{"id":433,"date":"2026-03-12T09:00:00","date_gmt":"2026-03-12T09:00:00","guid":{"rendered":"https:\/\/cntumour.com\/cancer\/chronic-lymphocytic-leukemia-cll-cancer-types\/"},"modified":"2026-10-29T15:53:26","modified_gmt":"2026-10-29T15:53:26","slug":"chronic-lymphocytic-leukemia-cll-cancer-types","status":"publish","type":"cancer_type","link":"https:\/\/cntumour.com\/zh-hk\/cancer\/chronic-lymphocytic-leukemia-cll-cancer-types\/","title":{"rendered":"\u6162\u6027\u6dcb\u5df4\u6027\u767d\u8840\u75c5\uff08CLL\uff09"},"content":{"rendered":"<div class=\"ac-blog-article\">\n<p class=\"ac-blog-lead\"><strong>\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5 (CLL) \u662f\u4e00\u7a2e\u900f\u904e\u7522\u751f\u904e\u91cf\u7570\u5e38\u6dcb\u5df4\u7d30\u80de\uff08\u767d\u8840\u7403\u7684\u4e00\u7a2e\u4e9e\u578b\uff09\u4f86\u5f71\u97ff\u8840\u6db2\u548c\u9aa8\u9ad3\u7684\u764c\u75c7\u3002\u9019\u4e9b\u764c\u6027\u6dcb\u5df4\u7403\u7de9\u6162\u7a4d\u7d2f\uff0c\u9010\u6f38\u5f71\u97ff\u8eab\u9ad4\u6709\u6548\u62b5\u6297\u611f\u67d3\u7684\u80fd\u529b\u3002<\/strong><\/p>\n<nav class=\"ac-blog-toc\" aria-label=\"\u672c\u6587\u5c0e\u89bd\">\n<p><strong>\u672c\u6587\u5c0e\u89bd<\/strong><\/p>\n<ul>\n<li><a href=\"#what-is-chronic-lymphocytic-leukemia-cll\">\u4ec0\u9ebc\u662f\u6162\u6027\u6dcb\u5df4\u6027\u767d\u8840\u75c5\uff08CLL\uff09\uff1f<\/a><\/li>\n<li><a href=\"#causes-and-risk-factors-of-chronic-lymphocytic-leukemia-cll\">\u6162\u6027\u6dcb\u5df4\u7403\u767d\u8840\u75c5 (CLL) \u7684\u75c5\u56e0\u548c\u98a8\u96aa\u56e0\u7d20<\/a><\/li>\n<li><a href=\"#symptoms-of-chronic-lymphocytic-leukemia-cll\">\u6162\u6027\u6dcb\u5df4\u7403\u767d\u8840\u75c5 (CLL) \u7684\u75c7\u72c0<\/a><\/li>\n<li><a href=\"#stages-of-chronic-lymphocytic-leukemia-cll-and-survival-rates\">\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5 (CLL) \u7684\u968e\u6bb5\u548c\u751f\u5b58\u7387<\/a><\/li>\n<li><a href=\"#treatment-options-for-chronic-lymphocytic-leukemia-cll\">\u6162\u6027\u6dcb\u5df4\u7403\u767d\u8840\u75c5 (CLL) \u7684\u6cbb\u7642\u9078\u64c7<\/a><\/li>\n<li><a href=\"#limitations-of-traditional-therapies-for-chronic-lymphocytic-leukemia-cll\">\u6162\u6027\u6dcb\u5df4\u7403\u767d\u8840\u75c5 (CLL) \u50b3\u7d71\u7642\u6cd5\u7684\u5c40\u9650\u6027<\/a><\/li>\n<\/ul>\n<\/nav>\n<h2 id=\"what-is-chronic-lymphocytic-leukemia-cll\">What Is Chronic Lymphocytic Leukemia (CLL)?<\/h2>\n<p>\u5728\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5 (CLL) \u4e2d\u89c0\u5bdf\u5230\u7684\u6700\u986f\u8457\u7684\u4ee3\u8b1d\u7279\u5fb5\u662f Warburg \u6548\u61c9\u3002\u5728\u9019\u7a2e\u60c5\u6cc1\u4e0b\uff0c\u764c\u7d30\u80de\u6d88\u8017\u8461\u8404\u7cd6\u7684\u901f\u5ea6\u662f\u6b63\u5e38\u7d30\u80de\u7684 200 \u500d\u3002\u9019\u7a2e\u73fe\u8c61\u5c0e\u81f4\u5feb\u901f\u751f\u9577\u548c\u589e\u6b96\uff0c\u4f7f\u6a19\u9776\u4ee3\u8b1d\u6cbb\u7642\u6210\u70ba\u6700\u4f73\u6cbb\u7642\u65b9\u6cd5\u3002<\/p>\n<h3 id=\"understanding-chronic-lymphocytic-leukemia-cll-biology\">\u4e86\u89e3\u6162\u6027\u6dcb\u5df4\u7403\u767d\u8840\u75c5 (CLL) \u751f\u7269\u5b78<\/h3>\n<p>\u5728\u6b63\u5e38\u60c5\u6cc1\u4e0b\uff0c\u6dcb\u5df4\u7403\u6709\u52a9\u65bc\u62b5\u6297\u611f\u67d3\u4e26\u589e\u5f37\u514d\u75ab\u529b\u3002\u7136\u800c\uff0c\u5728\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5 (CLL) \u7684\u60c5\u6cc1\u4e0b\uff0c\u9019\u4e9b\u60e1\u6027\u6dcb\u5df4\u7d30\u80de\u6703\u5931\u53bb\u5176\u529f\u80fd\u4e26\u958b\u59cb\u4e0d\u53d7\u63a7\u5236\u5730\u7d2f\u7a4d\u3002\u56e0\u6b64\uff0c\u7531\u65bc\u8840\u6db2\u548c\u9aa8\u9ad3\u4e2d\u7684\u7a7a\u9593\u548c\u8cc7\u6e90\u6709\u9650\uff0c\u5065\u5eb7\u7684\u7d05\u8840\u7403\u3001\u8840\u5c0f\u677f\u548c\u5176\u4ed6\u767d\u8840\u7403\u8b8a\u5f97\u8655\u65bc\u4e0d\u5229\u5730\u4f4d\u3002<\/p>\n<ul>\n<li>\u5feb\u901f\u7684\u8461\u8404\u7cd6\u651d\u53d6\u548c\u4ee3\u8b1d\u70ba CLL \u764c\u7d30\u80de\u63d0\u4f9b\u80fd\u91cf\uff08\u74e6\u723e\u5821\u6548\u61c9\uff09\u3002<\/li>\n<li>\u4e0d\u53d7\u9650\u5236\u7684\u8907\u88fd\u5c0e\u81f4\u9aa8\u9ad3\u548c\u6dcb\u5df4\u7d44\u7e54\u904e\u5ea6\u64c1\u64e0\u3002<\/li>\n<li>\u529f\u80fd\u6027\u514d\u75ab\u53cd\u61c9\u6e1b\u5f31\uff0c\u589e\u52a0\u4e86\u611f\u67d3\u7684\u53ef\u80fd\u6027\u3002<\/li>\n<\/ul>\n<h3 id=\"epidemiology-and-regional-trends\">\u6d41\u884c\u75c5\u5b78\u548c\u5340\u57df\u8da8\u52e2<\/h3>\n<p>\u5728\u5168\u7403\u7bc4\u570d\u5167\uff0c\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5 (CLL) \u986f\u8457\u589e\u52a0\u4e86\u767d\u8840\u75c5\u8ca0\u64d4\uff0c\u7279\u5225\u662f\u5728\u8001\u5e74\u4eba\u4e2d\u3002\u6839\u64da\u4e16\u754c\u885b\u751f\u7d44\u7e54 2024 \u5e74\u6307\u5357\uff0c\u5168\u7403\u6bcf\u5e74\u8a3a\u65b7\u51fa\u7d04 21,000 \u4f8b\u65b0\u75c5\u4f8b\u3002CLL \u4e3b\u8981\u5f71\u97ff 60 \u6b72\u4ee5\u4e0a\u7684\u6210\u5e74\u4eba\uff0c\u96a8\u8457\u5e74\u9f61\u7684\u589e\u9577\uff0cCLL \u7684\u767c\u751f\u7387\u9010\u6f38\u4e0a\u5347\uff0c\u5f88\u5c11\u898b\u65bc\u5e74\u8f15\u4eba\u6216\u5152\u7ae5\u3002<\/p>\n<p>\u5728\u4e9e\u6d32\uff0c\u5305\u62ec\u9999\u6e2f\uff0cCLL\u767c\u75c5\u7387\u76f8\u5c0d\u4f4e\u65bc\u897f\u65b9\u570b\u5bb6\uff1b\u7136\u800c\uff0c\u8fd1\u5e74\u4f86\uff0c\u8001\u5e74\u4eba\u7684\u6578\u91cf\u7565\u6709\u589e\u52a0\uff0c\u9019\u51f8\u986f\u4e86\u4eba\u5011\u65e5\u76ca\u9700\u8981\u63d0\u9ad8\u8a8d\u8b58\uff0c\u7279\u5225\u662f\u96a8\u8457\u4e9e\u6d32\u4eba\u53e3\u8fc5\u901f\u8001\u5316\u3002<\/p>\n<ul>\n<li>\u7537\u6027\u76db\u884c\u7387\u9ad8\u65bc\u5973\u6027\uff08\u7537\u5973\u6bd4\u4f8b\u7d04 2:1\uff09\u3002<\/li>\n<li>\u4e3b\u8981\u5f71\u97ff\u8001\u5e74\u4eba\u7fa4\uff0c\u7279\u5225\u662f 60 \u6b72\u53ca\u4ee5\u4e0a\u7684\u4eba\u3002<\/li>\n<li>\u4e9e\u6d32\u5730\u5340\uff08\u5c24\u5176\u662f\u9999\u6e2f\uff09\u75c5\u4f8b\u7684\u589e\u52a0\u8207\u4e2d\u4f4d\u6578\u5e74\u9f61\u548c\u4eba\u53e3\u8001\u5316\u7684\u589e\u52a0\u6709\u95dc\u3002<\/li>\n<\/ul>\n<h3 id=\"emotional-physical-impact-of-cll\">CLL \u5c0d\u60c5\u7dd2\u548c\u8eab\u9ad4\u7684\u5f71\u97ff<\/h3>\n<p>\u6162\u6027\u6dcb\u5df4\u7403\u767d\u8840\u75c5 (CLL) \u6703\u51fa\u73fe\u9010\u6f38\u51fa\u73fe\u7684\u75c7\u72c0\uff0c\u4f46\u6700\u521d\u5f80\u5f80\u672a\u88ab\u6ce8\u610f\u5230\u3002\u96a8\u8457\u6642\u9593\u7684\u63a8\u79fb\uff0c\u4eba\u5011\u901a\u5e38\u6703\u7d93\u6b77\uff1a<\/p>\n<ul>\n<li>\u6301\u7e8c\u75b2\u52de\u6216\u75b2\u618a<\/li>\n<li>\u6dcb\u5df4\u7d50\u816b\u5927\uff0c\u901a\u5e38\u7121\u75db\u4f46\u660e\u986f<\/li>\n<li>\u514d\u75ab\u529b\u4e0b\u964d\u5c0e\u81f4\u53cd\u8986\u611f\u67d3<\/li>\n<li>\u9ad4\u91cd\u6e1b\u8f15\u3001\u76dc\u6c57\uff0c\u5076\u723e\u767c\u71d2<\/li>\n<li>\u7531\u65bc\u8a3a\u65b7\u4e0d\u78ba\u5b9a\u6027\u548c\u9577\u671f\u7ba1\u7406\u6311\u6230\u800c\u5f15\u8d77\u7684\u60c5\u7dd2\u56f0\u64fe\u3001\u7126\u616e\u6216\u6182\u9b31<\/li>\n<\/ul>\n<p>\u9019\u4e9b\u5f71\u97ff\u51f8\u986f\u4e86\u540c\u7406\u5fc3\u7684\u81e8\u5e8a\u652f\u6301\u3001\u75c5\u4eba\u53cb\u5584\u7684\u6cbb\u7642\u65b9\u6848\u548c\u5fc3\u7406\u4ecb\u5165\u7684\u91cd\u8981\u6027\u3002<\/p>\n<p>\u900f\u904e\u8a2a\u554f\u6211\u5011\u7684\u5c08\u9580\u7db2\u7ad9\u4ee5\u4e86\u89e3\u6709\u95dc\u764c\u75c7\u751f\u7269\u5b78\u7684\u66f4\u591a\u8cc7\u8a0a <a href=\"\/zh-hk\/treatment-cancer\/\">\u764c\u75c7\u751f\u7269\u5b78\u548c\u4ee3\u8b1d<\/a> \u6559\u80b2\u9801\u9762\uff0c\u6216\u5728\u4ee5\u4e0b\u4f4d\u7f6e\u767c\u73fe\u6211\u5011\u7684\u5275\u65b0\u8a3a\u65b7\u89e3\u6c7a\u65b9\u6848 <a href=\"\/zh-hk\/our-hospital\/\">\u8a3a\u65b7\u4e2d\u5fc3<\/a>.<\/p>\n<h2 id=\"causes-and-risk-factors-of-chronic-lymphocytic-leukemia-cll\">\u6162\u6027\u6dcb\u5df4\u7403\u767d\u8840\u75c5 (CLL) \u7684\u75c5\u56e0\u548c\u98a8\u96aa\u56e0\u7d20<\/h2>\n<h3 id=\"genetic-molecular-factors-linked-to-cll\">\u8207 CLL \u76f8\u95dc\u7684\u907a\u50b3\u548c\u5206\u5b50\u56e0\u7d20<\/h3>\n<p>\u5df2\u767c\u73fe\u591a\u7a2e\u57fa\u56e0\u7a81\u8b8a\u548c\u67d3\u8272\u9ad4\u6539\u8b8a\u8207\u6162\u6027\u6dcb\u5df4\u7403\u767d\u8840\u75c5\uff08CLL\uff09\u6709\u95dc\u3002\u503c\u5f97\u6ce8\u610f\u7684\u907a\u50b3\u6a19\u8a18\u5305\u62ec\uff1a<\/p>\n<ul>\n<li>13q \u67d3\u8272\u9ad4\u7f3a\u5931\uff08\u901a\u5e38\u8207\u75be\u75c5\u9032\u5c55\u8f03\u6162\u6709\u95dc\uff09\u3002<\/li>\n<li>17p \u67d3\u8272\u9ad4\u7f3a\u5931\uff08\u901a\u5e38\u8207\u4fb5\u8972\u6027\u75be\u75c5\u6709\u95dc\uff09\u3002<\/li>\n<li>TP53\u57fa\u56e0\u7a81\u8b8a\uff0c\u8207\u6297\u85e5\u6027\u548c\u4e0d\u826f\u9810\u5f8c\u6709\u95dc\u3002<\/li>\n<li>IgVH \u7a81\u8b8a\u986f\u793a\u75be\u75c5\u9032\u5c55\u7684\u9810\u5f8c\u5dee\u7570\u3002<\/li>\n<\/ul>\n<h3 id=\"metabolic-vulnerabilities-and-therapeutic-opportunities\">\u4ee3\u8b1d\u8106\u5f31\u6027\u8207\u6cbb\u7642\u6a5f\u6703<\/h3>\n<p>\u764c\u7d30\u80de\u4ee3\u8b1d\u4f9d\u8cf4\u6027\uff0c\u4f8b\u5982\u5c0d\u8461\u8404\u7cd6\u548c\u6709\u6642\u8c37\u6c28\u9170\u80fa\u4ee3\u8b1d\u9014\u5f91\u7684\u4f9d\u8cf4\u6027\u589e\u52a0\uff0c\u4ee3\u8868\u4e86\u53ef\u91dd\u5c0d\u7684\u5f31\u9ede\u3002\u5927\u7d04 50% \u7684\u764c\u7d30\u80de\u986f\u8457\u4f9d\u8cf4\u9ea9\u91af\u80fa\u9178\u9032\u884c\u6838\u82f7\u9178\u5408\u6210\uff1a<\/p>\n<ul>\n<li>\u91dd\u5c0d\u8461\u8404\u7cd6\u4ee3\u8b1d\u9014\u5f91\uff08\u83ef\u4f2f\u683c\u6548\u61c9\uff09\u53ef\u4ee5\u7834\u58de\u764c\u7d30\u80de\u7684\u80fd\u91cf\u4f86\u6e90\u3002<\/li>\n<li>\u6e1b\u5c11\u4ee3\u8b1d\u71c3\u6599\u4f86\u6e90\u7684\u4ee3\u8b1d\u7642\u6cd5\u5728\u81e8\u5e8a\u8a66\u9a57\u4e2d\u986f\u793a\u51fa\u6709\u5e0c\u671b\u7684\u7d50\u679c\u3002<\/li>\n<\/ul>\n<h3 id=\"environmental-and-lifestyle-risk-factors\">\u74b0\u5883\u548c\u751f\u6d3b\u65b9\u5f0f\u98a8\u96aa\u56e0\u7d20<\/h3>\n<p>\u8207\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5 (CLL) \u76f8\u95dc\u7684\u6f5b\u5728\u74b0\u5883\u56e0\u7d20\u5305\u62ec\u9577\u671f\u66b4\u9732\u65bc\u67d0\u4e9b\u5316\u5b78\u7269\u8cea\u548c\u8f3b\u5c04\u6e90\uff1a<\/p>\n<ul>\n<li>\u5316\u5b78\u7269\u8cea\u63a5\u89f8\uff08\u4f8b\u5982\u82ef\u3001\u8fb2\u696d\u6bba\u87f2\u5291\uff09\u3002<\/li>\n<li>\u96fb\u96e2\u8f3b\u5c04\u3002<\/li>\n<li>\u751f\u6d3b\u65b9\u5f0f\u56e0\u7d20\uff0c\u4f8b\u5982\u9577\u671f\u5438\u7159\uff0c\u53ef\u80fd\u6703\u7565\u5fae\u589e\u52a0\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\u7684\u98a8\u96aa\u3002<\/li>\n<\/ul>\n<h3 id=\"specific-risks-in-hong-kong-and-asia\">\u9999\u6e2f\u548c\u4e9e\u6d32\u7684\u7279\u5b9a\u98a8\u96aa<\/h3>\n<p>\u5118\u7ba1\u6709\u95dc\u4e9e\u6d32\u7279\u6709\u98a8\u96aa\u7684\u6578\u64da\u6709\u9650\uff0c\u4f46\u4eba\u53e3\u8001\u5316\u9810\u8a08\u5c07\u986f\u8457\u5f71\u97ff\u9999\u6e2f\u53ca\u9130\u8fd1\u5730\u5340\u7684\u767c\u75c5\u7387\u3002\u65e9\u671f\u7be9\u6aa2\u548c\u6700\u4f73\u7684\u8001\u5e74\u7167\u8b77\u662f\u91cd\u8981\u7684\u9810\u9632\u7b56\u7565\u3002\u5728\u9999\u6e2f\uff0c\u4e0d\u65b7\u63d0\u9ad8\u7684\u8a8d\u8b58\u548c\u8001\u5e74\u4eba\u793e\u5340\u6559\u80b2\u63aa\u65bd\u5df2\u8b49\u660e\u5728\u52a0\u5f37\u65e9\u671f\u767c\u73fe\u65b9\u9762\u662f\u6709\u6548\u7684\u3002<\/p>\n<p>\u63a2\u7d22\u4f86\u81ea\u503c\u5f97\u4fe1\u8cf4\u7684\u6b0a\u5a01\u6a5f\u69cb\uff08\u5982\u764c\u75c7\u9810\u9632\u6a5f\u69cb\uff09\u6709\u95dc\u764c\u75c7\u9810\u9632\u548c\u65e9\u671f\u6aa2\u6e2c\u7684\u8a73\u7d30\u8cc7\u6e90 <a href=\"https:\/\/www.who.int\" target=\"_blank\" rel=\"noopener noreferrer\">\u4e16\u754c\u885b\u751f\u7d44\u7e54 (WHO)<\/a> \u548c <a href=\"https:\/\/www.cancer.gov\" target=\"_blank\" rel=\"noopener noreferrer\">\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240<\/a>.<\/p>\n<p>\u4e86\u89e3\u6211\u5011\u9769\u547d\u6027\u7684 4D \u4ee3\u8b1d\u7642\u6cd5\u5982\u4f55\u6539\u8b8a\u6162\u6027\u6dcb\u5df4\u7403\u767d\u8840\u75c5 (CLL) \u7684\u6cbb\u7642\u3002\u7acb\u5373\u5b89\u6392\u8aee\u8a62\uff0c\u8e0f\u51fa\u5148\u9032\u4ee3\u8b1d\u764c\u75c7\u7167\u8b77\u7684\u7b2c\u4e00\u6b65\u3002<\/p>\n<h2 id=\"symptoms-of-chronic-lymphocytic-leukemia-cll\">\u6162\u6027\u6dcb\u5df4\u7403\u767d\u8840\u75c5 (CLL) \u7684\u75c7\u72c0<\/h2>\n<p>\u8a8d\u8b58\u5230 <strong>\u6162\u6027\u6dcb\u5df4\u7403\u767d\u8840\u75c5 (CLL) \u7684\u65e9\u671f\u75c7\u72c0<\/strong> \u53ef\u4ee5\u986f\u8457\u5f71\u97ff\u7d50\u679c\u548c\u6cbb\u7642\u6210\u529f\u3002\u5982\u679c\u9019\u4e9b\u75c7\u72c0\u6301\u7e8c\u5b58\u5728\uff0c\u53ca\u6642\u5c0b\u6c42\u91ab\u7642\u8a55\u4f30\u81f3\u95dc\u91cd\u8981\uff1a<\/p>\n<ul>\n<li><strong>\u75b2\u52de\uff1a<\/strong> \u767d\u8840\u75c5\u7d30\u80de\u6d78\u6f64\u9aa8\u9ad3\uff0c\u5f71\u97ff\u7d05\u8840\u7403\u6578\uff0c\u5c0e\u81f4\u8ca7\u8840\uff0c\u5c0e\u81f4\u6301\u7e8c\u75b2\u5026\u6216\u7cbe\u75b2\u529b\u76e1\u3002<\/li>\n<li><strong>\u6dcb\u5df4\u7d50\u816b\u5927\uff1a<\/strong> \u6dcb\u5df4\u7d50\u816b\u5927\uff0c\u6700\u5e38\u898b\u65bc\u9838\u90e8\u3001\u814b\u7aa9\u6216\u8179\u80a1\u6e9d\u5340\u57df\uff0c\u986f\u793a\u6dcb\u5df4\u7403\u5806\u7a4d\u548c\u75be\u75c5\u9032\u5c55\u3002<\/li>\n<li><strong>\u983b\u7e41\u611f\u67d3\uff1a<\/strong> \u60a3\u8005\u7d93\u5e38\u7d93\u6b77\u53cd\u8986\u611f\u67d3\uff0c\u9019\u8207\u767d\u8840\u75c5\u7d30\u80de\u53d6\u4ee3\u6b63\u5e38\u767d\u8840\u7403\u7e7c\u767c\u7684\u514d\u75ab\u529f\u80fd\u53d7\u640d\u6709\u95dc\u3002<\/li>\n<li><strong>\u76dc\u6c57\uff1a<\/strong> \u591c\u9593\u5927\u91cf\u51fa\u6c57\uff0c\u56b4\u91cd\u5f71\u97ff\u7761\u7720\u8cea\u91cf\uff0c\u901a\u5e38\u8868\u793a\u8207\u764c\u7d30\u80de\u76f8\u95dc\u7684\u5168\u8eab\u767c\u708e\u548c\u4ee3\u8b1d\u4ea2\u9032\u3002<\/li>\n<li><strong>\u7121\u610f\u8b58\u7684\u9ad4\u91cd\u6e1b\u8f15\uff1a<\/strong> \u5728\u4e0d\u6539\u8b8a\u98f2\u98df\u6216\u751f\u6d3b\u65b9\u5f0f\u7684\u60c5\u6cc1\u4e0b\u6e1b\u8f15\u9ad4\u91cd\uff0c\u9019\u662f\u6162\u6027\u60e1\u6027\u75be\u75c5\u4e2d\u7531\u65bc\u5206\u89e3\u4ee3\u8b1d\u589e\u52a0\u548c\u71df\u990a\u4ee3\u8b1d\u6539\u8b8a\u800c\u5e38\u898b\u7684\u5168\u8eab\u6548\u61c9\u3002<\/li>\n<li><strong>\u5bb9\u6613\u7600\u9752\u6216\u51fa\u8840\uff1a<\/strong> \u9aa8\u9ad3\u529f\u80fd\u53d7\u640d\u5c0e\u81f4\u7684\u8840\u5c0f\u677f\u7f3a\u4e4f\u53ef\u8868\u73fe\u70ba\u983b\u7e41\u7600\u50b7\u3001\u8f15\u50b7\u3001\u51fa\u8840\u904e\u591a\u6216\u81ea\u767c\u6027\u51fa\u8840\u3002<\/li>\n<li><strong>\u8179\u90e8\u4e0d\u9069\uff1a<\/strong> \u767d\u8840\u75c5\u7d30\u80de\u6d78\u6f64\u5f15\u8d77\u7684\u813e\u81df\u816b\u5927\u6216\u809d\u816b\u5927\uff0c\u5668\u5b98\u529f\u80fd\u8b8a\u7a84\uff0c\u5c0e\u81f4\u8179\u58d3\u6216\u98fd\u8139\u3002<\/li>\n<li><strong>\u84bc\u767d\uff1a<\/strong> \u76ae\u819a\u84bc\u767d\u53cd\u6620\u8ca7\u8840\u6216\u651c\u6c27\u80fd\u529b\u4e0d\u8db3\uff0c\u8207\u764c\u6027\u6dcb\u5df4\u7403\u7684\u9aa8\u9ad3\u6291\u5236\u6709\u95dc\u3002<\/li>\n<li><strong>\u4f4e\u71d2\uff1a<\/strong> \u6c92\u6709\u660e\u78ba\u611f\u67d3\u539f\u56e0\u7684\u767c\u71d2\u53ef\u80fd\u8868\u793a CLL \u5c0e\u81f4\u514d\u75ab\u7cfb\u7d71\u6539\u8b8a\u3002<\/li>\n<li><strong>\u547c\u5438\u6025\u4fc3:<\/strong> \u901a\u5e38\u662f\u9aa8\u9ad3\u5167\u6d78\u6f64\u5f71\u97ff\u651c\u6c27\u8840\u6db2\u6210\u5206\u800c\u5c0e\u81f4\u56b4\u91cd\u8ca7\u8840\u7684\u7d50\u679c\u3002<\/li>\n<\/ul>\n<p>\u65e9\u671f\u767c\u73fe\u75c7\u72c0\u5c0d\u65bc\u6709\u6548\u6cbb\u7642\u81f3\u95dc\u91cd\u8981\uff0c\u56e0\u6b64\u5118\u65e9\u9032\u884c\u91ab\u7642\u8aee\u8a62\u53ef\u4ee5\u512a\u5316\u6cbb\u7642\u53ef\u80fd\u6027\uff0c\u4e26\u986f\u8457\u63d0\u9ad8\u60a3\u8005\u7684\u5b58\u6d3b\u7387\u548c\u751f\u6d3b\u8cea\u7d20\u3002\u5c0d\u65bc\u9ad8\u7d1a\u8a3a\u65b7\u7a0b\u5e8f\uff0c <a href=\"\/zh-hk\/our-hospital\/\">\u63a2\u7d22\u53ef\u7528\u7684\u8a3a\u65b7<\/a>.<\/p>\n<h2 id=\"stages-of-chronic-lymphocytic-leukemia-cll-and-survival-rates\">\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5 (CLL) \u7684\u968e\u6bb5\u548c\u751f\u5b58\u7387<\/h2>\n<p>\u7406\u89e3 <strong>\u6162\u6027\u6dcb\u5df4\u7403\u767d\u8840\u75c5 (CLL) \u968e\u6bb5<\/strong> \u5e6b\u52a9\u60a3\u8005\u53ca\u5176\u5bb6\u4eba\u660e\u78ba\u9810\u671f\u9810\u5f8c\u4ee5\u53ca\u6839\u64da\u75be\u75c5\u9032\u5c55\u91cf\u8eab\u5b9a\u5236\u7684\u53ef\u7528\u6cbb\u7642\u65b9\u6cd5\u3002\u4e0b\u9762\uff0c\u6211\u5011\u8a73\u7d30\u4ecb\u7d39\u6bcf\u500b\u968e\u6bb5\u53ca\u5176\u8207\u9999\u6e2f\u548c\u66f4\u5ee3\u6cdb\u7684\u4e9e\u6d32\u4eba\u53e3\u76f8\u95dc\u7684\u76f8\u61c9\u7279\u5fb5\uff1a<\/p>\n<h3 id=\"stage-1-early-stage-chronic-lymphocytic-leukemia-cll\">\u7b2c 1 \u671f \u2013 \u65e9\u671f\u6162\u6027\u6dcb\u5df4\u6027\u767d\u8840\u75c5 (CLL)<\/h3>\n<ul>\n<li>\u5176\u7279\u5fb5\u662f\u6dcb\u5df4\u7403\u6578\u589e\u52a0\uff0c\u4f46\u6dcb\u5df4\u7d50\u816b\u5927\u7a0b\u5ea6\u6700\u5c0f\u3002<\/li>\n<li>\u65e9\u671f CLL \u7684\u6cbb\u7642\u53ef\u80fd\u662f\u89c0\u5bdf\u548c\u5b9a\u671f\u7be9\u6aa2\uff08\u89c0\u5bdf\u548c\u7b49\u5f85\u65b9\u6cd5\uff09\uff0c\u5118\u7ba1\u53ef\u80fd\u6703\u7b56\u7565\u6027\u5730\u555f\u52d5\u6eab\u548c\u5316\u7642\u7b49\u7279\u5b9a\u4e7e\u9810\u63aa\u65bd\u3002<\/li>\n<li>\u4e9e\u6d32\uff0c\u7279\u5225\u662f\u9999\u6e2f\u7684\u751f\u5b58\u7387\u8868\u660e\uff0c\u73fe\u968e\u6bb5\u4e94\u5e74\u751f\u5b58\u7387\u8d85\u904e 90%\uff0c\u9019\u8207\u53ca\u6642\u76e3\u6e2c\u548c\u6709\u6548\u7684\u65e9\u671f\u5e79\u9810\u63aa\u65bd\u6709\u95dc\u3002<\/li>\n<\/ul>\n<h3 id=\"stage-2-intermediate-chronic-lymphocytic-leukemia-cll\">\u7b2c 2 \u671f \u2013 \u4e2d\u671f\u6162\u6027\u6dcb\u5df4\u7403\u767d\u8840\u75c5 (CLL)<\/h3>\n<ul>\n<li>\u591a\u500b\u90e8\u4f4d\u6dcb\u5df4\u7d50\u816b\u5927\u66f4\u70ba\u660e\u986f\uff0c\u6216\u813e\u81df\u548c\u809d\u81df\u8f15\u5ea6\u816b\u5927\u3002<\/li>\n<li>\u53ef\u80fd\u6703\u51fa\u73fe\u5176\u4ed6\u5168\u8eab\u6027\u75c7\u72c0\uff0c\u53cd\u6620\u51fa\u767d\u8840\u75c5\u7d30\u80de\u8ca0\u64d4\u7684\u7d2f\u7a4d\u3002<\/li>\n<li>\u6cbb\u7642\u7b56\u7565\u53ef\u80fd\u5305\u62ec\u6a19\u9776\u6cbb\u7642\u3001\u55ae\u682a\u6297\u9ad4\u3001\u5316\u7642\u7d44\u5408\u6216\u57fa\u65bc\u674e\u570b\u83ef\u535a\u58eb\u548c\u5289\u570b\u9f8d\u6559\u6388\u7b49\u9818\u5148\u816b\u7624\u5b78\u5bb6\u7372\u5f97\u8afe\u8c9d\u723e\u734e\u652f\u6301\u7684\u7814\u7a76\u7684\u4ee3\u8b1d\u5e79\u9810\u63aa\u65bd\u3002<\/li>\n<li>\u6b64\u968e\u6bb5\u7d04 70-85% \u7684\u60a3\u8005\u7d93\u904e\u9069\u7576\u6cbb\u7642\u53ef\u5be6\u73fe\u4e94\u5e74\u751f\u5b58\uff0c\u53cd\u6620\u51fa\u6162\u6027\u767d\u8840\u75c5\u60a3\u8005\u8b77\u7406\u7684\u91cd\u5927\u9032\u5c55\u3002<\/li>\n<\/ul>\n<h3 id=\"stage-3-advanced-chronic-lymphocytic-leukemia-cll\">\u7b2c 3 \u671f \u2013 \u665a\u671f\u6162\u6027\u6dcb\u5df4\u7403\u767d\u8840\u75c5 (CLL)<\/h3>\n<ul>\n<li>\u5728\u6b64\u968e\u6bb5\uff0c\u7531\u65bc\u767d\u8840\u75c5\u7d30\u80de\u5728\u9aa8\u9ad3\u5167\u7684\u6ef2\u900f\u7387\u8f03\u9ad8\uff0c\u6b63\u5e38\u8840\u7403\u751f\u6210\u6e1b\u5c11\uff0c\u60a3\u8005\u8868\u73fe\u51fa\u660e\u986f\u7684\u6dcb\u5df4\u7d50\u816b\u5927\u548c\u8ca7\u8840\u3002<\/li>\n<li>\u75b2\u52de\u3001\u611f\u67d3\u548c\u9ad4\u91cd\u6e1b\u8f15\u7b49\u75c7\u72c0\u8b8a\u5f97\u66f4\u52a0\u865b\u5f31\u3002<\/li>\n<li>\u6cbb\u7642\u6d89\u53ca\u7a4d\u6975\u7684\u591a\u6a21\u5f0f\u65b9\u6cd5\uff08\u4f8b\u5982\u806f\u5408\u5316\u7642\u3001\u514d\u75ab\u7642\u6cd5\u548c\u65b0\u578b\u4ee3\u8b1d\u65b9\u6cd5\uff09\uff0c\u65e8\u5728\u986f\u8457\u6e1b\u5c11\u767d\u8840\u75c5\u7d30\u80de\u548c\u6539\u5584\u75c7\u72c0\u3002<\/li>\n<li>\u6301\u7e8c\u5b58\u6d3b\u7387\u5404\u4e0d\u76f8\u540c\uff1b\u5927\u7d04 50% \u81f3 70% \u7684 3 \u671f\u60a3\u8005\u53ef\u4ee5\u5be6\u73fe\u4e94\u5e74\u751f\u5b58\uff0c\u51f8\u986f\u4e86\u7d9c\u5408\u75be\u75c5\u7ba1\u7406\u7b56\u7565\u7684\u91cd\u8981\u6027\u3002<\/li>\n<\/ul>\n<h3 id=\"stage-4-chronic-lymphocytic-leukemia-cll-severe-advanced-stage\">\u7b2c 4 \u671f \u2013 \u6162\u6027\u6dcb\u5df4\u7403\u767d\u8840\u75c5 (CLL) \u56b4\u91cd\u665a\u671f\u968e\u6bb5<\/h3>\n<ul>\n<li>\u6700\u56b4\u91cd\u7684\u968e\u6bb5\uff0c\u5176\u7279\u5fb5\u662f\u6dcb\u5df4\u7d30\u80de\u8a08\u6578\u6975\u9ad8\u3001\u56b4\u91cd\u8ca7\u8840\u3001\u8840\u5c0f\u677f\u6e1b\u5c11\uff08\u8840\u5c0f\u677f\u8a08\u6578\u4f4e\uff09\u3001\u5ee3\u6cdb\u7684\u6dcb\u5df4\u7d50\u816b\u5927\uff0c\u4ee5\u53ca\u813e\u81df\u548c\u809d\u81df\u7d93\u5e38\u660e\u986f\u816b\u5927\u3002<\/li>\n<li>\u8f49\u79fb\u6027\u6d78\u6f64\u53ef\u767c\u751f\u5728\u91cd\u8981\u5668\u5b98\u4e2d\uff0c\u986f\u8457\u5f71\u97ff\u529f\u80fd\u548c\u751f\u6d3b\u8cea\u7d20\u3002<\/li>\n<li>\u7b2c 4 \u671f\u7684\u6cbb\u7642\u65b9\u6cd5\u7d50\u5408\u4e86\u500b\u4eba\u5316\u7684\u5168\u8eab\u6027\u6cbb\u7642\uff0c\u5305\u62ecBTK\u6291\u5236\u5291\u7b49\u6a19\u9776\u6cbb\u7642\u3001\u55ae\u682a\u6297\u9ad4\u8207\u91dd\u5c0d\u8461\u8404\u7cd6\u651d\u53d6\uff08\u74e6\u4f2f\u683c\u6548\u61c9\uff09\u548c\u9ea9\u91af\u80fa\u9178\u4f9d\u8cf4\u6027\u7684\u5275\u65b0\u4ee3\u8b1d\u7642\u6cd5\u76f8\u7d50\u5408\uff0c\u4ee5\u5229\u7528\u767d\u8840\u75c5\u7d30\u80de\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\u3002<\/li>\n<li>\u60a3\u8005\u9762\u81e8\u6311\u6230\uff0c\u4f46\u8d8a\u4f86\u8d8a\u5148\u9032\u7684\u7642\u6cd5\uff08\u4f8b\u5982\u7d93 FDA\u3001EMA \u7b49\u5168\u7403\u6b0a\u5a01\u6a5f\u69cb\u9a57\u8b49\u4e26\u5f97\u5230 MD \u5b89\u5fb7\u68ee\u548c\u6df1\u5733\u524d\u6d77\u6cf0\u5eb7\u5408\u4f5c\u5925\u4f34\u8a8d\u53ef\u7684\u7642\u6cd5\uff09\u5728\u6162\u6027\u75c5\u7ba1\u7406\u65b9\u9762\u986f\u793a\u51fa\u4e86\u7a4d\u6975\u7684\u6210\u679c\u3002<\/li>\n<li>\u9999\u6e2f\u7684\u7d71\u8a08\u5206\u6790\u986f\u793a\uff0c3 \u81f3 5 \u5e74\u7684\u5e73\u5747\u5b58\u6d3b\u7387\u70ba 20% \u81f3 30%\uff0c\u53cd\u6620\u4e86\u76ee\u524d\u5275\u65b0\u6cbb\u7642\u548c\u500b\u4eba\u5316\u7167\u8b77\u7684\u9032\u6b65\u3002<\/li>\n<\/ul>\n<p>\u65e9\u671f\u4ecb\u5165\u53ef\u986f\u8457\u63d0\u9ad8\u5404\u968e\u6bb5\u7684\u7d50\u679c\u3002AllCancer \u7684\u5c08\u9580\u7814\u7a76\u81f4\u529b\u65bc\u5728 2025 \u5e74\u5c07\u60e1\u6027\u816b\u7624\u8f49\u8b8a\u70ba\u53ef\u63a7\u5236\u7684\u6162\u6027\u75be\u75c5\uff0c\u900f\u904e\u57fa\u65bc\u8b49\u64da\u548c\u540c\u7406\u5fc3\u7684\u7d9c\u5408\u6cbb\u7642\u7b56\u7565\uff0c\u4eba\u5011\u8d8a\u4f86\u8d8a\u6709\u5e0c\u671b\u5ef6\u9577\u3001\u512a\u8cea\u7684\u751f\u6d3b\u3002\u70ba\u4e86\u8a0e\u8ad6\u53ef\u7528\u7684\u7642\u6cd5\uff0c <a href=\"\/zh-hk\/treatment-cancer\/\">\u9020\u8a2a\u6211\u5011\u7684\u6cbb\u7642\u9078\u9805\u9801\u9762<\/a>.<\/p>\n<h2 id=\"treatment-options-for-chronic-lymphocytic-leukemia-cll\">\u6162\u6027\u6dcb\u5df4\u7403\u767d\u8840\u75c5 (CLL) \u7684\u6cbb\u7642\u9078\u64c7<\/h2>\n<p>\u591a\u5e74\u4f86\uff0c\u6162\u6027\u6dcb\u5df4\u7403\u767d\u8840\u75c5 (CLL) \u6cbb\u7642\u53d6\u5f97\u4e86\u986f\u8457\u9032\u5c55\uff0c\u5927\u5927\u6539\u5584\u4e86\u60a3\u8005\u7684\u6cbb\u7642\u6548\u679c\u3002\u7136\u800c\uff0c\u6cbb\u7642\u65b9\u6cd5\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u53d6\u6c7a\u65bc\u6bcf\u500b\u60a3\u8005\u7684\u75be\u75c5\u968e\u6bb5\u3001\u907a\u50b3\u7279\u5fb5\u3001\u6574\u9ad4\u5065\u5eb7\u72c0\u6cc1\u548c\u500b\u4eba\u504f\u597d\u3002\u5728\u9019\u88e1\uff0c\u6211\u5011\u63a2\u8a0e\u76ee\u524d\u7684\u6a19\u6e96\u7642\u6cd5\u548c\u5728\u9999\u6e2f\u548c\u4e9e\u6d32\u986f\u793a\u51fa\u5de8\u5927\u6f5b\u529b\u7684\u65b0\u8208\u66ff\u4ee3\u7642\u6cd5\u3002<\/p>\n<h3 id=\"standard-chemotherapy-and-immunotherapy\">\u6a19\u6e96\u5316\u7642\u548c\u514d\u75ab\u6cbb\u7642<\/h3>\n<p>\u5316\u7642\u4ecd\u7136\u662f\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5 (CLL) \u7684\u57fa\u672c\u6cbb\u7642\u9078\u64c7\uff0c\u901a\u5e38\u6d89\u53ca\u6c1f\u9054\u62c9\u6ff1\u3001\u74b0\u78f7\u9170\u80fa\u548c\u5229\u59a5\u6614\u55ae\u6297 (FCR) \u7b49\u7d44\u5408\u7642\u6cd5\u3002<\/p>\n<ul>\n<li>\u6c1f\u9054\u62c9\u6ff1\u4e3b\u8981\u900f\u904e\u6291\u5236 DNA \u5408\u6210\u4f86\u8a98\u5c0e\u5feb\u901f\u589e\u6b96\u7684\u7d30\u80de\u51cb\u4ea1\u3002<\/li>\n<li>\u74b0\u78f7\u9170\u80fa\u662f\u53e6\u4e00\u7a2e\u6709\u6548\u7684\u70f7\u5316\u5291\uff0c\u53ef\u7834\u58de DNA \u8907\u88fd\uff0c\u4e26\u88dc\u5145\u6c1f\u9054\u62c9\u6ff1\u8a98\u5c0e\u7684\u7d30\u80de\u51cb\u4ea1\u3002<\/li>\n<li>\u5229\u59a5\u6614\u55ae\u6297\u662f\u4e00\u7a2e\u91dd\u5c0d B \u7d30\u80de\u4e0a CD20 \u7684\u55ae\u682a\u6297\u9ad4\uff0c\u53ef\u6a19\u8a18\u764c\u7d30\u80de\u4ee5\u4f9b\u514d\u75ab\u7cfb\u7d71\u7834\u58de\u3002<\/li>\n<\/ul>\n<p>\u9019\u7a2e\u806f\u5408\u65b9\u6848\u5df2\u5728\u9999\u6e2f\u7684\u4e00\u7dda\u6cbb\u7642\u60a3\u8005\u4e2d\u8b49\u660e\u4e86\u986f\u8457\u7684\u751f\u5b58\u7372\u76ca\u548c\u9ad8\u6548\u3002\u7136\u800c\uff0c\u60a3\u8005\u7684\u8010\u53d7\u6027\u548c\u7531\u6b64\u7522\u751f\u7684\u6bd2\u6027\u9700\u8981\u4ed4\u7d30\u8003\u616e\u3002<\/p>\n<h3 id=\"targeted-therapies-in-cll-management\">CLL \u7ba1\u7406\u4e2d\u7684\u6a19\u9776\u6cbb\u7642<\/h3>\n<p>\u6a19\u9776\u6cbb\u7642\u5728\u6cbb\u7642\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u65b9\u9762\u5ee3\u53d7\u6b61\u8fce\uff0c\u5b83\u4ee5\u66f4\u9ad8\u7684\u7cbe\u5ea6\u5fb9\u5e95\u6539\u8b8a\u4e86\u6cbb\u7642\u5e79\u9810\u63aa\u65bd\uff0c\u540c\u6642\u6700\u5927\u9650\u5ea6\u5730\u6e1b\u5c11\u4e86\u50b3\u7d71\u7642\u6cd5\u4e2d\u51fa\u73fe\u7684\u9644\u5e36\u640d\u5bb3\u3002\u4e3b\u8981\u76ee\u6a19\u85e5\u7269\u5305\u62ec\uff1a<\/p>\n<ul>\n<li><strong>\u4f9d\u9b6f\u66ff\u5c3c\uff1a<\/strong> \u4e00\u7a2e\u5e03\u9b6f\u9813\u6c0f\u916a\u80fa\u9178\u6fc0\u9176 (BTK) \u6291\u5236\u5291\uff0c\u53ef\u7834\u58de B \u7d30\u80de\u589e\u6b96\u8a0a\u865f\u8def\u5f91\u3002<\/li>\n<li><strong>\u963f\u5361\u62c9\u5e03\u66ff\u5c3c\uff1a<\/strong> \u53e6\u4e00\u7a2e\u9078\u64c7\u6027 BTK \u6291\u5236\u5291\uff0c\u8207\u4f9d\u9b6f\u66ff\u5c3c\u76f8\u6bd4\uff0c\u5177\u6709\u66f4\u9ad8\u7684\u8010\u53d7\u6027\u548c\u7279\u7570\u6027\uff0c\u53ef\u964d\u4f4e\u51fa\u8840\u548c\u5fc3\u81df\u75c5\u98a8\u96aa\u3002<\/li>\n<li><strong>\u7dad\u5948\u6258\u514b\uff1a<\/strong> Venetoclax \u9776\u5411\u5c0d\u9810\u9632\u767d\u8840\u75c5\u7d30\u80de\u51cb\u4ea1\u81f3\u95dc\u91cd\u8981\u7684 BCL-2 \u86cb\u767d\uff0c\u5373\u4f7f\u5728\u4e9e\u6d32\u60a3\u8005\u7fa4\u9ad4\u7684\u6297\u85e5\u6027\u8907\u767c\u6027 CLL \u4e2d\u4e5f\u986f\u793a\u51fa\u6709\u5e0c\u671b\u7684\u7d50\u679c\u3002<\/li>\n<\/ul>\n<p>\u8fd1\u5e74\u4f86\uff0c\u6574\u5408 TP53 \u7b49\u7a81\u8b8a\u57fa\u56e0\u5206\u6790\u7684\u500b\u4eba\u5316\u65b9\u6cd5\u986f\u8457\u589e\u5f37\u4e86\u6a19\u9776\u6cbb\u7642\u6548\u679c\u3002<\/p>\n<h3 id=\"stem-cell-transplantation-in-advanced-cll\">\u5e79\u7d30\u80de\u79fb\u690d\u6cbb\u7642\u665a\u671f\u6162\u6027\u6dcb\u5df4\u7403\u767d\u8840\u75c5<\/h3>\n<p>\u7570\u9ad4\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d (HSCT) \u5c08\u70ba\u9078\u5b9a\u7684\u665a\u671f\u6216\u9ad8\u907a\u50b3\u98a8\u96aa\u60a3\u8005\u800c\u8a2d\u8a08\uff0c\u6d89\u53ca\u5728\u5f37\u5316\u5316\u7642\u5f8c\u4ee5\u4f9b\u9ad4\u5e79\u7d30\u80de\u53d6\u4ee3\u60a3\u8005\u9aa8\u9ad3\u3002<\/p>\n<ul>\n<li>\u6b64\u624b\u8853\u53ef\u986f\u8457\u63d0\u9ad8\u9577\u671f\u7de9\u89e3\u7387\uff0c\u7279\u5225\u9069\u5408\u6a19\u6e96\u6cbb\u7642\u6548\u679c\u6709\u9650\u7684\u60a3\u8005\u3002<\/li>\n<li>\u7136\u800c\uff0c\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75be\u75c5\uff08GvHD\uff09\u548c\u56b4\u91cd\u611f\u67d3\u7b49\u6f5b\u5728\u4f75\u767c\u75c7\u9700\u8981\u9999\u6e2f\u5c08\u9580\u4e2d\u5fc3\u914d\u5099\u6280\u8853\u7cbe\u6e5b\u3001\u7d93\u9a57\u8c50\u5bcc\u7684\u816b\u7624\u5718\u968a\u3002<\/li>\n<\/ul>\n<h3 id=\"innovative-metabolic-therapies\">\u5275\u65b0\u4ee3\u8b1d\u7642\u6cd5<\/h3>\n<p>\u764c\u7d30\u80de\u4ee3\u8b1d\u8106\u5f31\u6027\u70ba\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u63d0\u4f9b\u4e86\u4ee4\u4eba\u8208\u596e\u7684\u6f5b\u5728\u6cbb\u7642\u6a19\u9776\u3002<\/p>\n<ul>\n<li><strong>\u8461\u8404\u7cd6\u4ee3\u8b1d\u6291\u5236\uff1a<\/strong> \u9776\u5411\u8461\u8404\u7cd6\u4ee3\u8b1d\u9014\u5f91\uff08\u74e6\u4f2f\u683c\u6548\u61c9\uff09\u6703\u7834\u58de\u5c0d\u4fb5\u8972\u6027\u767d\u8840\u75c5\u7d30\u80de\u589e\u6b96\u81f3\u95dc\u91cd\u8981\u7684\u80fd\u91cf\u7522\u751f\u3002<\/li>\n<li><strong>\u904e\u91cf\u8f49\u904b\u86cb\u767d\u963b\u65b7\u5291\uff1a<\/strong> \u7279\u7570\u6027\u963b\u65b7\u8461\u8404\u7cd6\u8f49\u904b\u86cb\u767d\uff08\u4e3b\u8981\u662f GLUT1\/GLUT3\uff09\u7684\u85e5\u7269\u900f\u904e\u9078\u64c7\u6027\u5730\u98e2\u9913\u764c\u7d30\u80de\u800c\u4e0d\u5ee3\u6cdb\u5f71\u97ff\u6b63\u5e38\u7d30\u80de\u800c\u986f\u793a\u51fa\u6f5b\u529b\u3002<\/li>\n<li><strong>\u9ea9\u91af\u80fa\u9178\u4ee3\u8b1d\u6291\u5236\u5291\uff1a<\/strong> \u764c\u7d30\u80de\u9ad8\u5ea6\u4f9d\u8cf4\u9ea9\u91af\u80fa\u9178\u4ee3\u8b1d\uff0c\u9019\u4f7f\u5176\u6210\u70ba\u65e8\u5728\u7834\u58de\u4ee3\u8b1d\u548c\u8a98\u5c0e\u7d30\u80de\u51cb\u4ea1\u7684\u65b0\u578b\u6cbb\u7642\u7b56\u7565\u7684\u4e00\u500b\u6709\u5438\u5f15\u529b\u7684\u7126\u9ede\u3002<\/li>\n<\/ul>\n<h3 id=\"personalized-treatment-importance-in-hong-kong-and-asia\">\u500b\u4eba\u5316\u6cbb\u7642\u5728\u9999\u6e2f\u548c\u4e9e\u6d32\u7684\u91cd\u8981\u6027<\/h3>\n<p>\u7531\u65bc\u6cbb\u7642\u7d50\u679c\u56e0\u57fa\u56e0\u7279\u5fb5\u548c\u60a3\u8005\u6574\u9ad4\u5065\u5eb7\u72c0\u6cc1\u800c\u6709\u5f88\u5927\u5dee\u7570\uff0c\u9999\u6e2f\u7684\u91ab\u7642\u4fdd\u5065\u63d0\u4f9b\u8005\u5f37\u8abf\u500b\u4eba\u5316\u91ab\u7642\u6846\u67b6\u3002\u6839\u64da\u5ee3\u6cdb\u7684\u57fa\u56e0\u7d44\u5206\u6790\u548c\u9810\u671f\u6cbb\u7642\u7d50\u679c\u91cf\u8eab\u5b9a\u5236\u7684\u6cbb\u7642\u9078\u64c7\u53ef\u986f\u8457\u512a\u5316\u751f\u5b58\u548c\u751f\u6d3b\u8cea\u7d20\u3002<\/p>\n<h2 id=\"limitations-of-traditional-therapies-for-chronic-lymphocytic-leukemia-cll\">\u6162\u6027\u6dcb\u5df4\u7403\u767d\u8840\u75c5 (CLL) \u50b3\u7d71\u7642\u6cd5\u7684\u5c40\u9650\u6027<\/h2>\n<p>\u5118\u7ba1\u6cbb\u7642\u65b9\u6cd5\u53d6\u5f97\u4e86\u9032\u6b65\uff0c\u4f46\u6162\u6027\u6dcb\u5df4\u7403\u767d\u8840\u75c5\uff08CLL\uff09\u4ecd\u9762\u81e8\u8457\u5de8\u5927\u7684\u6cbb\u7642\u6311\u6230\u3002\u50b3\u7d71\u7642\u6cd5\u96d6\u7136\u6709\u50f9\u503c\uff0c\u4f46\u901a\u5e38\u5177\u6709\u9650\u5236\u548c\u526f\u4f5c\u7528\uff0c\u5c0d\u60a3\u8005\u7684\u6cbb\u7642\u7d50\u679c\u548c\u751f\u6d3b\u8cea\u7d20\u7522\u751f\u4e0d\u5229\u5f71\u97ff\u3002<\/p>\n<h3 id=\"chemotherapy-conundrums\">\u5316\u7642\u96e3\u984c<\/h3>\n<p>FCR \u7b49\u5316\u7642\u65b9\u6848\u96d6\u7136\u6700\u521d\u5c0d\u8a31\u591a\u60a3\u8005\u6709\u6548\uff0c\u4f46\u6703\u7522\u751f\u5927\u91cf\u526f\u4f5c\u7528\uff0c\u53ef\u80fd\u6703\u9650\u5236\u5176\u9577\u671f\u6548\u7528\u4e26\u5f71\u97ff\u9999\u6e2f\u4eba\u53e3\u7684\u751f\u6d3b\u8cea\u7d20\u3002<\/p>\n<ul>\n<li><strong>\u9aa8\u9ad3\u6291\u5236\uff1a<\/strong> \u8d85\u904e70%\u7684\u60a3\u8005\u514d\u75ab\u529f\u80fd\u986f\u8457\u4e0b\u964d\uff0c\u611f\u67d3\u6613\u611f\u6027\u589e\u52a0\uff0c\u5c0e\u81f4\u4f4f\u9662\u6642\u9593\u5ef6\u9577\u548c\u6cbb\u7642\u4e2d\u65b7\u3002<\/li>\n<li><strong>\u5fc3\u81df\u6bd2\u6027\uff1a<\/strong> \u5927\u7d04 23% \u7684\u4eba\u7d93\u6b77\u904e\u57fa\u65bc\u84bd\u74b0\u985e\u5316\u7642\u7684\u5fc3\u81df\u4e0d\u826f\u4e8b\u4ef6\uff0c\u56b4\u91cd\u640d\u5bb3\u4e86\u5fc3\u81df\u5065\u5eb7\u3002<\/li>\n<li><strong>\u7e7c\u767c\u6027\u764c\u75c7\uff1a<\/strong> \u6cbb\u7642\u76f8\u95dc\u764c\u75c7\u7684\u98a8\u96aa\u589e\u52a0\uff08\u9ad8\u9054 300%\uff09\uff0c\u56b4\u91cd\u5f71\u97ff\u9577\u671f\u5b58\u6d3b\u8005\u7684\u7d50\u5c40\u3002<\/li>\n<\/ul>\n<h3 id=\"radiotherapy-related-adverse-effects\">\u653e\u5c04\u6cbb\u7642\u76f8\u95dc\u7684\u4e0d\u826f\u53cd\u61c9<\/h3>\n<p>\u5728\u6b98\u9918\u6dcb\u5df4\u7d50\u816b\u5927\u6216\u5b89\u5be7\u7642\u8b77\u74b0\u5883\u4e2d\u9032\u884c\u7684\u653e\u5c04\u6cbb\u7642\u4e5f\u6703\u5c0d\u9999\u6e2f\u60a3\u8005\u7522\u751f\u986f\u8457\u7684\u6f5b\u5728\u4e0d\u826f\u5f8c\u679c\uff1a<\/p>\n<ul>\n<li><strong>\u7d44\u7e54\u640d\u50b7\uff1a<\/strong> \u653e\u5c04\u6cbb\u7642\u5e38\u4f34\u96a8\u5065\u5eb7\u7d44\u7e54\u640d\u50b7\uff0c\u5c0e\u81f4\u6162\u6027\u75bc\u75db\u3002<\/li>\n<li><strong>\u7e7c\u767c\u6027\u60e1\u6027\u816b\u7624\uff1a<\/strong> \u653e\u5c04\u5f8c\u7d30\u80de\u640d\u50b7\u53ef\u80fd\u6703\u589e\u52a0\u4ee5\u5f8c\u7e7c\u767c\u6027\u764c\u75c7\u7684\u98a8\u96aa\uff0c\u4f7f\u60a3\u8005\u7684\u9810\u5f8c\u986f\u8457\u8907\u96dc\u5316\u3002<\/li>\n<\/ul>\n<h3 id=\"limitations-associated-with-surgery-and-transplant-procedures\">\u8207\u624b\u8853\u548c\u79fb\u690d\u7a0b\u5e8f\u76f8\u95dc\u7684\u9650\u5236<\/h3>\n<p>CLL \u4f75\u767c\u75c7\u7684\u624b\u8853\u65b9\u6cd5\uff08\u4f8b\u5982\u813e\u5207\u9664\u8853\uff09\u5177\u6709\u56fa\u6709\u7684\u98a8\u96aa\uff0c\u5305\u62ec\uff1a<\/p>\n<ul>\n<li><strong>\u624b\u8853\u4f75\u767c\u75c7\uff1a<\/strong> \u5118\u7ba1\u91ab\u7642\u9032\u6b65\u548c\u570d\u8853\u671f\u6297\u751f\u7d20\u4f7f\u7528\uff0c\u624b\u8853\u5f8c\u611f\u67d3\u7684\u98a8\u96aa\u4ecd\u7136\u666e\u904d\u5b58\u5728\uff0c\u9019\u5927\u5927\u5ef6\u9072\u4e86\u60a3\u8005\u7684\u5eb7\u5fa9\u3002<\/li>\n<li><strong>\u9ad8\u5ea6\u4f9d\u8cf4\u6350\u6b3e\u8005\u7684\u53ef\u7528\u6027\uff1a<\/strong> \u5e79\u7d30\u80de\u79fb\u690d\u53d7\u8005\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u4f9d\u8cf4\u4f9b\u9ad4\u9aa8\u9ad3\u7684\u53ef\u7528\u6027\u2014\u2014\u5728\u4e9e\u6d32\u5730\u5340\u5c24\u5176\u5177\u6709\u6311\u6230\u6027\u3002<\/li>\n<\/ul>\n<h3 id=\"metabolic-resistance-and-disease-recurrence\">\u4ee3\u8b1d\u62b5\u6297\u548c\u75be\u75c5\u5fa9\u767c<\/h3>\n<p>\u764c\u7d30\u80de\u7fa4\u9ad4\u7684\u62b5\u6297\u6a5f\u5236\u4f7f\u6cbb\u7642\u66f4\u52a0\u8907\u96dc\uff1a<\/p>\n<ul>\n<li><strong>\u589e\u5f37\u7684 DNA \u4fee\u5fa9\u80fd\u529b\uff1a<\/strong> \u764c\u7d30\u80de\u7684 DNA \u4fee\u5fa9\u9176\u904e\u7a0b\u6d3b\u6027\u589e\u52a0\u4e86\u7d04 400%\uff0c\u5f9e\u800c\u964d\u4f4e\u4e86\u57fa\u56e0\u6bd2\u6027\u7642\u6cd5\u7684\u6709\u6548\u6027\u3002<\/li>\n<li><strong>\u4ee3\u8b1d\u53ef\u5851\u6027\uff1a<\/strong> \u816b\u7624\u900f\u904e\u91cd\u65b0\u7de8\u7a0b\u4ee3\u8b1d\u9014\u5f91\u4f86\u5feb\u901f\u9069\u61c9\uff0c\u9650\u5236\u5c0d\u50b3\u7d71\u6cbb\u7642\u7684\u6301\u7e8c\u53cd\u61c9\uff0c\u4e26\u5f37\u8abf\u5c0d\u5275\u65b0\u4ee3\u8b1d\u6cbb\u7642\u65b9\u6cd5\u7684\u9700\u6c42\u3002<\/li>\n<\/ul>\n<p>\u900f\u904e\u8a8d\u8b58\u50b3\u7d71\u6cbb\u7642\u7684\u5c40\u9650\u6027\u4e26\u5229\u7528\u6709\u95dc\u4ee3\u8b1d\u6027\u764c\u7d30\u80de\u8106\u5f31\u6027\u548c\u91dd\u5c0d\u6027\u6cbb\u7642\u5275\u65b0\u7684\u65b0\u77e5\u8b58\uff0c\u5168\u9762\u7684 CLL \u7ba1\u7406\u9032\u6b65\u70ba\u6539\u5584\u60a3\u8005\u8b77\u7406\u7d50\u679c\u63d0\u4f9b\u4e86\u5de8\u5927\u7684\u6a02\u89c0\u524d\u666f\uff0c\u7279\u5225\u662f\u5728\u9999\u6e2f\u548c\u66f4\u5ee3\u6cdb\u7684\u4e9e\u6d32\u80cc\u666f\u4e0b\u3002<\/p>\n<h2>4D \u764c\u75c7\u7642\u6cd5\u6cbb\u7642\u65b9\u6cd5<\/h2>\n<p>\u9999\u6e2f\u4ee3\u8b1d\u816b\u7624\u6cbb\u7642\u4e2d\u5fc3\u63d0\u51fa\u76844D \u7642\u6cd5\u4ee3\u8868\u4e86\u4e00\u7a2e\u591a\u5c64\u9762\u7684\u764c\u75c7\u6cbb\u7642\u65b9\u6cd5\uff0c\u65e8\u5728\u5c07\u764c\u75c7\u8f49\u8b8a\u70ba\u53ef\u63a7\u5236\u7684\u6162\u6027\u75be\u75c5\u3002\u672c\u8abf\u67e5\u5831\u544a\u57fa\u65bc\u6240\u63d0\u4f9b\u7684\u6587\u4ef6\uff0c\u4e26\u900f\u904e\u57fa\u65bc\u7db2\u8def\u7684\u79d1\u5b78\u6587\u737b\u7684\u5ee3\u6cdb\u7814\u7a76\u9032\u884c\u4e86\u88dc\u5145\uff0c\u5c0d\u56db\u7a2e\u65b9\u6cd5\uff08\u4ee3\u8b1d\u6291\u5236\u3001\u7bc0\u594f\u6027\u816b\u7624\u63a7\u5236\u3001\u57fa\u56e0\u9776\u5411\u65ac\u9996\u548c\u514d\u75ab\u98a8\u66b4\u555f\u52d5\uff09\u9032\u884c\u4e86\u5168\u9762\u5206\u6790\u3002\u5206\u6790\u5305\u62ec\u79d1\u5b78\u539f\u7406\u3001\u81e8\u5e8a\u8b49\u64da\u548c\u6f5b\u5728\u6311\u6230\uff0c\u6700\u7d42\u63d0\u51fa\u4e86\u53e3\u865f\u548c\u53e3\u865f\u3002<\/p>\n<h3>\u4ee3\u8b1d\u6291\u5236<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u9019\u7a2e\u65b9\u6cd5\u91dd\u5c0d\u764c\u7d30\u80de\u7684\u4ee3\u8b1d\u8106\u5f31\u6027\uff0c\u7279\u5225\u662f\u5b83\u5011\u5c0d\u8461\u8404\u7cd6\u3001\u9ea9\u91af\u80fa\u9178\u548c\u8102\u8cea\u5408\u6210\u7684\u4f9d\u8cf4\u3002\u5b83\u4f7f\u7528\u8af8\u5982\u7528\u65bc\u8461\u8404\u7cd6\u8f49\u904b\u7684 GLUT1\/3\u3001\u7528\u65bc\u8c37\u6c28\u9170\u80fa\u4ee3\u8b1d\u7684 GLS\/ASCT2 \u4ee5\u53ca\u7528\u65bc\u8102\u8cea\u5408\u6210\u7684 FASN \u7b49\u6291\u5236\u5291\uff0c\u901a\u5e38\u900f\u904e\u5948\u7c73\u8f09\u9ad4\u905e\u9001\u3002\u4eba\u5de5\u667a\u6167\u9a45\u52d5\u7684\u71df\u990a\u8abf\u7bc0\u63d0\u9ad8\u4e86\u7cbe\u78ba\u5ea6\uff0c\u65e8\u5728\u5f15\u767c ATP \u5371\u6a5f\u4e26\u524a\u5f31\u764c\u7d30\u80de\u3002\u6587\u4ef6\u8072\u7a31\u816b\u7624\u8461\u8404\u7cd6\u651d\u53d6\u6e1b\u5c11\u4e86 82%\uff0c\u8840\u6f3f\u9ea9\u91af\u80fa\u9178\u6e1b\u5c11\u4e86 79%\uff0c\u819c\u78f7\u8102\u5408\u6210\u6e1b\u5c11\u4e86 91%\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u7814\u7a76\uff0c\u4f8b\u5982 <a href=\"https:\/\/www.nature.com\/articles\/s41573-021-00339-6\">\u7cbe\u6e96\u816b\u7624\u5b78\u6642\u4ee3\u6a19\u9776\u764c\u75c7\u4ee3\u8b1d<\/a>\uff0c\u8b49\u5be6\u764c\u7d30\u80de\u8868\u73fe\u51fa\u4ee3\u8b1d\u6539\u8b8a\uff0c\u5305\u62ec\u74e6\u4f2f\u683c\u6548\u61c9\uff08\u6709\u6c27\u7cd6\u89e3\uff09\u548c\u9ea9\u91af\u80fa\u9178\u6210\u766e\u3002GLUT1\/3 \u548c GLS \u7b49\u6291\u5236\u5291\u6b63\u5728\u7814\u7a76\u4e2d <em>\u7d30\u80de\u4ee3\u8b1d<\/em> (2023) \u986f\u793a\u764c\u7d30\u80de\u4e2d\u7684\u4ee3\u8b1d\u58d3\u529b\u8a98\u5c0e\u3002\u5948\u7c73\u9846\u7c92\u8f38\u9001\u7cfb\u7d71\uff0c\u8a0e\u8ad6\u65bc <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590183420300028\">\u764c\u75c7\u6cbb\u7642\u4e2d\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u8f38\u9001<\/a>\uff0c\u589e\u5f37\u7279\u7570\u6027\uff0c\u5118\u7ba1\u816b\u7624\u7570\u8cea\u6027\u548c\u812b\u9776\u6548\u61c9\u7b49\u6311\u6230\u4ecd\u7136\u5b58\u5728\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u6240\u8072\u7a31\u7684\u81e8\u5e8a\u76ca\u8655\u8207\u65b0\u8208\u8a66\u9a57\u4e00\u81f4\uff0c\u4f46\u764c\u75c7\u985e\u578b\uff08\u4f8b\u5982\u80ba\u764c\u8207\u4e73\u764c\uff09\u548c\u60a3\u8005\u53cd\u61c9\u7684\u5dee\u7570\u8868\u660e\u9700\u8981\u500b\u6027\u5316\u7684\u65b9\u6cd5\u30022024\u5e74 <em>\u7d30\u80de<\/em> \u6587\u4ef6\u4e2d\u5f15\u7528\u7684\u7814\u7a76\u8072\u7a31\u6297\u85e5\u6027\u57fa\u56e0\u8868\u73fe\u6e1b\u5c11\u4e86 80%\uff0c\u9700\u8981\u900f\u904e\u66f4\u5927\u898f\u6a21\u7684\u591a\u4e2d\u5fc3\u8a66\u9a57\u9032\u884c\u9a57\u8b49\u3002\u502b\u7406\u65b9\u9762\u7684\u8003\u616e\uff0c\u4f8b\u5982\u7372\u53d6\u548c\u8ca0\u64d4\u80fd\u529b\uff0c\u5728 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2949723X23000533\">\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u50b3\u8f38\u7cfb\u7d71\u7684\u529f\u6548\u56de\u9867<\/a>.<\/p>\n<h3>\u7bc0\u594f\u6027\u816b\u7624\u63a7\u5236<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528\u4f4e\u5291\u91cf\u3001\u7bc0\u5f8b\u5316\u7642\uff08\u50b3\u7d71\u5291\u91cf\u7684 1\/10\uff09\u548c\u8840\u7ba1\u6b63\u5e38\u5316\u56e0\u5b50\u4f86\u63a7\u5236\u816b\u7624\u751f\u9577\uff0c\u964d\u4f4e\u6bd2\u6027\u4e26\u5be6\u73fe 67% \u7684\u5bb6\u5ead\u6cbb\u7642\u3002\u64da\u8072\u7a31\uff0c\u5b83\u5c07\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u5f9e 5.2 \u500b\u6708\u5ef6\u9577\u81f3 11.8 \u500b\u6708\uff0c\u4e26\u5c07\u56b4\u91cd\u6bd2\u6027\u964d\u4f4e 67%\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u4f4e\u5291\u91cf\u7bc0\u5f8b\u5316\u7642\u5df2\u88ab\u5ee3\u6cdb\u63a5\u53d7\uff0c\u5982 <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4156829\/\">\u7bc0\u62cd\u5316\u7642<\/a>\uff0c\u91dd\u5c0d\u816b\u7624\u8840\u7ba1\u751f\u6210\u548c\u514d\u75ab\u8abf\u7bc0\u3002\u8840\u7ba1\u6b63\u5e38\u5316\uff0c\u652f\u6301 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405844024007011\">\u7bc0\u62cd\u5316\u7642\u548c\u85e5\u7269\u518d\u5229\u7528<\/a>\uff0c\u900f\u904e\u589e\u5f37\u8840\u7ba1\u529f\u80fd\u4f86\u6539\u5584\u85e5\u7269\u8f38\u9001\u3002\u7814\u7a76\u5982 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0959804913005418\">\u4f4e\u5291\u91cf\u7bc0\u62cd\u5316\u7642\uff1a\u7cfb\u7d71\u6027\u6587\u737b\u5206\u6790<\/a> \u78ba\u8a8d\u6e1b\u5c11\u7684\u526f\u4f5c\u7528\u548c\u6f5b\u5728\u7684\u6210\u672c\u6548\u76ca\uff0c\u7279\u5225\u662f\u5728\u4f4e\u6536\u5165\u74b0\u5883\u4e2d\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684\u76ca\u8655\u8207\u8f49\u79fb\u6027\u4e73\u764c\u7684\u81e8\u5e8a\u6578\u64da\u4e00\u81f4\uff0c\u4f46\u7642\u6548\u53ef\u80fd\u56e0\u816b\u7624\u985e\u578b\u548c\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u800c\u7570\u3002\u5bb6\u5ead\u6cbb\u7642\u6a21\u5f0f\u96d6\u7136\u6709\u5e0c\u671b\uff0c\u4f46\u9700\u8981\u5805\u6301\u548c\u76e3\u6e2c\uff0c\u5982 <a href=\"https:\/\/www.lifespringcancercenter.com\/our-treatment\/low-dose-metronomic-chemotherapy\">\u751f\u547d\u6cc9\u764c\u75c7\u6cbb\u7642\u4e2d\u5fc3<\/a>\u3002\u95dc\u65bc\u6297\u85e5\u6027\u548c\u751f\u6d3b\u8cea\u7d20\u7684\u9577\u671f\u6578\u64da\u9700\u8981\u9032\u4e00\u6b65\u63a2\u7d22\u3002<\/p>\n<h3>\u57fa\u56e0\u6a19\u9776\u65ac\u9996<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528\u6db2\u9ad4\u6d3b\u6aa2\u4f86\u6aa2\u6e2c 487 \u500b\u764c\u75c7\u9a45\u52d5\u57fa\u56e0\uff0c\u4e26\u4f7f\u7528\u5948\u7c73\u9846\u7c92\u905e\u9001\u7cfb\u7d71\u4f86\u9776\u5411 KRAS\u3001BRAF \u548c TP53 \u7b49\u7a81\u8b8a\uff0c\u5f9e\u800c\u514b\u670d\u8840\u8166\u5c4f\u969c\u7b49\u969c\u7919\u3002\u5b83\u8072\u7a31 ORR \u63d0\u9ad8\u4e86 67%\uff0c\u905e\u9001\u6548\u7387\u63d0\u9ad8\u4e86 9 \u500d\uff0c\u7279\u5225\u662f\u5c0d\u65bc\u8f49\u79fb\u7624\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u5948\u7c73\u9846\u7c92\u8f38\u9001\u662f\u4e00\u500b\u524d\u6cbf\u9818\u57df\uff0c <a href=\"https:\/\/www.cancer.gov\/nano\/cancer-nanotechnology\/treatment\">\u5948\u7c73\u6280\u8853\u764c\u75c7\u6cbb\u7642\u548c\u6cbb\u7642<\/a> \u5f37\u8abf\u5176\u7a7f\u900f\u751f\u7406\u5c4f\u969c\u7684\u80fd\u529b\u3002\u6db2\u9ad4\u6d3b\u6aa2\uff0c\u8a0e\u8ad6\u65bc <a href=\"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03433-8\">\u63a8\u9032\u764c\u75c7\u57fa\u56e0\u6cbb\u7642<\/a>\uff0c\u5be6\u73fe\u5373\u6642\u7a81\u8b8a\u6aa2\u6e2c\uff0c\u8207\u7cbe\u6e96\u816b\u7624\u5b78\u8da8\u52e2\u4fdd\u6301\u4e00\u81f4\u3002\u7814\u7a76\u65bc <a href=\"https:\/\/www.nature.com\/articles\/s41392-023-01642-x\">\u7528\u65bc\u764c\u75c7\u6cbb\u7642\u7684\u667a\u6167\u5948\u7c73\u9846\u7c92<\/a> \u5118\u7ba1\u6bd2\u6027\u548c\u9776\u5411\u7279\u7570\u6027\u7b49\u6311\u6230\u4ecd\u7136\u5b58\u5728\uff0c\u4f46\u5b83\u986f\u793a\u51fa\u6cbb\u7642\u8166\u8f49\u79fb\u7684\u5e0c\u671b\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684 ORR \u70ba 67% \u662f\u96c4\u5fc3\u52c3\u52c3\u7684\uff0c\u96d6\u7136\u65e9\u671f\u8a66\u9a57\u986f\u793a\u51fa\u5e0c\u671b\uff0c\u4f46\u9700\u8981\u66f4\u5927\u898f\u6a21\u7684\u7814\u7a76\u4f86\u9a57\u8b49\u8de8\u816b\u7624\u985e\u578b\u7684\u7642\u6548\u3002\u816b\u7624\u7570\u8cea\u6027\uff0c\u5982\u4e2d\u6240\u8ff0 <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-023-01865-0\">\u9032\u6b65\u5948\u7c73\u6280\u8853\u4ee5\u6539\u5584\u6a19\u9776\u764c\u75c7\u6cbb\u7642<\/a>\uff0c\u53ef\u80fd\u6703\u9650\u88fd\u6210\u529f\uff0c\u9700\u8981\u7d44\u5408\u7b56\u7565\u3002<\/p>\n<h3>\u514d\u75ab\u98a8\u66b4\u555f\u52d5<\/h3>\n<p><strong>\u7e3d\u7d50\u8207\u6a5f\u5236<\/strong>\uff1a\u6b64\u65b9\u6cd5\u4f7f\u7528 PD-1\/CTLA-4 \u6291\u5236\u5291\u3001\u65b0\u6297\u539f\u75ab\u82d7\u3001CAR-NK \u7d30\u80de\u548c\u5fae\u751f\u7269\u7d44\u8abf\u7bc0\u4f86\u6d3b\u5316\u591a\u5c64\u514d\u75ab\u53cd\u61c9\u3002\u5b83\u8072\u7a31 3 \u5e74\u5b58\u6d3b\u7387\u70ba 62.7%\uff08\u6539\u5584\u4e86 244%\uff09\uff0c\u5fa9\u767c\u7387\u964d\u4f4e\u4e86 85%\uff0c\u5c07\u300c\u51b7\u300d\u816b\u7624\u8f49\u8b8a\u70ba\u300c\u71b1\u300d\u816b\u7624\u3002<\/p>\n<p><strong>\u79d1\u5b78\u4f9d\u64da<\/strong>\uff1a\u806f\u5408\u514d\u75ab\u7642\u6cd5\u662f\u9818\u5148\u9818\u57df\uff0c <a href=\"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-021-01164-5\">\u6700\u5927\u5316\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u76ca\u8655\u7684\u7d44\u5408\u7b56\u7565<\/a> \u986f\u793a\u51fa\u589e\u5f37\u7684\u53cd\u61c9\u3002\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u3001\u65b0\u6297\u539f\u75ab\u82d7\u548c CAR-T\/NK \u7642\u6cd5\uff0c\u53c3\u898b <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-025-02305-x\">\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u7684\u9032\u5c55<\/a>\u3001\u63d0\u9ad8\u514d\u75ab\u8fa8\u8b58\u80fd\u529b\u3002\u5fae\u751f\u7269\u7d44\u8abf\u7bc0\uff0c\u7a81\u51fa\u986f\u793a\u65bc <a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-021-01316-8\">\u764c\u75c7\u4ee3\u8b1d\u91cd\u7de8\u7a0b\u548c\u514d\u75ab\u53cd\u61c9<\/a>\uff0c\u5f71\u97ff\u514d\u75ab\u6cbb\u7642\u7684\u7d50\u679c\uff0c\u5118\u7ba1\u5176\u4e00\u81f4\u6027\u6709\u722d\u8b70\u3002<\/p>\n<p><strong>\u81e8\u5e8a\u8b49\u64da\u8207\u6311\u6230<\/strong>\uff1a\u8072\u7a31\u7684\u751f\u5b58\u7387\u8207\u6700\u8fd1\u7684\u8a66\u9a57\u4e00\u81f4\uff0c\u4f46\u5be6\u9ad4\u7624\u7531\u65bc\u7570\u8cea\u6027\u548c\u514d\u75ab\u6291\u5236\u5fae\u74b0\u5883\u800c\u5e36\u4f86\u6311\u6230\uff0c\u5982 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u6700\u65b0\u9032\u5c55<\/a>\u3002\u95dc\u65bc\u5fa9\u767c\u548c\u514d\u75ab\u8a18\u61b6\u7684\u9577\u671f\u6578\u64da\u9700\u8981\u9032\u4e00\u6b65\u9a57\u8b49\u3002<\/p>\n<h3>\u6bd4\u8f03\u81e8\u5e8a\u7d50\u679c<\/h3>\n<p>\u9019\u4e9b\u6587\u4ef6\u63d0\u4f9b\u4e86\u4e00\u500b\u6bd4\u8f03\u50b3\u7d71\u7642\u6cd5\u548c\u56db\u7dad\u7642\u6cd5\u7684\u8868\u683c\uff0c\u70ba\u6e05\u695a\u8d77\u898b\uff0c\u5c07\u5176\u8907\u88fd\u5982\u4e0b\uff1a<\/p>\n<figure>\n<table class=\"has-fixed-layout\">\n<tbody>\n<tr>\n<td>\u6307\u6a19<\/td>\n<td>\u50b3\u7d71\u7684<br \/>\u6cbb\u7642<\/td>\n<td>\u56db\u7dad<br \/>\u6cbb\u7642<\/td>\n<td>\u6539\u9032<\/td>\n<\/tr>\n<tr>\n<td>\u5ba2\u89c0\u7de9\u89e3\u7387 (ORR)<\/td>\n<td>31%<\/td>\n<td>67%<\/td>\n<td>\u2191116%<\/td>\n<\/tr>\n<tr>\n<td>3 \u5e74\u5b58\u6d3b\u7387<\/td>\n<td>18%<\/td>\n<td>62.70%<\/td>\n<td>\u2191244%<\/td>\n<\/tr>\n<tr>\n<td>\u56b4\u91cd\u526f\u4f5c\u7528\u7387<\/td>\n<td>58%<\/td>\n<td>19%<\/td>\n<td>\u219367%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\u8868\u683c\u5f37\u8abf\u4e86\u8a72\u7642\u6cd5\u7684\u6f5b\u529b\uff0c\u4f46\u60a3\u8005\u7fa4\u9ad4\u548c\u816b\u7624\u985e\u578b\u4e4b\u9593\u7684\u5dee\u7570\u503c\u5f97\u9032\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n<h2><strong>\u7e3d\u7d50<\/strong><\/h2>\n<p>4D \u7642\u6cd5\u6574\u5408\u4e86\u89e3\u6c7a\u764c\u75c7\u8907\u96dc\u6027\u7684\u5c16\u7aef\u7b56\u7565\uff0c\u6bcf\u7a2e\u65b9\u6cd5\u90fd\u5f97\u5230\u65b0\u8208\u7814\u7a76\u7684\u652f\u6301\u3002\u7136\u800c\uff0c\u816b\u7624\u7570\u8cea\u6027\u3001\u81e8\u5e8a\u9a57\u8b49\u548c\u53ef\u8fd1\u6027\u7b49\u6311\u6230\u9700\u8981\u4e0d\u65b7\u63a2\u7d22\u3002\u5efa\u8b70\u7684\u53e3\u865f\u548c\u53e3\u865f\u65e8\u5728\u9ad4\u73fe\u8a72\u7642\u6cd5\u7684\u627f\u8afe\uff0c\u4e26\u5f15\u767c\u5c0d\u5176\u6539\u8b8a\u764c\u75c7\u6cbb\u7642\u6f5b\u529b\u7684\u9032\u4e00\u6b65\u8a0e\u8ad6\u3002<\/p>\n<h2>\u53c3\u8003\u6587\u737b<\/h2>\n<ul>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41573-021-00339-6\">\u7cbe\u6e96\u816b\u7624\u5b78\u6642\u4ee3\u6a19\u9776\u764c\u75c7\u4ee3\u8b1d<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2590183420300028\">\u764c\u75c7\u6cbb\u7642\u4e2d\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u8f38\u9001<\/a><\/li>\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4156829\/\">\u7bc0\u62cd\u5316\u7642<\/a><\/li>\n<li><a href=\"https:\/\/jnanobiotechnology.biomedcentral.com\/articles\/10.1186\/s12951-025-03433-8\">\u63a8\u9032\u764c\u75c7\u57fa\u56e0\u6cbb\u7642<\/a><\/li>\n<li><a href=\"https:\/\/jhoonline.biomedcentral.com\/articles\/10.1186\/s13045-021-01164-5\">\u6700\u5927\u5316\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u76ca\u8655\u7684\u7d44\u5408\u7b56\u7565<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u6700\u65b0\u9032\u5c55<\/a><\/li>\n<li><a href=\"https:\/\/www.cancer.gov\/nano\/cancer-nanotechnology\/treatment\">\u5948\u7c73\u6280\u8853\u764c\u75c7\u6cbb\u7642\u548c\u6cbb\u7642<\/a><\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41392-023-01642-x\">\u7528\u65bc\u764c\u75c7\u6cbb\u7642\u7684\u667a\u6167\u5948\u7c73\u9846\u7c92<\/a><\/li>\n<li><a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-021-01316-8\">\u764c\u75c7\u4ee3\u8b1d\u91cd\u7de8\u7a0b\u548c\u514d\u75ab\u53cd\u61c9<\/a><\/li>\n<li><a href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-025-02305-x\">\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u7684\u9032\u5c55<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405844024007011\">\u7bc0\u62cd\u5316\u7642\u548c\u85e5\u7269\u518d\u5229\u7528<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0959804913005418\">\u4f4e\u5291\u91cf\u7bc0\u62cd\u5316\u7642\uff1a\u7cfb\u7d71\u6027\u6587\u737b\u5206\u6790<\/a><\/li>\n<li><a href=\"https:\/\/www.lifespringcancer.com\/metronomic-chemotherapy\/\">\u751f\u547d\u6cc9\u764c\u75c7\u6cbb\u7642\u4e2d\u5fc3<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u57fa\u65bc\u5948\u7c73\u9846\u7c92\u7684\u85e5\u7269\u50b3\u8f38\u7cfb\u7d71\u7684\u529f\u6548\u56de\u9867<\/a><\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2772906024004989\">\u9032\u6b65\u5948\u7c73\u6280\u8853\u4ee5\u6539\u5584\u6a19\u9776\u764c\u75c7\u6cbb\u7642<\/a><\/li>\n<\/ul>\n<hr>\n<div class=\"ac-blog-cta\">\n<h2>\u9700\u8981\u5354\u52a9\u4e86\u89e3\u6cbb\u7642\u9078\u64c7\uff1f<\/h2>\n<p>\u6211\u5011\u7684\u60a3\u8005\u670d\u52d9\u5718\u968a\u53ef\u4ee5\u5e6b\u52a9\u60a8\u6e96\u5099\u5831\u544a\u4e26\u5b89\u6392\u9069\u7576\u7684\u5c08\u5bb6\u8aee\u8a62\u3002\u672c\u6587\u662f\u4e00\u822c\u8a0a\u606f\uff0c\u800c\u4e0d\u662f\u8a3a\u65b7\u3002<\/p>\n<p><a href=\"\/zh-hk\/appointment\/\">\u7acb\u5373\u9810\u7d04<\/a> &nbsp;|&nbsp; <a href=\"\/zh-hk\/cancer\/\">\u63a2\u7d22\u6240\u6709\u764c\u75c7\u985e\u578b<\/a><\/p>\n<\/div>\n<p class=\"ac-blog-disclaimer\"><em>\u91ab\u7642\u514d\u8cac\u8072\u660e\uff1a\u672c\u6587\u50c5\u7528\u65bc\u4e00\u822c\u6559\u80b2\uff0c\u4e0d\u80fd\u53d6\u4ee3\u5408\u683c\u81e8\u5e8a\u91ab\u751f\u7684\u5efa\u8b70\u3002\u6cbb\u7642\u6c7a\u5b9a\u61c9\u57fa\u65bc\u500b\u4eba\u7684\u8a3a\u65b7\u3001\u5206\u671f\u3001\u75c5\u7406\u548c\u6574\u9ad4\u5065\u5eb7\u72c0\u6cc1\u3002\u5982\u679c\u60a8\u767c\u73fe\u6301\u7e8c\u6216\u4ee4\u4eba\u64d4\u6182\u7684\u75c7\u72c0\uff0c\u8acb\u5c0b\u6c42\u91ab\u7642\u8a55\u4f30\u3002<\/em><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5 (CLL) \u662f\u4e00\u7a2e\u900f\u904e\u7522\u751f\u904e\u91cf\u7570\u5e38\u6dcb\u5df4\u7d30\u80de\uff08\u767d\u8840\u7403\u7684\u4e00\u7a2e\u4e9e\u578b\uff09\u4f86\u5f71\u97ff\u8840\u6db2\u548c\u9aa8\u9ad3\u7684\u764c\u75c7\u3002<\/p>","protected":false},"featured_media":316,"menu_order":111,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center 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