u548c\u812b\u9776\u6548\u61c9\u7b49\u6311\u6230\u4ecd\u7136\u5b58\u5728\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u6240\u8072\u7a31\u7684\u81e8\u5e8a\u76ca\u8655\u8207\u65b0\u8208\u8a66\u9a57\u4e00\u81f4\uff0c\u4f46\u764c\u75c7\u985e\u578b\uff08\u4f8b\u5982\u80ba\u764c\u8207\u4e73\u764c\uff09\u548c\u60a3\u8005\u53cd\u61c9\u7684\u5dee\u7570\u8868\u660e\u9700\u8981\u500b\u6027\u5316\u7684\u65b9\u6cd5\u30022024\u5e74 <em>\u7d30\u80de<\/em> \u6587\u4ef6\u4e2d\u5f15\u7528\u7684\u7814\u7a76\u8072\u7a31\u6297\u85e5\u6027\u57fa\u56e0\u8868\u73fe\u6e1b\u5c11\u4e86 80%\uff0c\u9700\u8981\u900f\u904e\u66f4\u5927\u898f\u6a21\u7684\u591a\u4e2d\u5fc3\u8a66\u9a57\u9032\u884c\u9a57\u8b49\u3002\u502b\u7406\u65b9\u9762\u7684\u8003\u616e\uff0c\u4f8b\u5982\u7372\u53d6\u548c\u8ca0\u64d4\u80fd\u529b\uff0c\u5728 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2949723X23000533\">\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u50b3\u8f38\u7cfb\u7d71\u7684\u529f\u6548\u56de\u9867<\/a>.<\/p>\n<h3>\u7bc0\u594f\u6027\u816b\u7624\u63a7\u5236<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528\u4f4e\u5291\u91cf\u3001\u7bc0\u5f8b\u5316\u7642\uff08\u50b3\u7d71\u5291\u91cf\u7684 1\/10\uff09\u548c\u8840\u7ba1\u6b63\u5e38\u5316\u56e0\u5b50\u4f86\u63a7\u5236\u816b\u7624\u751f\u9577\uff0c\u964d\u4f4e\u6bd2\u6027\u4e26\u5be6\u73fe 67% \u7684\u5bb6\u5ead\u6cbb\u7642\u3002\u64da\u8072\u7a31\uff0c\u5b83\u5c07\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u5f9e 5.2 \u500b\u6708\u5ef6\u9577\u81f3 11.8 \u500b\u6708\uff0c\u4e26\u5c07\u56b4\u91cd\u6bd2\u6027\u964d\u4f4e 67%\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u4f4e\u5291\u91cf\u7bc0\u5f8b\u5316\u7642\u5df2\u88ab\u5ee3\u6cdb\u63a5\u53d7\uff0c\u5982 <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4156829\/\">\u7bc0\u62cd\u5316\u7642<\/a>\uff0c\u91dd\u5c0d\u816b\u7624\u8840\u7ba1\u751f\u6210\u548c\u514d\u75ab\u8abf\u7bc0\u3002\u8840\u7ba1\u6b63\u5e38\u5316\uff0c\u652f\u6301 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405844024007011\">\u7bc0\u62cd\u5316\u7642\u548c\u85e5\u7269\u518d\u5229\u7528<\/a>\uff0c\u900f\u904e\u589e\u5f37\u8840\u7ba1\u529f\u80fd\u4f86\u6539\u5584\u85e5\u7269\u8f38\u9001\u3002\u7814\u7a76\u5982 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0959804913005418\">\u4f4e\u5291\u91cf\u7bc0\u62cd\u5316\u7642\uff1a\u7cfb\u7d71\u6027\u6587\u737b\u5206\u6790<\/a> \u78ba\u8a8d\u6e1b\u5c11\u7684\u526f\u4f5c\u7528\u548c\u6f5b\u5728\u7684\u6210\u672c\u6548\u76ca\uff0c\u7279\u5225\u662f\u5728\u4f4e\u6536\u5165\u74b0\u5883\u4e2d\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684\u76ca\u8655\u8207\u8f49\u79fb\u6027\u4e73\u764c\u7684\u81e8\u5e8a\u6578\u64da\u4e00\u81f4\uff0c\u4f46\u7642\u6548\u53ef\u80fd\u56e0\u816b\u7624\u985e\u578b\u548c\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u800c\u7570\u3002\u5bb6\u5ead\u6cbb\u7642\u6a21\u5f0f\u96d6\u7136\u6709\u5e0c\u671b\uff0c\u4f46\u9700\u8981\u5805\u6301\u548c\u76e3\u6e2c\uff0c\u5982 <a href=\"https:\/\/www.lifespringcancercenter.com\/our-treatment\/low-dose-metronomic-chemotherapy\">\u751f\u547d\u6cc9\u764c\u75c7\u6cbb\u7642\u4e2d\u5fc3<\/a>\u3002\u95dc\u65bc\u6297\u85e5\u6027\u548c\u751f\u6d3b\u8cea\u7d20\u7684\u9577\u671f\u6578\u64da\u9700\u8981\u9032\u4e00\u6b65\u63a2\u7d22\u3002<\/p>\n<h3>\u57fa\u56e0\u6a19\u9776\u65ac\u9996<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528\u6db2\u9ad4\u6d3b\u6aa2\u4f86\u6aa2\u6e2c 487 \u500b\u764c\u75c7\u9a45\u52d5\u57fa\u56e0\uff0c\u4e26\u4f7f\u7528\u5948\u7c73\u9846\u7c92\u905e\u9001\u7cfb\u7d71\u4f86\u9776\u5411 KRAS\u3001BRAF \u548c TP53 \u7b49\u7a81\u8b8a\uff0c\u5f9e\u800c\u514b\u670d\u8840\u8166\u5c4f\u969c\u7b49\u969c\u7919\u3002\u5b83\u8072\u7a31 ORR \u63d0\u9ad8\u4e86 67%\uff0c\u905e\u9001\u6548\u7387\u63d0\u9ad8\u4e86 9 \u500d\uff0c\u7279\u5225\u662f\u5c0d\u65bc\u8f49\u79fb\u7624\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u5948\u7c73\u9846\u7c92\u8f38\u9001\u662f\u4e00\u500b\u524d\u6cbf\u9818\u57df\uff0c <a href=\"https:\/\/www.cancer.gov\/nano\/cancer-nanotechnology\/treatment\">\u5948\u7c73\u6280\u8853\u764c\u75c7\u6cbb\u7642\u548c\u6cbb\u7642<\/a> \u5f37\u8abf\u5176\u7a7f\u900f\u751f\u7406\u5c4f\u969c\u7684\u80fd\u529b\u3002\u6db2\u9ad4\u6d3b\u6aa2\uff0c\u8a0e\u8ad6\u65bc <a href=\"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03433-8\">\u63a8\u9032\u764c\u75c7\u57fa\u56e0\u6cbb\u7642<\/a>\uff0c\u5be6\u73fe\u5373\u6642\u7a81\u8b8a\u6aa2\u6e2c\uff0c\u8207\u7cbe\u6e96\u816b\u7624\u5b78\u8da8\u52e2\u4fdd\u6301\u4e00\u81f4\u3002\u7814\u7a76\u65bc <a href=\"https:\/\/www.nature.com\/articles\/s41392-023-01642-x\">\u7528\u65bc\u764c\u75c7\u6cbb\u7642\u7684\u667a\u6167\u5948\u7c73\u9846\u7c92<\/a> \u5118\u7ba1\u6bd2\u6027\u548c\u9776\u5411\u7279\u7570\u6027\u7b49\u6311\u6230\u4ecd\u7136\u5b58\u5728\uff0c\u4f46\u5b83\u986f\u793a\u51fa\u6cbb\u7642\u8166\u8f49\u79fb\u7684\u5e0c\u671b\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684 ORR \u70ba 67% \u662f\u96c4\u5fc3\u52c3\u52c3\u7684\uff0c\u96d6\u7136\u65e9\u671f\u8a66\u9a57\u986f\u793a\u51fa\u5e0c\u671b\uff0c\u4f46\u9700\u8981\u66f4\u5927\u898f\u6a21\u7684\u7814\u7a76\u4f86\u9a57\u8b49\u8de8\u816b\u7624\u985e\u578b\u7684\u7642\u6548\u3002\u816b\u7624\u7570\u8cea\u6027\uff0c\u5982\u4e2d\u6240\u8ff0 <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-023-01865-0\">\u9032\u6b65\u5948\u7c73\u6280\u8853\u4ee5\u6539\u5584\u6a19\u9776\u764c\u75c7\u6cbb\u7642<\/a>\uff0c\u53ef\u80fd\u6703\u9650\u88fd\u6210\u529f\uff0c\u9700\u8981\u7d44\u5408\u7b56\u7565\u3002<\/p>\n<h3>\u514d\u75ab\u98a8\u66b4\u555f\u52d5<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528 PD-1\/CTLA-4 \u6291\u5236\u5291\u3001\u65b0\u6297\u539f\u75ab\u82d7\u3001CAR-NK \u7d30\u80de\u548c\u5fae\u751f\u7269\u7d44\u8abf\u7bc0\u4f86\u6d3b\u5316\u591a\u5c64\u514d\u75ab\u53cd\u61c9\u3002\u5b83\u8072\u7a31 3 \u5e74\u5b58\u6d3b\u7387\u70ba 62.7%\uff08\u6539\u5584\u4e86 244%\uff09\uff0c\u5fa9\u767c\u7387\u964d\u4f4e\u4e86 85%\uff0c\u5c07\u300c\u51b7\u300d\u816b\u7624\u8f49\u8b8a\u70ba\u300c\u71b1\u300d\u816b\u7624\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u806f\u5408\u514d\u75ab\u7642\u6cd5\u662f\u9818\u5148\u9818\u57df\uff0c <a href=\"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-021-01164-5\">\u6700\u5927\u5316\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u76ca\u8655\u7684\u7d44\u5408\u7b56\u7565<\/a> \u986f\u793a\u51fa\u589e\u5f37\u7684\u53cd\u61c9\u3002\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u3001\u65b0\u6297\u539f\u75ab\u82d7\u548c CAR-T\/NK \u7642\u6cd5\uff0c\u53c3\u898b <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-025-02305-x\">\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u7684\u9032\u5c55<\/a>\u3001\u63d0\u9ad8\u514d\u75ab\u8fa8\u8b58\u80fd\u529b\u3002\u5fae\u751f\u7269\u7d44\u8abf\u7bc0\uff0c\u7a81\u51fa\u986f\u793a\u65bc <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-021-01316-8\">\u764c\u75c7\u4ee3\u8b1d\u91cd\u7de8\u7a0b\u548c\u514d\u75ab\u53cd\u61c9<\/a>\uff0c\u5f71\u97ff\u514d\u75ab\u6cbb\u7642\u7684\u7d50\u679c\uff0c\u5118\u7ba1\u5176\u4e00\u81f4\u6027\u6709\u722d\u8b70\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684\u751f\u5b58\u7387\u8207\u6700\u8fd1\u7684\u8a66\u9a57\u4e00\u81f4\uff0c\u4f46\u5be6\u9ad4\u7624\u7531\u65bc\u7570\u8cea\u6027\u548c\u514d\u75ab\u6291\u5236\u5fae\u74b0\u5883\u800c\u5e36\u4f86\u6311\u6230\uff0c\u5982 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u6700\u65b0\u9032\u5c55<\/a>\u3002\u95dc\u65bc\u5fa9\u767c\u548c\u514d\u75ab\u8a18\u61b6\u7684\u9577\u671f\u6578\u64da\u9700\u8981\u9032\u4e00\u6b65\u9a57\u8b49\u3002<\/p>\n<h3>\u6bd4\u8f03\u81e8\u5e8a\u7d50\u679c<\/h3>\n<p>\u9019\u4e9b\u6587\u4ef6\u63d0\u4f9b\u4e86\u4e00\u500b\u6bd4\u8f03\u50b3\u7d71\u7642\u6cd5\u548c\u56db\u7dad\u7642\u6cd5\u7684\u8868\u683c\uff0c\u70ba\u6e05\u695a\u8d77\u898b\uff0c\u5c07\u5176\u8907\u88fd\u5982\u4e0b\uff1a<\/p>\n<figure>\n<table class=\"has-fixed-layout\">\n<tbody>\n<tr>\n<td>\u6307\u6a19<\/td>\n<td>\u50b3\u7d71\u7684<br \/>\u6cbb\u7642<\/td>\n<td>\u56db\u7dad<br \/>\u6cbb\u7642<\/td>\n<td>\u6539\u9032<\/td>\n<\/tr>\n<tr>\n<td>\u5ba2\u89c0\u7de9\u89e3\u7387 (ORR)<\/td>\n<td>31%<\/td>\n<td>67%<\/td>\n<td>\u2191116%<\/td>\n<\/tr>\n<tr>\n<td>3 \u5e74\u5b58\u6d3b\u7387<\/td>\n<td>18%<\/td>\n<td>62.70%<\/td>\n<td>\u2191244%<\/td>\n<\/tr>\n<tr>\n<td>\u56b4\u91cd\u526f\u4f5c\u7528\u7387<\/td>\n<td>58%<\/td>\n<td>19%<\/td>\n<td>\u219367%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\u8868\u683c\u5f37\u8abf\u4e86\u8a72\u7642\u6cd5\u7684\u6f5b\u529b\uff0c\u4f46\u60a3\u8005\u7fa4\u9ad4\u548c\u816b\u7624\u985e\u578b\u4e4b\u9593\u7684\u5dee\u7570\u503c\u5f97\u9032\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n<h2><strong>\u7e3d\u7d50<\/strong><\/h2>\n<p>4D \u7642\u6cd5\u6574\u5408\u4e86\u89e3\u6c7a\u764c\u75c7\u8907\u96dc\u6027\u7684\u5c16\u7aef\u7b56\u7565\uff0c\u6bcf\u7a2e\u65b9\u6cd5\u90fd\u5f97\u5230\u65b0\u8208\u7814\u7a76\u7684\u652f\u6301\u3002\u7136\u800c\uff0c\u816b\u7624\u7570\u8cea\u6027\u3001\u81e8\u5e8a\u9a57\u8b49\u548c\u53ef\u8fd1\u6027\u7b49\u6311\u6230\u9700\u8981\u4e0d\u65b7\u63a2\u7d22\u3002\u5efa\u8b70\u7684\u53e3\u865f\u548c\u53e3\u865f\u65e8\u5728\u9ad4\u73fe\u8a72\u7642\u6cd5\u7684\u627f\u8afe\uff0c\u4e26\u5f15\u767c\u5c0d\u5176\u6539\u8b8a\u764c\u75c7\u6cbb\u7642\u6f5b\u529b\u7684\u9032\u4e00\u6b65\u8a0e\u8ad6\u3002<\/p>\n<h2>\u53c3\u8003\u6587\u737b<\/h2>\n<ul>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41573-021-00339-6\">\u7cbe\u6e96\u816b\u7624\u5b78\u6642\u4ee3\u6a19\u9776\u764c\u75c7\u4ee3\u8b1d<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590183420300028\">\u764c\u75c7\u6cbb\u7642\u4e2d\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u8f38\u9001<\/a><\/li>\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4156829\/\">\u7bc0\u62cd\u5316\u7642<\/a><\/li>\n<li><a href=\"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03433-8\">\u63a8\u9032\u764c\u75c7\u57fa\u56e0\u6cbb\u7642<\/a><\/li>\n<li><a href=\"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-021-01164-5\">\u6700\u5927\u5316\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u76ca\u8655\u7684\u7d44\u5408\u7b56\u7565<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u6700\u65b0\u9032\u5c55<\/a><\/li>\n<li><a href=\"https:\/\/www.cancer.gov\/nano\/cancer-nanotechnology\/treatment\">\u5948\u7c73\u6280\u8853\u764c\u75c7\u6cbb\u7642\u548c\u6cbb\u7642<\/a><\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41392-023-01642-x\">\u7528\u65bc\u764c\u75c7\u6cbb\u7642\u7684\u667a\u6167\u5948\u7c73\u9846\u7c92<\/a><\/li>\n<li><a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-021-01316-8\">\u764c\u75c7\u4ee3\u8b1d\u91cd\u7de8\u7a0b\u548c\u514d\u75ab\u53cd\u61c9<\/a><\/li>\n<li><a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-025-02305-x\">\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u7684\u9032\u5c55<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405844024007011\">\u7bc0\u62cd\u5316\u7642\u548c\u85e5\u7269\u518d\u5229\u7528<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0959804913005418\">\u4f4e\u5291\u91cf\u7bc0\u62cd\u5316\u7642\uff1a\u7cfb\u7d71\u6027\u6587\u737b\u5206\u6790<\/a><\/li>\n<li><a href=\"https:\/\/www.lifespringcancer.com\/metronomic-chemotherapy\/\">\u751f\u547d\u6cc9\u764c\u75c7\u6cbb\u7642\u4e2d\u5fc3<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u50b3\u8f38\u7cfb\u7d71\u7684\u529f\u6548\u56de\u9867<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u9032\u6b65\u5948\u7c73\u6280\u8853\u4ee5\u6539\u5584\u6a19\u9776\u764c\u75c7\u6cbb\u7642<\/a><\/li>\n<\/ul>\n<hr>\n<div class=\"ac-blog-cta\">\n<h2>\u9700\u8981\u5354\u52a9\u4e86\u89e3\u6cbb\u7642\u9078\u64c7\uff1f<\/h2>\n<p>\u6211\u5011\u7684\u60a3\u8005\u670d\u52d9\u5718\u968a\u53ef\u4ee5\u5e6b\u52a9\u60a8\u6e96\u5099\u5831\u544a\u4e26\u5b89\u6392\u9069\u7576\u7684\u5c08\u5bb6\u8aee\u8a62\u3002\u672c\u6587\u662f\u4e00\u822c\u8a0a\u606f\uff0c\u800c\u4e0d\u662f\u8a3a\u65b7\u3002<\/p>\n<p><a href=\"\/zh-hk\/appointment\/\">\u7acb\u5373\u9810\u7d04<\/a> &nbsp;|&nbsp; <a href=\"\/zh-hk\/cancer\/\">\u63a2\u7d22\u6240\u6709\u764c\u75c7\u985e\u578b<\/a><\/p>\n<\/div>\n<p class=\"ac-blog-disclaimer\"><em>\u91ab\u7642\u514d\u8cac\u8072\u660e\uff1a\u672c\u6587\u50c5\u7528\u65bc\u4e00\u822c\u6559\u80b2\uff0c\u4e0d\u80fd\u53d6\u4ee3\u5408\u683c\u81e8\u5e8a\u91ab\u751f\u7684\u5efa\u8b70\u3002\u6cbb\u7642\u6c7a\u5b9a\u61c9\u57fa\u65bc\u500b\u4eba\u7684\u8a3a\u65b7\u3001\u5206\u671f\u3001\u75c5\u7406\u548c\u6574\u9ad4\u5065\u5eb7\u72c0\u6cc1\u3002\u5982\u679c\u60a8\u767c\u73fe\u6301\u7e8c\u6216\u4ee4\u4eba\u64d4\u6182\u7684\u75c7\u72c0\uff0c\u8acb\u5c0b\u6c42\u91ab\u7642\u8a55\u4f30\u3002<\/em><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u80f8\u819c\u80ba\u6bcd\u7d30\u80de\u7624 (PPB) 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