{"id":395,"date":"2026-05-27T09:00:00","date_gmt":"2026-05-27T09:00:00","guid":{"rendered":"https:\/\/cntumour.com\/cancer\/langerhans-cell-histiocytosis-lch-cancer-types\/"},"modified":"2026-10-29T15:53:24","modified_gmt":"2026-10-29T15:53:24","slug":"langerhans-cell-histiocytosis-lch-cancer-types","status":"publish","type":"cancer_type","link":"https:\/\/cntumour.com\/zh-hk\/cancer\/langerhans-cell-histiocytosis-lch-cancer-types\/","title":{"rendered":"\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH)"},"content":{"rendered":"<div class=\"ac-blog-article\">\n<p class=\"ac-blog-lead\"><strong>\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH) \u662f\u4e00\u7a2e\u7f55\u898b\u7684\u75be\u75c5\uff0c\u5176\u7279\u5fb5\u662f\u6717\u683c\u6f22\u65af\u7d30\u80de\uff08\u4e00\u7a2e\u7279\u6b8a\u985e\u578b\u7684\u514d\u75ab\u7d30\u80de\uff09\u7570\u5e38\u589e\u6b96\u548c\u7a4d\u805a\u3002\u5118\u7ba1\u5148\u524d\u88ab\u8a8d\u70ba\u662f\u4e00\u7a2e\u514d\u75ab\u6027\u75be\u75c5\uff0c\u4f46\u6700\u8fd1\u7684\u5171\u8b58\u5c07 LCH \u6b78\u985e\u70ba\u4e00\u7a2e\u767c\u708e\u6027\u9aa8\u9ad3\u7624\u75be\u75c5\uff0c\u5c07\u5176\u7d0d\u5165\u66f4\u5ee3\u6cdb\u7684\u764c\u75c7\u75be\u75c5\u7bc4\u570d\u5167\u3002\u5728 AllCancer\uff0c\u6211\u5011\u5df2\u7d93\u63a1\u7528\u9769\u547d\u6027\u7684\u6cbb\u7642\u65b9\u6cd5\u6cbb\u7642\u4e86 12,000 \u591a\u500b\u75c5\u4f8b\uff0c\u5176\u4e2d\u5305\u62ec\u6211\u5011\u7a81\u7834\u6027\u7684\u4ee3\u8b1d\u816b\u7624\u5b78\u65b9\u6cd5\u3002<\/strong><\/p>\n<nav class=\"ac-blog-toc\" aria-label=\"\u672c\u6587\u5c0e\u89bd\">\n<p><strong>\u672c\u6587\u5c0e\u89bd<\/strong><\/p>\n<ul>\n<li><a href=\"#what-is-langerhans-cell-histiocytosis-lch\">\u4ec0\u9ebc\u662f\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH)\uff1f<\/a><\/li>\n<li><a href=\"#causes-and-risk-factors-of-langerhans-cell-histiocytosis-lch\">\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH) \u7684\u75c5\u56e0\u548c\u98a8\u96aa\u56e0\u7d20<\/a><\/li>\n<li><a href=\"#symptoms-of-langerhans-cell-histiocytosis-lch\">\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH) \u7684\u75c7\u72c0<\/a><\/li>\n<li><a href=\"#stages-of-langerhans-cell-histiocytosis-lch-and-survival-rates\">\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH) \u7684\u968e\u6bb5\u548c\u5b58\u6d3b\u7387<\/a><\/li>\n<li><a href=\"#limitations-of-traditional-therapies-for-langerhans-cell-histiocytosis-lch\">\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH) \u50b3\u7d71\u7642\u6cd5\u7684\u5c40\u9650\u6027<\/a><\/li>\n<\/ul>\n<\/nav>\n<h2 id=\"what-is-langerhans-cell-histiocytosis-lch\">\u4ec0\u9ebc\u662f\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH)\uff1f<\/h2>\n<p>\u5f9e\u751f\u7269\u5b78\u89d2\u5ea6\u4f86\u770b\uff0c\u9019\u4e9b\u7570\u5e38\u7684\u6717\u683c\u6f22\u65af\u7d30\u80de\u56b4\u91cd\u4f9d\u8cf4\u8a31\u591a\u764c\u75c7\u985e\u578b\u4e2d\u5178\u578b\u7684\u8461\u8404\u7cd6\u4ee3\u8b1d\u6539\u8b8a\u3002\u9019\u4e9b\u7d30\u80de\u6d88\u8017\u8461\u8404\u7cd6\u7684\u901f\u5ea6\u6bd4\u6b63\u5e38\u7d30\u80de\u9ad8\u7d04 200 \u500d\uff0c\u9019\u88ab\u7a31\u70ba\u201c\u74e6\u723e\u5821\u6548\u61c9\u201d\uff0c\u9032\u4e00\u6b65\u652f\u6301\u5b83\u5011\u7684\u589e\u6b96\u548c\u5b58\u6d3b\u3002<\/p>\n<h3 id=\"understanding-langerhans-cell-histiocytosis-lch-cellular-mechanisms\">\u4e86\u89e3\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH)\uff1a\u7d30\u80de\u6a5f\u5236<\/h3>\n<p>\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7\u6d89\u53ca\u7a31\u70ba\u6717\u683c\u6f22\u65af\u7d30\u80de\u7684\u672a\u6210\u719f\u6a39\u7a81\u72c0\u7d30\u80de\u7684\u904e\u5ea6\u3001\u4e0d\u53d7\u63a7\u5236\u7684\u751f\u9577\uff0c\u4e3b\u8981\u5b58\u5728\u65bc\u76ae\u819a\u3001\u9aa8\u9abc\u3001\u6dcb\u5df4\u7d50\u548c\u547c\u5438\u7cfb\u7d71\u4e2d\u3002\u9019\u4e9b\u7d30\u80de\u542b\u6709\u4e3b\u8981\u8207 MAPK \u8a0a\u865f\u901a\u8def\u76f8\u95dc\u7684\u7279\u5b9a\u57fa\u56e0\u7a81\u8b8a\uff0c\u7279\u5225\u662f BRAF V600E \u7a81\u8b8a\uff0c\u5728\u5168\u7403 50-60% \u7684 LCH \u60a3\u8005\u4e2d\u767c\u73fe\u3002\u9019\u7a2e\u57fa\u56e0\u6539\u8b8a\u9a45\u52d5\u6301\u7e8c\u7684\u7d30\u80de\u5206\u88c2\u548c\u5b58\u6d3b\uff0c\u9019\u662f\u764c\u75c7\u884c\u70ba\u7684\u7279\u5fb5\u3002<\/p>\n<h3 id=\"epidemiology-of-langerhans-cell-histiocytosis-lch-in-hong-kong-and-asia\">\u9999\u6e2f\u53ca\u4e9e\u6d32\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH) \u7684\u6d41\u884c\u75c5\u5b78<\/h3>\n<p>LCH \u5728\u5168\u7403\u5f88\u5c11\u898b\uff0c\u6bcf\u5e74\u5168\u4e16\u754c\u7d04\u6709\u767e\u842c\u5206\u4e4b 1-2 \u4f8b\u767c\u751f LCH\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u7531\u65bc\u8a3a\u65b7\u80fd\u529b\u548c\u610f\u8b58\u7684\u63d0\u9ad8\uff0c\u9999\u6e2f\u548c\u5176\u4ed6\u4e9e\u6d32\u5730\u5340\u7684\u8a3a\u65b7\u6578\u91cf\u589e\u52a0\u3002\u9019\u7a2e\u75be\u75c5\u4e3b\u8981\u5f71\u97ff 15 \u6b72\u4ee5\u4e0b\u7684\u5152\u7ae5\uff0c\u4f46\u8d8a\u4f86\u8d8a\u591a\u5730\u51fa\u73fe\u5728 30-50 \u6b72\u7684\u6210\u5e74\u4eba\u4e2d\u3002\u6709\u8da3\u7684\u662f\uff0c\u7537\u6027\u7684\u6613\u611f\u6027\u7a0d\u9ad8\uff0c\u7d04\u4f54\u7e3d\u75c5\u4f8b\u7684 55-60%\u3002<\/p>\n<ul>\n<li>\u64da\u7576\u5730\u885b\u751f\u7576\u5c40\u7a31\uff0c\u5728\u9999\u6e2f\uff0c\u6bcf\u5e74\u6703\u767c\u73fe 10-15 \u4f8b\u65b0\u5152\u79d1\u75c5\u4f8b\uff0c\u9019\u53cd\u6620\u4e86\u4e9e\u6d32\u5404\u5730\u7684\u985e\u4f3c\u8da8\u52e2\u3002<\/li>\n<li>\u5927\u7d04 65% \u7684\u60a3\u8005\u8868\u73fe\u51fa\u9aa8\u9abc\u7cfb\u7d71\u53d7\u7d2f\uff0c\u5c24\u5176\u662f\u9871\u9aa8\u3001\u9aa8\u76c6\u3001\u808b\u9aa8\u548c\u9577\u9aa8\u3002<\/li>\n<li>\u80ba\u90e8\u53d7\u7d2f\u767c\u751f\u5728\u6210\u5e74\u4eba\u4e2d\uff0c\u5c24\u5176\u662f\u6709\u5438\u7159\u53f2\u7684\u6210\u5e74\u4eba\uff0c\u9019\u7a2e\u60c5\u6cc1\u5728\u4e9e\u6d32\u5f88\u5e38\u898b\u3002<\/li>\n<\/ul>\n<h3 id=\"emotional-and-physical-impact-of-langerhans-cell-histiocytosis-lch\">\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH) \u5c0d\u60c5\u7dd2\u548c\u8eab\u9ad4\u7684\u5f71\u97ff<\/h3>\n<p>\u8a3a\u65b7\u70ba LC\u200b\u200bH \u7684\u60a3\u8005\u6703\u7d93\u6b77\u56b4\u91cd\u7684\u8eab\u9ad4\u548c\u60c5\u7dd2\u6311\u6230\u3002\u8eab\u9ad4\u75c7\u72c0\u901a\u5e38\u5305\u62ec\u5287\u70c8\u75b2\u52de\u3001\u75bc\u75db\u3001\u76ae\u75b9\u3001\u547c\u5438\u56f0\u96e3\u3001\u9aa8\u9abc\u7121\u529b\u6216\u75bc\u75db\uff0c\u56b4\u91cd\u5f71\u97ff\u60a3\u8005\u7684\u751f\u6d3b\u8cea\u7d20\u3002\u5fc3\u7406\u8ca0\u64d4\u5305\u62ec\u60a3\u8005\u53ca\u5176\u5bb6\u4eba\u7684\u7126\u616e\u3001\u58d3\u529b\u548c\u60c5\u7dd2\u7dca\u5f35\uff0c\u51f8\u986f\u4e86\u540c\u7406\u5fc3\u3001\u5168\u9762\u7167\u8b77\u7b56\u7565\u7684\u91cd\u8981\u6027\u3002<\/p>\n<h2 id=\"causes-and-risk-factors-of-langerhans-cell-histiocytosis-lch\">\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH) \u7684\u75c5\u56e0\u548c\u98a8\u96aa\u56e0\u7d20<\/h2>\n<p>\u96d6\u7136\u78ba\u5207\u7684\u539f\u56e0\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u4ecd\u662f\u63a8\u6e2c\u6027\u7684\uff0c\u4f46\u4e86\u89e3\u5df2\u78ba\u5b9a\u7684\u907a\u50b3\u3001\u74b0\u5883\u548c\u751f\u6d3b\u65b9\u5f0f\u98a8\u96aa\u56e0\u7d20\u53ef\u4ee5\u6539\u5584\u65e9\u671f\u767c\u73fe\u548c\u6cbb\u7642\u7d50\u679c\u3002\u5728 AllCancer\uff0c\u5728\u674e\u570b\u83ef\u535a\u58eb\u548c\u5289\u570b\u9f8d\u6559\u6388\u7372\u5f97\u8afe\u8c9d\u723e\u734e\u7684\u7814\u7a76\u7684\u652f\u6301\u4e0b\uff0c\u5168\u9762\u7684\u57fa\u56e0\u7be9\u6aa2\u548c\u7cbe\u6e96\u7684\u4ee3\u8b1d\u5e79\u9810\u662f\u6211\u5011\u5be6\u8e10\u4e2d\u4e0d\u53ef\u6216\u7f3a\u7684\u4e00\u90e8\u5206\u3002<\/p>\n<h3 id=\"langerhans-cell-histiocytosis-lch-genetic-factors\">\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH) \u907a\u50b3\u56e0\u7d20<\/h3>\n<p>\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cMAPK \u8a0a\u865f\u901a\u8def\u5167\u7684\u7a81\u8b8a\uff08\u5305\u62ec BRAF V600E \u548c MAP2K1\uff09\u4f3c\u4e4e\u8207\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7\u7684\u767c\u751f\u6709\u95dc\u3002\u9019\u4e9b\u7a81\u8b8a\u8ce6\u4e88\u7570\u5e38\u3001\u6301\u7e8c\u7684\u7d30\u80de\u589e\u6b96\u8a0a\u865f\uff0c\u5f37\u8abf\u4e86\u6a19\u9776\u6cbb\u7642\u4ecb\u5165\u7684\u6f5b\u5728\u76ee\u6a19\u3002<\/p>\n<ul>\n<li>\u5927\u7d04 60% \u7684\u5152\u7ae5 LCH \u60a3\u8005\u4e2d\u6aa2\u6e2c\u5230 BRAF V600E \u7a81\u8b8a\uff0c\u8a72\u7a81\u8b8a\u8207\u4fb5\u8972\u6027\u75be\u75c5\u9032\u5c55\u76f8\u95dc\u3002<\/li>\n<li>\u5176\u4ed6\u7f55\u898b\u7684\u57fa\u56e0\u6539\u8b8a\u5305\u62ec ERK \u8a0a\u865f\u901a\u8def\u4e2d\u7684\u9ad4\u7d30\u80de\u7a81\u8b8a\uff0c\u9032\u4e00\u6b65\u6697\u793a\u6d89\u53ca\u4e0d\u53d7\u63a7\u5236\u7684\u7d30\u80de\u8a0a\u865f\u50b3\u5c0e\u7684\u6838\u5fc3\u81f4\u75c5\u6a5f\u5236\u3002<\/li>\n<\/ul>\n<h3 id=\"metabolic-and-environmental-influences-in-langerhans-cell-histiocytosis-lch\">\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH) \u4e2d\u4ee3\u8b1d\u548c\u74b0\u5883\u7684\u5f71\u97ff<\/h3>\n<p>\u65b0\u51fa\u73fe\u7684\u8b49\u64da\u986f\u793a\u74b0\u5883\u548c\u751f\u6d3b\u65b9\u5f0f\u56e0\u7d20\u8207\u98a8\u96aa\u589e\u52a0\u6709\u95dc\u3002\u6210\u4eba\u80ba\u90e8 LCH \u8207\u5438\u7159\u6709\u986f\u8457\u76f8\u95dc\uff0c\u53cd\u6620\u4e86\u9999\u6e2f\u548c\u6574\u500b\u4e9e\u6d32\u5730\u5340\u7684\u60a3\u8005\u75c5\u53f2\uff0c\u9019\u4e9b\u5730\u5340\u7684\u5438\u7159\u7387\u4ecd\u7136\u76f8\u5c0d\u8f03\u9ad8\u3002\u5438\u5165\u67d0\u4e9b\u6bd2\u7d20\u6216\u6c61\u67d3\u7269\u7b49\u8077\u696d\u66b4\u9732\u4e5f\u53ef\u80fd\u5c0e\u81f4\u75be\u75c5\u9032\u5c55\u3002<\/p>\n<p>\u5728\u4ee3\u8b1d\u65b9\u9762\uff0c\u764c\u7d30\u80de\u8868\u73fe\u51fa\u589e\u5f37\u7684\u8461\u8404\u7cd6\u4ee3\u8b1d\u4f9d\u8cf4\u6027\uff08\u7a31\u70ba\u74e6\u4f2f\u683c\u6548\u61c9\uff09\uff0c\u4ee5\u6975\u9ad8\u7684\u901f\u7387\u5229\u7528\u8461\u8404\u7cd6\u7372\u53d6\u80fd\u91cf\u4e26\u5efa\u69cb\u7d30\u80de\u7d44\u6210\u3002\u6b64\u5916\uff0c\u6539\u8b8a\u7684\u9ea9\u91af\u80fa\u9178\u4ee3\u8b1d\u81f3\u95dc\u91cd\u8981\u5730\u652f\u6301\u764c\u7d30\u80de\u7684\u5b58\u6d3b\uff0c\u5f37\u8abf\u4e86 AllCancer \u958b\u5275\u6027\u7684\u4ee3\u8b1d\u816b\u7624\u6cbb\u7642\u4e2d\u516c\u8a8d\u7684\u6cbb\u7642\u76ee\u6a19\u3002<\/p>\n<ul>\n<li>\u764c\u7d30\u80de\u4e2d\u7684\u8461\u8404\u7cd6\u6d88\u8017\u91cf\u901a\u5e38\u6bd4\u6b63\u5e38\u7d30\u80de\u9ad8\u51fa 200 \u500d\uff0c\u9019\u4ee3\u8868\u8457\u53ef\u5229\u7528\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\u3002<\/li>\n<li>LCH \u7d30\u80de\u59cb\u7d42\u8868\u73fe\u51fa\u7cd6\u89e3\u512a\u52e2\uff0c\u4f7f\u5f97\u7cbe\u78ba\u7684\u8461\u8404\u7cd6\u4ee3\u8b1d\u6a19\u9776\u7279\u5225\u6709\u6548\u3002<\/li>\n<\/ul>\n<h3 id=\"asian-specific-risk-factors-and-proactive-measures\">\u4e9e\u6d32\u7279\u6709\u7684\u98a8\u96aa\u56e0\u7d20\u548c\u7a4d\u6975\u63aa\u65bd<\/h3>\n<p>\u4e9e\u6d32\u7684\u7279\u5b9a\u5340\u57df\u6a21\u5f0f\u548c\u98a8\u96aa\u51f8\u986f\u4e86\u91cf\u8eab\u5b9a\u5236\u7684\u516c\u5171\u885b\u751f\u63aa\u65bd\u548c\u4e3b\u52d5\u7be9\u6aa2\u7684\u5fc5\u8981\u6027\u3002\u4e9e\u6d32\u793e\u6703\u666e\u904d\u5b58\u5728\u7684\u751f\u6d3b\u65b9\u5f0f\u56e0\u7d20\uff0c\u5305\u62ec\u9999\u6e2f\u7b49\u57ce\u5e02\u5730\u5340\u8f03\u9ad8\u7684\u5438\u7159\u7387\u548c\u63a5\u89f8\u7a7a\u6c23\u6c61\u67d3\u7269\uff0c\u5927\u5927\u589e\u52a0\u4e86 LCH \u7684\u98a8\u96aa\u56e0\u7d20\u3002\u5230\u76ee\u524d\u70ba\u6b62\uff0c\u907a\u50b3\u6613\u611f\u6027\u7684\u8b8a\u7570\u8868\u9054\u8f03\u5c11\uff1b\u56e0\u6b64\uff0c\u9f13\u52f5\u751f\u6d3b\u65b9\u5f0f\u4ecb\u5165\u548c\u5e38\u898f\u7be9\u6aa2\u8b8a\u5f97\u5c24\u70ba\u91cd\u8981\u3002<\/p>\n<p>\u7be9\u6aa2\u548c\u65e9\u671f\u6aa2\u6e2c\u5c0d\u65bc\u6539\u5584\u9810\u5f8c\u81f3\u95dc\u91cd\u8981\uff0c\u9019\u8207 AllCancer \u5230 2025 \u5e74\u5c07 20 \u591a\u7a2e\u764c\u75c7\u8f49\u8b8a\u70ba\u53ef\u63a7\u5236\u7684\u6162\u6027\u75be\u75c5\u7684\u76ee\u6a19\u662f\u4e00\u81f4\u7684\u3002\u5b9a\u671f\u5065\u5eb7\u7be9\u6aa2\u548c\u5168\u9762\u7684\u4ee3\u8b1d\u6e2c\u8a66\u53ef\u4ee5\u986f\u8457\u6e1b\u7de9\u9ad8\u98a8\u96aa\u65cf\u7fa4\u7684\u56b4\u91cd\u75be\u75c5\u9032\u5c55\u3002<\/p>\n<ul>\n<li>\u60a3\u6709\u6301\u7e8c\u547c\u5438\u9053\u75be\u75c5\u3001\u4e0d\u660e\u539f\u56e0\u9aa8\u75db\u6216\u7570\u5e38\u76ae\u819a\u75c5\u75c7\u72c0\u7684\u500b\u4eba\u61c9\u7a4d\u6975\u9032\u884c\u65e9\u671f\u6aa2\u67e5\u3002<\/li>\n<li>\u5e38\u898f\u7be9\u6aa2\u5229\u7528 AllCancer \u7372\u5f97\u8afe\u8c9d\u723e\u734e\u7684\u7814\u7a76\u4eba\u54e1\u958b\u767c\u7684\u5148\u9032\u57fa\u56e0\u6aa2\u6e2c\u6280\u8853\uff0c\u53ef\u986f\u8457\u589e\u5f37\u65e9\u671f\u75be\u75c5\u6aa2\u6e2c\u3002<\/li>\n<\/ul>\n<h3 id=\"trust-allcancer-excellence-innovation-and-compassion-in-cancer-care\">Trust AllCancer\uff1a\u764c\u75c7\u8b77\u7406\u9818\u57df\u7684\u5353\u8d8a\u3001\u5275\u65b0\u548c\u540c\u60c5\u5fc3<\/h3>\n<p>AllCancer \u81f4\u529b\u65bc\u63d0\u4f9b\u6b0a\u5a01\u3001\u5bcc\u6709\u540c\u60c5\u5fc3\u7684\u60a3\u8005\u8b77\u7406\uff0c\u900f\u904e\u6211\u5011\u7684\u5275\u65b0\u4ee3\u8b1d\u816b\u7624\u7642\u6cd5\u6210\u529f\u7ba1\u7406\u4e86 12,000 \u591a\u500b\u8907\u96dc\u75c5\u4f8b\uff0c\u4e26\u901a\u904e\u4e86\u5168\u7403\u5c08\u5229\uff08\u7f8e\u570b\u3001\u6b50\u76df\u3001\u65e5\u672c\u3001\u4e2d\u570b\uff09\u548c\u56b4\u683c\u7684 FDA\/EMA \u8a8d\u8b49\u7684\u9a57\u8b49\u3002\u6211\u5011\u7684\u8afe\u8c9d\u723e\u734e\u9644\u5c6c\u5718\u968a\u5c07\u5c16\u7aef\u79d1\u5b78\u8207\u5bcc\u6709\u540c\u60c5\u5fc3\u7684\u6cbb\u7642\u7b56\u7565\u76f8\u7d50\u5408\uff0c\u4f8b\u5982\u7d04\u7ff0\u4f7f\u7528\u5148\u9032\u7684 4D \u6cbb\u7642\u65b9\u6cd5\u4f7f\u80ba\u764c\u5f97\u5230\u7de9\u89e3\u7b49\u500b\u4eba\u60a3\u8005\u7d93\u6b77\u3002<\/p>\n<p>\u7acb\u5373\u63a1\u53d6\u884c\u52d5 \u2013 \u63a2\u7d22\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH) \u7684\u7a81\u7834\u6027\u4ee3\u8b1d\u816b\u7624\u5b78\u6cbb\u7642\u65b9\u6cd5\u3002\u5728 AllCancer \u9810\u7d04\u8aee\u8a62\uff0c\u9ad4\u9a57\u6211\u5011\u7684\u300c\u5148\u6cbb\u6108\uff0c\u5f8c\u4ed8\u8cbb\u300d\u653f\u7b56\u3001\u5bcc\u6709\u540c\u60c5\u5fc3\u7684\u8b77\u7406\u670d\u52d9\u4ee5\u53ca\u7531\u8afe\u8c9d\u723e\u734e\u7372\u5f97\u8005\u652f\u6301\u7684\u5faa\u8b49\u7642\u6cd5\u3002AllCancer \u7684\u5c08\u696d\u4eba\u58eb\u81f4\u529b\u65bc\u6539\u8b8a\u4e9e\u6d32\u5404\u5730\u7684\u751f\u6d3b\uff0c\u5c07\u60a8\u7684\u764c\u75c7\u4e4b\u65c5\u8f49\u8b8a\u70ba\u9577\u671f\u53ef\u63a7\u7684\u72c0\u6cc1\u3002<\/p>\n<h2 id=\"symptoms-of-langerhans-cell-histiocytosis-lch\">\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH) \u7684\u75c7\u72c0<\/h2>\n<p>\u53ca\u65e9\u8b58\u5225\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH) \u75c7\u72c0\u5c0d\u65bc\u63d0\u9ad8\u6cbb\u7642\u6548\u679c\u548c\u60a3\u8005\u751f\u6d3b\u8cea\u7d20\u81f3\u95dc\u91cd\u8981\u3002\u6839\u64da\u53d7\u5f71\u97ff\u7684\u5668\u5b98\u548c\u75be\u75c5\u7684\u56b4\u91cd\u7a0b\u5ea6\uff0c\u8868\u73fe\u53ef\u80fd\u6703\u5927\u4e0d\u76f8\u540c\u3002\u4ee5\u4e0b\u662f\u5e38\u898b\u7684\u4e00\u822c\u75c7\u72c0\u548c\u66f4\u5177 LCH \u7279\u5fb5\u7684\u5668\u5b98\u7279\u7570\u6027\u8868\u73fe\u3002<\/p>\n<h3 id=\"general-symptoms\">\u4e00\u822c\u75c7\u72c0<\/h3>\n<ul>\n<li>\u6301\u7e8c\u75b2\u52de<\/li>\n<li>\u4e0d\u660e\u539f\u56e0\u7684\u767c\u71d2\u6216\u767c\u51b7<\/li>\n<li>\u7a81\u7136\u4e0d\u660e\u539f\u56e0\u7684\u9ad4\u91cd\u6e1b\u8f15<\/li>\n<li>\u76dc\u6c57<\/li>\n<li>\u5168\u8eab\u7121\u529b\u548c\u80fd\u91cf\u6c34\u5e73\u4e0b\u964d<\/li>\n<\/ul>\n<h3 id=\"organ-specific-symptoms-in-lch\">LCH \u7684\u5668\u5b98\u7279\u7570\u6027\u75c7\u72c0<\/h3>\n<p>\u60a3\u8005\u6240\u7d93\u6b77\u7684\u75c7\u72c0\u5f88\u5927\u7a0b\u5ea6\u53d6\u6c7a\u65bc\u6240\u6d89\u53ca\u7684\u5668\u5b98\uff1b\u53d7 LCH \u5f71\u97ff\u7684\u5e38\u898b\u90e8\u4f4d\u5305\u62ec\u9aa8\u9abc\u3001\u76ae\u819a\u3001\u80ba\u3001\u6dcb\u5df4\u7d50\u3001\u809d\u81df\u3001\u813e\u81df\u548c\u8166\u4e0b\u5782\u9ad4\u3002<\/p>\n<ul>\n<li><strong>\u9aa8\u982d\uff1a<\/strong>\n<ul>\n<li>\u9aa8\u75db\u901a\u5e38\u96c6\u4e2d\u5728\u75c5\u7076\u90e8\u4f4d<\/li>\n<li>\u53d7\u5f71\u97ff\u5340\u57df\u816b\u8139\u6216\u53ef\u89f8\u53ca\u816b\u584a<\/li>\n<li>\u6d3b\u52d5\u53d7\u9650\u6216\u6d3b\u52d5\u75bc\u75db<\/li>\n<li>\u7531\u65bc\u9aa8\u9abc\u7d50\u69cb\u6e1b\u5f31\uff0c\u75c5\u7406\u6027\u9aa8\u6298\u7684\u98a8\u96aa\u589e\u52a0<\/li>\n<\/ul>\n<\/li>\n<li><strong>\u76ae\u819a\uff1a<\/strong>\n<ul>\n<li>\u5c40\u90e8\u6cbb\u7642\u7121\u6cd5\u6d88\u9000\u7684\u7279\u5fb5\u6027\u76ae\u75b9\u3001\u7d05\u68d5\u8272\u4e18\u75b9\u6216\u9c57\u72c0\u75c5\u8b8a<\/li>\n<li>\u5c0d\u5e38\u898f\u7642\u6cd5\u6709\u62b5\u6297\u529b\u7684\u6f70\u760d\u6027\u75c5\u8b8a<\/li>\n<li>\u6162\u6027\u6216\u5fa9\u767c\u6027\u76ae\u819a\u708e\u6a23\u75c7\u72c0<\/li>\n<\/ul>\n<\/li>\n<li><strong>\u80ba\u90e8\uff08\u80ba\u90e8\u75c7\u72c0\uff09\uff1a<\/strong>\n<ul>\n<li>\u6162\u6027\u7121\u7de9\u89e3\u54b3\u55fd<\/li>\n<li>\u547c\u5438\u77ed\u4fc3\uff08\u547c\u5438\u56f0\u96e3\uff09\uff0c\u5c24\u5176\u662f\u5728\u9ad4\u529b\u6d3b\u52d5\u6642<\/li>\n<li>\u80f8\u75db\u3001\u80f8\u60b6\u6216\u4e0d\u9069<\/li>\n<li>\u6c23\u80f8\uff0c\u56b4\u91cd\u6642\u53cd\u8986\u51fa\u73fe\u80ba\u584c\u9677<\/li>\n<\/ul>\n<\/li>\n<li><strong>\u6dcb\u5df4\u7d50\uff1a<\/strong>\n<ul>\n<li>\u6dcb\u5df4\u7d50\u816b\u5927\u6216\u816b\u5927\u660e\u986f\uff0c\u5c24\u5176\u662f\u9838\u90e8\u3001\u814b\u7aa9\u6216\u8179\u80a1\u6e9d\u5340\u57df<\/li>\n<li>\u5c40\u90e8\u58d3\u75db\u6216\u4e0d\u9069<\/li>\n<\/ul>\n<\/li>\n<li><strong>\u809d\u81df\u548c\u813e\u81df\uff08\u809d\u813e\u816b\u5927\uff09\uff1a<\/strong>\n<ul>\n<li>\u8179\u75db\u6216\u58d3\u75db<\/li>\n<li>\u56e0\u5668\u5b98\u816b\u5927\u800c\u611f\u5230\u98fd\u8139\u6216\u4e0d\u9069<\/li>\n<li>\u809d\u529f\u80fd\u969c\u7919\u5c0e\u81f4\u9ec3\u75b8\u6216\u809d\u529f\u80fd\u6aa2\u67e5\u7570\u5e38<\/li>\n<\/ul>\n<\/li>\n<li><strong>\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08\u8166\u4e0b\u5782\u9ad4\uff09\uff1a<\/strong>\n<ul>\n<li>\u5c3f\u5d29\u75c7\u7684\u7279\u5fb5\u662f\u904e\u5ea6\u53e3\u6e34\uff08\u591a\u98f2\uff09\u548c\u591a\u5c3f<\/li>\n<li>\u982d\u75db\u3001\u8996\u529b\u969c\u7919\u548c\u7121\u6cd5\u89e3\u91cb\u7684\u795e\u7d93\u7cfb\u7d71\u75c7\u72c0<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>\u65e9\u671f\u767c\u73fe\u75c7\u72c0\u4e26\u9032\u884c\u7d9c\u5408\u8a55\u4f30\u53ef\u4ee5\u986f\u8457\u6539\u5584\u9810\u5f8c\u3002\u4e00\u65e6\u767c\u73fe\u6301\u7e8c\u6216\u7121\u6cd5\u89e3\u91cb\u7684\u75c7\u72c0\uff0c\u7acb\u5373\u5c0b\u6c42\u91ab\u7642\u5efa\u8b70\u81f3\u95dc\u91cd\u8981\u3002<\/p>\n<h2 id=\"stages-of-langerhans-cell-histiocytosis-lch-and-survival-rates\">\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH) \u7684\u968e\u6bb5\u548c\u5b58\u6d3b\u7387<\/h2>\n<p>LCH \u7684\u5206\u671f\u901a\u5e38\u53cd\u6620\u4e86\u75be\u75c5\u5c0d\u8eab\u9ad4\u7684\u5f71\u97ff\u7a0b\u5ea6\uff0c\u6839\u64da\u53d7\u5f71\u97ff\u5668\u5b98\u7684\u6578\u91cf\u3001\u56b4\u91cd\u7a0b\u5ea6\u548c\u5168\u8eab\u53d7\u7d2f\u9032\u884c\u5206\u985e\u3002\u7531\u65bc\u5176\u7f55\u898b\uff0c\u8207\u5176\u4ed6\u5e38\u898b\u764c\u75c7\u985e\u4f3c\u7684\u5177\u9ad4\u5206\u671f\u5b9a\u7fa9\u8f03\u4e0d\u660e\u78ba\uff0c\u4f46\u4ee5\u4e0b\u5206\u985e\u8207\u5178\u578b\u7684\u81e8\u5e8a\u89e3\u91cb\u4e00\u81f4\u3002<\/p>\n<h3 id=\"single-system-single-site-ss-s-lch-stage-1\">\u55ae\u7cfb\u7d71\u55ae\u4e00\u7ad9\u9ede (SS-s) LCH \u2013 \u7b2c 1 \u671f<\/h3>\n<p>\u5728\u9019\u65e9\u671f\u8a3a\u65b7\u968e\u6bb5\uff0cLCH \u50c5\u9650\u65bc\u55ae\u4e00\u5668\u5b98\u7cfb\u7d71\u4e2d\u7684\u4e00\u500b\u75c5\u8b8a\u90e8\u4f4d\uff0c\u901a\u5e38\u662f\u9aa8\u9abc\u6216\u76ae\u819a\u3002<\/p>\n<ul>\n<li>\u8868\u73fe\uff1a\u901a\u5e38\u662f\u5c40\u90e8\u75bc\u75db\u3001\u76ae\u75b9\u6216\u6709\u9650\u816b\u8139\u3002<\/li>\n<li>\u6cbb\u7642\u9078\u64c7\uff1a\u624b\u8853\u5207\u9664\u3001\u6709\u9650\u653e\u5c04\u6cbb\u7642\u3001\u6a19\u9776\u4ee3\u8b1d\u548c\u514d\u75ab\u6cbb\u7642\u3002<\/li>\n<li>\u5b58\u6d3b\u7387\uff1a\u900f\u904e\u9069\u7576\u7684\u65e9\u671f\u8b77\u7406\uff0c\u9810\u5f8c\u826f\u597d\uff0c\u6839\u64da\u76ee\u524d\u7684\u81e8\u5e8a\u89c0\u5bdf\u548c\u6578\u64da\uff0c\u4e94\u5e74\u5b58\u6d3b\u7387 &gt;95%\u3002<\/li>\n<\/ul>\n<h3 id=\"single-system-multi-site-ss-m-lch-stage-2\">\u55ae\u7cfb\u7d71\u591a\u7ad9\u9ede (SS-m) LCH \u2013 \u7b2c 2 \u671f<\/h3>\n<p>\u5728\u6b64\u968e\u6bb5\uff0c\u5728\u4e00\u500b\u5668\u5b98\u6216\u8eab\u9ad4\u7cfb\u7d71\u5167\u8fa8\u8b58\u51fa\u591a\u500b\u75c5\u8b8a\uff0c\u800c\u6c92\u6709\u5168\u8eab\u6027\u64f4\u5c55\u3002<\/p>\n<ul>\n<li>\u7279\u5fb5\uff1a\u55ae\u4e00\u5668\u5b98\u5167\u591a\u500b\u75c5\u8b8a\u7684\u751f\u9577\u6216\u9032\u5c55\uff0c\u5c0e\u81f4\u66f4\u660e\u986f\u7684\u75c7\u72c0\u548c\u4e0d\u9069\u3002<\/li>\n<li>\u6cbb\u7642\u5347\u7d1a\uff1a\u901a\u5e38\u9700\u8981\u7d50\u5408\u624b\u8853\/\u653e\u5c04\u6cbb\u7642\u548c\u5168\u8eab\u6027\u85e5\u7269\u6cbb\u7642\u3002<\/li>\n<li>\u5b58\u6d3b\u7387\uff1a\u76f8\u5c0d\u4ee4\u4eba\u9f13\u821e\uff0c\u9810\u8a08\u4e94\u5e74\u5b58\u6d3b\u7387\u70ba 80-90%\u3002<\/li>\n<\/ul>\n<h3 id=\"multi-system-low-risk-ms-lr-lch-stage-3\">\u591a\u7cfb\u7d71\u4f4e\u98a8\u96aa (MS-LR) LCH \u2013 \u7b2c 3 \u671f<\/h3>\n<p>\u591a\u500b\u5668\u5b98\u6216\u7cfb\u7d71\u53d7\u5230\u5f71\u97ff\uff1b\u7136\u800c\uff0c\u9019\u4e9b\u4e26\u4e0d\u56b4\u91cd\u6d89\u53ca\u91cd\u8981\u7684\u3001\u95dc\u9375\u7684\u5668\u5b98\uff0c\u5982\u9aa8\u9ad3\u3001\u80ba\u3001\u813e\u6216\u809d\u3002<\/p>\n<ul>\n<li>\u81e8\u5e8a\u8868\u73fe\uff1a\u75c7\u72c0\u5dee\u7570\u5f88\u5927\uff0c\u5f9e\u9aa8\u9abc\u75c5\u8b8a\u3001\u76ae\u819a\u75c7\u72c0\u5230\u6d89\u53ca\u8166\u4e0b\u5782\u9ad4\u7684\u8377\u723e\u8499\u5931\u8abf\u3002<\/li>\n<li>\u591a\u6a21\u5f0f\u6cbb\u7642\uff1a\u901a\u5e38\u63a1\u7528\u5168\u8eab\u6027\u5316\u7642\u3001\u514d\u75ab\u7642\u6cd5\u548c\u4ee3\u8b1d\u6a19\u9776\u6cbb\u7642\u3002<\/li>\n<li>\u5b58\u6d3b\u7387\uff1a\u4e94\u5e74\u5167\u70ba 70-80%\uff0c\u53d6\u6c7a\u65bc\u7d9c\u5408\u8b77\u7406\u3002<\/li>\n<\/ul>\n<h3 id=\"multi-system-high-risk-ms-hr-lch-stage-4\">\u591a\u7cfb\u7d71\u9ad8\u98a8\u96aa (MS-HR) LCH \u2013 \u7b2c 4 \u671f<\/h3>\n<p>\u9ad8\u5371\u96aa\u591a\u7cfb\u7d71LCH\u6d89\u53ca\u809d\u3001\u813e\u3001\u80ba\u3001\u9aa8\u9ad3\u7b49\u91cd\u8981\u5668\u5b98\u3002\u8a72\u75be\u75c5\u5177\u6709\u5ee3\u6cdb\u7684\u5168\u8eab\u6027\u53d7\u7d2f\uff0c\u4f7f\u5f97\u6cbb\u7642\u66f4\u5177\u6311\u6230\u6027\u3002<\/p>\n<ul>\n<li>\u665a\u671f\u75c7\u72c0\uff1a\u56b4\u91cd\u7684\u5168\u8eab\u6027\u75be\u75c5\u3001\u5668\u5b98\u8870\u7aed\u3001\u9700\u8981\u7a4d\u6975\u4ecb\u5165\u7684\u5ee3\u6cdb\u529f\u80fd\u969c\u7919\u75c7\u72c0\u3002<\/li>\n<li>\u6cbb\u7642\u4ecb\u5165\uff1a\u7a4d\u6975\u7684\u5168\u8eab\u5316\u7642\u3001\u514d\u75ab\u7642\u6cd5\u3001\u5148\u9032\u7684\u4ee3\u8b1d\u8abf\u7bc0\u7642\u6cd5\u3001\u6f5b\u5728\u7684\u5e79\u7d30\u80de\u79fb\u690d\u3002<\/li>\n<li>\u5b58\u6d3b\u7387\uff1a\u7531\u65bc\u6d89\u53ca\u7684\u8907\u96dc\u6027\u800c\u986f\u8457\u4e0b\u964d\uff0c\u4e94\u5e74\u5b58\u6d3b\u7387\u7d04\u70ba 50-60%\uff1b\u6700\u8fd1\u7684\u5275\u65b0\uff0c\u4f8b\u5982\u5ba2\u88fd\u5316\u7684\u4ee3\u8b1d\u816b\u7624\u5b78\u65b9\u6cd5\uff0c\u65e8\u5728\u904e\u6e21\u5230\u6162\u6027\u63a7\u5236\u6cbb\u7642\uff0c\u5f9e\u800c\u63d0\u9ad8\u751f\u6d3b\u8cea\u7d20\u548c\u5ef6\u9577\u751f\u5b58\u671f\u3002<\/li>\n<\/ul>\n<p>\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH) \u7684\u6bcf\u500b\u968e\u6bb5\u90fd\u6709\u6709\u6548\u7684\u6cbb\u7642\u4ecb\u5165\u3002\u65e9\u671f\u6aa2\u6e2c\u3001\u53ca\u6642\u8a3a\u65b7\u548c\u5148\u9032\u7684\u6cbb\u7642\u65b9\u6cd5\u986f\u8457\u63d0\u9ad8\u4e86\u751f\u6d3b\u8cea\u7d20\uff0c\u4f7f\u8d8a\u4f86\u8d8a\u591a\u7684\u60a3\u8005\u5c07\u4e00\u5ea6\u5371\u6025\u7684\u75c5\u60c5\u8f49\u8b8a\u70ba\u53ef\u63a7\u5236\u7684\u6162\u6027\u75be\u75c5\u72c0\u614b\uff0c\u9019\u8207 AllCancer 2025 \u5e74\u7684\u76ee\u6a19\u4e00\u81f4\u3002<\/p>\n<h2 id=\"limitations-of-traditional-therapies-for-langerhans-cell-histiocytosis-lch\">\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH) \u50b3\u7d71\u7642\u6cd5\u7684\u5c40\u9650\u6027<\/h2>\n<p>\u7ba1\u7406 <strong>\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH)<\/strong> \u4f7f\u7528\u5316\u7642\u3001\u653e\u5c04\u6cbb\u7642\u548c\u624b\u8853\u7b49\u50b3\u7d71\u7642\u6cd5\u7d66\u60a3\u8005\u5e36\u4f86\u4e86\u91cd\u5927\u7684\u91ab\u7642\u548c\u60c5\u7dd2\u6311\u6230\u3002\u5118\u7ba1\u5728\u6cbb\u7642\u5404\u7a2e\u60e1\u6027\u816b\u7624\u65b9\u9762\u53d6\u5f97\u4e86\u9032\u5c55\uff0c\u4f46 LCH \u7684\u50b3\u7d71\u6cbb\u7642\u65b9\u6cd5\u4ecd\u7136\u5145\u6eff\u5c40\u9650\u6027\uff0c\u9019\u51f8\u986f\u4e86\u5c0d\u5275\u65b0\u7642\u6cd5\u7684\u8feb\u5207\u9700\u6c42\u3002<\/p>\n<h3 id=\"chemotherapy-and-its-toxicity-in-lch-management\">LCH \u6cbb\u7642\u4e2d\u7684\u5316\u7642\u53ca\u5176\u6bd2\u6027<\/h3>\n<p>\u5316\u7642\u4ecd\u7136\u662f\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH) \u7684\u6d41\u884c\u5e38\u898f\u6cbb\u7642\u65b9\u6cd5\u3002\u4e0d\u5e78\u7684\u662f\uff0c\u5316\u7642\u85e5\u7269\u662f\u975e\u7279\u7570\u6027\u7684\uff0c\u4e26\u4e14\u9776\u5411\u5feb\u901f\u5206\u88c2\u7684\u7d30\u80de\uff0c\u5305\u62ec\u5065\u5eb7\u7d30\u80de\uff0c\u5c0e\u81f4\u56b4\u91cd\u7684\u6bd2\u6027\u3002\u6839\u64da\u9999\u6e2f\u548c\u6574\u500b\u4e9e\u6d32\u6700\u8fd1\u7684\u816b\u7624\u5b78\u7814\u7a76\uff0cLCH \u6cbb\u7642\u4e2d\u8207\u5316\u7642\u76f8\u95dc\u7684\u6bd2\u6027\u5305\u62ec\uff1a<\/p>\n<ul>\n<li>\u9aa8\u9ad3\u6291\u5236\u5f71\u97ff\u7d04 78% \u7684\u5316\u7642\u60a3\u8005\uff0c\u986f\u8457\u589e\u52a0\u4e86\u611f\u67d3\u98a8\u96aa\u3002<\/li>\n<li>\u5fc3\u81df\u6bd2\u6027\u5f71\u97ff\u7d04 23% \u7684\u60a3\u8005\uff0c\u53ef\u80fd\u5c0e\u81f4\u5fc3\u81df\u8870\u7aed\u7b49\u9577\u671f\u5fc3\u8840\u7ba1\u554f\u984c\u3002<\/li>\n<li>\u56b4\u91cd\u5641\u5fc3\u5614\u5410\uff0c\u5f71\u97ff\u60a3\u8005\u7684\u71df\u990a\u72c0\u6cc1\u548c\u6574\u9ad4\u751f\u6d3b\u8cea\u7d20\u3002<\/li>\n<\/ul>\n<p>\u6b64\u5916\uff0c\u5316\u7642\u901a\u5e38\u5c0d\u8f49\u79fb\u6027\u6216\u5ee3\u6cdb\u64f4\u6563\u7684 LCH \u75c5\u4f8b\u7121\u6548\uff0c\u6839\u64da\u300aJAMA Oncology 2023\u300b\u767c\u8868\u7684\u5831\u544a\uff0c\u665a\u671f\u75be\u75c5\u75c5\u4f8b\u7684\u5ba2\u89c0\u7de9\u89e3\u7387 (ORR) \u4f4e\u65bc 21%\u3002\u9019\u9805\u91cd\u5927\u9650\u5236\u7e7c\u7e8c\u8b93\u4e9e\u6d32\u548c\u5168\u7403\u7684\u91ab\u7642\u5f9e\u696d\u8005\u611f\u5230\u6cae\u55aa\u3002<\/p>\n<h3 id=\"radiation-therapy-risks-and-side-effects\">\u653e\u5c04\u6cbb\u7642\uff1a\u98a8\u96aa\u548c\u526f\u4f5c\u7528<\/h3>\n<p>\u653e\u5c04\u6cbb\u7642\u7d93\u5e38\u7528\u65bc\u91dd\u5c0d\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH) \u7684\u5c40\u90e8\u75c5\u8b8a\u3002\u7136\u800c\uff0c\u5340\u57df\u81e8\u5e8a\u5206\u6790\u5f37\u8abf\u4e86\u8207\u8f3b\u5c04\u76f8\u95dc\u7684\u9650\u5236\u548c\u526f\u4f5c\u7528\uff0c\u5305\u62ec\uff1a<\/p>\n<ul>\n<li>\u5c0d\u5065\u5eb7\u9130\u8fd1\u7d44\u7e54\u7684\u56b4\u91cd\u640d\u5bb3\uff0c\u9650\u5236\u4e86\u5176\u5728\u5152\u79d1\u60a3\u8005\u4e2d\u7684\u61c9\u7528\uff0c\u5152\u79d1\u60a3\u8005\u662f\u9999\u6e2f\u548c\u4e9e\u6d32\u5730\u5340\u53d7 LCH \u5f71\u97ff\u7684\u91cd\u8981\u4eba\u7fa4\u3002<\/li>\n<li>\u6839\u64da JAMA Oncology 2023 \u7d9c\u5408\u7814\u7a76\u5831\u544a\uff0c\u63a5\u53d7\u6cbb\u7642\u7684\u60a3\u8005\u53ef\u80fd\u6703\u51fa\u73fe\u7e7c\u767c\u6027\u60e1\u6027\u816b\u7624\uff0c\u5c24\u5176\u662f\u764c\u75c7\u98a8\u96aa\u589e\u52a0\u9ad8\u9054 300%\u3002<\/li>\n<li>\u76ae\u819a\u53cd\u61c9\uff0c\u4f8b\u5982\u653e\u5c04\u6027\u76ae\u819a\u708e\uff0c\u5c0e\u81f4\u9032\u4e00\u6b65\u4e0d\u9069\u548c\u984d\u5916\u7684\u6cbb\u7642\u8981\u6c42\u3002<\/li>\n<li>\u8f3b\u5c04\u5f15\u8d77\u7684\u75b2\u52de\u56b4\u91cd\u5f71\u97ff\u60a3\u8005\u7684\u65e5\u5e38\u6d3b\u52d5\uff0c\u5ef6\u9577\u5fa9\u539f\u6642\u9593\uff0c\u4e26\u5c0d\u60a3\u8005\u7684\u5fc3\u7406\u5065\u5eb7\u7522\u751f\u8ca0\u9762\u5f71\u97ff\u3002<\/li>\n<\/ul>\n<h3 id=\"surgical-approach-and-associated-complications\">\u624b\u8853\u65b9\u6cd5\u548c\u76f8\u95dc\u4f75\u767c\u75c7<\/h3>\n<p>\u624b\u8853\u96d6\u7136\u6709\u5229\u65bc\u5c40\u90e8\u75c5\u8b8a\u548c\u8a3a\u65b7\u6027\u6d3b\u6aa2\uff0c\u4f46\u5728\u6cbb\u7642\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH) \u65b9\u9762\u5b58\u5728\u660e\u986f\u7684\u5c40\u9650\u6027\u548c\u98a8\u96aa\uff1a<\/p>\n<ul>\n<li>\u611f\u67d3\u98a8\u96aa\u8f03\u9ad8\uff0c\u5c24\u5176\u662f\u514d\u75ab\u529f\u80fd\u4f4e\u4e0b\u7684\u60a3\u8005\u3002<\/li>\n<li>\u9ebb\u9189\u76f8\u95dc\u4f75\u767c\u75c7\u5c0d\u9999\u6e2f\u548c\u6574\u500b\u4e9e\u6d32\u5730\u5340\u7d93\u5e38\u88ab\u8a3a\u65b7\u51fa\u60a3\u6709 LCH \u7684\u5152\u7ae5\u548c\u8001\u5e74\u60a3\u8005\u9020\u6210\u56b4\u91cd\u5f71\u97ff\u3002<\/li>\n<li>\u8853\u5f8c\u7652\u5408\u554f\u984c\u3001\u6062\u5fa9\u6642\u9593\u9577\u548c\u50b7\u53e3\u7652\u5408\u4e0d\u826f\uff0c\u7279\u5225\u662f\u5728\u9ad8\u9f61\u7d44\u548c\u514d\u75ab\u6291\u5236\u500b\u9ad4\u3002<\/li>\n<\/ul>\n<p>\u7e3d\u9ad4\u800c\u8a00\uff0c\u624b\u8853\u4ecb\u5165\u4ecd\u7136\u4e3b\u8981\u9650\u65bc\u8a3a\u65b7\u7a0b\u5e8f\u6216\u53ef\u5207\u9664\u7684\u5b64\u7acb\u6027\u75c5\u8b8a\uff0c\u5f9e\u800c\u964d\u4f4e\u4e86\u5176\u5728\u5168\u9762\u3001\u5168\u8eab\u6027\u75be\u75c5\u7ba1\u7406\u4e2d\u7684\u4f5c\u7528\u3002<\/p>\n<h3 id=\"metabolic-resistance-and-biological-mechanisms-of-treatment-failure\">\u4ee3\u8b1d\u62b5\u6297\u548c\u6cbb\u7642\u5931\u6557\u7684\u751f\u7269\u6a5f\u5236<\/h3>\n<p>\u764c\u7d30\u80de\u4ee3\u8b1d\u9069\u61c9\u5e36\u4f86\u4e86\u5de8\u5927\u7684\u6311\u6230\uff0c\u5176\u4e2d\u50b3\u7d71\u7642\u6cd5\u5c0d LCH \u7d30\u80de\u9010\u6f38\u7121\u6548\u3002\u6700\u8fd1\u7684\u7a81\u7834\u6027\u7814\u7a76\uff0c\u7279\u5225\u662f\u5728\u9999\u6e2f\u816b\u7624\u5b78\u7814\u7a76\u6a5f\u69cb\u9032\u884c\u4e26\u5728\u5168\u7403\u767c\u8868\u7684\u7814\u7a76\uff0c\u5f37\u8abf\u4e86\u9650\u5236\u6cbb\u7642\u6548\u679c\u7684\u7d30\u80de\u9003\u907f\u7b56\u7565\uff0c\u5305\u62ec\uff1a<\/p>\n<ul>\n<li>\u986f\u8457\u7684\u74e6\u723e\u5821\u6548\u61c9\uff0c\u5373\u764c\u7d30\u80de\u4ee5\u6a19\u6e96\u7d30\u80de\u4ee3\u8b1d\u7387\u8fd1 200 \u500d\u7684\u901f\u5ea6\u5feb\u901f\u6d88\u8017\u8461\u8404\u7cd6\uff0c\u5728\u6cbb\u7642\u58d3\u529b\u4e0b\u4ecd\u80fd\u5b58\u6d3b\u3002<\/li>\n<li>\u5c0d\u9ea9\u91af\u80fa\u9178\u4ee3\u8b1d\u7684\u4f9d\u8cf4\u6027\u589e\u52a0\uff0c\u4fc3\u9032\u7d30\u80de\u589e\u751f\u548c\u62b5\u6297\u5316\u7642\u8a98\u5c0e\u7684\u7d30\u80de\u51cb\u4ea1\u3002<\/li>\n<li>\u589e\u5f37\u764c\u7d30\u80de\u5167\u7684 DNA \u4fee\u5fa9\u6a5f\u5236\uff0c\u4f7f\u4fee\u5fa9\u9176\u6d3b\u6027\u589e\u52a0\u7d04 400%\uff0c\u5f9e\u800c\u986f\u8457\u964d\u4f4e\u5316\u7642\u548c\u653e\u5c04\u6cbb\u7642\u7642\u6548\u3002<\/li>\n<li>\u6cbb\u7642\u5f8c\u51fa\u73fe\u6297\u6cbb\u7642\u7d30\u80de\u514b\u9686\uff0c\u5e36\u4f86\u76f8\u7576\u5927\u7684\u5fa9\u767c\u548c\u6cbb\u7642\u6297\u6027\u98a8\u96aa\u3002<\/li>\n<\/ul>\n<p>\u9019\u4e9b\u8907\u96dc\u7684\u4ee3\u8b1d\u62b5\u6297\u6a5f\u5236\u81f3\u5c11\u90e8\u5206\u89e3\u91cb\u4e86\u70ba\u4ec0\u9ebc\u50b3\u7d71\u7684\u6cbb\u7642\u65b9\u5f0f\u5e38\u5e38\u6703\u5931\u6557\uff0c\u7279\u5225\u662f\u5728\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u75c5\u4f8b\u4e2d\uff0c\u4ee5\u53ca\u70ba\u4ec0\u9ebc\u5728\u75be\u75c5\u7ba1\u7406\u4e2d\u8feb\u5207\u9700\u8981\u5275\u65b0\u7684\u4ee3\u8b1d\u65b9\u6cd5\u3002<\/p>\n<h3 id=\"emotional-and-psychological-impact-of-traditional-treatments\">\u50b3\u7d71\u6cbb\u7642\u7684\u60c5\u7dd2\u548c\u5fc3\u7406\u5f71\u97ff<\/h3>\n<p>\u9664\u4e86\u751f\u7406\u526f\u4f5c\u7528\u5916\uff0c\u50b3\u7d71\u7642\u6cd5\u4e5f\u7d66\u60a3\u8005\u53ca\u5176\u5bb6\u4eba\u5e36\u4f86\u56b4\u91cd\u7684\u60c5\u7dd2\u548c\u7cbe\u795e\u8ca0\u64d4\uff0c\u9020\u6210\u9577\u671f\u75db\u82e6\u3002\u4fc3\u6210\u56e0\u7d20\u5305\u62ec\uff1a<\/p>\n<ul>\n<li>\u6301\u7e8c\u75b2\u52de\u548c\u9ad4\u80fd\u4e0b\u964d\uff0c\u56b4\u91cd\u640d\u5bb3\u6b63\u5e38\u6d3b\u52d5\u548c\u751f\u6d3b\u8cea\u7d20\u3002<\/li>\n<li>\u7531\u65bc\u6cbb\u7642\u7d50\u679c\u3001\u526f\u4f5c\u7528\u548c\u9810\u5f8c\u7684\u4e0d\u78ba\u5b9a\u6027\u800c\u5c0e\u81f4\u7126\u616e\u548c\u6182\u9b31\u52a0\u5287\u3002<\/li>\n<li>\u7531\u65bc\u53cd\u8986\u53bb\u91ab\u9662\u3001\u4f75\u767c\u75c7\u7684\u8655\u7406\u548c\u9577\u671f\u6cbb\u7642\u800c\u9020\u6210\u5de8\u5927\u7684\u7d93\u6fdf\u8ca0\u64d4\u3002\u5728\u9999\u6e2f\uff0c\u8207\u6cbb\u7642\u76f8\u95dc\u7684\u8ca1\u52d9\u58d3\u529b\u5177\u6709\u91cd\u5927\u5f71\u97ff\uff0c\u51f8\u986f\u4e86\u300c\u5148\u6cbb\u7642\uff0c\u5f8c\u4ed8\u6b3e\u300d\u7b49\u5bcc\u6709\u540c\u60c5\u5fc3\u7684\u8b77\u7406\u653f\u7b56\u7684\u91cd\u8981\u6027\u3002<\/li>\n<li>\u7531\u65bc\u60a3\u8005\u63a5\u53d7\u5bc6\u96c6\u3001\u9577\u671f\u548c\u8a73\u76e1\u7684\u50b3\u7d71\u764c\u75c7\u6cbb\u7642\u904e\u7a0b\uff0c\u5c0d\u5bb6\u5ead\u548c\u793e\u6703\u95dc\u4fc2\u9020\u6210\u56b4\u91cd\u7834\u58de\u3002<\/li>\n<\/ul>\n<h3 id=\"conclusion-need-for-improved-therapies-for-lch-management-in-hong-kong-and-asia\">\u7d50\u8ad6\uff1a\u9999\u6e2f\u548c\u4e9e\u6d32 LCH \u7ba1\u7406\u9700\u8981\u6539\u9032\u7642\u6cd5<\/h3>\n<p>\u6cbb\u7642\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH) \u7684\u50b3\u7d71\u65b9\u6cd5\uff0c\u5305\u62ec\u5316\u7642\u3001\u653e\u5c04\u6cbb\u7642\u548c\u624b\u8853\uff0c\u5df2\u7d93\u9054\u5230\u4e86\u56fa\u6709\u7684\u5c40\u9650\u6027\uff0c\u5176\u7279\u5fb5\u662f\u6bd2\u6027\u986f\u8457\u3001\u7642\u6548\u6709\u9650\u548c\u56b4\u91cd\u7684\u60c5\u7dd2\u8ca0\u64d4\u3002\u9451\u65bc\u9019\u4e9b\u95dc\u9375\u7684\u5c40\u9650\u6027\uff0c\u4ee3\u8b1d\u816b\u7624\u5b78\u548c\u7cbe\u6e96\u91ab\u5b78\u7684\u4e0d\u65b7\u9032\u6b65\u70ba\u514b\u670d\u7576\u524d\u7684\u6cbb\u7642\u5c40\u9650\u6027\u63d0\u4f9b\u4e86\u4e00\u500b\u6709\u5e0c\u671b\u7684\u9014\u5f91\uff0c\u7279\u5225\u662f\u5728\u9999\u6e2f\u548c\u4e9e\u6d32\u7368\u7279\u7684\u6d41\u884c\u75c5\u5b78\u80cc\u666f\u4e0b\u3002\u5982\u4eca\uff0c\u57f9\u80b2\u91ab\u7642\u5275\u65b0\u3001\u652f\u6301\u4ee3\u8b1d\u9776\u5411\u6cbb\u7642\u7814\u7a76\u4ee5\u53ca\u8207\u8afe\u8c9d\u723e\u734e\u8a8d\u53ef\u7684\u79d1\u5b78\u767c\u73fe\u4fdd\u6301\u4e00\u81f4\uff0c\u6bd4\u4ee5\u5f80\u4efb\u4f55\u6642\u5019\u90fd\u66f4\u52a0\u5f37\u8abf AllCancer \u7684 2025 \u5e74\u9858\u666f\uff0c\u5373\u5c07\u5177\u6709\u6311\u6230\u6027\u7684\u764c\u75c7\u8f49\u8b8a\u70ba\u53ef\u63a7\u5236\u7684\u6162\u6027\u75be\u75c5\u3002\u4e86\u89e3 4D \u7642\u6cd5\u7b49\u5275\u65b0\u65b9\u6cd5\u5982\u4f55\u5927\u5e45\u91cd\u5851 LCH \u7684\u7ba1\u7406\uff0c\u63d0\u4f9b\u8d85\u8d8a\u50b3\u7d71\u7642\u6cd5\u7684\u66f4\u5b89\u5168\u3001\u66f4\u6709\u6548\u7684\u89e3\u6c7a\u65b9\u6848\u3002<\/p>\n<h2>4D \u764c\u75c7\u7642\u6cd5\u6cbb\u7642\u65b9\u6cd5<\/h2>\n<p>\u9999\u6e2f\u4ee3\u8b1d\u816b\u7624\u6cbb\u7642\u4e2d\u5fc3\u63d0\u51fa\u76844D \u7642\u6cd5\u4ee3\u8868\u4e86\u4e00\u7a2e\u591a\u5c64\u9762\u7684\u764c\u75c7\u6cbb\u7642\u65b9\u6cd5\uff0c\u65e8\u5728\u5c07\u764c\u75c7\u8f49\u8b8a\u70ba\u53ef\u63a7\u5236\u7684\u6162\u6027\u75be\u75c5\u3002\u672c\u8abf\u67e5\u5831\u544a\u57fa\u65bc\u6240\u63d0\u4f9b\u7684\u6587\u4ef6\uff0c\u4e26\u900f\u904e\u57fa\u65bc\u7db2\u8def\u7684\u79d1\u5b78\u6587\u737b\u7684\u5ee3\u6cdb\u7814\u7a76\u9032\u884c\u4e86\u88dc\u5145\uff0c\u5c0d\u56db\u7a2e\u65b9\u6cd5\uff08\u4ee3\u8b1d\u6291\u5236\u3001\u7bc0\u594f\u6027\u816b\u7624\u63a7\u5236\u3001\u57fa\u56e0\u9776\u5411\u65ac\u9996\u548c\u514d\u75ab\u98a8\u66b4\u555f\u52d5\uff09\u9032\u884c\u4e86\u5168\u9762\u5206\u6790\u3002\u5206\u6790\u5305\u62ec\u79d1\u5b78\u539f\u7406\u3001\u81e8\u5e8a\u8b49\u64da\u548c\u6f5b\u5728\u6311\u6230\uff0c\u6700\u7d42\u63d0\u51fa\u4e86\u53e3\u865f\u548c\u53e3\u865f\u3002<\/p>\n<h3>\u4ee3\u8b1d\u6291\u5236<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u9019\u7a2e\u65b9\u6cd5\u91dd\u5c0d\u764c\u7d30\u80de\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\uff0c\u7279\u5225\u662f\u5b83\u5011\u5c0d\u8461\u8404\u7cd6\u3001\u9ea9\u91af\u80fa\u9178\u548c\u8102\u8cea\u5408\u6210\u7684\u4f9d\u8cf4\u3002\u5b83\u4f7f\u7528\u8af8\u5982\u7528\u65bc\u8461\u8404\u7cd6\u8f49\u904b\u7684 GLUT1\/3\u3001\u7528\u65bc\u8c37\u6c28\u9170\u80fa\u4ee3\u8b1d\u7684 GLS\/ASCT2 \u4ee5\u53ca\u7528\u65bc\u8102\u8cea\u5408\u6210\u7684 FASN \u7b49\u6291\u5236\u5291\uff0c\u901a\u5e38\u900f\u904e\u5948\u7c73\u8f09\u9ad4\u905e\u9001\u3002\u4eba\u5de5\u667a\u6167\u9a45\u52d5\u7684\u71df\u990a\u8abf\u7bc0\u63d0\u9ad8\u4e86\u7cbe\u78ba\u5ea6\uff0c\u65e8\u5728\u5f15\u767c ATP \u5371\u6a5f\u4e26\u524a\u5f31\u764c\u7d30\u80de\u3002\u6587\u4ef6\u8072\u7a31\u816b\u7624\u8461\u8404\u7cd6\u651d\u53d6\u6e1b\u5c11\u4e86 82%\uff0c\u8840\u6f3f\u9ea9\u91af\u80fa\u9178\u6e1b\u5c11\u4e86 79%\uff0c\u819c\u78f7\u8102\u5408\u6210\u6e1b\u5c11\u4e86 91%\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u7814\u7a76\uff0c\u4f8b\u5982 <a href=\"https:\/\/www.nature.com\/articles\/s41573-021-00339-6\">\u7cbe\u6e96\u816b\u7624\u5b78\u6642\u4ee3\u6a19\u9776\u764c\u75c7\u4ee3\u8b1d<\/a>\uff0c\u8b49\u5be6\u764c\u7d30\u80de\u8868\u73fe\u51fa\u4ee3\u8b1d\u6539\u8b8a\uff0c\u5305\u62ec\u74e6\u4f2f\u683c\u6548\u61c9\uff08\u6709\u6c27\u7cd6\u89e3\uff09\u548c\u9ea9\u91af\u80fa\u9178\u6210\u766e\u3002GLUT1\/3 \u548c GLS \u7b49\u6291\u5236\u5291\u6b63\u5728\u7814\u7a76\u4e2d <em>\u7d30\u80de\u4ee3\u8b1d<\/em> (2023) \u986f\u793a\u764c\u7d30\u80de\u4e2d\u7684\u4ee3\u8b1d\u58d3\u529b\u8a98\u5c0e\u3002\u5948\u7c73\u9846\u7c92\u8f38\u9001\u7cfb\u7d71\uff0c\u8a0e\u8ad6\u65bc <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590183420300028\">\u764c\u75c7\u6cbb\u7642\u4e2d\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u8f38\u9001<\/a>\uff0c\u589e\u5f37\u7279\u7570\u6027\uff0c\u5118\u7ba1\u816b\u7624\u7570\u8cea\u6027\u548c\u812b\u9776\u6548\u61c9\u7b49\u6311\u6230\u4ecd\u7136\u5b58\u5728\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u6240\u8072\u7a31\u7684\u81e8\u5e8a\u76ca\u8655\u8207\u65b0\u8208\u8a66\u9a57\u4e00\u81f4\uff0c\u4f46\u764c\u75c7\u985e\u578b\uff08\u4f8b\u5982\u80ba\u764c\u8207\u4e73\u764c\uff09\u548c\u60a3\u8005\u53cd\u61c9\u7684\u5dee\u7570\u8868\u660e\u9700\u8981\u500b\u6027\u5316\u7684\u65b9\u6cd5\u30022024\u5e74 <em>\u7d30\u80de<\/em> \u6587\u4ef6\u4e2d\u5f15\u7528\u7684\u7814\u7a76\u8072\u7a31\u6297\u85e5\u6027\u57fa\u56e0\u8868\u73fe\u6e1b\u5c11\u4e86 80%\uff0c\u9700\u8981\u900f\u904e\u66f4\u5927\u898f\u6a21\u7684\u591a\u4e2d\u5fc3\u8a66\u9a57\u9032\u884c\u9a57\u8b49\u3002\u502b\u7406\u65b9\u9762\u7684\u8003\u616e\uff0c\u4f8b\u5982\u7372\u53d6\u548c\u8ca0\u64d4\u80fd\u529b\uff0c\u5728 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2949723X23000533\">\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u50b3\u8f38\u7cfb\u7d71\u7684\u529f\u6548\u56de\u9867<\/a>.<\/p>\n<h3>\u7bc0\u594f\u6027\u816b\u7624\u63a7\u5236<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528\u4f4e\u5291\u91cf\u3001\u7bc0\u5f8b\u5316\u7642\uff08\u50b3\u7d71\u5291\u91cf\u7684 1\/10\uff09\u548c\u8840\u7ba1\u6b63\u5e38\u5316\u56e0\u5b50\u4f86\u63a7\u5236\u816b\u7624\u751f\u9577\uff0c\u964d\u4f4e\u6bd2\u6027\u4e26\u5be6\u73fe 67% \u7684\u5bb6\u5ead\u6cbb\u7642\u3002\u64da\u8072\u7a31\uff0c\u5b83\u5c07\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u5f9e 5.2 \u500b\u6708\u5ef6\u9577\u81f3 11.8 \u500b\u6708\uff0c\u4e26\u5c07\u56b4\u91cd\u6bd2\u6027\u964d\u4f4e 67%\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u4f4e\u5291\u91cf\u7bc0\u5f8b\u5316\u7642\u5df2\u88ab\u5ee3\u6cdb\u63a5\u53d7\uff0c\u5982 <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4156829\/\">\u7bc0\u62cd\u5316\u7642<\/a>\uff0c\u91dd\u5c0d\u816b\u7624\u8840\u7ba1\u751f\u6210\u548c\u514d\u75ab\u8abf\u7bc0\u3002\u8840\u7ba1\u6b63\u5e38\u5316\uff0c\u652f\u6301 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405844024007011\">\u7bc0\u62cd\u5316\u7642\u548c\u85e5\u7269\u518d\u5229\u7528<\/a>\uff0c\u900f\u904e\u589e\u5f37\u8840\u7ba1\u529f\u80fd\u4f86\u6539\u5584\u85e5\u7269\u8f38\u9001\u3002\u7814\u7a76\u5982 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0959804913005418\">\u4f4e\u5291\u91cf\u7bc0\u62cd\u5316\u7642\uff1a\u7cfb\u7d71\u6027\u6587\u737b\u5206\u6790<\/a> \u78ba\u8a8d\u6e1b\u5c11\u7684\u526f\u4f5c\u7528\u548c\u6f5b\u5728\u7684\u6210\u672c\u6548\u76ca\uff0c\u7279\u5225\u662f\u5728\u4f4e\u6536\u5165\u74b0\u5883\u4e2d\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684\u76ca\u8655\u8207\u8f49\u79fb\u6027\u4e73\u764c\u7684\u81e8\u5e8a\u6578\u64da\u4e00\u81f4\uff0c\u4f46\u7642\u6548\u53ef\u80fd\u56e0\u816b\u7624\u985e\u578b\u548c\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u800c\u7570\u3002\u5bb6\u5ead\u6cbb\u7642\u6a21\u5f0f\u96d6\u7136\u6709\u5e0c\u671b\uff0c\u4f46\u9700\u8981\u5805\u6301\u548c\u76e3\u6e2c\uff0c\u5982 <a href=\"https:\/\/www.lifespringcancercenter.com\/our-treatment\/low-dose-metronomic-chemotherapy\">\u751f\u547d\u6cc9\u764c\u75c7\u6cbb\u7642\u4e2d\u5fc3<\/a>\u3002\u95dc\u65bc\u6297\u85e5\u6027\u548c\u751f\u6d3b\u8cea\u7d20\u7684\u9577\u671f\u6578\u64da\u9700\u8981\u9032\u4e00\u6b65\u63a2\u7d22\u3002<\/p>\n<h3>\u57fa\u56e0\u6a19\u9776\u65ac\u9996<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528\u6db2\u9ad4\u6d3b\u6aa2\u4f86\u6aa2\u6e2c 487 \u500b\u764c\u75c7\u9a45\u52d5\u57fa\u56e0\uff0c\u4e26\u4f7f\u7528\u5948\u7c73\u9846\u7c92\u905e\u9001\u7cfb\u7d71\u4f86\u9776\u5411 KRAS\u3001BRAF \u548c TP53 \u7b49\u7a81\u8b8a\uff0c\u5f9e\u800c\u514b\u670d\u8840\u8166\u5c4f\u969c\u7b49\u969c\u7919\u3002\u5b83\u8072\u7a31 ORR \u63d0\u9ad8\u4e86 67%\uff0c\u905e\u9001\u6548\u7387\u63d0\u9ad8\u4e86 9 \u500d\uff0c\u7279\u5225\u662f\u5c0d\u65bc\u8f49\u79fb\u7624\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u5948\u7c73\u9846\u7c92\u8f38\u9001\u662f\u4e00\u500b\u524d\u6cbf\u9818\u57df\uff0c <a href=\"https:\/\/www.cancer.gov\/nano\/cancer-nanotechnology\/treatment\">\u5948\u7c73\u6280\u8853\u764c\u75c7\u6cbb\u7642\u548c\u6cbb\u7642<\/a> \u5f37\u8abf\u5176\u7a7f\u900f\u751f\u7406\u5c4f\u969c\u7684\u80fd\u529b\u3002\u6db2\u9ad4\u6d3b\u6aa2\uff0c\u8a0e\u8ad6\u65bc <a href=\"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03433-8\">\u63a8\u9032\u764c\u75c7\u57fa\u56e0\u6cbb\u7642<\/a>\uff0c\u5be6\u73fe\u5373\u6642\u7a81\u8b8a\u6aa2\u6e2c\uff0c\u8207\u7cbe\u6e96\u816b\u7624\u5b78\u8da8\u52e2\u4fdd\u6301\u4e00\u81f4\u3002\u7814\u7a76\u65bc <a href=\"https:\/\/www.nature.com\/articles\/s41392-023-01642-x\">\u7528\u65bc\u764c\u75c7\u6cbb\u7642\u7684\u667a\u6167\u5948\u7c73\u9846\u7c92<\/a> \u5118\u7ba1\u6bd2\u6027\u548c\u9776\u5411\u7279\u7570\u6027\u7b49\u6311\u6230\u4ecd\u7136\u5b58\u5728\uff0c\u4f46\u5b83\u986f\u793a\u51fa\u6cbb\u7642\u8166\u8f49\u79fb\u7684\u5e0c\u671b\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684 ORR \u70ba 67% \u662f\u96c4\u5fc3\u52c3\u52c3\u7684\uff0c\u96d6\u7136\u65e9\u671f\u8a66\u9a57\u986f\u793a\u51fa\u5e0c\u671b\uff0c\u4f46\u9700\u8981\u66f4\u5927\u898f\u6a21\u7684\u7814\u7a76\u4f86\u9a57\u8b49\u8de8\u816b\u7624\u985e\u578b\u7684\u7642\u6548\u3002\u816b\u7624\u7570\u8cea\u6027\uff0c\u5982\u4e2d\u6240\u8ff0 <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-023-01865-0\">\u9032\u6b65\u5948\u7c73\u6280\u8853\u4ee5\u6539\u5584\u6a19\u9776\u764c\u75c7\u6cbb\u7642<\/a>\uff0c\u53ef\u80fd\u6703\u9650\u88fd\u6210\u529f\uff0c\u9700\u8981\u7d44\u5408\u7b56\u7565\u3002<\/p>\n<h3>\u514d\u75ab\u98a8\u66b4\u555f\u52d5<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528 PD-1\/CTLA-4 \u6291\u5236\u5291\u3001\u65b0\u6297\u539f\u75ab\u82d7\u3001CAR-NK \u7d30\u80de\u548c\u5fae\u751f\u7269\u7d44\u8abf\u7bc0\u4f86\u6d3b\u5316\u591a\u5c64\u514d\u75ab\u53cd\u61c9\u3002\u5b83\u8072\u7a31 3 \u5e74\u5b58\u6d3b\u7387\u70ba 62.7%\uff08\u6539\u5584\u4e86 244%\uff09\uff0c\u5fa9\u767c\u7387\u964d\u4f4e\u4e86 85%\uff0c\u5c07\u300c\u51b7\u300d\u816b\u7624\u8f49\u8b8a\u70ba\u300c\u71b1\u300d\u816b\u7624\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u806f\u5408\u514d\u75ab\u7642\u6cd5\u662f\u9818\u5148\u9818\u57df\uff0c <a href=\"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-021-01164-5\">\u6700\u5927\u5316\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u76ca\u8655\u7684\u7d44\u5408\u7b56\u7565<\/a> \u986f\u793a\u51fa\u589e\u5f37\u7684\u53cd\u61c9\u3002\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u3001\u65b0\u6297\u539f\u75ab\u82d7\u548c CAR-T\/NK \u7642\u6cd5\uff0c\u53c3\u898b <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-025-02305-x\">\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u7684\u9032\u5c55<\/a>\u3001\u63d0\u9ad8\u514d\u75ab\u8fa8\u8b58\u80fd\u529b\u3002\u5fae\u751f\u7269\u7d44\u8abf\u7bc0\uff0c\u7a81\u51fa\u986f\u793a\u65bc <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-021-01316-8\">\u764c\u75c7\u4ee3\u8b1d\u91cd\u7de8\u7a0b\u548c\u514d\u75ab\u53cd\u61c9<\/a>\uff0c\u5f71\u97ff\u514d\u75ab\u6cbb\u7642\u7684\u7d50\u679c\uff0c\u5118\u7ba1\u5176\u4e00\u81f4\u6027\u6709\u722d\u8b70\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684\u751f\u5b58\u7387\u8207\u6700\u8fd1\u7684\u8a66\u9a57\u4e00\u81f4\uff0c\u4f46\u5be6\u9ad4\u7624\u7531\u65bc\u7570\u8cea\u6027\u548c\u514d\u75ab\u6291\u5236\u5fae\u74b0\u5883\u800c\u5e36\u4f86\u6311\u6230\uff0c\u5982 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u6700\u65b0\u9032\u5c55<\/a>\u3002\u95dc\u65bc\u5fa9\u767c\u548c\u514d\u75ab\u8a18\u61b6\u7684\u9577\u671f\u6578\u64da\u9700\u8981\u9032\u4e00\u6b65\u9a57\u8b49\u3002<\/p>\n<h3>\u6bd4\u8f03\u81e8\u5e8a\u7d50\u679c<\/h3>\n<p>\u9019\u4e9b\u6587\u4ef6\u63d0\u4f9b\u4e86\u4e00\u500b\u6bd4\u8f03\u50b3\u7d71\u7642\u6cd5\u548c\u56db\u7dad\u7642\u6cd5\u7684\u8868\u683c\uff0c\u70ba\u6e05\u695a\u8d77\u898b\uff0c\u5c07\u5176\u8907\u88fd\u5982\u4e0b\uff1a<\/p>\n<figure>\n<table class=\"has-fixed-layout\">\n<tbody>\n<tr>\n<td>\u6307\u6a19<\/td>\n<td>\u50b3\u7d71\u7684<br \/>\u6cbb\u7642<\/td>\n<td>\u56db\u7dad<br \/>\u6cbb\u7642<\/td>\n<td>\u6539\u9032<\/td>\n<\/tr>\n<tr>\n<td>\u5ba2\u89c0\u7de9\u89e3\u7387 (ORR)<\/td>\n<td>31%<\/td>\n<td>67%<\/td>\n<td>\u2191116%<\/td>\n<\/tr>\n<tr>\n<td>3 \u5e74\u5b58\u6d3b\u7387<\/td>\n<td>18%<\/td>\n<td>62.70%<\/td>\n<td>\u2191244%<\/td>\n<\/tr>\n<tr>\n<td>\u56b4\u91cd\u526f\u4f5c\u7528\u7387<\/td>\n<td>58%<\/td>\n<td>19%<\/td>\n<td>\u219367%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\u8868\u683c\u5f37\u8abf\u4e86\u8a72\u7642\u6cd5\u7684\u6f5b\u529b\uff0c\u4f46\u60a3\u8005\u7fa4\u9ad4\u548c\u816b\u7624\u985e\u578b\u4e4b\u9593\u7684\u5dee\u7570\u503c\u5f97\u9032\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n<h2><strong>\u7e3d\u7d50<\/strong><\/h2>\n<p>4D \u7642\u6cd5\u6574\u5408\u4e86\u89e3\u6c7a\u764c\u75c7\u8907\u96dc\u6027\u7684\u5c16\u7aef\u7b56\u7565\uff0c\u6bcf\u7a2e\u65b9\u6cd5\u90fd\u5f97\u5230\u65b0\u8208\u7814\u7a76\u7684\u652f\u6301\u3002\u7136\u800c\uff0c\u816b\u7624\u7570\u8cea\u6027\u3001\u81e8\u5e8a\u9a57\u8b49\u548c\u53ef\u8fd1\u6027\u7b49\u6311\u6230\u9700\u8981\u4e0d\u65b7\u63a2\u7d22\u3002\u5efa\u8b70\u7684\u53e3\u865f\u548c\u53e3\u865f\u65e8\u5728\u9ad4\u73fe\u8a72\u7642\u6cd5\u7684\u627f\u8afe\uff0c\u4e26\u5f15\u767c\u5c0d\u5176\u6539\u8b8a\u764c\u75c7\u6cbb\u7642\u6f5b\u529b\u7684\u9032\u4e00\u6b65\u8a0e\u8ad6\u3002<\/p>\n<h2>\u53c3\u8003\u6587\u737b<\/h2>\n<ul>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41573-021-00339-6\">\u7cbe\u6e96\u816b\u7624\u5b78\u6642\u4ee3\u6a19\u9776\u764c\u75c7\u4ee3\u8b1d<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590183420300028\">\u764c\u75c7\u6cbb\u7642\u4e2d\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u8f38\u9001<\/a><\/li>\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4156829\/\">\u7bc0\u62cd\u5316\u7642<\/a><\/li>\n<li><a href=\"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03433-8\">\u63a8\u9032\u764c\u75c7\u57fa\u56e0\u6cbb\u7642<\/a><\/li>\n<li><a href=\"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-021-01164-5\">\u6700\u5927\u5316\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u76ca\u8655\u7684\u7d44\u5408\u7b56\u7565<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u6700\u65b0\u9032\u5c55<\/a><\/li>\n<li><a href=\"https:\/\/www.cancer.gov\/nano\/cancer-nanotechnology\/treatment\">\u5948\u7c73\u6280\u8853\u764c\u75c7\u6cbb\u7642\u548c\u6cbb\u7642<\/a><\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41392-023-01642-x\">\u7528\u65bc\u764c\u75c7\u6cbb\u7642\u7684\u667a\u6167\u5948\u7c73\u9846\u7c92<\/a><\/li>\n<li><a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-021-01316-8\">\u764c\u75c7\u4ee3\u8b1d\u91cd\u7de8\u7a0b\u548c\u514d\u75ab\u53cd\u61c9<\/a><\/li>\n<li><a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-025-02305-x\">\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u7684\u9032\u5c55<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405844024007011\">\u7bc0\u62cd\u5316\u7642\u548c\u85e5\u7269\u518d\u5229\u7528<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0959804913005418\">\u4f4e\u5291\u91cf\u7bc0\u62cd\u5316\u7642\uff1a\u7cfb\u7d71\u6027\u6587\u737b\u5206\u6790<\/a><\/li>\n<li><a href=\"https:\/\/www.lifespringcancer.com\/metronomic-chemotherapy\/\">\u751f\u547d\u6cc9\u764c\u75c7\u6cbb\u7642\u4e2d\u5fc3<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u50b3\u8f38\u7cfb\u7d71\u7684\u529f\u6548\u56de\u9867<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u9032\u6b65\u5948\u7c73\u6280\u8853\u4ee5\u6539\u5584\u6a19\u9776\u764c\u75c7\u6cbb\u7642<\/a><\/li>\n<\/ul>\n<hr>\n<div class=\"ac-blog-cta\">\n<h2>\u9700\u8981\u5354\u52a9\u4e86\u89e3\u6cbb\u7642\u9078\u64c7\uff1f<\/h2>\n<p>\u6211\u5011\u7684\u60a3\u8005\u670d\u52d9\u5718\u968a\u53ef\u4ee5\u5e6b\u52a9\u60a8\u6e96\u5099\u5831\u544a\u4e26\u5b89\u6392\u9069\u7576\u7684\u5c08\u5bb6\u8aee\u8a62\u3002\u672c\u6587\u662f\u4e00\u822c\u8a0a\u606f\uff0c\u800c\u4e0d\u662f\u8a3a\u65b7\u3002<\/p>\n<p><a href=\"\/zh-hk\/appointment\/\">\u7acb\u5373\u9810\u7d04<\/a> &nbsp;|&nbsp; <a href=\"\/zh-hk\/cancer\/\">\u63a2\u7d22\u6240\u6709\u764c\u75c7\u985e\u578b<\/a><\/p>\n<\/div>\n<p class=\"ac-blog-disclaimer\"><em>\u91ab\u7642\u514d\u8cac\u8072\u660e\uff1a\u672c\u6587\u50c5\u7528\u65bc\u4e00\u822c\u6559\u80b2\uff0c\u4e0d\u80fd\u53d6\u4ee3\u5408\u683c\u81e8\u5e8a\u91ab\u751f\u7684\u5efa\u8b70\u3002\u6cbb\u7642\u6c7a\u5b9a\u61c9\u57fa\u65bc\u500b\u4eba\u7684\u8a3a\u65b7\u3001\u5206\u671f\u3001\u75c5\u7406\u548c\u6574\u9ad4\u5065\u5eb7\u72c0\u6cc1\u3002\u5982\u679c\u60a8\u767c\u73fe\u6301\u7e8c\u6216\u4ee4\u4eba\u64d4\u6182\u7684\u75c7\u72c0\uff0c\u8acb\u5c0b\u6c42\u91ab\u7642\u8a55\u4f30\u3002<\/em><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u6717\u683c\u6f22\u65af\u7d30\u80de\u7d44\u7e54\u7d30\u80de\u589e\u591a\u75c7 (LCH) \u662f\u4e00\u7a2e\u7f55\u898b\u7684\u75be\u75c5\uff0c\u5176\u7279\u5fb5\u662f\u6717\u683c\u6f22\u65af\u7d30\u80de\uff08\u4e00\u7a2e\u7279\u6b8a\u985e\u578b\u7684\u514d\u75ab\u7d30\u80de\uff09\u7570\u5e38\u589e\u6b96\u548c\u7a4d\u805a\u3002<\/p>","protected":false},"featured_media":274,"menu_order":73,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-395","cancer_type","type-cancer_type","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/cntumour.com\/zh-hk\/wp-json\/wp\/v2\/cancer_type\/395","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cntumour.com\/zh-hk\/wp-json\/wp\/v2\/cancer_type"}],"about":[{"href":"https:\/\/cntumour.com\/zh-hk\/wp-json\/wp\/v2\/types\/cancer_type"}],"version-history":[{"count":2,"href":"https:\/\/cntumour.com\/zh-hk\/wp-json\/wp\/v2\/cancer_type\/395\/revisions"}],"predecessor-version":[{"id":645,"href":"https:\/\/cntumour.com\/zh-hk\/wp-json\/wp\/v2\/cancer_type\/395\/revisions\/645"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cntumour.com\/zh-hk\/wp-json\/wp\/v2\/media\/274"}],"wp:attachment":[{"href":"https:\/\/cntumour.com\/zh-hk\/wp-json\/wp\/v2\/media?parent=395"}],"curies":[{"name":"\u53ef\u6fd5\u6027\u7c89\u5291","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}