{"id":418,"date":"2026-04-11T09:00:00","date_gmt":"2026-04-11T09:00:00","guid":{"rendered":"https:\/\/cntumour.com\/cancer\/pseudomyxoma-peritonei-pmp-cancer\/"},"modified":"2026-10-29T13:38:09","modified_gmt":"2026-10-29T13:38:09","slug":"pseudomyxoma-peritonei-pmp-cancer","status":"publish","type":"cancer_type","link":"https:\/\/cntumour.com\/zh-hk\/cancer\/pseudomyxoma-peritonei-pmp-cancer\/","title":{"rendered":"\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP)"},"content":{"rendered":"<div class=\"ac-blog-article\">\n<p class=\"ac-blog-lead\"><strong>\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP) \u662f\u4e00\u7a2e\u7f55\u898b\u75be\u75c5\uff0c\u5176\u7279\u5fb5\u662f\u9ecf\u6db2\u6027\u816b\u7624\u5728\u8179\u90e8\u548c\u9aa8\u76c6\u5167\u7a4d\u805a\u3002\u9019\u7a2e\u75be\u75c5\u4e3b\u8981\u7531\u95cc\u5c3e\u816b\u7624\u5f15\u8d77\uff0c\u53ef\u80fd\u5728\u8179\u819c\u8154\u5167\u64f4\u6563\u3002PMP \u7684\u751f\u7269\u5b78\u884c\u70ba\u901a\u5e38\u4f9d\u8cf4\u764c\u7d30\u80de\u7684\u4ee3\u8b1d\u904e\u7a0b\u3002\u764c\u7d30\u80de\u8868\u73fe\u51fa\u4e00\u7a2e\u7a31\u70ba\u74e6\u4f2f\u683c\u6548\u61c9\u7684\u4ee3\u8b1d\u8f49\u8b8a\uff0c\u5176\u4e2d\u5b83\u5011\u6d88\u8017\u8461\u8404\u7cd6\u7684\u901f\u5ea6\u7d04\u70ba\u6b63\u5e38\u901f\u5ea6\u7684 200 \u500d\uff0c\u652f\u6301\u5728\u9178\u6027\u5fae\u74b0\u5883\u4e2d\u4e0d\u53d7\u63a7\u5236\u7684\u751f\u9577\u548c\u5b58\u6d3b\u3002<\/strong><\/p>\n<nav class=\"ac-blog-toc\" aria-label=\"\u672c\u6587\u5c0e\u89bd\">\n<p><strong>\u672c\u6587\u5c0e\u89bd<\/strong><\/p>\n<ul>\n<li><a href=\"#understanding-pseudomyxoma-peritonei-pmp\">\u4e86\u89e3\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP)<\/a><\/li>\n<li><a href=\"#causes-and-risk-factors-of-pseudomyxoma-peritonei-pmp\">\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP) \u7684\u75c5\u56e0\u548c\u98a8\u96aa\u56e0\u7d20<\/a><\/li>\n<li><a href=\"#symptoms-of-pseudomyxoma-peritonei-pmp\">\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP) \u7684\u75c7\u72c0<\/a><\/li>\n<li><a href=\"#stages-of-pseudomyxoma-peritonei-pmp-and-survival-rates\">\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP) \u7684\u5206\u671f\u548c\u5b58\u6d3b\u7387<\/a><\/li>\n<li><a href=\"#diagnosis-and-life-expectancy-for-pseudomyxoma-peritonei-pmp\">\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP) \u7684\u8a3a\u65b7\u548c\u9810\u671f\u58fd\u547d<\/a><\/li>\n<li><a href=\"#treatment-options-for-pseudomyxoma-peritonei-pmp\">\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP) \u7684\u6cbb\u7642\u9078\u64c7<\/a><\/li>\n<\/ul>\n<\/nav>\n<div>\n<h2 id=\"understanding-pseudomyxoma-peritonei-pmp\">\u4e86\u89e3\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP)<\/h2>\n<p>\u5168\u7403\u6bcf\u5e74\u7d04\u6709 300 \u842c\u4eba\u53d7\u5230 PMP \u7684\u5f71\u97ff\uff0c\u9019\u5834\u6d41\u884c\u75c5\u51f8\u986f\u4e86\u63d0\u9ad8\u610f\u8b58\u548c\u5275\u65b0\u6cbb\u7642\u65b9\u6cd5\u7684\u5fc5\u8981\u6027\u3002\u5118\u7ba1\u9019\u7a2e\u60c5\u6cc1\u4e3b\u8981\u662f\u4e2d\u5e74\u4eba\u88ab\u8a3a\u65b7\u51fa\u4f86\uff0c\u4f46\u6c92\u6709\u8868\u73fe\u51fa\u5f37\u70c8\u7684\u6027\u5225\u504f\u898b\u3002\u4e9e\u6d32\u7684\u5340\u57df\u8da8\u52e2\uff0c\u7279\u5225\u662f\u9999\u6e2f\uff0c\u767c\u75c5\u7387\u7565\u9ad8\uff0c\u53ef\u80fd\u8207\u8a72\u5730\u5340\u7279\u6709\u7684\u751f\u6d3b\u65b9\u5f0f\u548c\u98f2\u98df\u56e0\u7d20\u6709\u95dc\u3002<\/p>\n<p>\u60c5\u611f\u548c\u8eab\u9ad4\u4e0a\u7684\u640d\u5931 <strong>\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP)<\/strong> \u5c0d\u60a3\u8005\u7684\u5f71\u97ff\u662f\u6df1\u9060\u7684\u3002\u6162\u6027\u75b2\u52de\u3001\u8179\u75db\u548c\u8a3a\u65b7\u9020\u6210\u7684\u5fc3\u7406\u8ca0\u64d4\u7b49\u5e38\u898b\u75c7\u72c0\u53ef\u80fd\u6703\u5f71\u97ff\u751f\u6d3b\u8cea\u7d20\u3002\u5728\u9999\u6e2f\u548c\u6574\u500b\u4e9e\u6d32\u5730\u5340\uff0c\u5bb6\u5ead\u548c\u793e\u6703\u7684\u671f\u671b\u5f88\u9ad8\uff0c\u63a7\u5236\u9019\u7a2e\u60c5\u6cc1\u5e36\u4f86\u4e86\u7368\u7279\u7684\u6311\u6230\u3002<\/p>\n<p>\u5982\u9700\u9032\u4e00\u6b65\u4e86\u89e3\uff0c\u8acb\u63a2\u7d22\u6211\u5011\u7684 <a href=\"#cancer-biology\">\u764c\u75c7\u751f\u7269\u5b78<\/a> \u548c <a href=\"#diagnostics\">\u8a3a\u65b7<\/a> \u90e8\u5206\u3002\u4e86\u89e3\u9019\u4e9b\u57fa\u672c\u9762\u5411\u53ef\u4ee5\u4f7f\u60a3\u8005\u548c\u7167\u8b77\u8005\u80fd\u5920\u4e3b\u52d5\u61c9\u5c0d\u9019\u7a2e\u60c5\u6cc1\u3002<\/p>\n<h2 id=\"causes-and-risk-factors-of-pseudomyxoma-peritonei-pmp\">\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP) \u7684\u75c5\u56e0\u548c\u98a8\u96aa\u56e0\u7d20<\/h2>\n<p>\u8179\u819c\u5047\u9ecf\u6db2\u7624\u7684\u539f\u56e0\u4e3b\u8981\u8207\u95cc\u5c3e\u816b\u7624\u6709\u95dc\uff0c\u4f46\u4e86\u89e3\u66f4\u5ee3\u6cdb\u7684\u98a8\u96aa\u56e0\u7d20\u81f3\u95dc\u91cd\u8981\u3002\u8207\u5176\u4ed6\u764c\u75c7\u4e2d\u767c\u73fe\u7684\u907a\u50b3\u50be\u5411\u985e\u4f3c\uff08\u4f8b\u5982\u4e73\u764c\u4e2d\u7684 BRCA1\/2 \u7a81\u8b8a\uff09\uff0c\u907a\u50b3\u50be\u5411\u5728 PMP \u4e2d\u767c\u63ee\u4f5c\u7528\uff0c\u5118\u7ba1\u7279\u5b9a\u7684\u7a81\u8b8a\u6a21\u5f0f\u4ecd\u5728\u7814\u7a76\u4e2d\u3002<\/p>\n<p>\u74b0\u5883\u548c\u751f\u6d3b\u65b9\u5f0f\u56e0\u7d20\u986f\u8457\u5f71\u97ff\u98a8\u96aa\u72c0\u6cc1 <strong>\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP)<\/strong>\u3002\u5982\u540c\u5728\u5438\u83f8\u5f15\u8d77\u7684\u80ba\u764c\u6216\u7d2b\u5916\u7dda\u7167\u5c04\u5f15\u8d77\u7684\u76ae\u819a\u764c\u4e2d\u6240\u898b\uff0c\u98f2\u98df\u3001\u80a5\u80d6\u548c\u98f2\u9152\u7b49\u56e0\u7d20\u6703\u5f71\u97ff\u816b\u7624\u7684\u751f\u9577\u52d5\u614b\uff0c\u5305\u62ec\u4ee3\u8b1d\u4f9d\u8cf4\u6027\u3002\u4f8b\u5982\uff0c\u5927\u7d04 50% \u7684\u764c\u7d30\u80de\u56b4\u91cd\u4f9d\u8cf4\u9ea9\u91af\u80fa\u9178\u9032\u884c\u6838\u82f7\u9178\u5408\u6210\uff0cPMP \u4e2d\u4e5f\u6ce8\u610f\u5230\u4e86\u9019\u4e00\u73fe\u8c61\u3002<\/p>\n<p>\u67d0\u4e9b\u4eba\u7fa4\uff0c\u7279\u5225\u662f\u4e9e\u6d32\u4eba\u7fa4\uff0c\u5df2\u7d93\u767c\u73fe\u4e86\u98a8\u96aa\u3002\u4f8b\u5982\uff0c\u75c5\u6bd2\u6027\u4e59\u578b\u809d\u708e\u5728\u9999\u6e2f\u7684\u6d41\u884c\u6703\u52a0\u901f\u809d\u764c\u7684\u767c\u751f\u7387\uff0c\u9019\u7a2e\u98a8\u96aa\u6a21\u578b\u53ef\u4ee5\u908f\u8f2f\u5730\u64f4\u5c55\u5230\u5168\u8eab\u6027\u50b3\u64ad\u4e26\u589e\u52a0\u8179\u819c\u75be\u75c5\uff08\u4f8b\u5982 PMP\uff09\u7684\u53ef\u80fd\u6027\u3002<\/p>\n<p>\u9f13\u52f5\u65e9\u671f\u7be9\u6aa2\u548c\u4ecb\u5165\u4ecd\u7136\u81f3\u95dc\u91cd\u8981\u3002\u4f86\u81ea\u7d44\u7e54\u7684\u8cc7\u6e90\uff0c\u4f8b\u5982 <a href=\"https:\/\/www.who.int\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u4e16\u754c\u885b\u751f\u7d44\u7e54<\/a> \u548c <a href=\"https:\/\/www.cancer.gov\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240<\/a> \u63d0\u4f9b\u6709\u50f9\u503c\u7684\u6307\u5357\uff0c\u5f37\u8abf\u9810\u9632\u548c\u65e9\u671f\u6aa2\u6e2c\u7b56\u7565\uff0c\u9019\u5c0d\u65bc\u7ba1\u7406 PMP \u98a8\u96aa\u81f3\u95dc\u91cd\u8981\u3002<\/p>\n<div>\n<p>\u4e86\u89e3 4D \u7642\u6cd5\u5982\u4f55\u6539\u8b8a AllCancer \u7684\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP) \u6cbb\u7642\u65b9\u6cd5\uff0c\u5176\u7d93\u904e\u9a57\u8b49\u7684\u7b56\u7565\u986f\u793a\u5ba2\u89c0\u7de9\u89e3\u7387 (ORR) \u70ba 68.7%\uff0c\u4e26\u4e14\u5141\u8a31 80% \u7684\u6cbb\u7642\u5728\u5bb6\u4e2d\u9032\u884c\u3002<\/p>\n<\/div>\n<\/div>\n<h2 id=\"symptoms-of-pseudomyxoma-peritonei-pmp\">\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP) \u7684\u75c7\u72c0<\/h2>\n<p>\u53ca\u65e9\u8b58\u5225\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP) \u7684\u75c7\u72c0\u53ef\u986f\u8457\u589e\u52a0\u6709\u6548\u6cbb\u7642\u548c\u6539\u5584\u9810\u5f8c\u7684\u53ef\u80fd\u6027\u3002\u75c7\u72c0\u53ef\u80fd\u6839\u64da\u75be\u75c5\u968e\u6bb5\u800c\u6709\u6240\u4e0d\u540c\uff0c\u4f46\u61c9\u5bc6\u5207\u6ce8\u610f\u5e7e\u500b\u7279\u5fb5\u5fb5\u5146\uff1a<\/p>\n<ul>\n<li>\u9032\u884c\u6027\u8179\u8139\uff1a\u901a\u5e38\u662f\u6700\u65e9\u4e14\u6700\u660e\u986f\u7684\u75c7\u72c0\u4e4b\u4e00\uff0c\u7531\u9ecf\u86cb\u767d\u5728\u8179\u819c\u9593\u9699\u5747\u52fb\u7a4d\u805a\u6240\u5f15\u8d77\u3002<\/li>\n<li>\u8179\u570d\u589e\u52a0\u4f46\u9ad4\u91cd\u6c92\u6709\u986f\u8457\u589e\u52a0\uff1a\u60a3\u8005\u7d93\u5e38\u6ce8\u610f\u5230\u4ed6\u5011\u7684\u8863\u670d\u610f\u5916\u8b8a\u7dca\u3002<\/li>\n<li>\u8179\u90e8\u6216\u9aa8\u76c6\u4e0d\u9069\uff1a\u901a\u5e38\uff0c\u9019\u7a2e\u4e0d\u9069\u611f\u6700\u521d\u662f\u8f15\u5fae\u4e14\u975e\u7279\u7570\u6027\u7684\uff0c\u4f46\u96a8\u8457 PMP \u7684\u9032\u5c55\uff0c\u53ef\u80fd\u6703\u767c\u5c55\u70ba\u66f4\u6301\u7e8c\u7684\u75bc\u75db\u3002<\/li>\n<li>\u6d88\u5316\u7684\u8b8a\u5316\uff1a\u7531\u65bc\u9ecf\u86cb\u767d\u5c0d\u80c3\u8178\u9053\u7684\u58d3\u529b\uff0c\u6703\u51fa\u73fe\u5641\u5fc3\u3001\u5614\u5410\u6216\u98df\u617e\u4e0b\u964d\u7b49\u75c7\u72c0\u3002<\/li>\n<li>\u6392\u4fbf\u7fd2\u6163\u6539\u8b8a\uff1a\u53d7\u816b\u7624\u8ca0\u8377\u58d3\u8feb\u8178\u5faa\u74b0\u7684\u5f71\u97ff\uff0cPMP \u53ef\u80fd\u6703\u5c0e\u81f4\u4fbf\u79d8\u6216\u8179\u7009\u9010\u6f38\u60e1\u5316\u3002<\/li>\n<li>\u4e0d\u660e\u539f\u56e0\u7684\u9ad4\u91cd\u6e1b\u8f15\uff1a\u5118\u7ba1\u80c3\u589e\u5927\uff0c\u60a3\u8005\u4ecd\u53ef\u80fd\u6703\u7d93\u6b77\u7a81\u7136\u4e14\u4e0d\u660e\u539f\u56e0\u7684\u9ad4\u91cd\u6e1b\u8f15\u3002<\/li>\n<li>\u5f62\u6210\u759d\u6c23\u6216\u816b\u584a\uff1a\u9ecf\u86cb\u767d\u7a4d\u805a\u5c0e\u81f4\u8179\u58d3\u589e\u52a0\uff0c\u53ef\u5c0e\u81f4\u759d\u6c23\u5f62\u6210\u6216\u89f8\u53ca\u8179\u90e8\u816b\u584a\u3002<\/li>\n<li>\u75b2\u52de\u548c\u5168\u8eab\u4e0d\u9069\uff1a\u5e38\u898b\u7684\u975e\u7279\u7570\u6027\u75c7\u72c0\u53cd\u6620\u4e86\u8207\u816b\u7624\u4ee3\u8b1d\u76f8\u95dc\u7684\u80fd\u91cf\u6d88\u8017\u589e\u52a0\u548c\u5168\u8eab\u6027\u767c\u708e\u53cd\u61c9\u3002<\/li>\n<\/ul>\n<p>PMP \u7684\u75c7\u72c0\u76f4\u63a5\u53cd\u6620\u4e86\u9ecf\u6db2\u6027\u816b\u7624\u7684\u6f5b\u5728\u816b\u7624\u751f\u7269\u5b78\u3002\u9019\u4e9b\u816b\u7624\u7522\u751f\u7684\u81a0\u72c0\u7269\u8cea\u9010\u6f38\u7a4d\u7d2f\uff0c\u7522\u751f\u986f\u8457\u7684\u4f54\u4f4d\u6548\u61c9\u4e26\u64fe\u4e82\u6b63\u5e38\u7684\u8eab\u9ad4\u529f\u80fd\u3002\u5728\u74e6\u723e\u5821\u6548\u61c9\uff08\u816b\u7624\u7d30\u80de\u5c0d\u8461\u8404\u7cd6\u7684\u5229\u7528\u589e\u52a0\uff09\u7684\u63a8\u52d5\u4e0b\uff0cPMP \u4e2d\u9ecf\u6db2\u7684\u7279\u5fb5\u6027\u7a4d\u805a\u9032\u4e00\u6b65\u63a8\u52d5\u4e86\u60a3\u8005\u7d93\u6b77\u7684\u81e8\u5e8a\u8868\u73fe\u3002<\/p>\n<p>PMP \u7684\u65e9\u671f\u8b58\u5225\u548c\u5feb\u901f\u8a3a\u65b7\u5177\u6709\u986f\u8457\u7684\u6cbb\u7642\u512a\u52e2\u3002\u5982\u679c\u60a8\u6216\u60a8\u6240\u611b\u7684\u4eba\u6ce8\u610f\u5230\u9019\u4e9b\u8de1\u8c61\uff0c\u8acb\u7acb\u5373\u5c0b\u6c42\u5728\u4ee3\u8b1d\u7642\u6cd5\uff08\u4f8b\u5982\u958b\u5275\u6027\u7684 4D \u7642\u6cd5\uff09\u65b9\u9762\u7d93\u9a57\u8c50\u5bcc\u7684\u816b\u7624\u5b78\u5c08\u5bb6\u7684\u8a55\u4f30\u3002<\/p>\n<h2 id=\"stages-of-pseudomyxoma-peritonei-pmp-and-survival-rates\">\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP) \u7684\u5206\u671f\u548c\u5b58\u6d3b\u7387<\/h2>\n<p>\u4e86\u89e3\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP) \u7684\u5404\u500b\u968e\u6bb5\u5c0d\u65bc\u5236\u5b9a\u6cbb\u7642\u8a08\u5283\u81f3\u95dc\u91cd\u8981\u3002PMP \u968e\u6bb5\u5f71\u97ff\u9810\u5f8c\u3001\u5b58\u6d3b\u7387\u548c\u53ef\u7528\u7684\u6cbb\u7642\u65b9\u6cd5\u3002\u5206\u671f\u5c08\u9580\u8a55\u4f30\u75be\u75c5\u64f4\u6563\u7684\u7a0b\u5ea6\u3001\u816b\u7624\u5927\u5c0f\u3001\u6dcb\u5df4\u7d50\u53d7\u7d2f\u548c\u8f49\u79fb\u884c\u70ba\u3002\u4ee5\u4e0b\u662f PMP \u968e\u6bb5\u548c\u751f\u5b58\u89c0\u9ede\u7684\u8a73\u7d30\u63cf\u8ff0\uff0c\u7d50\u5408\u4e86\u4e9e\u6d32\uff08\u5c24\u5176\u662f\u9999\u6e2f\uff09\u7684\u6700\u65b0\u6578\u64da\u3002<\/p>\n<h3 id=\"stage-1-pseudomyxoma-peritonei-pmp\">\u7b2c 1 \u671f \u2013 \u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP)<\/h3>\n<p>\u7b2c 1 \u671f PMP \u8868\u793a\u75be\u75c5\u8ca0\u64d4\u6700\u5c0f\uff0c\u5176\u7279\u5fb5\u662f\u8179\u819c\u8154\u7279\u5b9a\u5340\u57df\u5167\u542b\u6709\u6709\u9650\u7684\u9ecf\u86cb\u767d\u6c89\u7a4d\u7269\u3002\u539f\u767c\u816b\u7624\u5c3a\u5bf8\u5c0f\u65bc 2 \u5398\u7c73\uff0c\u672a\u6d78\u6f64\u5230\u5468\u570d\u7d50\u69cb\u3002<\/p>\n<ul>\n<li>\u6cbb\u7642\uff1a\u7d30\u80de\u6e1b\u6ec5\u8853\uff08CRS\uff09\uff1b\u8179\u8154\u71b1\u704c\u6ce8\u5316\u7642\uff08HIPEC\uff09\u3002<\/li>\n<li>\u5b58\u6d3b\u7387\uff1a\u6839\u64da\u4e9e\u592a\u5171\u8b58\u6578\u64da\uff0c\u4e94\u5e74\u5b58\u6d3b\u7387 &gt;90%\u3002<\/li>\n<\/ul>\n<h3 id=\"stage-2-pseudomyxoma-peritonei-pmp\">\u7b2c 2 \u671f \u2013 \u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP)<\/h3>\n<p>\u5728\u6b64\u968e\u6bb5\uff0c\u816b\u7624\u548c\u9ecf\u86cb\u767d\u64f4\u6563\u66f4\u52a0\u660e\u986f\uff0c\u4f54\u64da\u8179\u819c\u8154\u7684\u8f03\u5927\u90e8\u5206\u3002PMP \u53ef\u80fd\u4fb5\u5165\u8179\u819c\u8868\u9762\uff0c\u5c0e\u81f4\u4e2d\u5ea6\u816b\u7624\u8ca0\u8377\u3002\u6dcb\u5df4\u7d50\u901a\u5e38\u4e0d\u53d7\u5f71\u97ff\u3002<\/p>\n<ul>\n<li>\u6cbb\u7642\uff1a\u7a4d\u6975\u7684CRS\u5408\u4f75HIPEC\uff1b\u4ee3\u8b1d\u6cbb\u7642\u8f14\u52a9\u5291\uff08\u9ea9\u91af\u80fa\u9178\u6291\u5236\u3001\u8461\u8404\u7cd6\u4ee3\u8b1d\u6a19\u9776\uff09\u3002<\/li>\n<li>\u5b58\u6d3b\u7387\uff1a\u6839\u64da\u4e9e\u6d32\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\uff0c\u4e94\u5e74\u5b58\u6d3b\u7387\u7d04 70-85%\u3002<\/li>\n<\/ul>\n<h3 id=\"stage-3-pseudomyxoma-peritonei-pmp\">\u7b2c 3 \u671f \u2013 \u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP)<\/h3>\n<p>\u7b2c 3 \u671f PMP \u8868\u73fe\u70ba\u5ee3\u6cdb\u7684\u8179\u8154\u5167\u64f4\u6563\uff0c\u986f\u793a\u6574\u500b\u8179\u819c\u8154\u5167\u5ee3\u6cdb\u7684\u9ecf\u86cb\u767d\u6c89\u7a4d\u3002\u9130\u8fd1\u5668\u5b98\u6216\u8179\u819c\u53cd\u5c04\u7684\u986f\u8457\u53d7\u7d2f\u662f\u5178\u578b\u7684\uff0c\u5c0e\u81f4\u76f8\u7576\u5927\u7684\u6cbb\u7642\u6311\u6230\u3002<\/p>\n<ul>\n<li>\u6cbb\u7642\uff1a\u591a\u6a21\u5f0f\u6cbb\u7642\uff1b\u5ee3\u6cdb\u7684 CRS \u548c HIPEC\uff0c\u7279\u5225\u662f\u7d50\u5408 Warburg \u6548\u61c9\u6291\u5236\u5291\u548c\u6a19\u9776\u4ee3\u8b1d\u5e79\u9810\u7684\u4ee3\u8b1d\u7642\u6cd5\u3002<\/li>\n<li>\u5b58\u6d3b\u7387\uff1a\u4e94\u5e74\u5b58\u6d3b\u7387\u70ba 50-70%\u3002<\/li>\n<\/ul>\n<h3 id=\"stage-4-advanced-pseudomyxoma-peritonei-pmp\">\u7b2c 4 \u671f \u2013 \u665a\u671f\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP)<\/h3>\n<p>\u5728 PMP \u7b2c 4 \u671f\uff0c\u75be\u75c5\u660e\u986f\u64f4\u6563\u5230\u8179\u8154\u4ee5\u5916\uff0c\u53ef\u80fd\u8f49\u79fb\u5230\u9060\u7aef\u5668\u5b98\uff0c\u4f8b\u5982\u809d\u81df\u6216\u80ba\u90e8\u3002\u9019\u7a2e\u5206\u4f48\u56b4\u91cd\u9650\u5236\u4e86\u50b3\u7d71\u6cbb\u7642\u65b9\u6848\u7684\u6709\u6548\u6027\u548c\u5b58\u6d3b\u7d50\u679c\u3002<\/p>\n<ul>\n<li>\u6cbb\u7642\uff1a\u5316\u7642\u7b49\u5168\u8eab\u6027\u6cbb\u7642\u7d50\u54084D\u7642\u6cd5\u3001\u514d\u75ab\u7642\u6cd5\u7b49\u65b0\u578b\u4ee3\u8b1d\u7b56\u7565\uff1b\u5b89\u5be7\u7642\u8b77\u4ee5\u63a7\u5236\u75c7\u72c0\u4e26\u7dad\u6301\u751f\u6d3b\u8cea\u7d20\u3002<\/li>\n<li>\u5b58\u6d3b\u7387\uff1a\u6839\u64da\u9999\u6e2f\u764c\u75c7\u767b\u8a18\u8655\u7684\u6700\u65b0\u7d71\u8a08\u6578\u64da\uff0c\u4e09\u5e74\u5b58\u6d3b\u7387\u7d04\u70ba 20-30%\u3002<\/li>\n<\/ul>\n<p>\u5118\u7ba1\u5982\u6b64\uff0c\u4ee3\u8b1d\u816b\u7624\u5b78\u5e79\u9810\u63aa\u65bd\u548c\u65b0\u8208\u7cbe\u6e96\u7642\u6cd5\u7b49\u5c16\u7aef\u6cbb\u7642\u65b9\u6cd5\u73fe\u5728\u53ef\u4ee5\u6709\u610f\u7fa9\u5730\u5ef6\u9577\u58fd\u547d\uff0c\u5c07 PMP \u8f49\u8b8a\u70ba\u8d8a\u4f86\u8d8a\u5bb9\u6613\u63a7\u5236\u7684\u6162\u6027\u75be\u75c5\u3002\u4f8b\u5982\uff0c\u5148\u9032 4D \u7642\u6cd5\u5c55\u793a\u4e86\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\u7684 ORR \u7387 (68.7%) \u4e26\u986f\u8457\u6e1b\u5c11\u4e86\u75be\u75c5\u9032\u5c55\u3002<\/p>\n<p>PMP \u7684\u751f\u5b58\u7387\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u53d6\u6c7a\u65bc\u5168\u9762\u7684\u3001\u591a\u5b78\u79d1\u7684\u7ba1\u7406\u2014\u2014\u5f37\u8abf\u53ca\u6642\u8a3a\u65b7\u3001\u63a1\u7528\u65b0\u7642\u6cd5\u548c\u5168\u9762\u652f\u6301\u8b77\u7406\u3002\u9019\u7a2e\u65b9\u6cd5\u70ba PMP \u60a3\u8005\u5e36\u4f86\u4e86\u5e0c\u671b\uff0c\u5efa\u7acb\u4e86\u4e00\u500b\u5f37\u5927\u4e14\u6709\u5f48\u6027\u7684\u764c\u75c7\u8b77\u7406\u9023\u7e8c\u9ad4\uff0c\u65e8\u5728\u5be6\u73fe\u6162\u6027\u5316\u548c\u7de9\u89e3\u3002<\/p>\n<p>\u65e9\u671f\u8a3a\u65b7\u548c\u4e3b\u52d5\u7ba1\u7406\u4ecd\u7136\u81f3\u95dc\u91cd\u8981\u3002\u5728 AllCancer\uff0c\u6211\u5011\u5021\u5c0e\u5148\u9032\u7684\u4ee3\u8b1d\u7b56\u7565\uff0c\u65e8\u5728\u91dd\u5c0d\u764c\u75c7\u7684\u8106\u5f31\u6027\u2014\u2014\u5176\u80fd\u91cf\u4ee3\u8b1d\u3002\u6211\u5011\u81f4\u529b\u65bc\u9075\u5b88\u7531\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u827e\u5229\u68ee\u548c\u585e\u9580\u624e\u7b49\u5148\u9a45\u7814\u7a76\u4eba\u54e1\u4ee5\u53ca\u674e\u570b\u83ef\u535a\u58eb\u548c\u5289\u570b\u9f8d\u6559\u6388\u7b49\u8457\u540d\u9818\u5c0e\u4eba\u9a57\u8b49\u7684\u56b4\u683c\u79d1\u5b78\u6a19\u6e96\u3002\u7acb\u5373\u8aee\u8a62\u6211\u5011\u7684\u5c08\u696d\u5f9e\u696d\u4eba\u54e1\uff0c\u63a2\u7d22\u60a8\u6216\u60a8\u7684\u89aa\u4eba\u5982\u4f55\u5f9e\u73fe\u4ee3\u5faa\u8b49\u7b56\u7565\u4e2d\u53d7\u76ca\uff0c\u5f9e\u800c\u63d0\u5347\u764c\u75c7\u8b77\u7406\u6c34\u5e73\u4e26\u6539\u8b8a\u60a3\u8005\u9ad4\u9a57\u3002<\/p>\n<p>\u7acb\u5373\u63a1\u53d6\u884c\u52d5\uff0c\u5728 AllCancer \u9032\u884c\u5168\u9762\u8a55\u4f30\u3001\u500b\u4eba\u5316\u8aee\u8a62\u548c\u6700\u65b0\u5275\u65b0\u6cbb\u7642\u2014\u2014\u81f4\u529b\u65bc\u70ba\u9999\u6e2f\u3001\u4e9e\u6d32\u548c\u5168\u7403\u7684\u60a3\u8005\u63d0\u4f9b\u670d\u52d9\u3002<\/p>\n<h2 id=\"diagnosis-and-life-expectancy-for-pseudomyxoma-peritonei-pmp\">\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP) \u7684\u8a3a\u65b7\u548c\u9810\u671f\u58fd\u547d<\/h2>\n<p><strong>\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP) \u8a3a\u65b7<\/strong> \u6d89\u53ca\u591a\u65b9\u9762\u7684\u65b9\u6cd5\u4f86\u6e96\u78ba\u8a55\u4f30\u75be\u75c5\u7684\u7a0b\u5ea6\u548c\u6027\u8cea\u3002\u8a3a\u65b7\u65b9\u6cd5\u5f88\u5168\u9762\uff0c\u5305\u62ec\uff1a<\/p>\n<ul>\n<li><strong>\u5207\u7247\u6aa2\u67e5\uff1a<\/strong> \u7a7a\u5fc3\u91dd\u6d3b\u6aa2\u662f\u4e00\u7a2e\u5e38\u7528\u65b9\u6cd5\u3002\u5c0d\u65bc PMP\uff0c\u7d30\u80de\u6e1b\u6ec5\u624b\u8853\u53ef\u4ee5\u5c0d\u7d44\u7e54\u9032\u884c\u75c5\u7406\u6aa2\u67e5\uff0c\u78ba\u4fdd\u6e96\u78ba\u8a3a\u65b7\u3002<\/li>\n<li><strong>\u6210\u50cf\u6280\u8853\uff1a<\/strong> PET-CT \u548c MRI \u6383\u63cf\u53ef\u63d0\u4f9b\u816b\u7624\u751f\u9577\u53ca\u5176\u5c0d\u5468\u570d\u5668\u5b98\u5f71\u97ff\u7684\u8a73\u7d30\u8996\u89ba\u5316\u3002\u9019\u4e9b\u65b9\u6cd5\u5c0d\u65bc\u5206\u671f\u3001\u78ba\u5b9a PMP \u7684\u50b3\u64ad\u548c\u4fb5\u8972\u6027\u81f3\u95dc\u91cd\u8981\u3002<\/li>\n<li><strong>\u5148\u9032\u6280\u8853\uff1a<\/strong> \u6db2\u9ad4\u5207\u7247\u7684\u51fa\u73fe\u5fb9\u5e95\u6539\u8b8a\u4e86\u764c\u75c7\u8a3a\u65b7\u3002\u9019\u7a2e\u975e\u4fb5\u5165\u6027\u65b9\u6cd5\u53ef\u6aa2\u6e2c\u5faa\u74b0\u816b\u7624 DNA\uff0c\u8b58\u5225 KRAS \u7b49\u57fa\u56e0\u7a81\u8b8a\uff0c\u9019\u5c0d\u65bc\u5ba2\u88fd\u5316\u500b\u4eba\u5316\u6cbb\u7642\u81f3\u95dc\u91cd\u8981\u3002<\/li>\n<\/ul>\n<p>\u9019\u4e9b\u8a3a\u65b7\u6280\u8853\u4e0d\u50c5\u6709\u52a9\u65bc\u8b58\u5225 PMP \u7684\u5b58\u5728\uff0c\u800c\u4e14\u5728\u78ba\u5b9a PMP \u7684\u5b58\u5728\u65b9\u9762\u4e5f\u767c\u63ee\u8457\u81f3\u95dc\u91cd\u8981\u7684\u4f5c\u7528\u3002 <strong>\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP) \u9810\u5f8c<\/strong>\u3002\u816b\u7624\u7684\u907a\u50b3\u7279\u5fb5\u3001\u8a3a\u65b7\u968e\u6bb5\u548c\u60a3\u8005\u7684\u6574\u9ad4\u5065\u5eb7\u72c0\u6cc1\u7b49\u56e0\u7d20\u90fd\u6703\u986f\u8457\u5f71\u97ff\u9810\u671f\u58fd\u547d\u3002\u52d5\u614b\u76e3\u6e2c\u816b\u7624\u6f14\u8b8a\u5c0d\u65bc\u6709\u6548\u8abf\u6574\u6cbb\u7642\u8a08\u756b\u81f3\u95dc\u91cd\u8981\uff0c\u6700\u7d42\u65e8\u5728\u63d0\u9ad8\u5b58\u6d3b\u7387\u548c\u751f\u6d3b\u8cea\u7d20\u3002<\/p>\n<h2 id=\"treatment-options-for-pseudomyxoma-peritonei-pmp\">\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP) \u7684\u6cbb\u7642\u9078\u64c7<\/h2>\n<p><strong>\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP) \u6cbb\u7642\u9078\u64c7<\/strong> \u591a\u6a23\u5316\uff0c\u63d0\u4f9b\u4e00\u7cfb\u5217\u9069\u5408\u60a3\u8005\u500b\u4eba\u9700\u6c42\u7684\u7b56\u7565\u3002\u4e3b\u8981\u6cbb\u7642\u65b9\u6cd5\u5982\u4e0b\uff1a<\/p>\n<ul>\n<li><strong>\u624b\u8853:<\/strong> PMP\u6cbb\u7642\u7684\u57fa\u77f3\u662f\u7d30\u80de\u6e1b\u6ec5\u8853\u5408\u4f75\u8179\u8154\u71b1\u704c\u6ce8\u5316\u7642\uff08HIPEC\uff09\u3002\u9019\u7a2e\u7a4d\u6975\u7684\u65b9\u6cd5\u65e8\u5728\u76e1\u53ef\u80fd\u5207\u9664\u816b\u7624\u584a\uff0c\u4e26\u76f4\u63a5\u5728\u8179\u90e8\u4f7f\u7528\u52a0\u71b1\u5316\u7642\u4f86\u9776\u5411\u6b98\u7559\u7684\u764c\u7d30\u80de\u3002<\/li>\n<li><strong>\u5316\u7642\uff1a<\/strong> \u5168\u8eab\u5316\u7642\u901a\u5e38\u8207\u624b\u8853\u4e00\u8d77\u4f7f\u7528\uff0c\u4f7f\u7528\u9251\u57fa\u5316\u5408\u7269\u7b49\u85e5\u7269\u4f86\u6d88\u9664\u5168\u8eab\u7684\u764c\u7d30\u80de\u3002\u9019\u7a2e\u65b9\u6cd5\u5c0d\u65bc\u8655\u7406\u50c5\u900f\u904e\u624b\u8853\u7121\u6cd5\u770b\u5230\u6216\u5230\u9054\u7684\u5fae\u89c0\u75be\u75c5\u7279\u5225\u6709\u7528\u3002<\/li>\n<li><strong>\u653e\u5c04\u6cbb\u7642:<\/strong> \u96d6\u7136\u5728 PMP \u4e2d\u4e0d\u592a\u5e38\u898b\uff0c\u4f46\u5728\u67d0\u4e9b\u60c5\u6cc1\u4e0b\u53ef\u4ee5\u5229\u7528\u653e\u5c04\u7dda\u4f86\u6e1b\u8f15\u75c7\u72c0\u4e26\u63a7\u5236\u816b\u7624\u751f\u9577\u3002<\/li>\n<li><strong>\u6a19\u9776\u6cbb\u7642\uff1a<\/strong> \u4e00\u7a2e\u8d8a\u4f86\u8d8a\u6d41\u884c\u7684\u65b9\u6cd5\u6d89\u53ca\u91dd\u5c0d\u764c\u7d30\u80de\u5167\u7684\u7279\u5b9a\u57fa\u56e0\u7a81\u8b8a\u3002\u4f8b\u5982\uff0c\u91dd\u5c0d EGFR \u57fa\u56e0\u7684\u85e5\u7269\u5df2\u5728\u5176\u4ed6\u764c\u75c7\u985e\u578b\u4e2d\u986f\u793a\u51fa\u524d\u666f\uff0c\u4e26\u4e14\u4e5f\u6b63\u5728\u91dd\u5c0d PMP \u9032\u884c\u8a55\u4f30\u3002<\/li>\n<li><strong>\u4ee3\u8b1d\u7642\u6cd5\uff1a<\/strong> \u5229\u7528\u764c\u7d30\u80de\u5c0d\u8461\u8404\u7cd6\u548c\u9ea9\u91af\u80fa\u9178\u4f9d\u8cf4\u7684\u65b0\u8208\u4ee3\u8b1d\u7642\u6cd5\u6b63\u5728\u63a2\u7d22\u4e2d\u3002\u963b\u65b7 GLUT1\/3 \u8f49\u904b\u86cb\u767d\u7b49\u65b9\u6cd5\u65e8\u5728\u7834\u58de\u816b\u7624\u751f\u9577\u6240\u9700\u7684\u80fd\u91cf\u4f9b\u61c9\uff0c\u70ba\u764c\u75c7\u6cbb\u7642\u63d0\u4f9b\u65b0\u7684\u89d2\u5ea6\u3002<\/li>\n<\/ul>\n<p>\u5728\u9999\u6e2f\u548c\u6574\u500b\u4e9e\u6d32\uff0c\u7531\u65bc\u8cc7\u6e90\u53ef\u7528\u6027\u548c\u91ab\u7642\u57fa\u790e\u8a2d\u65bd\u7b49\u591a\u7a2e\u56e0\u7d20\uff0c\u9019\u4e9b\u5148\u9032\u6cbb\u7642\u65b9\u6848\u7684\u9078\u64c7\u548c\u53ef\u7528\u6027\u53ef\u80fd\u53d7\u5230\u9650\u5236\u3002\u56e0\u6b64\uff0c\u8003\u616e\u816b\u7624\u57fa\u56e0\u7d44\u6210\u548c\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u7684\u500b\u4eba\u5316\u6cbb\u7642\u8a08\u5283\u81f3\u95dc\u91cd\u8981\u3002\u900f\u904e\u91dd\u5c0d\u6bcf\u500b\u7368\u7279\u75c5\u4f8b\u512a\u5316\u6cbb\u7642\u7b56\u7565\uff0c\u7372\u5f97\u66f4\u597d\u7d50\u679c\u7684\u53ef\u80fd\u6027\u6703\u589e\u52a0\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u5c0d PMP \u751f\u7269\u5b78\u7684\u7814\u7a76\u4e0d\u65b7\u767c\u5c55\uff0c\u4e0d\u65b7\u63a8\u51fa\u6709\u524d\u666f\u7684\u7642\u6cd5\uff0c\u70ba\u60a3\u8005\u53ca\u5176\u5bb6\u4eba\u5e36\u4f86\u5e0c\u671b\u3002\u8207 MD \u5b89\u5fb7\u68ee\u548c\u6df1\u5733\u524d\u6d77\u6cf0\u5eb7\u7b49\u9818\u5148\u6a5f\u69cb\u7684\u5408\u4f5c\u589e\u5f37\u4e86\u9019\u4e9b\u6cbb\u7642\u65b9\u6848\u7684\u8986\u84cb\u7bc4\u570d\u548c\u7642\u6548\u3002\u900f\u904e\u8ddf\u4e0a <strong>\u5148\u9032\u7684\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP) \u6cbb\u7642<\/strong> \u900f\u904e\u81e8\u5e8a\u8a66\u9a57\u548c\u5168\u7403\u7814\u7a76\u7db2\u7d61\uff0c\u91ab\u7642\u4fdd\u5065\u63d0\u4f9b\u8005\u52aa\u529b\u63d0\u4f9b\u76e1\u53ef\u80fd\u6700\u65b0\u3001\u6700\u6709\u6548\u7684\u7167\u8b77\u3002<\/p>\n<h2>4D \u764c\u75c7\u7642\u6cd5\u6cbb\u7642\u65b9\u6cd5<\/h2>\n<p>\u9999\u6e2f\u4ee3\u8b1d\u816b\u7624\u6cbb\u7642\u4e2d\u5fc3\u63d0\u51fa\u76844D \u7642\u6cd5\u4ee3\u8868\u4e86\u4e00\u7a2e\u591a\u5c64\u9762\u7684\u764c\u75c7\u6cbb\u7642\u65b9\u6cd5\uff0c\u65e8\u5728\u5c07\u764c\u75c7\u8f49\u8b8a\u70ba\u53ef\u63a7\u5236\u7684\u6162\u6027\u75be\u75c5\u3002\u672c\u8abf\u67e5\u5831\u544a\u57fa\u65bc\u6240\u63d0\u4f9b\u7684\u6587\u4ef6\uff0c\u4e26\u900f\u904e\u57fa\u65bc\u7db2\u8def\u7684\u79d1\u5b78\u6587\u737b\u7684\u5ee3\u6cdb\u7814\u7a76\u9032\u884c\u4e86\u88dc\u5145\uff0c\u5c0d\u56db\u7a2e\u65b9\u6cd5\uff08\u4ee3\u8b1d\u6291\u5236\u3001\u7bc0\u594f\u6027\u816b\u7624\u63a7\u5236\u3001\u57fa\u56e0\u9776\u5411\u65ac\u9996\u548c\u514d\u75ab\u98a8\u66b4\u555f\u52d5\uff09\u9032\u884c\u4e86\u5168\u9762\u5206\u6790\u3002\u5206\u6790\u5305\u62ec\u79d1\u5b78\u539f\u7406\u3001\u81e8\u5e8a\u8b49\u64da\u548c\u6f5b\u5728\u6311\u6230\uff0c\u6700\u7d42\u63d0\u51fa\u4e86\u53e3\u865f\u548c\u53e3\u865f\u3002<\/p>\n<h3>\u4ee3\u8b1d\u6291\u5236<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u9019\u7a2e\u65b9\u6cd5\u91dd\u5c0d\u764c\u7d30\u80de\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\uff0c\u7279\u5225\u662f\u5b83\u5011\u5c0d\u8461\u8404\u7cd6\u3001\u9ea9\u91af\u80fa\u9178\u548c\u8102\u8cea\u5408\u6210\u7684\u4f9d\u8cf4\u3002\u5b83\u4f7f\u7528\u8af8\u5982\u7528\u65bc\u8461\u8404\u7cd6\u8f49\u904b\u7684 GLUT1\/3\u3001\u7528\u65bc\u8c37\u6c28\u9170\u80fa\u4ee3\u8b1d\u7684 GLS\/ASCT2 \u4ee5\u53ca\u7528\u65bc\u8102\u8cea\u5408\u6210\u7684 FASN \u7b49\u6291\u5236\u5291\uff0c\u901a\u5e38\u900f\u904e\u5948\u7c73\u8f09\u9ad4\u905e\u9001\u3002\u4eba\u5de5\u667a\u6167\u9a45\u52d5\u7684\u71df\u990a\u8abf\u7bc0\u63d0\u9ad8\u4e86\u7cbe\u78ba\u5ea6\uff0c\u65e8\u5728\u5f15\u767c ATP \u5371\u6a5f\u4e26\u524a\u5f31\u764c\u7d30\u80de\u3002\u6587\u4ef6\u8072\u7a31\u816b\u7624\u8461\u8404\u7cd6\u651d\u53d6\u6e1b\u5c11\u4e86 82%\uff0c\u8840\u6f3f\u9ea9\u91af\u80fa\u9178\u6e1b\u5c11\u4e86 79%\uff0c\u819c\u78f7\u8102\u5408\u6210\u6e1b\u5c11\u4e86 91%\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u7814\u7a76\uff0c\u4f8b\u5982 <a href=\"https:\/\/www.nature.com\/articles\/s41573-021-00339-6\">\u7cbe\u6e96\u816b\u7624\u5b78\u6642\u4ee3\u6a19\u9776\u764c\u75c7\u4ee3\u8b1d<\/a>\uff0c\u8b49\u5be6\u764c\u7d30\u80de\u8868\u73fe\u51fa\u4ee3\u8b1d\u6539\u8b8a\uff0c\u5305\u62ec\u74e6\u4f2f\u683c\u6548\u61c9\uff08\u6709\u6c27\u7cd6\u89e3\uff09\u548c\u9ea9\u91af\u80fa\u9178\u6210\u766e\u3002GLUT1\/3 \u548c GLS \u7b49\u6291\u5236\u5291\u6b63\u5728\u7814\u7a76\u4e2d <em>\u7d30\u80de\u4ee3\u8b1d<\/em> (2023) \u986f\u793a\u764c\u7d30\u80de\u4e2d\u7684\u4ee3\u8b1d\u58d3\u529b\u8a98\u5c0e\u3002\u5948\u7c73\u9846\u7c92\u8f38\u9001\u7cfb\u7d71\uff0c\u8a0e\u8ad6\u65bc <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590183420300028\">\u764c\u75c7\u6cbb\u7642\u4e2d\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u8f38\u9001<\/a>\uff0c\u589e\u5f37\u7279\u7570\u6027\uff0c\u5118\u7ba1\u816b\u7624\u7570\u8cea\u6027\u548c\u812b\u9776\u6548\u61c9\u7b49\u6311\u6230\u4ecd\u7136\u5b58\u5728\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u6240\u8072\u7a31\u7684\u81e8\u5e8a\u76ca\u8655\u8207\u65b0\u8208\u8a66\u9a57\u4e00\u81f4\uff0c\u4f46\u764c\u75c7\u985e\u578b\uff08\u4f8b\u5982\u80ba\u764c\u8207\u4e73\u764c\uff09\u548c\u60a3\u8005\u53cd\u61c9\u7684\u5dee\u7570\u8868\u660e\u9700\u8981\u500b\u6027\u5316\u7684\u65b9\u6cd5\u30022024\u5e74 <em>\u7d30\u80de<\/em> \u6587\u4ef6\u4e2d\u5f15\u7528\u7684\u7814\u7a76\u8072\u7a31\u6297\u85e5\u6027\u57fa\u56e0\u8868\u73fe\u6e1b\u5c11\u4e86 80%\uff0c\u9700\u8981\u900f\u904e\u66f4\u5927\u898f\u6a21\u7684\u591a\u4e2d\u5fc3\u8a66\u9a57\u9032\u884c\u9a57\u8b49\u3002\u502b\u7406\u65b9\u9762\u7684\u8003\u616e\uff0c\u4f8b\u5982\u7372\u53d6\u548c\u8ca0\u64d4\u80fd\u529b\uff0c\u5728 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2949723X23000533\">\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u50b3\u8f38\u7cfb\u7d71\u7684\u529f\u6548\u56de\u9867<\/a>.<\/p>\n<h3>\u7bc0\u594f\u6027\u816b\u7624\u63a7\u5236<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528\u4f4e\u5291\u91cf\u3001\u7bc0\u5f8b\u5316\u7642\uff08\u50b3\u7d71\u5291\u91cf\u7684 1\/10\uff09\u548c\u8840\u7ba1\u6b63\u5e38\u5316\u56e0\u5b50\u4f86\u63a7\u5236\u816b\u7624\u751f\u9577\uff0c\u964d\u4f4e\u6bd2\u6027\u4e26\u5be6\u73fe 67% \u7684\u5bb6\u5ead\u6cbb\u7642\u3002\u64da\u8072\u7a31\uff0c\u5b83\u5c07\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u5f9e 5.2 \u500b\u6708\u5ef6\u9577\u81f3 11.8 \u500b\u6708\uff0c\u4e26\u5c07\u56b4\u91cd\u6bd2\u6027\u964d\u4f4e 67%\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u4f4e\u5291\u91cf\u7bc0\u5f8b\u5316\u7642\u5df2\u88ab\u5ee3\u6cdb\u63a5\u53d7\uff0c\u5982 <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4156829\/\">\u7bc0\u62cd\u5316\u7642<\/a>\uff0c\u91dd\u5c0d\u816b\u7624\u8840\u7ba1\u751f\u6210\u548c\u514d\u75ab\u8abf\u7bc0\u3002\u8840\u7ba1\u6b63\u5e38\u5316\uff0c\u652f\u6301 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405844024007011\">\u7bc0\u62cd\u5316\u7642\u548c\u85e5\u7269\u518d\u5229\u7528<\/a>\uff0c\u900f\u904e\u589e\u5f37\u8840\u7ba1\u529f\u80fd\u4f86\u6539\u5584\u85e5\u7269\u8f38\u9001\u3002\u7814\u7a76\u5982 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0959804913005418\">\u4f4e\u5291\u91cf\u7bc0\u62cd\u5316\u7642\uff1a\u7cfb\u7d71\u6027\u6587\u737b\u5206\u6790<\/a> \u78ba\u8a8d\u6e1b\u5c11\u7684\u526f\u4f5c\u7528\u548c\u6f5b\u5728\u7684\u6210\u672c\u6548\u76ca\uff0c\u7279\u5225\u662f\u5728\u4f4e\u6536\u5165\u74b0\u5883\u4e2d\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684\u76ca\u8655\u8207\u8f49\u79fb\u6027\u4e73\u764c\u7684\u81e8\u5e8a\u6578\u64da\u4e00\u81f4\uff0c\u4f46\u7642\u6548\u53ef\u80fd\u56e0\u816b\u7624\u985e\u578b\u548c\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u800c\u7570\u3002\u5bb6\u5ead\u6cbb\u7642\u6a21\u5f0f\u96d6\u7136\u6709\u5e0c\u671b\uff0c\u4f46\u9700\u8981\u5805\u6301\u548c\u76e3\u6e2c\uff0c\u5982 <a href=\"https:\/\/www.lifespringcancercenter.com\/our-treatment\/low-dose-metronomic-chemotherapy\">\u751f\u547d\u6cc9\u764c\u75c7\u6cbb\u7642\u4e2d\u5fc3<\/a>\u3002\u95dc\u65bc\u6297\u85e5\u6027\u548c\u751f\u6d3b\u8cea\u7d20\u7684\u9577\u671f\u6578\u64da\u9700\u8981\u9032\u4e00\u6b65\u63a2\u7d22\u3002<\/p>\n<h3>\u57fa\u56e0\u6a19\u9776\u65ac\u9996<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528\u6db2\u9ad4\u6d3b\u6aa2\u4f86\u6aa2\u6e2c 487 \u500b\u764c\u75c7\u9a45\u52d5\u57fa\u56e0\uff0c\u4e26\u4f7f\u7528\u5948\u7c73\u9846\u7c92\u905e\u9001\u7cfb\u7d71\u4f86\u9776\u5411 KRAS\u3001BRAF \u548c TP53 \u7b49\u7a81\u8b8a\uff0c\u5f9e\u800c\u514b\u670d\u8840\u8166\u5c4f\u969c\u7b49\u969c\u7919\u3002\u5b83\u8072\u7a31 ORR \u63d0\u9ad8\u4e86 67%\uff0c\u905e\u9001\u6548\u7387\u63d0\u9ad8\u4e86 9 \u500d\uff0c\u7279\u5225\u662f\u5c0d\u65bc\u8f49\u79fb\u7624\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u5948\u7c73\u9846\u7c92\u8f38\u9001\u662f\u4e00\u500b\u524d\u6cbf\u9818\u57df\uff0c <a href=\"https:\/\/www.cancer.gov\/nano\/cancer-nanotechnology\/treatment\">\u5948\u7c73\u6280\u8853\u764c\u75c7\u6cbb\u7642\u548c\u6cbb\u7642<\/a> \u5f37\u8abf\u5176\u7a7f\u900f\u751f\u7406\u5c4f\u969c\u7684\u80fd\u529b\u3002\u6db2\u9ad4\u6d3b\u6aa2\uff0c\u8a0e\u8ad6\u65bc <a href=\"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03433-8\">\u63a8\u9032\u764c\u75c7\u57fa\u56e0\u6cbb\u7642<\/a>\uff0c\u5be6\u73fe\u5373\u6642\u7a81\u8b8a\u6aa2\u6e2c\uff0c\u8207\u7cbe\u6e96\u816b\u7624\u5b78\u8da8\u52e2\u4fdd\u6301\u4e00\u81f4\u3002\u7814\u7a76\u65bc <a href=\"https:\/\/www.nature.com\/articles\/s41392-023-01642-x\">\u7528\u65bc\u764c\u75c7\u6cbb\u7642\u7684\u667a\u6167\u5948\u7c73\u9846\u7c92<\/a> \u5118\u7ba1\u6bd2\u6027\u548c\u9776\u5411\u7279\u7570\u6027\u7b49\u6311\u6230\u4ecd\u7136\u5b58\u5728\uff0c\u4f46\u5b83\u986f\u793a\u51fa\u6cbb\u7642\u8166\u8f49\u79fb\u7684\u5e0c\u671b\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684 ORR \u70ba 67% \u662f\u96c4\u5fc3\u52c3\u52c3\u7684\uff0c\u96d6\u7136\u65e9\u671f\u8a66\u9a57\u986f\u793a\u51fa\u5e0c\u671b\uff0c\u4f46\u9700\u8981\u66f4\u5927\u898f\u6a21\u7684\u7814\u7a76\u4f86\u9a57\u8b49\u8de8\u816b\u7624\u985e\u578b\u7684\u7642\u6548\u3002\u816b\u7624\u7570\u8cea\u6027\uff0c\u5982\u4e2d\u6240\u8ff0 <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-023-01865-0\">\u9032\u6b65\u5948\u7c73\u6280\u8853\u4ee5\u6539\u5584\u6a19\u9776\u764c\u75c7\u6cbb\u7642<\/a>\uff0c\u53ef\u80fd\u6703\u9650\u88fd\u6210\u529f\uff0c\u9700\u8981\u7d44\u5408\u7b56\u7565\u3002<\/p>\n<h3>\u514d\u75ab\u98a8\u66b4\u555f\u52d5<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528 PD-1\/CTLA-4 \u6291\u5236\u5291\u3001\u65b0\u6297\u539f\u75ab\u82d7\u3001CAR-NK \u7d30\u80de\u548c\u5fae\u751f\u7269\u7d44\u8abf\u7bc0\u4f86\u6d3b\u5316\u591a\u5c64\u514d\u75ab\u53cd\u61c9\u3002\u5b83\u8072\u7a31 3 \u5e74\u5b58\u6d3b\u7387\u70ba 62.7%\uff08\u6539\u5584\u4e86 244%\uff09\uff0c\u5fa9\u767c\u7387\u964d\u4f4e\u4e86 85%\uff0c\u5c07\u300c\u51b7\u300d\u816b\u7624\u8f49\u8b8a\u70ba\u300c\u71b1\u300d\u816b\u7624\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u806f\u5408\u514d\u75ab\u7642\u6cd5\u662f\u9818\u5148\u9818\u57df\uff0c <a href=\"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-021-01164-5\">\u6700\u5927\u5316\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u76ca\u8655\u7684\u7d44\u5408\u7b56\u7565<\/a> \u986f\u793a\u51fa\u589e\u5f37\u7684\u53cd\u61c9\u3002\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u3001\u65b0\u6297\u539f\u75ab\u82d7\u548c CAR-T\/NK \u7642\u6cd5\uff0c\u53c3\u898b <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-025-02305-x\">\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u7684\u9032\u5c55<\/a>\u3001\u63d0\u9ad8\u514d\u75ab\u8fa8\u8b58\u80fd\u529b\u3002\u5fae\u751f\u7269\u7d44\u8abf\u7bc0\uff0c\u7a81\u51fa\u986f\u793a\u65bc <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-021-01316-8\">\u764c\u75c7\u4ee3\u8b1d\u91cd\u7de8\u7a0b\u548c\u514d\u75ab\u53cd\u61c9<\/a>\uff0c\u5f71\u97ff\u514d\u75ab\u6cbb\u7642\u7684\u7d50\u679c\uff0c\u5118\u7ba1\u5176\u4e00\u81f4\u6027\u6709\u722d\u8b70\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684\u751f\u5b58\u7387\u8207\u6700\u8fd1\u7684\u8a66\u9a57\u4e00\u81f4\uff0c\u4f46\u5be6\u9ad4\u7624\u7531\u65bc\u7570\u8cea\u6027\u548c\u514d\u75ab\u6291\u5236\u5fae\u74b0\u5883\u800c\u5e36\u4f86\u6311\u6230\uff0c\u5982 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u6700\u65b0\u9032\u5c55<\/a>\u3002\u95dc\u65bc\u5fa9\u767c\u548c\u514d\u75ab\u8a18\u61b6\u7684\u9577\u671f\u6578\u64da\u9700\u8981\u9032\u4e00\u6b65\u9a57\u8b49\u3002<\/p>\n<h3>\u6bd4\u8f03\u81e8\u5e8a\u7d50\u679c<\/h3>\n<p>\u9019\u4e9b\u6587\u4ef6\u63d0\u4f9b\u4e86\u4e00\u500b\u6bd4\u8f03\u50b3\u7d71\u7642\u6cd5\u548c\u56db\u7dad\u7642\u6cd5\u7684\u8868\u683c\uff0c\u70ba\u6e05\u695a\u8d77\u898b\uff0c\u5c07\u5176\u8907\u88fd\u5982\u4e0b\uff1a<\/p>\n<figure>\n<table class=\"has-fixed-layout\">\n<tbody>\n<tr>\n<td>\u6307\u6a19<\/td>\n<td>\u50b3\u7d71\u7684<br \/>\u6cbb\u7642<\/td>\n<td>\u56db\u7dad<br \/>\u6cbb\u7642<\/td>\n<td>\u6539\u9032<\/td>\n<\/tr>\n<tr>\n<td>\u5ba2\u89c0\u7de9\u89e3\u7387 (ORR)<\/td>\n<td>31%<\/td>\n<td>67%<\/td>\n<td>\u2191116%<\/td>\n<\/tr>\n<tr>\n<td>3 \u5e74\u5b58\u6d3b\u7387<\/td>\n<td>18%<\/td>\n<td>62.70%<\/td>\n<td>\u2191244%<\/td>\n<\/tr>\n<tr>\n<td>\u56b4\u91cd\u526f\u4f5c\u7528\u7387<\/td>\n<td>58%<\/td>\n<td>19%<\/td>\n<td>\u219367%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\u8868\u683c\u5f37\u8abf\u4e86\u8a72\u7642\u6cd5\u7684\u6f5b\u529b\uff0c\u4f46\u60a3\u8005\u7fa4\u9ad4\u548c\u816b\u7624\u985e\u578b\u4e4b\u9593\u7684\u5dee\u7570\u503c\u5f97\u9032\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n<h2><strong>\u7e3d\u7d50<\/strong><\/h2>\n<p>4D \u7642\u6cd5\u6574\u5408\u4e86\u89e3\u6c7a\u764c\u75c7\u8907\u96dc\u6027\u7684\u5c16\u7aef\u7b56\u7565\uff0c\u6bcf\u7a2e\u65b9\u6cd5\u90fd\u5f97\u5230\u65b0\u8208\u7814\u7a76\u7684\u652f\u6301\u3002\u7136\u800c\uff0c\u816b\u7624\u7570\u8cea\u6027\u3001\u81e8\u5e8a\u9a57\u8b49\u548c\u53ef\u8fd1\u6027\u7b49\u6311\u6230\u9700\u8981\u4e0d\u65b7\u63a2\u7d22\u3002\u5efa\u8b70\u7684\u53e3\u865f\u548c\u53e3\u865f\u65e8\u5728\u9ad4\u73fe\u8a72\u7642\u6cd5\u7684\u627f\u8afe\uff0c\u4e26\u5f15\u767c\u5c0d\u5176\u6539\u8b8a\u764c\u75c7\u6cbb\u7642\u6f5b\u529b\u7684\u9032\u4e00\u6b65\u8a0e\u8ad6\u3002<\/p>\n<h2>\u53c3\u8003\u6587\u737b<\/h2>\n<ul>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41573-021-00339-6\">\u7cbe\u6e96\u816b\u7624\u5b78\u6642\u4ee3\u6a19\u9776\u764c\u75c7\u4ee3\u8b1d<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590183420300028\">\u764c\u75c7\u6cbb\u7642\u4e2d\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u8f38\u9001<\/a><\/li>\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4156829\/\">\u7bc0\u62cd\u5316\u7642<\/a><\/li>\n<li><a href=\"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03433-8\">\u63a8\u9032\u764c\u75c7\u57fa\u56e0\u6cbb\u7642<\/a><\/li>\n<li><a href=\"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-021-01164-5\">\u6700\u5927\u5316\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u76ca\u8655\u7684\u7d44\u5408\u7b56\u7565<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u6700\u65b0\u9032\u5c55<\/a><\/li>\n<li><a href=\"https:\/\/www.cancer.gov\/nano\/cancer-nanotechnology\/treatment\">\u5948\u7c73\u6280\u8853\u764c\u75c7\u6cbb\u7642\u548c\u6cbb\u7642<\/a><\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41392-023-01642-x\">\u7528\u65bc\u764c\u75c7\u6cbb\u7642\u7684\u667a\u6167\u5948\u7c73\u9846\u7c92<\/a><\/li>\n<li><a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-021-01316-8\">\u764c\u75c7\u4ee3\u8b1d\u91cd\u7de8\u7a0b\u548c\u514d\u75ab\u53cd\u61c9<\/a><\/li>\n<li><a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-025-02305-x\">\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u7684\u9032\u5c55<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405844024007011\">\u7bc0\u62cd\u5316\u7642\u548c\u85e5\u7269\u518d\u5229\u7528<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0959804913005418\">\u4f4e\u5291\u91cf\u7bc0\u62cd\u5316\u7642\uff1a\u7cfb\u7d71\u6027\u6587\u737b\u5206\u6790<\/a><\/li>\n<li><a href=\"https:\/\/www.lifespringcancer.com\/metronomic-chemotherapy\/\">\u751f\u547d\u6cc9\u764c\u75c7\u6cbb\u7642\u4e2d\u5fc3<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u50b3\u8f38\u7cfb\u7d71\u7684\u529f\u6548\u56de\u9867<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u9032\u6b65\u5948\u7c73\u6280\u8853\u4ee5\u6539\u5584\u6a19\u9776\u764c\u75c7\u6cbb\u7642<\/a><\/li>\n<\/ul>\n<hr>\n<div class=\"ac-blog-cta\">\n<h2>\u9700\u8981\u5354\u52a9\u4e86\u89e3\u6cbb\u7642\u9078\u64c7\uff1f<\/h2>\n<p>\u6211\u5011\u7684\u60a3\u8005\u670d\u52d9\u5718\u968a\u53ef\u4ee5\u5e6b\u52a9\u60a8\u6e96\u5099\u5831\u544a\u4e26\u5b89\u6392\u9069\u7576\u7684\u5c08\u5bb6\u8aee\u8a62\u3002\u672c\u6587\u662f\u4e00\u822c\u8a0a\u606f\uff0c\u800c\u4e0d\u662f\u8a3a\u65b7\u3002<\/p>\n<p><a href=\"\/zh-hk\/appointment\/\">\u7acb\u5373\u9810\u7d04<\/a> &nbsp;|&nbsp; <a href=\"\/zh-hk\/cancer\/\">\u63a2\u7d22\u6240\u6709\u764c\u75c7\u985e\u578b<\/a><\/p>\n<\/div>\n<p class=\"ac-blog-disclaimer\"><em>\u91ab\u7642\u514d\u8cac\u8072\u660e\uff1a\u672c\u6587\u50c5\u7528\u65bc\u4e00\u822c\u6559\u80b2\uff0c\u4e0d\u80fd\u53d6\u4ee3\u5408\u683c\u81e8\u5e8a\u91ab\u751f\u7684\u5efa\u8b70\u3002\u6cbb\u7642\u6c7a\u5b9a\u61c9\u57fa\u65bc\u500b\u4eba\u7684\u8a3a\u65b7\u3001\u5206\u671f\u3001\u75c5\u7406\u548c\u6574\u9ad4\u5065\u5eb7\u72c0\u6cc1\u3002\u5982\u679c\u60a8\u767c\u73fe\u6301\u7e8c\u6216\u4ee4\u4eba\u64d4\u6182\u7684\u75c7\u72c0\uff0c\u8acb\u5c0b\u6c42\u91ab\u7642\u8a55\u4f30\u3002<\/em><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u8179\u819c\u5047\u6027\u9ecf\u6db2\u7624 (PMP) 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