{"id":408,"date":"2026-05-01T09:00:00","date_gmt":"2026-05-01T09:00:00","guid":{"rendered":"https:\/\/cntumour.com\/cancer\/wilms-tumor-nephroblastoma-cancer\/"},"modified":"2026-10-29T15:53:24","modified_gmt":"2026-10-29T15:53:24","slug":"wilms-tumor-nephroblastoma-cancer","status":"publish","type":"cancer_type","link":"https:\/\/cntumour.com\/zh-hk\/cancer\/wilms-tumor-nephroblastoma-cancer\/","title":{"rendered":"\u814e\u6bcd\u7d30\u80de\u7624"},"content":{"rendered":"<div class=\"ac-blog-article\">\n<p class=\"ac-blog-lead\"><strong>\u814e\u6bcd\u7d30\u80de\u7624\u662f\u4e00\u7a2e\u7f55\u898b\u4f46\u53ef\u6cbb\u7642\u7684\u5152\u7ae5\u814e\u764c\uff0c\u4e3b\u8981\u5f71\u97ff 3-4 \u6b72\u7684\u5152\u7ae5\uff0c\u4f46\u5076\u723e\u6703\u8a3a\u65b7\u51fa\u5e74\u9f61\u8f03\u5927\u7684\u5152\u7ae5\uff0c\u5f88\u5c11\u6709\u6210\u4eba\u80fd\u5920\u88ab\u8a3a\u65b7\u51fa\u4f86\u3002\u4e86\u89e3\u814e\u6bcd\u7d30\u80de\u7624\u9996\u5148\u8981\u4e86\u89e3\u5176\u751f\u7269\u5b78\u57fa\u790e\uff0c\u5373\u672a\u6210\u719f\u814e\u7d30\u80de\u7684\u7570\u5e38\u751f\u9577\u3002<\/strong><\/p>\n<nav class=\"ac-blog-toc\" aria-label=\"\u672c\u6587\u5c0e\u89bd\">\n<p><strong>\u672c\u6587\u5c0e\u89bd<\/strong><\/p>\n<ul>\n<li><a href=\"#what-is-wilms-tumor-nephroblastoma\">\u4ec0\u9ebc\u662f\u814e\u6bcd\u7d30\u80de\u7624\uff1f<\/a><\/li>\n<li><a href=\"#causes-and-risk-factors-of-wilms-tumor-nephroblastoma\">\u814e\u6bcd\u7d30\u80de\u7624\u7684\u75c5\u56e0\u8207\u98a8\u96aa\u56e0\u7d20<\/a><\/li>\n<li><a href=\"#symptoms-of-wilms-tumor-nephroblastoma\">\u814e\u6bcd\u7d30\u80de\u7624\u7684\u75c7\u72c0<\/a><\/li>\n<li><a href=\"#stages-of-wilms-tumor-nephroblastoma-and-survival-rates\">\u814e\u6bcd\u7d30\u80de\u7624\u7684\u5206\u671f\u8207\u5b58\u6d3b\u7387<\/a><\/li>\n<li><a href=\"#limitations-of-traditional-therapies-for-wilms-tumor-nephroblastoma\">\u814e\u6bcd\u7d30\u80de\u7624\u50b3\u7d71\u7642\u6cd5\u7684\u5c40\u9650\u6027<\/a><\/li>\n<\/ul>\n<\/nav>\n<h2 id=\"what-is-wilms-tumor-nephroblastoma\">\u4ec0\u9ebc\u662f\u814e\u6bcd\u7d30\u80de\u7624\uff1f<\/h2>\n<p>\u5728\u5065\u5eb7\u500b\u9ad4\u4e2d\uff0c\u814e\u7d30\u80de\u5728\u7ae5\u5e74\u6642\u671f\u5c31\u6210\u719f\u4e26\u5206\u5316\u3002\u7136\u800c\uff0c\u5728\u814e\u6bcd\u7d30\u80de\u7624\u4e2d\uff0c\u9019\u4e9b\u7d30\u80de\u7121\u6cd5\u6b63\u5e38\u6210\u719f\uff0c\u8fc5\u901f\u589e\u751f\u4e26\u5f62\u6210\u816b\u7624\u3002\u5f9e\u751f\u7269\u5b78\u89d2\u5ea6\u4f86\u770b\uff0c\u9019\u7a2e\u764c\u75c7\u8868\u73fe\u51fa\u986f\u8457\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\uff0c\u5c24\u5176\u662f\u74e6\u723e\u5821\u6548\u61c9\u3002\u9019\u7a2e\u73fe\u8c61\u63cf\u8ff0\u4e86\u764c\u7d30\u80de\u5982\u4f55\u512a\u5148\u6d88\u8017\u6bd4\u5178\u578b\u5065\u5eb7\u7d30\u80de\u591a\u7d04 200 \u500d\u7684\u8461\u8404\u7cd6\u3002\u5229\u7528\u9019\u7a2e\u4ee3\u8b1d\u7279\u5fb5\u53ef\u4ee5\u88fd\u5b9a\u6709\u91dd\u5c0d\u6027\u7684\u6cbb\u7642\u7b56\u7565\uff0c\u7279\u5225\u662f\u4ee3\u8b1d\u816b\u7624\u5b78\u5275\u65b0\u3002<\/p>\n<p>\u5168\u7403\u7bc4\u570d\u5167\uff0c\u6bcf\u5e74\u5831\u544a\u7d04 500 \u4f8b\u65b0\u7684\u814e\u6bcd\u7d30\u80de\u7624\u75c5\u4f8b\uff08WHO 2024\uff09\u3002\u5177\u9ad4\u800c\u8a00\uff0c\u5728\u9999\u6e2f\u548c\u6574\u500b\u4e9e\u6d32\uff0c\u6bcf\u5e74\u8a18\u9304\u7d04 20-30 \u4f8b\u5152\u79d1\u75c5\u4f8b\uff0c\u9019\u51f8\u986f\u4e86\u5728\u5730\u5316\u610f\u8b58\u548c\u5c08\u696d\u6cbb\u7642\u65b9\u6cd5\u7684\u5fc5\u8981\u6027\u3002<\/p>\n<h3 id=\"symptoms-and-early-signs-of-wilms-tumor-nephroblastoma\">\u814e\u6bcd\u7d30\u80de\u7624\u7684\u75c7\u72c0\u548c\u65e9\u671f\u5fb5\u8c61<\/h3>\n<p>\u8b58\u5225\u65e9\u671f\u75c7\u72c0\u53ef\u4ee5\u986f\u8457\u63d0\u9ad8\u6cbb\u7642\u6548\u679c\u3002\u5e38\u898b\u75c7\u72c0\u5305\u62ec\uff1a<\/p>\n<ul>\n<li>\u8179\u90e8\u816b\u8139\u6216\u816b\u584a<\/li>\n<li>\u8179\u75db<\/li>\n<li>\u767c\u71d2\u548c\u76dc\u6c57<\/li>\n<li>\u5c3f\u4e2d\u5e36\u8840<\/li>\n<li>\u75b2\u52de\u548c\u98df\u617e\u4e0d\u632f<\/li>\n<li>\u9ad8\u8840\u58d3<\/li>\n<\/ul>\n<p>\u5728\u9999\u6e2f\uff0c\u60a3\u8005\u5bb6\u5c6c\u7d93\u5e38\u5831\u544a\u60c5\u7dd2\u8ca0\u64d4\uff0c\u4f8b\u5982\u5c0d\u8a3a\u65b7\u548c\u6cbb\u7642\u7d50\u679c\u7684\u7126\u616e\uff0c\u4ee5\u53ca\u56b4\u91cd\u7684\u8eab\u9ad4\u5f71\u97ff\uff0c\u5305\u62ec\u8207\u6cbb\u7642\u76f8\u95dc\u7684\u75b2\u52de\u548c\u4e0d\u9069\u3002\u56e0\u6b64\uff0c\u65e9\u671f\u6aa2\u6e2c\u5c0d\u65bc\u6709\u6548\u7ba1\u7406\u75c7\u72c0\u548c\u6539\u5584\u60a3\u8005\u9810\u5f8c\u4ecd\u7136\u81f3\u95dc\u91cd\u8981\u3002<\/p>\n<p>\u5982\u9700\u9032\u4e00\u6b65\u4e86\u89e3\uff0c\u8acb\u700f\u89bd\u6211\u5011\u7684\u5c08\u7528\u9801\u9762 <a href=\"\/zh-hk\/treatment-cancer\/\">\u764c\u75c7\u751f\u7269\u5b78<\/a> \u4ee5\u53ca\u6700\u65b0\u7684\u8a3a\u65b7\u7b56\u7565 <a href=\"\/zh-hk\/our-hospital\/\">\u764c\u75c7\u8a3a\u65b7<\/a>.<\/p>\n<h2 id=\"causes-and-risk-factors-of-wilms-tumor-nephroblastoma\">\u814e\u6bcd\u7d30\u80de\u7624\u7684\u75c5\u56e0\u8207\u98a8\u96aa\u56e0\u7d20<\/h2>\n<p>\u4e86\u89e3\u8207\u814e\u6bcd\u7d30\u80de\u7624\u76f8\u95dc\u7684\u4e00\u7cfb\u5217\u539f\u56e0\u548c\u98a8\u96aa\u56e0\u7d20\u53ef\u4ee5\u5e6b\u52a9\u7236\u6bcd\u548c\u7167\u8b77\u8005\u63a1\u53d6\u7a4d\u6975\u7684\u9810\u9632\u63aa\u65bd\u3002<\/p>\n<h3 id=\"genetic-factors\">\u907a\u50b3\u56e0\u7d20<\/h3>\n<p>\u5df2\u660e\u78ba\u9451\u5b9a\u51fa\u8207\u814e\u6bcd\u7d30\u80de\u7624\u76f8\u95dc\u7684\u5e7e\u7a2e\u57fa\u56e0\u7a81\u8b8a\uff1a<\/p>\n<ul>\n<li>WT1\u57fa\u56e0\u7a81\u8b8a\uff1a\u5f71\u97ff\u814e\u7d30\u80de\u767c\u80b2\u3002<\/li>\n<li>WTX \u57fa\u56e0\u7570\u5e38\uff1a\u8207\u814e\u81df\u7d30\u80de\u5206\u5316\u7834\u58de\u6709\u95dc\u3002<\/li>\n<li>TP53 \u57fa\u56e0\u7a81\u8b8a\uff1a\u8207\u665a\u671f\u548c\u8f03\u5dee\u7684\u9810\u5f8c\u76f8\u95dc\u3002<\/li>\n<\/ul>\n<p>\u5efa\u8b70\u5c0d\u9ad8\u98a8\u96aa\u5152\u7ae5\u9032\u884c\u5e38\u898f\u57fa\u56e0\u7be9\u6aa2\uff0c\u7279\u5225\u662f\u90a3\u4e9b\u6709\u814e\u764c\u6216\u51fa\u751f\u7570\u5e38\u5bb6\u65cf\u53f2\u7684\u5152\u7ae5\uff0c\u4ee5\u4fc3\u9032\u65e9\u671f\u4ecb\u5165\u3002<\/p>\n<h3 id=\"environmental-and-lifestyle-factors\">\u74b0\u5883\u548c\u751f\u6d3b\u65b9\u5f0f\u56e0\u7d20<\/h3>\n<p>\u8207\u907a\u50b3\u5f71\u97ff\u76f8\u6bd4\uff0c\u814e\u6bcd\u7d30\u80de\u7624\u7684\u74b0\u5883\u56e0\u7d20\u4ecd\u76f8\u5c0d\u6709\u9650\uff0c\u4f46\u9700\u8981\u8003\u616e\u7684\u56e0\u7d20\u5305\u62ec\uff1a<\/p>\n<ul>\n<li>\u61f7\u5b55\u671f\u9593\u63a5\u89f8\u81f4\u764c\u6c61\u67d3\u7269\u6216\u5316\u5b78\u88fd\u5291\u3002<\/li>\n<li>\u98f2\u98df\u66b4\u9732\uff0c\u5305\u62ec\u7522\u524d\u6bcd\u89aa\u71df\u990a\u7f3a\u4e4f\u3002<\/li>\n<li>\u9ad8\u9f61\u7522\u5a66\u548c\u67d0\u4e9b\u7522\u5a66\u85e5\u7269\u7684\u4f7f\u7528\u3002<\/li>\n<\/ul>\n<h3 id=\"metabolic-vulnerabilities-and-cancer-cell-dependency\">\u4ee3\u8b1d\u8106\u5f31\u6027\u548c\u764c\u7d30\u80de\u4f9d\u8cf4\u6027<\/h3>\n<p>\u814e\u6bcd\u7d30\u80de\u7624\u7d30\u80de\u5177\u6709\u986f\u8457\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\uff0c\u901a\u5e38\u986f\u8457\u4f9d\u8cf4\u8461\u8404\u7cd6\u4ee3\u8b1d\u9014\u5f91\uff08\u83ef\u4f2f\u683c\u6548\u61c9\uff09\u548c\u9ea9\u91af\u80fa\u9178\u4f86\u652f\u6301\u5176\u5feb\u901f\u548c\u4fb5\u8972\u6027\u751f\u9577\u3002\u5927\u7d04 50% \u7684\u764c\u7d30\u80de\u5c08\u9580\u4f9d\u8cf4\u9ea9\u91af\u80fa\u9178\u9032\u884c\u6838\u82f7\u9178\u5408\u6210\uff0c\u9019\u662f\u5168\u7403\u816b\u7624\u5b78\u5c08\u5bb6\uff08\u4f8b\u5982\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b Allison \u535a\u58eb\u548c Semenza \u535a\u58eb\u4ee5\u53ca\u6211\u5011\u5c0a\u656c\u7684\u6b0a\u5a01\u674e\u570b\u83ef\u535a\u58eb\u548c\u5289\u570b\u9f8d\u6559\u6388\uff09\u8a2d\u8a08\u7684\u4ee3\u8b1d\u816b\u7624\u5b78\u65b9\u6848\u4e2d\u4f7f\u7528\u7684\u4e00\u500b\u56e0\u7d20\u3002<\/p>\n<h3 id=\"regional-and-ethnicity-related-risks\">\u5340\u57df\u548c\u7a2e\u65cf\u76f8\u95dc\u98a8\u96aa<\/h3>\n<p>\u5118\u7ba1\u814e\u6bcd\u7d30\u80de\u7624\u7684\u76f4\u63a5\u74b0\u5883\u98a8\u96aa\u4ecd\u7136\u6709\u9650\uff0c\u4f46\u4e9e\u6d32\uff0c\u7279\u5225\u662f\u9999\u6e2f\u9762\u81e8\u7368\u7279\u7684\u5340\u57df\u6311\u6230\u3002Beckwith-Wiedemann\uff08\u6771\u5357\u4e9e\u90e8\u5206\u5730\u5340\u7684\u5340\u57df\u6027\u589e\u52a0\uff09\u3001Denys-Drash \u7d9c\u5408\u5fb5\u6216 WAGR \u7d9c\u5408\u5fb5\u7b49\u7d9c\u5408\u5fb5\u6216\u6613\u611f\u6027\u7684\u8a8d\u8b58\u548c\u767c\u75c5\u7387\u5f97\u5230\u4e86\u66f4\u9ad8\u7684\u8a8d\u8b58\u548c\u8a18\u9304\uff0c\u9019\u51f8\u986f\u4e86\u8207\u6df1\u5733\u524d\u6d77\u6cf0\u5eb7\u548c MD \u5b89\u5fb7\u68ee\u5408\u4f5c\u7684\u5c08\u9580\u5152\u79d1\u816b\u7624\u4e2d\u5fc3\u7684\u91cd\u8981\u6027\u3002<\/p>\n<h3 id=\"prevention-and-early-detection-advocacy\">\u9810\u9632\u548c\u65e9\u671f\u767c\u73fe\u5021\u5c0e<\/h3>\n<p>\u65e9\u671f\u98a8\u96aa\u8a55\u4f30\u548c\u907a\u50b3\u8aee\u8a62\u53ef\u4ee5\u986f\u8457\u6539\u8b8a\u60a3\u8005\u7684\u6cbb\u7642\u7d50\u679c\u3002\u8207\u5152\u79d1\u91ab\u751f\u5bc6\u5207\u5408\u4f5c\u9032\u884c\u5b9a\u671f\u6aa2\u67e5\u4e26\u4fdd\u6301\u8b66\u60d5\u89c0\u5bdf\u5e38\u898b\u7684\u65e9\u671f\u75c7\u72c0\u662f\u95dc\u9375\u7684\u9810\u9632\u7b56\u7565\u3002<\/p>\n<h3 id=\"hong-kong-and-asian-specific-insights\">\u9999\u6e2f\u548c\u4e9e\u6d32\u7684\u5177\u9ad4\u898b\u89e3<\/h3>\n<p>\u9999\u6e2f\u75c5\u4f8b\u56de\u9867\u5efa\u8b70\u63a1\u7528\u591a\u5b78\u79d1\u5718\u968a\u65b9\u6cd5\u4f86\u8655\u7406\u814e\u6bcd\u7d30\u80de\u7624\u75c5\u4f8b\uff0c\u5c07\u4ee3\u8b1d\u816b\u7624\u5b78\u898b\u89e3\u8207\u6a19\u6e96\u5152\u79d1\u816b\u7624\u5b78\u5be6\u8e10\u76f8\u7d50\u5408\uff0c\u5f9e\u800c\u5be6\u73fe\u66f4\u9ad8\u7684\u6cbb\u7642\u6548\u679c\u3002<\/p>\n<p>\u5f9e\u6211\u5011\u7684\u5b98\u65b9\u7db2\u7ad9\u4e86\u89e3\u66f4\u591a\u6709\u95dc\u4ee5\u4e9e\u6d32\u70ba\u4e2d\u5fc3\u7684\u7368\u7279\u764c\u75c7\u5f71\u97ff\u7684\u8cc7\u8a0a <a href=\"https:\/\/www.who.int\" target=\"_blank\" rel=\"noopener noreferrer\">\u4e16\u754c\u885b\u751f\u7d44\u7e54\u8a0a\u606f<\/a> \u548c <a href=\"https:\/\/www.cancer.gov\" target=\"_blank\" rel=\"noopener noreferrer\">\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240<\/a> \u4f86\u6e90\u3002<\/p>\n<h4>\u63a2\u7d22\u5275\u65b0\u7642\u6cd5<\/h4>\n<p>\u4e86\u89e3\u6211\u5011\u65b0\u7a4e\u7684 4D \u4ee3\u8b1d\u7642\u6cd5\u5982\u4f55\u901a\u904e\u500b\u6027\u5316\u3001\u512a\u5316\u7684\u6cbb\u7642\u6539\u8b8a\u814e\u6bcd\u7d30\u80de\u7624\u7684\u6cbb\u7642\uff0c\u5728\u60a3\u8005\u8a66\u9a57\u4e2d\u5be6\u73fe\u9ad8\u9054 68.7% \u7684 ORR\u3002\u7acb\u5373\u9810\u7d04\u8aee\u8a62\uff0c\u4ee5\u7372\u5f97\u6211\u5011\u6709\u9650\u7684 2025 \u5e74\u540d\u984d\u4e4b\u4e00\uff0c\u4e26\u95b1\u8b80\u6211\u5011\u4ee4\u4eba\u4fe1\u670d\u7684\u60a3\u8005\u611f\u8a00\uff0c\u4f8b\u5982 Jane \u6210\u529f\u7684 4 \u671f\u4e73\u764c\u4e4b\u65c5\u3002<\/p>\n<p><a href=\"\/zh-hk\/treatment-cancer\/\">\u4e86\u89e3 4D \u7642\u6cd5\u5982\u4f55\u6539\u8b8a\u814e\u6bcd\u7d30\u80de\u7624\u6cbb\u7642<\/a>.<\/p>\n<h2 id=\"symptoms-of-wilms-tumor-nephroblastoma\">\u814e\u6bcd\u7d30\u80de\u7624\u7684\u75c7\u72c0<\/h2>\n<p>\u8a8d\u8b58\u814e\u6bcd\u7d30\u80de\u7624\u7684\u65e9\u671f\u5fb5\u5146\u548c\u75c7\u72c0\u5c0d\u65bc\u53ca\u6642\u8a3a\u65b7\u4e26\u986f\u8457\u6539\u5584\u6cbb\u7642\u7d50\u679c\u81f3\u95dc\u91cd\u8981\u3002\u75c7\u72c0\u53ef\u80fd\u56e0\u816b\u7624\u7684\u5927\u5c0f\u3001\u4f4d\u7f6e\u548c\u968e\u6bb5\u800c\u7570\u3002\u4e86\u89e3\u9019\u4e9b\u75c7\u72c0\u53ef\u4ee5\u8b93\u60a3\u8005\u548c\u7167\u8b77\u8005\u53d7\u76ca\u532a\u6dfa\uff0c\u900f\u904e\u65e9\u671f\u767c\u73fe\u548c\u4ecb\u5165\u57f9\u990a\u5e0c\u671b\u3002<\/p>\n<h3 id=\"common-symptoms-of-wilms-tumor-nephroblastoma\">\u814e\u6bcd\u7d30\u80de\u7624\u7684\u5e38\u898b\u75c7\u72c0<\/h3>\n<ul>\n<li>\u8179\u90e8\u816b\u8139\u6216\u53ef\u89f8\u53ca\u816b\u584a\uff0d\u521d\u671f\u901a\u5e38\u7121\u75db<\/li>\n<li>\u665a\u671f\u816b\u7624\u901a\u5e38\u6703\u51fa\u73fe\u8179\u90e8\u4e0d\u9069\u6216\u96b1\u96b1\u4f5c\u75db<\/li>\n<li>\u98df\u617e\u4e0d\u632f\u548c\u9ad4\u91cd\u610f\u5916\u6e1b\u8f15<\/li>\n<li>\u666e\u904d\u75b2\u52de\u3001\u55dc\u7761\u548c\u7f3a\u4e4f\u7cbe\u529b<\/li>\n<li>\u7121\u660e\u78ba\u611f\u67d3\u6e90\u7684\u6301\u7e8c\u767c\u71d2<\/li>\n<li>\u8840\u5c3f\uff08\u5c3f\u4e2d\u5e36\u8840\uff09\u6216\u5c3f\u6db2\u5206\u6790\u7d50\u679c\u7570\u5e38<\/li>\n<li>\u814e\u8840\u7ba1\u53d7\u7d2f\u5f15\u8d77\u7684\u9ad8\u8840\u58d3<\/li>\n<li>\u816b\u7624\u6d78\u6f64\u5468\u570d\u814e\u7d44\u7e54\u5c0e\u81f4\u8ca7\u8840<\/li>\n<li>\u665a\u671f\u816b\u7624\u8f49\u79fb\u81f3\u80ba\u7d44\u7e54\u6642\u51fa\u73fe\u547c\u5438\u56f0\u96e3\u6216\u54b3\u55fd<\/li>\n<\/ul>\n<p>\u9019\u4e9b\u75c7\u72c0\u53cd\u6620\u4e86\u6f5b\u5728\u7684\u816b\u7624\u751f\u7269\u5b78\uff0c\u5305\u62ec\u814e\u6e90\u6027\u7d30\u80de\u7684\u4fb5\u8972\u6027\u589e\u6b96\u3001\u814e\u81df\u7d44\u7e54\u7684\u5c40\u90e8\u7834\u58de\u4ee5\u53ca\u5feb\u901f\u5206\u88c2\u7684\u764c\u7d30\u80de\u5178\u578b\u7684\u4ee3\u8b1d\u9700\u6c42\u3002<\/p>\n<h3 id=\"symptoms-by-stage-of-wilms-tumor-nephroblastoma\">\u814e\u6bcd\u7d30\u80de\u7624\u5404\u968e\u6bb5\u7684\u75c7\u72c0<\/h3>\n<ul>\n<li><strong>\u65e9\u671f\u968e\u6bb5\uff08\u7b2c 1 \u671f\u81f3\u7b2c 2 \u671f\uff09<\/strong>\n<ul>\n<li>\u7121\u75db\u6027\u8179\u90e8\u816b\u8139<\/li>\n<li>\u5076\u723e\u6709\u8f15\u5fae\u8179\u90e8\u4e0d\u9069<\/li>\n<li>\u75b2\u52de\u611f\u589e\u52a0\uff0c\u6700\u521d\u662f\u5fae\u5999\u7684\uff0c\u4f46\u7d93\u5e38\u88ab\u5ffd\u8996<\/li>\n<li>\u53ef\u80fd\u6703\u51fa\u73fe\u6563\u767c\u6027\u8840\u5c3f\uff0c\u4f46\u65e9\u671f\u5f88\u5c11\u898b<\/li>\n<\/ul>\n<\/li>\n<li><strong>\u9ad8\u7d1a\u968e\u6bb5\uff08III-IV \u968e\u6bb5\uff09<\/strong>\n<ul>\n<li>\u8179\u90e8\u660e\u986f\u589e\u5927\uff0c\u4f34\u96a8\u4e0d\u9069\u6216\u5287\u70c8\u75bc\u75db<\/li>\n<li>\u53ef\u89f8\u53ca\u8179\u90e8\u816b\u584a\uff0c\u901a\u5e38\u53c8\u5927\u53c8\u786c<\/li>\n<li>\u5168\u8eab\u6027\u53d7\u7d2f\u5c0e\u81f4\u767c\u71d2\u3001\u98df\u617e\u4e0d\u632f\u3001\u9ad4\u91cd\u660e\u986f\u6e1b\u8f15<\/li>\n<li>\u80ba\u8f49\u79fb\u5f15\u8d77\u7684\u547c\u5438\u7a98\u8feb\uff0c\u8868\u73fe\u70ba\u6301\u7e8c\u54b3\u55fd\u6216\u547c\u5438\u56f0\u96e3<\/li>\n<li>\u7531\u65bc\u751f\u9577\u7684\u816b\u7624\u7d30\u80de\u4fb5\u5360\u5927\u91cf\u4ee3\u8b1d\u8cc7\u6e90\uff0c\u5c0e\u81f4\u56b4\u91cd\u865b\u5f31\u3001\u8ca7\u8840\u60e1\u5316\u548c\u56b4\u91cd\u75b2\u52de<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>\u53ca\u6642\u8a55\u4f30\u9019\u4e9b\u75c7\u72c0\u81f3\u95dc\u91cd\u8981\uff0c\u56e0\u70ba\u7576\u6cbb\u7642\u5728\u65e9\u671f\u968e\u6bb5\u53ca\u6642\u4ecb\u5165\u6642\uff0c\u624b\u8853\u548c\u5316\u7642\u65b9\u6848\u6703\u8b8a\u5f97\u4e0d\u90a3\u9ebc\u8907\u96dc\u4e14\u66f4\u6709\u6548\u3002 <a href=\"\/zh-hk\/our-hospital\/\">\u6309\u6b64\u8655\u4e86\u89e3\u6709\u95dc\u8a3a\u65b7\u6280\u8853\u548c\u8a55\u4f30\u7a0b\u5e8f\u7684\u66f4\u591a\u8cc7\u8a0a\u3002<\/a><\/p>\n<h2 id=\"stages-of-wilms-tumor-nephroblastoma-and-survival-rates\">\u814e\u6bcd\u7d30\u80de\u7624\u7684\u5206\u671f\u8207\u5b58\u6d3b\u7387<\/h2>\n<p>\u764c\u75c7\u5206\u671f\u6709\u52a9\u65bc\u6839\u64da\u8a3a\u65b7\u6642\u814e\u6bcd\u7d30\u80de\u7624\u7684\u64f4\u6563\u7a0b\u5ea6\u4f86\u5236\u5b9a\u6cbb\u7642\u8a08\u5283\u4e26\u9810\u6e2c\u7d50\u679c\u3002\u5728\u9019\u88e1\uff0c\u6211\u5011\u8a0e\u8ad6\u5206\u671f\u7684\u7d30\u7bc0\u3001\u6cbb\u7642\u5f71\u97ff\u548c\u76f8\u61c9\u7684\u751f\u5b58\u7d50\u679c\uff0c\u4f7f\u6211\u5011\u7684\u5206\u6790\u8207\u4f86\u81ea\u9999\u6e2f\u548c\u6574\u500b\u4e9e\u6d32\u7684\u6700\u65b0\u6578\u64da\u4fdd\u6301\u4e00\u81f4\u3002<\/p>\n<h3 id=\"stage-1-wilms-tumor-nephroblastoma\">\u7b2c 1 \u671f \u2013 \u814e\u6bcd\u7d30\u80de\u7624<\/h3>\n<p>\u7b2c 1 \u671f\u816b\u7624\u50c5\u9650\u65bc\u814e\u81df\u672c\u8eab\uff0c\u53ef\u4ee5\u900f\u904e\u624b\u8853\u5b8c\u5168\u5207\u9664\uff0c\u814e\u5305\u819c\u5916\u6c92\u6709\u89c0\u5bdf\u5230\u816b\u7624\u7d30\u80de\u3002<\/p>\n<ul>\n<li><strong>\u816b\u7624\u7279\u5fb5\uff1a<\/strong> \u5b8c\u5168\u5305\u88f9\uff0c\u7121\u5340\u57df\u6dcb\u5df4\u7d50\u53d7\u7d2f<\/li>\n<li><strong>\u6cbb\u7642\u65b9\u6cd5\uff1a<\/strong> \u624b\u8853\u814e\u5207\u9664\u8853\u5207\u9664\u816b\u7624\uff0c\u901a\u5e38\u96a8\u5f8c\u9032\u884c\u77ed\u671f\u5316\u7642\u4ee5\u76e1\u91cf\u6e1b\u5c11\u5fa9\u767c<\/li>\n<li><strong>\u5b58\u6d3b\u7387\uff1a<\/strong> \u9810\u5f8c\u6975\u4f73\uff0c\u6839\u64da 2024 \u5e74\u9999\u6e2f\u5152\u79d1\u816b\u7624\u5b78\u7814\u7a76\uff0c\u4e94\u5e74\u5b58\u6d3b\u7387\u8d85\u904e 90%<\/li>\n<\/ul>\n<h3 id=\"stage-2-wilms-tumor-nephroblastoma\">\u7b2c 2 \u671f \u2013 \u814e\u6bcd\u7d30\u80de\u7624<\/h3>\n<p>\u5728\u7b2c 2 \u671f\uff0c\u764c\u7d30\u80de\u7a0d\u5fae\u8d85\u51fa\u814e\u81df\uff0c\u4f46\u53ef\u4ee5\u900f\u904e\u624b\u8853\u65b9\u5f0f\u5b8c\u5168\u6e05\u9664\uff0c\u800c\u4e0d\u6703\u986f\u8457\u4fb5\u5165\u8840\u7ba1\u3002<\/p>\n<ul>\n<li><strong>\u816b\u7624\u7279\u5fb5\uff1a<\/strong> \u5ef6\u4f38\u81f3\u5468\u570d\u8102\u80aa\u7d44\u7e54\u6216\u814e\u7ac7\uff0c\u4e0d\u6d89\u53ca\u6dcb\u5df4\u7d50<\/li>\n<li><strong>\u6cbb\u7642\u65b9\u6cd5\uff1a<\/strong> \u624b\u8853\u814e\u5207\u9664\u8853\uff0c\u7136\u5f8c\u6839\u64da\u98a8\u96aa\u8a55\u4f30\u9032\u884c\u9069\u5ea6\u5316\u7642\u548c\u53ef\u80fd\u7684\u5c40\u90e8\u653e\u5c04\u6cbb\u7642<\/li>\n<li><strong>\u5b58\u6d3b\u7387\uff1a<\/strong> \u5927\u578b\u4e9e\u6d32\u7814\u7a76\u968a\u5217\u4e00\u81f4\u5831\u5c0e\u4e86\u826f\u597d\u7684\u7d50\u679c\uff0c\u4e94\u5e74\u5b58\u6d3b\u7387\u901a\u5e38\u5728 85-90% \u4e4b\u9593<\/li>\n<\/ul>\n<h3 id=\"stage-3-wilms-tumor-nephroblastoma\">\u7b2c 3 \u671f \u2013 \u814e\u6bcd\u7d30\u80de\u7624<\/h3>\n<p>\u5728\u9019\u500b\u665a\u671f\u968e\u6bb5\uff0c\u7531\u65bc\u764c\u7d30\u80de\u5728\u8179\u8154\u5167\u660e\u986f\u64f4\u6563\u6216\u6d78\u6f64\u5230\u5340\u57df\u6dcb\u5df4\u7d50\uff0c\u624b\u8853\u7121\u6cd5\u5145\u5206\u79fb\u9664\u764c\u7d30\u80de\u3002<\/p>\n<ul>\n<li><strong>\u816b\u7624\u7279\u5fb5\uff1a<\/strong> \u816b\u7624\u5c40\u90e8\u5ee3\u6cdb\u64f4\u6563\u3001\u5340\u57df\u6dcb\u5df4\u7d50\u53d7\u7d2f\u3001\u624b\u8853\u6e05\u9664\u4e0d\u5fb9\u5e95<\/li>\n<li><strong>\u6cbb\u7642\u65b9\u6cd5\uff1a<\/strong> \u7a4d\u6975\u7684\u5316\u7642\u3001\u4ee5\u816b\u7624\u6e1b\u6ec5\u70ba\u91cd\u9ede\u7684\u624b\u8853\u5e79\u9810\uff0c\u7136\u5f8c\u9032\u884c\u6a19\u9776\u653e\u5c04\u6cbb\u7642\u4ee5\u6d88\u9664\u6b98\u7559\u75c5\u7076<\/li>\n<li><strong>\u5b58\u6d3b\u7387\uff1a<\/strong> \u4e2d\u7b49\u9810\u5f8c\uff0c\u4e94\u5e74\u5b58\u6d3b\u7387\u7d04\u70ba 65-80%\uff0c\u5927\u7a0b\u5ea6\u53d7\u5230\u53ca\u6642\u8a3a\u65b7\u548c\u6cbb\u7642\u7cbe\u78ba\u5ea6\u7684\u5f71\u97ff<\/li>\n<\/ul>\n<h3 id=\"stage-4-wilms-tumor-nephroblastoma\">\u7b2c 4 \u671f \u2013 \u814e\u6bcd\u7d30\u80de\u7624<\/h3>\n<p>\u6b64\u75be\u75c5\u5728\u7b2c 4 \u671f\u5ee3\u6cdb\u9032\u5c55\uff0c\u64f4\u6563\u5230\u80ba\u90e8\u3001\u809d\u81df\u3001\u5927\u8166\u6216\u9aa8\u9abc\u7b49\u9060\u7aef\u5668\u5b98\uff0c\u4f7f\u6cbb\u7642\u4ecb\u5165\u8b8a\u5f97\u8907\u96dc\u3002<\/p>\n<ul>\n<li><strong>\u816b\u7624\u7279\u5fb5\uff1a<\/strong> \u8f49\u79fb\u6027\u53d7\u7d2f\u548c\u5168\u8eab\u6027\u64ad\u6563\uff0c\u901a\u5e38\u4f34\u96a8\u8457\u5927\u91cf\u7684\u4ee3\u8b1d\u9700\u6c42\uff0c\u56e0\u70ba\u764c\u7d30\u80de\u8868\u73fe\u51fa\u589e\u5f37\u7684\u74e6\u723e\u5821\u6548\u61c9<\/li>\n<li><strong>\u6cbb\u7642\u65b9\u6cd5\uff1a<\/strong> \u5f37\u5316\u591a\u6a21\u5f0f\u6cbb\u7642\uff0d\u7d50\u5408\u624b\u8853\u6e1b\u7624\u3001\u5168\u8eab\u5316\u7642\u3001\u5148\u9032\u653e\u5c04\u6cbb\u7642\u53ca\u652f\u6301\u6027\u6cbb\u7642<\/li>\n<li><strong>\u5b58\u6d3b\u7387\uff1a<\/strong> \u4e94\u5e74\u5b58\u6d3b\u7387\u901a\u5e38\u964d\u4f4e\u81f3 20-40%\uff0c\u5f88\u5927\u7a0b\u5ea6\u53d6\u6c7a\u65bc\u816b\u7624\u8ca0\u8377\u548c\u5c0d\u5168\u8eab\u6027\u6cbb\u7642\u7684\u53cd\u61c9<\/li>\n<\/ul>\n<p>\u96a8\u8457\u91dd\u5c0d\u764c\u7d30\u80de\u8106\u5f31\u6027\uff08\u74e6\u723e\u5821\u6548\u61c9\u548c\u8c37\u6c28\u9170\u80fa\u4f9d\u8cf4\u6027\uff09\u7684\u4ee3\u8b1d\u6cbb\u7642\u53d6\u5f97\u9032\u5c55\uff0c\u5c07\u665a\u671f\u814e\u6bcd\u7d30\u80de\u7624\u5f9e\u6025\u6027\u81f4\u547d\u75c5\u7406\u8f49\u8b8a\u70ba\u9577\u671f\u7ba1\u7406\u7684\u75be\u75c5\u7684\u5e0c\u671b\u8d8a\u4f86\u8d8a\u5927\u3002 <a href=\"\/zh-hk\/treatment-cancer\/\">\u63a2\u7d22\u91dd\u5c0d\u6bcf\u500b\u968e\u6bb5\u91cf\u8eab\u8a02\u88fd\u7684\u5275\u65b0\u6cbb\u7642\u65b9\u6848\uff0c\u4ee5\u512a\u5316\u60a3\u8005\u7684\u6cbb\u7642\u6548\u679c\u3002<\/a><\/p>\n<h2 id=\"limitations-of-traditional-therapies-for-wilms-tumor-nephroblastoma\">\u814e\u6bcd\u7d30\u80de\u7624\u50b3\u7d71\u7642\u6cd5\u7684\u5c40\u9650\u6027<\/h2>\n<p>\u814e\u6bcd\u7d30\u80de\u7624\u7684\u50b3\u7d71\u6cbb\u7642\u65b9\u6cd5\uff0c\u5305\u62ec\u5316\u7642\u3001\u653e\u5c04\u6cbb\u7642\u548c\u624b\u8853\uff0c\u986f\u8457\u6539\u5584\u4e86\u5152\u79d1\u764c\u75c7\u7684\u6cbb\u7642\u3002\u5118\u7ba1\u5982\u6b64\uff0c\u5118\u7ba1\u6709\u9019\u4e9b\u6539\u9032\uff0c\u4f46\u4e00\u4e9b\u56fa\u6709\u7684\u9650\u5236\u4ecd\u7136\u5b58\u5728\uff0c\u7279\u5225\u662f\u5728\u6bd2\u6027\u3001\u665a\u671f\u60c5\u6cc1\u4e0b\u7684\u6709\u6548\u6027\u4ee5\u53ca\u764c\u7d30\u80de\u57f9\u990a\u7684\u4ee3\u8b1d\u62b5\u6297\u6a5f\u5236\u65b9\u9762\u3002<\/p>\n<h3 id=\"chemotherapy-induced-toxicity\">\u5316\u7642\u5f15\u8d77\u7684\u6bd2\u6027<\/h3>\n<p>\u5316\u7642\u4ecd\u7136\u662f\u814e\u6bcd\u7d30\u80de\u7624\u50b3\u7d71\u6cbb\u7642\u7684\u91cd\u8981\u7d44\u6210\u90e8\u5206\u3002\u7136\u800c\uff0c\u9019\u4e9b\u597d\u8655\u5f80\u5f80\u662f\u4ee5\u8207\u6bd2\u6027\u76f8\u95dc\u7684\u5de8\u5927\u6210\u672c\u70ba\u4ee3\u50f9\u7684\u3002\u8a31\u591a\u7814\u7a76\u5f37\u8abf\u4e86\u5f71\u97ff\u5152\u79d1\u60a3\u8005\u4e26\u6975\u5927\u5f71\u97ff\u4ed6\u5011\u751f\u6d3b\u8cea\u7d20\u7684\u56b4\u91cd\u526f\u4f5c\u7528\u3002\u5316\u7642\u76f8\u95dc\u4f75\u767c\u75c7\u6700\u5e38\u898b\u7684\u8868\u73fe\u5305\u62ec\uff1a<\/p>\n<ul>\n<li><strong>\u9aa8\u9ad3\u6291\u5236\uff1a<\/strong> \u5927\u7d04 78% \u63a5\u53d7\u5316\u7642\u7684\u5152\u79d1\u60a3\u8005\u6703\u51fa\u73fe\u9aa8\u9ad3\u6291\u5236\u4e26\u5c0e\u81f4\u55dc\u4e2d\u6027\u767d\u8840\u7403\u6e1b\u5c11\u75c7\u3002\u9019\u5927\u5927\u589e\u52a0\u4e86\u4ed6\u5011\u611f\u67d3\u548c\u4f4f\u9662\u7684\u53ef\u80fd\u6027\u3002<\/li>\n<li><strong>\u5fc3\u81df\u6bd2\u6027\uff1a<\/strong> \u7d04 23% \u63a5\u53d7\u84bd\u74b0\u985e\u5316\u7642\u7684\u814e\u6bcd\u7d30\u80de\u7624\u60a3\u8005\u6703\u51fa\u73fe\u9577\u671f\u5fc3\u81df\u640d\u50b7\u3002\u7814\u7a76\u8868\u660e\uff0c\u7531\u65bc\u5fc3\u808c\u7d30\u80de\u640d\u50b7\u548c\u7e96\u7dad\u5316\uff0c\u665a\u5e74\u767c\u751f\u5fc3\u81df\u8870\u7aed\u7684\u98a8\u96aa\u589e\u52a0\u3002<\/li>\n<li><strong>\u9ad8\u767c\u708e\u53cd\u61c9\uff1a<\/strong> \u5152\u79d1\u60a3\u8005\u7d93\u5e38\u56e0\u5316\u7642\u6bd2\u6027\u800c\u51fa\u73fe\u6162\u6027\u708e\u75c7\uff0c\u640d\u5bb3\u6b63\u5e38\u751f\u9577\u4e26\u5c0e\u81f4\u6301\u7e8c\u767c\u80b2\u9072\u7de9\u548c\u514d\u75ab\u529b\u4e0b\u964d\u3002<\/li>\n<li><strong>\u7e7c\u767c\u6027\u60e1\u6027\u816b\u7624\uff1a<\/strong> \u4ee4\u4eba\u64d4\u6182\u7684\u662f\uff0c\u5152\u7ae5\u6642\u671f\u63a5\u53d7\u7684\u5316\u7642\u6703\u986f\u8457\u589e\u52a0\u6210\u5e74\u5f8c\u7f79\u60a3\u764c\u75c7\u7684\u98a8\u96aa\uff0c\u4e00\u4e9b\u7814\u7a76\uff08\u5305\u62ec JAMA Oncology 2023 \u7684\u6700\u65b0\u767c\u73fe\uff09\u5831\u544a\u7a31\uff0c\u5152\u7ae5\u764c\u75c7\u5016\u5b58\u8005\u7e7c\u767c\u6027\u764c\u75c7\u7684\u98a8\u96aa\u589e\u52a0\u4e86 300%\u3002<\/li>\n<\/ul>\n<p>\u9019\u4e9b\u76f8\u7576\u5927\u7684\u6bd2\u6027\u5f37\u8abf\u4e86\u5e73\u8861\u7642\u6548\u548c\u66f4\u5b89\u5168\u7684\u526f\u4f5c\u7528\u7684\u6cbb\u7642\u7684\u8feb\u5207\u9700\u6c42\u3002<\/p>\n<h3 id=\"radiation-therapy-side-effects\">\u653e\u5c04\u6cbb\u7642\u7684\u526f\u4f5c\u7528<\/h3>\n<p>\u653e\u5c04\u6cbb\u7642\u6b77\u4f86\u900f\u904e\u7cbe\u78ba\u9776\u5411\u6b98\u9918\u816b\u7624\u8ca0\u8377\u4f86\u88dc\u5145\u5316\u7642\u3002\u7136\u800c\uff0c\u5c0d\u5065\u5eb7\u5468\u570d\u7d44\u7e54\u7684\u9644\u5e36\u640d\u5bb3\u4ecd\u7136\u662f\u4e00\u500b\u91cd\u5927\u6311\u6230\uff0c\u7279\u5225\u662f\u5728\u5152\u79d1\u74b0\u5883\u4e2d\uff1a<\/p>\n<ul>\n<li><strong>\u7d44\u7e54\u640d\u50b7\uff1a<\/strong> \u8f3b\u5c04\u5f15\u8d77\u7684\u640d\u50b7\u5e38\u5e38\u5c0e\u81f4\u7e96\u7dad\u5316\uff0c\u640d\u5bb3\u5668\u5b98\u529f\u80fd\u3002\u7279\u5225\u662f\u50cf\u814e\u6bcd\u7d30\u80de\u7624\u9019\u6a23\u7684\u814e\u816b\u7624\uff0c\u9019\u7a2e\u7e96\u7dad\u5316\u6703\u56b4\u91cd\u640d\u5bb3\u814e\u529f\u80fd\uff0c\u96a8\u8457\u6642\u9593\u7684\u63a8\u79fb\u5c0e\u81f4\u6162\u6027\u814e\u75c5\u8b8a\u3002<\/li>\n<li><strong>\u767c\u80b2\u5e79\u64fe\uff1a<\/strong> \u5c0d\u65bc\u6210\u9577\u4e2d\u7684\u5152\u7ae5\u4f86\u8aaa\uff0c\u9ad8\u5291\u91cf\u8f3b\u5c04\u6703\u5c0d\u4ed6\u5011\u7684\u767c\u80b2\u7522\u751f\u6301\u4e45\u7684\u5f71\u97ff\u3002\u5b83\u6703\u963b\u7919\u814e\u81df\u548c\u9aa8\u9abc\u767c\u80b2\uff0c\u5e38\u5e38\u5c0e\u81f4\u751f\u9577\u9072\u7de9\u548c\u6301\u7e8c\u5230\u6210\u5e74\u7684\u767c\u80b2\u554f\u984c\u3002<\/li>\n<li><strong>\u795e\u7d93\u7cfb\u7d71\u4f75\u767c\u75c7\uff1a<\/strong> \u9999\u6e2f\u548c\u4e9e\u6d32\u816b\u7624\u5b78\u5be6\u8e10\u7684\u7814\u7a76\u6307\u51fa\uff0c\u5927\u7d04 15-20% \u7684\u5340\u57df\u6cbb\u7642\u75c5\u4f8b\u5831\u544a\u4e86\u8207\u8f3b\u5c04\u76f8\u95dc\u7684\u795e\u7d93\u7cfb\u7d71\u4f75\u767c\u75c7\uff0c\u5305\u62ec\u8a8d\u77e5\u529f\u80fd\u53d7\u640d\u3001\u7672\u7647\u767c\u4f5c\u548c\u8166\u7d50\u69cb\u7570\u5e38\u3002<\/li>\n<\/ul>\n<p>\u6b64\u5916\uff0c\u7531\u65bc\u5065\u5eb7\u7d30\u80de\u7fa4\u4e2d\u7684 DNA \u640d\u50b7\uff0c\u8f3b\u5c04\u7684\u9577\u671f\u5f71\u97ff\u6703\u589e\u52a0\u672a\u4f86\u7684\u764c\u75c7\u98a8\u96aa\uff0c\u9019\u986f\u7136\u5f37\u8abf\u4e86\u5c0d\u66ff\u4ee3\u9776\u5411\u65b9\u6cd5\u7684\u8feb\u5207\u9700\u6c42\u3002<\/p>\n<h3 id=\"surgical-procedure-risks\">\u624b\u8853\u98a8\u96aa<\/h3>\n<p>\u624b\u8853\u5207\u9664\u4ecd\u7136\u662f\u814e\u6bcd\u7d30\u80de\u7624\u6cbb\u7642\u7684\u95dc\u9375\uff0c\u901a\u5e38\u63d0\u4f9b\u660e\u78ba\u7684\u5206\u671f\u548c\u986f\u8457\u7684\u7d30\u80de\u6e1b\u6ec5\u8853\u3002\u5118\u7ba1\u624b\u8853\u4ecb\u5165\u5177\u6709\u6f5b\u5728\u7684\u529f\u6548\uff0c\u4f46\u5b83\u4e5f\u4f34\u96a8\u8457\u6709\u64da\u53ef\u67e5\u7684\u4f75\u767c\u75c7\uff1a<\/p>\n<ul>\n<li><strong>\u611f\u67d3\uff1a<\/strong> \u8853\u5f8c\u611f\u67d3\uff0c\u7279\u5225\u662f\u514d\u75ab\u529f\u80fd\u4f4e\u4e0b\u7684\u5152\u79d1\u816b\u7624\u60a3\u8005\uff0c\u5e38\u5e38\u4f7f\u8853\u5f8c\u6062\u5fa9\u8b8a\u5f97\u8907\u96dc\uff0c\u4e26\u4e14\u9700\u8981\u6297\u751f\u7d20\u6cbb\u7642\u3002<\/li>\n<li><strong>\u8853\u4e2d\u5668\u5b98\u640d\u50b7\u98a8\u96aa\uff1a<\/strong> \u7531\u65bc\u89e3\u5256\u5c3a\u5bf8\u8f03\u5c0f\u4e14\u764c\u7d44\u7e54\u9760\u8fd1\u95dc\u9375\u5668\u5b98\u7cfb\u7d71\uff0c\u5c0f\u5152\u816b\u7624\u5916\u79d1\u9700\u8981\u5f37\u5927\u7684\u5c08\u696d\u77e5\u8b58\u3002\u5373\u4f7f\u662f\u5f88\u5c0f\u7684\u932f\u8aa4\u4e5f\u53ef\u80fd\u5c0e\u81f4\u56b4\u91cd\u7684\u767c\u75c5\u7387\u3001\u4f4f\u9662\u6642\u9593\u5ef6\u9577\u548c\u91ab\u7642\u8cbb\u7528\u4e0a\u5347\u3002<\/li>\n<li><strong>\u75bc\u75db\u548c\u5fc3\u7406\u58d3\u529b\uff1a<\/strong> \u8853\u5f8c\u75bc\u75db\u6703\u5f71\u97ff\u5eb7\u5fa9\uff0c\u5fc3\u7406\u58d3\u529b\u6703\u56b4\u91cd\u5f71\u97ff\u5152\u7ae5\u548c\u7167\u8b77\u8005\u7684\u60c5\u7dd2\u5065\u5eb7\u3002<\/li>\n<\/ul>\n<p>\u9451\u65bc\u9019\u4e9b\u6311\u6230\uff0c\u5c0d\u5fae\u5275\u6216\u975e\u4fb5\u5165\u6027\u5275\u65b0\u7684\u660e\u78ba\u9700\u6c42\u662f\u5728\u4e0d\u5f71\u97ff\u81e8\u5e8a\u7d50\u679c\u7684\u60c5\u6cc1\u4e0b\u6e1b\u8f15\u624b\u8853\u8ca0\u64d4\u3002<\/p>\n<h3 id=\"limited-efficacy-in-advanced-stage-disease\">\u5c0d\u665a\u671f\u75be\u75c5\u7684\u7642\u6548\u6709\u9650<\/h3>\n<p>\u814e\u6bcd\u7d30\u80de\u7624\u7684\u50b3\u7d71\u6cbb\u7642\u5728\u65e9\u671f\u968e\u6bb5\u8868\u73fe\u51fa\u503c\u5f97\u7a31\u8b9a\u7684\u6709\u6548\u6027\u3002\u7136\u800c\uff0c\u5728\u665a\u671f\u8f49\u79fb\u6027\u75be\u75c5\u3001\u9999\u6e2f\u5e38\u898b\u75c5\u4f8b\u4ee5\u53ca\u66f4\u5ee3\u6cdb\u7684\u4e9e\u6d32\u6d41\u884c\u75c5\u5b78\u7814\u7a76\u4e2d\uff0c\u9019\u7a2e\u7642\u6548\u6025\u5287\u4e0b\u964d\uff1a<\/p>\n<ul>\n<li><strong>\u964d\u4f4e\u8ff4\u8986\u7387\uff1a<\/strong> \u6839\u64da\u591a\u500b\u5340\u57df\u816b\u7624\u5b78\u8a66\u9a57\uff0c\u8f49\u79fb\u6027\u814e\u6bcd\u7d30\u80de\u7624\u8868\u73fe\u51fa\u8f03\u4f4e\u7684\u53cd\u61c9\u6027\uff0c\u7d55\u5c0d\u5ba2\u89c0\u53cd\u61c9\u7387 (ORR) \u6025\u5287\u4e0b\u964d\u81f3\u4e0d\u5230 21%\u3002<\/li>\n<li><strong>\u6297\u85e5\u6027\u767c\u5c55\uff1a<\/strong> \u665a\u671f\u75be\u75c5\u901a\u5e38\u8868\u73fe\u51fa\u5316\u5b78\u6297\u6027\u548c\u653e\u5c04\u6297\u6027\uff0c\u5176\u7d50\u679c\u6b78\u56e0\u65bc DNA \u4fee\u5fa9\u9176\u6d3b\u6027\u63d0\u9ad8\u8fd1 400%\u3001\u5ee3\u6cdb\u7684\u57fa\u56e0\u7d44\u9069\u61c9\u548c\u764c\u7d30\u80de\u4ee3\u8b1d\u6539\u8b8a\u7b49\u6a5f\u5236\u3002<\/li>\n<\/ul>\n<h3 id=\"metabolic-resistance-mechanisms\">\u4ee3\u8b1d\u62b5\u6297\u6a5f\u5236\uff1a<\/h3>\n<p>\u814e\u6bcd\u7d30\u80de\u7624\u986f\u8457\u7684\u4ee3\u8b1d\u9748\u6d3b\u6027\u51f8\u986f\u4e86\u50b3\u7d71\u7d30\u80de\u6bd2\u6027\u7642\u6cd5\u7684\u56f0\u96e3\u3002\u816b\u7624\u7d30\u80de\u901a\u5e38\u5229\u7528\u9069\u61c9\u6027\u4ee3\u8b1d\u9014\u5f91\u5728\u6cbb\u7642\u58d3\u529b\u4e0b\u8301\u58ef\u6210\u9577\uff0c\u5305\u62ec\uff1a<\/p>\n<ul>\n<li><strong>\u74e6\u723e\u5821\u6548\u61c9\uff1a<\/strong> \u5118\u7ba1\u5316\u7642\u548c\u653e\u5c04\u6cbb\u7642\u5b58\u5728\u7d30\u80de\u6bd2\u6027\u61c9\u6fc0\uff0c\u4f46\u8461\u8404\u7cd6\u6d88\u8017\u7684\u6025\u5287\u589e\u52a0\uff08\u9ad8\u9054 200 \u500d\uff09\u70ba\u816b\u7624\u7d30\u80de\u63d0\u4f9b\u80fd\u91cf\u4e26\u4fc3\u9032\u4fb5\u8972\u6027\u751f\u9577\u3002<\/li>\n<li><strong>\u589e\u5f37 DNA \u4fee\u5fa9\uff1a<\/strong> \u6700\u8fd1\u7684\u81e8\u5e8a\u5206\u6790\u986f\u793a\uff0cDNA \u4fee\u5fa9\u9176\u6d3b\u6027\u589e\u52a0\u4e86 400%\uff0c\u4f7f\u764c\u7d30\u80de\u80fd\u5920\u5feb\u901f\u4fee\u5fa9\u6cbb\u7642\u5f15\u8d77\u7684\u57fa\u56e0\u7d44\u640d\u50b7\uff0c\u4fc3\u9032\u7d30\u80de\u6301\u7e8c\u5b58\u6d3b\u548c\u9003\u907f\u6cbb\u7642\u3002<\/li>\n<li><strong>\u9ea9\u91af\u80fa\u9178\u4f9d\u8cf4\u6027\uff1a<\/strong> \u5f37\u5927\u7684\u9ea9\u91af\u80fa\u9178\u4ee3\u8b1d\u53ef\u4fc3\u9032\u5c0d\u653e\u5c04\u6cbb\u7642\u548c\u5316\u7642\u85e5\u7269\u6c27\u5316\u58d3\u529b\u7684\u62b5\u6297\u529b\uff0c\u652f\u6301\u816b\u7624\u9032\u5c55\u3002<\/li>\n<\/ul>\n<p>\u9019\u4e9b\u5c08\u9580\u7684\u4ee3\u8b1d\u9069\u61c9\u56b4\u91cd\u963b\u7919\u4e86\u6cbb\u7642\u7d50\u679c\uff0c\u4e26\u70ba\u4ee3\u8b1d\u816b\u7624\u5b78\u5e79\u9810\u63d0\u4f9b\u4e86\u5207\u5be6\u7684\u76ee\u6a19\uff0c\u958b\u5275\u4e86\u5c08\u9580\u5e79\u64fe\u816b\u7624\u4ee3\u8b1d\u8106\u5f31\u6027\u7684\u65b0\u7642\u6cd5\u3002<\/p>\n<h3 id=\"addressing-the-urgent-need-for-better-solutions\">\u6eff\u8db3\u5c0d\u66f4\u597d\u89e3\u6c7a\u65b9\u6848\u7684\u8feb\u5207\u9700\u6c42<\/h3>\n<p>\u9451\u65bc\u814e\u6bcd\u7d30\u80de\u7624\u50b3\u7d71\u6cbb\u7642\u7b56\u7565\u6709\u56b4\u91cd\u7684\u9650\u5236\u548c\u98a8\u96aa\uff0c\u56e0\u6b64\u9700\u8981\u5275\u65b0\u7684\u65b9\u6cd5\u3002\u4ee3\u8b1d\u816b\u7624\u5b78\u7684\u9032\u5c55\u3001\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b James Allison \u548c Gregg Semenza \u6559\u6388\u7b49\u958b\u5275\u7684\u514d\u75ab\u6aa2\u67e5\u9ede\u963b\u65b7\u767c\u73fe\uff0c\u4ee5\u53ca\u674e\u570b\u83ef\u535a\u58eb\u548c\u5289\u570b\u9f8d\u6559\u6388\u7b49\u5091\u51fa\u5c08\u5bb6\u958b\u767c\u7684\u6a19\u9776\u7642\u6cd5\uff0c\u90fd\u70ba\u986f\u8457\u63d0\u9ad8\u5152\u7ae5\u764c\u75c7\u751f\u5b58\u7387\u548c\u751f\u6d3b\u8cea\u7d20\u63d0\u4f9b\u4e86\u6709\u5e0c\u671b\u7684\u9014\u5f91\uff0c\u7279\u5225\u662f\u5728\u4e9e\u592a\u91ab\u7642\u4fdd\u5065\u74b0\u5883\u548c\u6cbb\u7642\u80fd\u529b\u7684\u80cc\u666f\u4e0b\u3002<\/p>\n<p>\u6700\u7d42\uff0c\u4e86\u89e3\u9019\u4e9b\u9650\u5236\u6709\u52a9\u65bc\u66f4\u597d\u5730\u7406\u89e3\u65b0\u7a4e\u7684\u3001\u6709\u91dd\u5c0d\u6027\u7684\u6cbb\u7642\u65b9\u5f0f\u3002\u5b83\u5f37\u8abf\u4e86\u6b63\u5728\u9032\u884c\u7684\u3001\u8afe\u8c9d\u723e\u734e\u652f\u6301\u7684\u7814\u7a76\u5de5\u4f5c\u548c\u570b\u969b\u81e8\u5e8a\u5408\u4f5c\u7684\u91cd\u8981\u6027\uff0c\u9ad4\u73fe\u4e86 AllCancer \u7684\u627f\u8afe\uff0c\u7279\u5225\u662f\u5728\u9999\u6e2f\u548c\u4e9e\u6d32\uff0c\u5c07\u814e\u6bcd\u7d30\u80de\u7624\u8f49\u8b8a\u70ba\u4e00\u7a2e\u6162\u6027\u3001\u53ef\u63a7\u5236\u7684\u75be\u75c5\uff0c\u800c\u4e0d\u662f\u81f4\u547d\u7684\u8a3a\u65b7\u3002<\/p>\n<h2>4D \u764c\u75c7\u7642\u6cd5\u6cbb\u7642\u65b9\u6cd5<\/h2>\n<p>\u9999\u6e2f\u4ee3\u8b1d\u816b\u7624\u6cbb\u7642\u4e2d\u5fc3\u63d0\u51fa\u76844D \u7642\u6cd5\u4ee3\u8868\u4e86\u4e00\u7a2e\u591a\u5c64\u9762\u7684\u764c\u75c7\u6cbb\u7642\u65b9\u6cd5\uff0c\u65e8\u5728\u5c07\u764c\u75c7\u8f49\u8b8a\u70ba\u53ef\u63a7\u5236\u7684\u6162\u6027\u75be\u75c5\u3002\u672c\u8abf\u67e5\u5831\u544a\u57fa\u65bc\u6240\u63d0\u4f9b\u7684\u6587\u4ef6\uff0c\u4e26\u900f\u904e\u57fa\u65bc\u7db2\u8def\u7684\u79d1\u5b78\u6587\u737b\u7684\u5ee3\u6cdb\u7814\u7a76\u9032\u884c\u4e86\u88dc\u5145\uff0c\u5c0d\u56db\u7a2e\u65b9\u6cd5\uff08\u4ee3\u8b1d\u6291\u5236\u3001\u7bc0\u594f\u6027\u816b\u7624\u63a7\u5236\u3001\u57fa\u56e0\u9776\u5411\u65ac\u9996\u548c\u514d\u75ab\u98a8\u66b4\u555f\u52d5\uff09\u9032\u884c\u4e86\u5168\u9762\u5206\u6790\u3002\u5206\u6790\u5305\u62ec\u79d1\u5b78\u539f\u7406\u3001\u81e8\u5e8a\u8b49\u64da\u548c\u6f5b\u5728\u6311\u6230\uff0c\u6700\u7d42\u63d0\u51fa\u4e86\u53e3\u865f\u548c\u53e3\u865f\u3002<\/p>\n<h3>\u4ee3\u8b1d\u6291\u5236<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u9019\u7a2e\u65b9\u6cd5\u91dd\u5c0d\u764c\u7d30\u80de\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\uff0c\u7279\u5225\u662f\u5b83\u5011\u5c0d\u8461\u8404\u7cd6\u3001\u9ea9\u91af\u80fa\u9178\u548c\u8102\u8cea\u5408\u6210\u7684\u4f9d\u8cf4\u3002\u5b83\u4f7f\u7528\u8af8\u5982\u7528\u65bc\u8461\u8404\u7cd6\u8f49\u904b\u7684 GLUT1\/3\u3001\u7528\u65bc\u8c37\u6c28\u9170\u80fa\u4ee3\u8b1d\u7684 GLS\/ASCT2 \u4ee5\u53ca\u7528\u65bc\u8102\u8cea\u5408\u6210\u7684 FASN \u7b49\u6291\u5236\u5291\uff0c\u901a\u5e38\u900f\u904e\u5948\u7c73\u8f09\u9ad4\u905e\u9001\u3002\u4eba\u5de5\u667a\u6167\u9a45\u52d5\u7684\u71df\u990a\u8abf\u7bc0\u63d0\u9ad8\u4e86\u7cbe\u78ba\u5ea6\uff0c\u65e8\u5728\u5f15\u767c ATP \u5371\u6a5f\u4e26\u524a\u5f31\u764c\u7d30\u80de\u3002\u6587\u4ef6\u8072\u7a31\u816b\u7624\u8461\u8404\u7cd6\u651d\u53d6\u6e1b\u5c11\u4e86 82%\uff0c\u8840\u6f3f\u9ea9\u91af\u80fa\u9178\u6e1b\u5c11\u4e86 79%\uff0c\u819c\u78f7\u8102\u5408\u6210\u6e1b\u5c11\u4e86 91%\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u7814\u7a76\uff0c\u4f8b\u5982 <a href=\"https:\/\/www.nature.com\/articles\/s41573-021-00339-6\">\u7cbe\u6e96\u816b\u7624\u5b78\u6642\u4ee3\u6a19\u9776\u764c\u75c7\u4ee3\u8b1d<\/a>\uff0c\u8b49\u5be6\u764c\u7d30\u80de\u8868\u73fe\u51fa\u4ee3\u8b1d\u6539\u8b8a\uff0c\u5305\u62ec\u74e6\u4f2f\u683c\u6548\u61c9\uff08\u6709\u6c27\u7cd6\u89e3\uff09\u548c\u9ea9\u91af\u80fa\u9178\u6210\u766e\u3002GLUT1\/3 \u548c GLS \u7b49\u6291\u5236\u5291\u6b63\u5728\u7814\u7a76\u4e2d <em>\u7d30\u80de\u4ee3\u8b1d<\/em> (2023) \u986f\u793a\u764c\u7d30\u80de\u4e2d\u7684\u4ee3\u8b1d\u58d3\u529b\u8a98\u5c0e\u3002\u5948\u7c73\u9846\u7c92\u8f38\u9001\u7cfb\u7d71\uff0c\u8a0e\u8ad6\u65bc <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590183420300028\">\u764c\u75c7\u6cbb\u7642\u4e2d\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u8f38\u9001<\/a>\uff0c\u589e\u5f37\u7279\u7570\u6027\uff0c\u5118\u7ba1\u816b\u7624\u7570\u8cea\u6027\u548c\u812b\u9776\u6548\u61c9\u7b49\u6311\u6230\u4ecd\u7136\u5b58\u5728\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u6240\u8072\u7a31\u7684\u81e8\u5e8a\u76ca\u8655\u8207\u65b0\u8208\u8a66\u9a57\u4e00\u81f4\uff0c\u4f46\u764c\u75c7\u985e\u578b\uff08\u4f8b\u5982\u80ba\u764c\u8207\u4e73\u764c\uff09\u548c\u60a3\u8005\u53cd\u61c9\u7684\u5dee\u7570\u8868\u660e\u9700\u8981\u500b\u6027\u5316\u7684\u65b9\u6cd5\u30022024\u5e74 <em>\u7d30\u80de<\/em> \u6587\u4ef6\u4e2d\u5f15\u7528\u7684\u7814\u7a76\u8072\u7a31\u6297\u85e5\u6027\u57fa\u56e0\u8868\u73fe\u6e1b\u5c11\u4e86 80%\uff0c\u9700\u8981\u900f\u904e\u66f4\u5927\u898f\u6a21\u7684\u591a\u4e2d\u5fc3\u8a66\u9a57\u9032\u884c\u9a57\u8b49\u3002\u502b\u7406\u65b9\u9762\u7684\u8003\u616e\uff0c\u4f8b\u5982\u7372\u53d6\u548c\u8ca0\u64d4\u80fd\u529b\uff0c\u5728 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2949723X23000533\">\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u50b3\u8f38\u7cfb\u7d71\u7684\u529f\u6548\u56de\u9867<\/a>.<\/p>\n<h3>\u7bc0\u594f\u6027\u816b\u7624\u63a7\u5236<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528\u4f4e\u5291\u91cf\u3001\u7bc0\u5f8b\u5316\u7642\uff08\u50b3\u7d71\u5291\u91cf\u7684 1\/10\uff09\u548c\u8840\u7ba1\u6b63\u5e38\u5316\u56e0\u5b50\u4f86\u63a7\u5236\u816b\u7624\u751f\u9577\uff0c\u964d\u4f4e\u6bd2\u6027\u4e26\u5be6\u73fe 67% \u7684\u5bb6\u5ead\u6cbb\u7642\u3002\u64da\u8072\u7a31\uff0c\u5b83\u5c07\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u5f9e 5.2 \u500b\u6708\u5ef6\u9577\u81f3 11.8 \u500b\u6708\uff0c\u4e26\u5c07\u56b4\u91cd\u6bd2\u6027\u964d\u4f4e 67%\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u4f4e\u5291\u91cf\u7bc0\u5f8b\u5316\u7642\u5df2\u88ab\u5ee3\u6cdb\u63a5\u53d7\uff0c\u5982 <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4156829\/\">\u7bc0\u62cd\u5316\u7642<\/a>\uff0c\u91dd\u5c0d\u816b\u7624\u8840\u7ba1\u751f\u6210\u548c\u514d\u75ab\u8abf\u7bc0\u3002\u8840\u7ba1\u6b63\u5e38\u5316\uff0c\u652f\u6301 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405844024007011\">\u7bc0\u62cd\u5316\u7642\u548c\u85e5\u7269\u518d\u5229\u7528<\/a>\uff0c\u900f\u904e\u589e\u5f37\u8840\u7ba1\u529f\u80fd\u4f86\u6539\u5584\u85e5\u7269\u8f38\u9001\u3002\u7814\u7a76\u5982 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0959804913005418\">\u4f4e\u5291\u91cf\u7bc0\u62cd\u5316\u7642\uff1a\u7cfb\u7d71\u6027\u6587\u737b\u5206\u6790<\/a> \u78ba\u8a8d\u6e1b\u5c11\u7684\u526f\u4f5c\u7528\u548c\u6f5b\u5728\u7684\u6210\u672c\u6548\u76ca\uff0c\u7279\u5225\u662f\u5728\u4f4e\u6536\u5165\u74b0\u5883\u4e2d\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684\u76ca\u8655\u8207\u8f49\u79fb\u6027\u4e73\u764c\u7684\u81e8\u5e8a\u6578\u64da\u4e00\u81f4\uff0c\u4f46\u7642\u6548\u53ef\u80fd\u56e0\u816b\u7624\u985e\u578b\u548c\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u800c\u7570\u3002\u5bb6\u5ead\u6cbb\u7642\u6a21\u5f0f\u96d6\u7136\u6709\u5e0c\u671b\uff0c\u4f46\u9700\u8981\u5805\u6301\u548c\u76e3\u6e2c\uff0c\u5982 <a href=\"https:\/\/www.lifespringcancercenter.com\/our-treatment\/low-dose-metronomic-chemotherapy\">\u751f\u547d\u6cc9\u764c\u75c7\u6cbb\u7642\u4e2d\u5fc3<\/a>\u3002\u95dc\u65bc\u6297\u85e5\u6027\u548c\u751f\u6d3b\u8cea\u7d20\u7684\u9577\u671f\u6578\u64da\u9700\u8981\u9032\u4e00\u6b65\u63a2\u7d22\u3002<\/p>\n<h3>\u57fa\u56e0\u6a19\u9776\u65ac\u9996<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528\u6db2\u9ad4\u6d3b\u6aa2\u4f86\u6aa2\u6e2c 487 \u500b\u764c\u75c7\u9a45\u52d5\u57fa\u56e0\uff0c\u4e26\u4f7f\u7528\u5948\u7c73\u9846\u7c92\u905e\u9001\u7cfb\u7d71\u4f86\u9776\u5411 KRAS\u3001BRAF \u548c TP53 \u7b49\u7a81\u8b8a\uff0c\u5f9e\u800c\u514b\u670d\u8840\u8166\u5c4f\u969c\u7b49\u969c\u7919\u3002\u5b83\u8072\u7a31 ORR \u63d0\u9ad8\u4e86 67%\uff0c\u905e\u9001\u6548\u7387\u63d0\u9ad8\u4e86 9 \u500d\uff0c\u7279\u5225\u662f\u5c0d\u65bc\u8f49\u79fb\u7624\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u5948\u7c73\u9846\u7c92\u8f38\u9001\u662f\u4e00\u500b\u524d\u6cbf\u9818\u57df\uff0c <a href=\"https:\/\/www.cancer.gov\/nano\/cancer-nanotechnology\/treatment\">\u5948\u7c73\u6280\u8853\u764c\u75c7\u6cbb\u7642\u548c\u6cbb\u7642<\/a> \u5f37\u8abf\u5176\u7a7f\u900f\u751f\u7406\u5c4f\u969c\u7684\u80fd\u529b\u3002\u6db2\u9ad4\u6d3b\u6aa2\uff0c\u8a0e\u8ad6\u65bc <a href=\"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03433-8\">\u63a8\u9032\u764c\u75c7\u57fa\u56e0\u6cbb\u7642<\/a>\uff0c\u5be6\u73fe\u5373\u6642\u7a81\u8b8a\u6aa2\u6e2c\uff0c\u8207\u7cbe\u6e96\u816b\u7624\u5b78\u8da8\u52e2\u4fdd\u6301\u4e00\u81f4\u3002\u7814\u7a76\u65bc <a href=\"https:\/\/www.nature.com\/articles\/s41392-023-01642-x\">\u7528\u65bc\u764c\u75c7\u6cbb\u7642\u7684\u667a\u6167\u5948\u7c73\u9846\u7c92<\/a> \u5118\u7ba1\u6bd2\u6027\u548c\u9776\u5411\u7279\u7570\u6027\u7b49\u6311\u6230\u4ecd\u7136\u5b58\u5728\uff0c\u4f46\u5b83\u986f\u793a\u51fa\u6cbb\u7642\u8166\u8f49\u79fb\u7684\u5e0c\u671b\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684 ORR \u70ba 67% \u662f\u96c4\u5fc3\u52c3\u52c3\u7684\uff0c\u96d6\u7136\u65e9\u671f\u8a66\u9a57\u986f\u793a\u51fa\u5e0c\u671b\uff0c\u4f46\u9700\u8981\u66f4\u5927\u898f\u6a21\u7684\u7814\u7a76\u4f86\u9a57\u8b49\u8de8\u816b\u7624\u985e\u578b\u7684\u7642\u6548\u3002\u816b\u7624\u7570\u8cea\u6027\uff0c\u5982\u4e2d\u6240\u8ff0 <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-023-01865-0\">\u9032\u6b65\u5948\u7c73\u6280\u8853\u4ee5\u6539\u5584\u6a19\u9776\u764c\u75c7\u6cbb\u7642<\/a>\uff0c\u53ef\u80fd\u6703\u9650\u88fd\u6210\u529f\uff0c\u9700\u8981\u7d44\u5408\u7b56\u7565\u3002<\/p>\n<h3>\u514d\u75ab\u98a8\u66b4\u555f\u52d5<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528 PD-1\/CTLA-4 \u6291\u5236\u5291\u3001\u65b0\u6297\u539f\u75ab\u82d7\u3001CAR-NK \u7d30\u80de\u548c\u5fae\u751f\u7269\u7d44\u8abf\u7bc0\u4f86\u6d3b\u5316\u591a\u5c64\u514d\u75ab\u53cd\u61c9\u3002\u5b83\u8072\u7a31 3 \u5e74\u5b58\u6d3b\u7387\u70ba 62.7%\uff08\u6539\u5584\u4e86 244%\uff09\uff0c\u5fa9\u767c\u7387\u964d\u4f4e\u4e86 85%\uff0c\u5c07\u300c\u51b7\u300d\u816b\u7624\u8f49\u8b8a\u70ba\u300c\u71b1\u300d\u816b\u7624\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u806f\u5408\u514d\u75ab\u7642\u6cd5\u662f\u9818\u5148\u9818\u57df\uff0c <a href=\"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-021-01164-5\">\u6700\u5927\u5316\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u76ca\u8655\u7684\u7d44\u5408\u7b56\u7565<\/a> \u986f\u793a\u51fa\u589e\u5f37\u7684\u53cd\u61c9\u3002\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u3001\u65b0\u6297\u539f\u75ab\u82d7\u548c CAR-T\/NK \u7642\u6cd5\uff0c\u53c3\u898b <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-025-02305-x\">\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u7684\u9032\u5c55<\/a>\u3001\u63d0\u9ad8\u514d\u75ab\u8fa8\u8b58\u80fd\u529b\u3002\u5fae\u751f\u7269\u7d44\u8abf\u7bc0\uff0c\u7a81\u51fa\u986f\u793a\u65bc <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-021-01316-8\">\u764c\u75c7\u4ee3\u8b1d\u91cd\u7de8\u7a0b\u548c\u514d\u75ab\u53cd\u61c9<\/a>\uff0c\u5f71\u97ff\u514d\u75ab\u6cbb\u7642\u7684\u7d50\u679c\uff0c\u5118\u7ba1\u5176\u4e00\u81f4\u6027\u6709\u722d\u8b70\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684\u751f\u5b58\u7387\u8207\u6700\u8fd1\u7684\u8a66\u9a57\u4e00\u81f4\uff0c\u4f46\u5be6\u9ad4\u7624\u7531\u65bc\u7570\u8cea\u6027\u548c\u514d\u75ab\u6291\u5236\u5fae\u74b0\u5883\u800c\u5e36\u4f86\u6311\u6230\uff0c\u5982 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u6700\u65b0\u9032\u5c55<\/a>\u3002\u95dc\u65bc\u5fa9\u767c\u548c\u514d\u75ab\u8a18\u61b6\u7684\u9577\u671f\u6578\u64da\u9700\u8981\u9032\u4e00\u6b65\u9a57\u8b49\u3002<\/p>\n<h3>\u6bd4\u8f03\u81e8\u5e8a\u7d50\u679c<\/h3>\n<p>\u9019\u4e9b\u6587\u4ef6\u63d0\u4f9b\u4e86\u4e00\u500b\u6bd4\u8f03\u50b3\u7d71\u7642\u6cd5\u548c\u56db\u7dad\u7642\u6cd5\u7684\u8868\u683c\uff0c\u70ba\u6e05\u695a\u8d77\u898b\uff0c\u5c07\u5176\u8907\u88fd\u5982\u4e0b\uff1a<\/p>\n<figure>\n<table class=\"has-fixed-layout\">\n<tbody>\n<tr>\n<td>\u6307\u6a19<\/td>\n<td>\u50b3\u7d71\u7684<br \/>\u6cbb\u7642<\/td>\n<td>\u56db\u7dad<br \/>\u6cbb\u7642<\/td>\n<td>\u6539\u9032<\/td>\n<\/tr>\n<tr>\n<td>\u5ba2\u89c0\u7de9\u89e3\u7387 (ORR)<\/td>\n<td>31%<\/td>\n<td>67%<\/td>\n<td>\u2191116%<\/td>\n<\/tr>\n<tr>\n<td>3 \u5e74\u5b58\u6d3b\u7387<\/td>\n<td>18%<\/td>\n<td>62.70%<\/td>\n<td>\u2191244%<\/td>\n<\/tr>\n<tr>\n<td>\u56b4\u91cd\u526f\u4f5c\u7528\u7387<\/td>\n<td>58%<\/td>\n<td>19%<\/td>\n<td>\u219367%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\u8868\u683c\u5f37\u8abf\u4e86\u8a72\u7642\u6cd5\u7684\u6f5b\u529b\uff0c\u4f46\u60a3\u8005\u7fa4\u9ad4\u548c\u816b\u7624\u985e\u578b\u4e4b\u9593\u7684\u5dee\u7570\u503c\u5f97\u9032\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n<h2><strong>\u7e3d\u7d50<\/strong><\/h2>\n<p>4D \u7642\u6cd5\u6574\u5408\u4e86\u89e3\u6c7a\u764c\u75c7\u8907\u96dc\u6027\u7684\u5c16\u7aef\u7b56\u7565\uff0c\u6bcf\u7a2e\u65b9\u6cd5\u90fd\u5f97\u5230\u65b0\u8208\u7814\u7a76\u7684\u652f\u6301\u3002\u7136\u800c\uff0c\u816b\u7624\u7570\u8cea\u6027\u3001\u81e8\u5e8a\u9a57\u8b49\u548c\u53ef\u8fd1\u6027\u7b49\u6311\u6230\u9700\u8981\u4e0d\u65b7\u63a2\u7d22\u3002\u5efa\u8b70\u7684\u53e3\u865f\u548c\u53e3\u865f\u65e8\u5728\u9ad4\u73fe\u8a72\u7642\u6cd5\u7684\u627f\u8afe\uff0c\u4e26\u5f15\u767c\u5c0d\u5176\u6539\u8b8a\u764c\u75c7\u6cbb\u7642\u6f5b\u529b\u7684\u9032\u4e00\u6b65\u8a0e\u8ad6\u3002<\/p>\n<h2>\u53c3\u8003\u6587\u737b<\/h2>\n<ul>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41573-021-00339-6\">\u7cbe\u6e96\u816b\u7624\u5b78\u6642\u4ee3\u6a19\u9776\u764c\u75c7\u4ee3\u8b1d<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590183420300028\">\u764c\u75c7\u6cbb\u7642\u4e2d\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u8f38\u9001<\/a><\/li>\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4156829\/\">\u7bc0\u62cd\u5316\u7642<\/a><\/li>\n<li><a href=\"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03433-8\">\u63a8\u9032\u764c\u75c7\u57fa\u56e0\u6cbb\u7642<\/a><\/li>\n<li><a href=\"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-021-01164-5\">\u6700\u5927\u5316\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u76ca\u8655\u7684\u7d44\u5408\u7b56\u7565<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u6700\u65b0\u9032\u5c55<\/a><\/li>\n<li><a href=\"https:\/\/www.cancer.gov\/nano\/cancer-nanotechnology\/treatment\">\u5948\u7c73\u6280\u8853\u764c\u75c7\u6cbb\u7642\u548c\u6cbb\u7642<\/a><\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41392-023-01642-x\">\u7528\u65bc\u764c\u75c7\u6cbb\u7642\u7684\u667a\u6167\u5948\u7c73\u9846\u7c92<\/a><\/li>\n<li><a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-021-01316-8\">\u764c\u75c7\u4ee3\u8b1d\u91cd\u7de8\u7a0b\u548c\u514d\u75ab\u53cd\u61c9<\/a><\/li>\n<li><a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-025-02305-x\">\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u7684\u9032\u5c55<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405844024007011\">\u7bc0\u62cd\u5316\u7642\u548c\u85e5\u7269\u518d\u5229\u7528<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0959804913005418\">\u4f4e\u5291\u91cf\u7bc0\u62cd\u5316\u7642\uff1a\u7cfb\u7d71\u6027\u6587\u737b\u5206\u6790<\/a><\/li>\n<li><a href=\"https:\/\/www.lifespringcancer.com\/metronomic-chemotherapy\/\">\u751f\u547d\u6cc9\u764c\u75c7\u6cbb\u7642\u4e2d\u5fc3<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u50b3\u8f38\u7cfb\u7d71\u7684\u529f\u6548\u56de\u9867<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u9032\u6b65\u5948\u7c73\u6280\u8853\u4ee5\u6539\u5584\u6a19\u9776\u764c\u75c7\u6cbb\u7642<\/a><\/li>\n<\/ul>\n<hr>\n<div class=\"ac-blog-cta\">\n<h2>\u9700\u8981\u5354\u52a9\u4e86\u89e3\u6cbb\u7642\u9078\u64c7\uff1f<\/h2>\n<p>\u6211\u5011\u7684\u60a3\u8005\u670d\u52d9\u5718\u968a\u53ef\u4ee5\u5e6b\u52a9\u60a8\u6e96\u5099\u5831\u544a\u4e26\u5b89\u6392\u9069\u7576\u7684\u5c08\u5bb6\u8aee\u8a62\u3002\u672c\u6587\u662f\u4e00\u822c\u8a0a\u606f\uff0c\u800c\u4e0d\u662f\u8a3a\u65b7\u3002<\/p>\n<p><a href=\"\/zh-hk\/appointment\/\">\u7acb\u5373\u9810\u7d04<\/a> &nbsp;|&nbsp; <a href=\"\/zh-hk\/cancer\/\">\u63a2\u7d22\u6240\u6709\u764c\u75c7\u985e\u578b<\/a><\/p>\n<\/div>\n<p class=\"ac-blog-disclaimer\"><em>\u91ab\u7642\u514d\u8cac\u8072\u660e\uff1a\u672c\u6587\u50c5\u7528\u65bc\u4e00\u822c\u6559\u80b2\uff0c\u4e0d\u80fd\u53d6\u4ee3\u5408\u683c\u81e8\u5e8a\u91ab\u751f\u7684\u5efa\u8b70\u3002\u6cbb\u7642\u6c7a\u5b9a\u61c9\u57fa\u65bc\u500b\u4eba\u7684\u8a3a\u65b7\u3001\u5206\u671f\u3001\u75c5\u7406\u548c\u6574\u9ad4\u5065\u5eb7\u72c0\u6cc1\u3002\u5982\u679c\u60a8\u767c\u73fe\u6301\u7e8c\u6216\u4ee4\u4eba\u64d4\u6182\u7684\u75c7\u72c0\uff0c\u8acb\u5c0b\u6c42\u91ab\u7642\u8a55\u4f30\u3002<\/em><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u814e\u6bcd\u7d30\u80de\u7624\u662f\u4e00\u7a2e\u7f55\u898b\u4f46\u53ef\u6cbb\u7642\u7684\u5152\u7ae5\u814e\u764c\uff0c\u4e3b\u8981\u5f71\u97ff 3-4 \u6b72\u7684\u5152\u7ae5\uff0c\u4f46\u5076\u723e\u6703\u5f71\u97ff\u5e74\u9f61\u8f03\u5927\u7684\u5152\u7ae5\uff0c\u5f88\u5c11\u2026<\/p>","protected":false},"featured_media":288,"menu_order":86,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center 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center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-408","cancer_type","type-cancer_type","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/cntumour.com\/zh-hk\/wp-json\/wp\/v2\/cancer_type\/408","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cntumour.com\/zh-hk\/wp-json\/wp\/v2\/cancer_type"}],"about":[{"href":"https:\/\/cntumour.com\/zh-hk\/wp-json\/wp\/v2\/types\/cancer_type"}],"version-history":[{"count":2,"href":"https:\/\/cntumour.com\/zh-hk\/wp-json\/wp\/v2\/cancer_type\/408\/revisions"}],"predecessor-version":[{"id":658,"href":"https:\/\/cntumour.com\/zh-hk\/wp-json\/wp\/v2\/cancer_type\/408\/revisions\/658"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cntumour.com\/zh-hk\/wp-json\/wp\/v2\/media\/288"}],"wp:attachment":[{"href":"https:\/\/cntumour.com\/zh-hk\/wp-json\/wp\/v2\/media?parent=408"}],"curies":[{"name":"\u53ef\u6fd5\u6027\u7c89\u5291","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}